CLUSTAL W (1.82) multiple sequence alignment SINFRUP00000141797 ------------------------------------------------------------ SINFRUP00000148078 ------------------------------------------------------------ SINFRUP00000127562 ------------------------------------------------------------ ENST00000261961 ------------------------------------------------------------ ENSMUST00000026994 ------------------------------------------------------------ ENST00000287272 ------------------------------------------------------------ SINFRUP00000140701 ------------------------------------------------------------ CG8166-RA MAVINKAGNVIALLLVKLQLILLFTLSVSGELPQLDYGSLSASLEEDAIDPLTAMAPFAN SINFRUP00000141797 ---------------------------------------DDDFLSLSELPETF------P SINFRUP00000148078 ---------------------------------------DDDFIGLGDLPETF------P SINFRUP00000127562 -------------------------------------------SDAEVLPDSF------P ENST00000261961 ------------------------------------------------------------ ENSMUST00000026994 ------------------MAVRPGLWPALLGIVLTAWLRGSGAQQSATVANPV------P ENST00000287272 -------------MILVLVKALSDVCAGTSGFLLDFSSQTSPGTDNGEALPES------I SINFRUP00000140701 ------------------------------------------------------------ CG8166-RA SLVTEESAQHKNNAELLGNSSEDENVRPQQGSSSSGLGSSGAAGGSGILLEEFNSGKLSP SINFRUP00000141797 SDPPEPLPHFLFEPEEGYIVKNKPVNLYCKATPATQIYFKCNSEWVHQKDHTVEERVDEN SINFRUP00000148078 SDPPEPLPVFLIEPEEAYIVKNKPVNLYCKATPATQIYFKCNSEWVHQKEHTVEERVDEN SINFRUP00000127562 SAPAE-LPEFLLEPEDAFIVKNRPVQLRCRASPATQ-YFKCNGEWVNQNDHITRESLDQI ENST00000261961 ------------------------------------------------------------ ENSMUST00000026994 GANPDLLPHFLVEPEDVYIVKNKPVLLVCKAVPATQIFFKCNGEWVRQVDHVIERSTDGS ENST00000287272 PSAPGTLPHFIEEPDDAYIIKSNPIALRCKARPAMQIFFKCNGEWVHQNEHVSEETLDES SINFRUP00000140701 -----TLPRFLEEPVDAYIIKSNPIKLRCQA-PALQIFFKCNGEWVHQSQHMSQEHTDLQ CG8166-RA GEASNTLPIFLIEPESVFVVKNRPAVLKCKASHSLQVIFKCSGSSQ-PPPSTHETHVDPH : :: :: : : SINFRUP00000141797 SGLVVREASIEITRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAHVRLAYLKKTFDQEPL SINFRUP00000148078 SGLVVREASIEITRQQVEELFGPEDFWCQCVAWSSAGTTKSRKAYVRIAYLRKTFDQEPL SINFRUP00000127562 TGLVVREVEISVSRTQVEELFGLEDYWCQCVAWSSAGTTKSNRAYVRIAYLRKNFEQEPL ENST00000261961 ------------------------------------------------------------ ENSMUST00000026994 SGLPTMEVRINVSRQQVEKVFGLEEYWCQCVAWSSSGTTKSQKAYIRIAYLRKNFEQEPL ENST00000287272 SGLKVREVFINVTRQQVEDFHGPEDYWCQCVAWSHLGTSKSRKASVRIAYLRKNFEQDPQ SINFRUP00000140701 TGLKIREVMINVSRQQVEDFHGPEDYWCLCVAWSHLGTSKSRKASVRIAYLRKNFEQDPQ CG8166-RA TGVNMEEVTATIHRDLVDEFFGDGPFKCECHAWSSRGVVKSQAATVHIAYIRKSFNQSPT : : : . : : : : SINFRUP00000141797 GKEVSMEQEVLLQCRPPQGIPAAEVEWLKNEEIIDPAEDRNFYITIDHNLIIKQARLSDT SINFRUP00000148078 GKEVSLEQEVLLQCRPPEGIPAAEVEWLKNEEVIDPADDRNFYITIDHNLIIKQARLSDT SINFRUP00000127562 GREVRLEQEVLLQCRPPEGMPAAEVDWLKNEDAIDPSQDSNFLITIDHDLIIKQARLSDT ENST00000261961 ------------------------------------------------------------ ENSMUST00000026994 AKEVSLEQGIVLPCRPPEGIPPAEVEWLRNEDLVDPSLDPNVYITREHSLVVRQARLADT ENST00000287272 GREVPIEGMIVLHCRPPEGVPAAEVEWLKNEEPIDSEQDENIDTRADHNLIIRQARLSDS SINFRUP00000140701 GTEVPLSGMIVLHCRPPEGVPVAEVEWLKNEEALVSEG--VADRTGDHSLVVSEAQLSDS CG8166-RA SLRLELGSRAELRCEPPGGFPEPKLTWHKNNAVITADSEPGITVSAG-TLIFRQVALQHM : : : . : : ::. : SINFRUP00000141797 ANYTCVAKNIVAKRRSTTATVIVYVNGGWSTWTEWSVCNSRCGRG-FQKRTRSCTNPAPL SINFRUP00000148078 ANYTCVAKNIVAKRRSTTATVIVYVNGGWSTWTEWSVCNSRCGRG-FQKRTRSCTNPAPL SINFRUP00000127562 ANYTCVARNVVAKRRSSTATLIVYVSGGWSSWTEWSECNAQCGRG-WQRRTRSCTNPAPL ENST00000261961 ------------------------------------------------------------ ENSMUST00000026994 ANYTCVAKNIVARRRSASAAVIVYVNGGWSTWTEWSVCSASCGRG-WQKRSRSCTNPAPL ENST00000287272 GNYTCMAANIVAKRRSLSATVVVYVNGGWSSWTEWSACNVRCGRG-WQKRSRTCTNPAPL SINFRUP00000140701 GNYTCVASNIVAKRRSATATVVVYVNGGWSSWTDWSPCNVRCGRG-VQKRSRTCTNPTPL CG8166-RA ANYSCSAENIAGRRVSDSAVLIVYVNGGWSTWSPWRECKCAGKPSQGRKRSRTCNNPMPL : ::: : : SINFRUP00000141797 NGGLPCDGQAIQKLTCTTLCTVDG-----------------EWTDWSKWSACGTECTQWR SINFRUP00000148078 NGGAICEGQGIQKLACNPLCPVDG-----------------LWTEWSKWSTCGTECTHWR SINFRUP00000127562 NGGAFCEGPPFQRVTCTTLCPVDG-----------------GWTEWAKWSACGTECTHWR ENST00000261961 ------------------------------------------------------------ ENSMUST00000026994 NGGAFCEGQNVQKTACATLCPVDG-----------------SWSPWSKWSACGLDCTHWR ENST00000287272 NGGAFCEGMSVQKITCTSLCPVDG-----------------SWEVWSEWSVCSPECEHLR SINFRUP00000140701 NGGAFCEGMSVQKSTCSTLCPVDG-----------------SWSEWGEWSACTPECERQR CG8166-RA NGGAQCPGPQIQKSADCAACPEDTQIVSPDGFDISSSKRMARWSAWSDWSICSAECIQVR . SINFRUP00000141797 RRDCNNP-------------------------------------------------APKN SINFRUP00000148078 RRECSAP-------------------------------------------------TPKN SINFRUP00000127562 SRECQAP-------------------------------------------------PPRN ENST00000261961 ------------------------------------------------------------ ENSMUST00000026994 SRECSDP-------------------------------------------------APRN ENST00000287272 IRECTAP-------------------------------------------------PPRN SINFRUP00000140701 GRECTAP-------------------------------------------------EPKH CG8166-RA RRKCLTQGQTQISSEAEEAGDLLLGAPGVGMAALIAAAGVGAVGSPSEATGSSSDIIPGY SINFRUP00000141797 GGKDCEGLVLQSQNCTDGLCMQT--------------------APSTDDVALYVGIVIAV SINFRUP00000148078 GGKDCEGMVLQSKNCTDGMCMQM--------------------APSTDDVALYVGIVIAV SINFRUP00000127562 GGKHCSGSMMESKNCTEGLCARS--------------------LAPDTGVAVYAGLVGAL ENST00000261961 ------------------------------------------------DVALYVGLI-AV ENSMUST00000026994 GGEECRGADLDTRNCTSDLCLHT--------------------SSGPEDVALYIGLV-AV ENST00000287272 GGKFCEGLSQESENCTDGLCILD---KKPLHEIKP------QSIENASDIALYSGLG--A SINFRUP00000140701 GGRLCDGVALATDNCTGGLCTQSGAGKVPHKSVRVCLSLPFQGVEGSSDVALYSGLA--A CG8166-RA GKSLCAGKDIQTAECRGEQCQIG---------------------KDDFDWTLYLGLAFIT . ::* *: SINFRUP00000141797 IMCLVISVIVALFVYR--KTHRDFDSDIIDTS-ALNGGFQSVNIKTARSAD----LLTAP SINFRUP00000148078 IMCLVISVVVALFIYR--KNHRDFDSDIIDTS-ALNGGFQPVSIKNARKAE----LLTAP SINFRUP00000127562 LLCVILVLCVGVLAYR--RRCRHLHGDITDSSSALTAAFHPGNYKPSRQDNPNPLHPSAP ENST00000261961 AVCLVLLLLVLILVYC--RKKEGLDSDVADSS-ILTSGFQPVSIKPSKADN--PHLLTIQ ENSMUST00000026994 AVCLILLLLVLVLIYC--RKKEGLDSDVADSS-ILTSGFQPVSIKPSKADN--PHLLTIQ ENST00000287272 AVVAVAVLVIGVTLYR--RSQSDYGVDVIDSS-ALTGGFQTFNFKTVRQGNSLLLNSAMQ SINFRUP00000140701 GVVTVVLLIIAVTLYR--RSQSEYGVDVIDSS-ALTGGFQSFSFKTSRQANPLLINPSMQ CG8166-RA AVCFAFGTALICCARRGIRTNPHYNMARSVMDADYMPGVVEKKEMRMHIEASNMGYDYVN : : : . .. . : SINFRUP00000141797 PDLTNAAAMYRGPVYALHDVSD----KIPMTNSPLLDPLPNLKIKVYNSSGLVTPQDDLG SINFRUP00000148078 PDLTSAAAMYRGPVYALHDVAD----KIPMTNSPLLDPLPNLKIKVYNSSGLVTPQDDLG SINFRUP00000127562 PDLTATAGTFRGPLFSLQQGANDSPHKIPMTTSPLLDPLPSLKIKVYNSSTLSS--LELP ENST00000261961 PDLSTTTTTYQGSLCPRQDGPSP---KFQLTNGHLLSPLGGGRHTLHHSS-----PTSEA ENSMUST00000026994 PDLSTTTTTYQGSLCPRQDGPSP---KFQLSNGHLLSPLGSGRHTLHHSS-----PTSEA ENST00000287272 PDLTVSR-TYSGPIC-LQDPLD----KELMTESSLFNPLSDIKVKVQSSFMVSLGVSERA SINFRUP00000140701 PDLTVSR-TYTSPMC-FQDSID----KELMAEHSLLDPLPDLQVKGQT------------ CG8166-RA PGHRYLPGEHIMGMGIGCGGVTEHHYDVPNLSANYTNPIDHLSVDYLSETGESSTADTSN *. . : . .*: SINFRUP00000141797 GDFTAKLSPKVTQTLLDNSD-TMN--LRNQSLARTRDPS---CTAHGSFNNHGGHLIVPN SINFRUP00000148078 GEFSSKLSPKLPHCLLDNSDSTMGRRAQTQTLLRTRDPS---CTALGSFSSQGGQLIVPN SINFRUP00000127562 ADVRSDG-----EILSLNSVGTVGRERDYYSHTLSREPG---LSTSATLGNLGGRLTIPN ENST00000261961 EEFVSRLS------------------TQNYFRSLPRGTS---NMTYGTFNFLGGRLMIPN ENSMUST00000026994 EDFVSRLS------------------TQNYFRSLPRGTS---NMAYGTFNFLGGRLMIPN ENST00000287272 EYHGKNHSRTFPHGNNHSFSTMHPRNKMPYIQNLSSLPTRTELRTTGVFGHLGGRLVMPN SINFRUP00000140701 ---------------------------AAYTQ--------------------GSRPRLAT CG8166-RA STFDMNG---------------------KLSILNASKSS-----TYEMLGSAGGQLRLYG : *.: : SINFRUP00000141797 SGVSLLVPAGAVPQGRVYEMYVTVHRKDSV-RPPVEDTQTLLSPVVSCGPPGALLTRPVI SINFRUP00000148078 SGT--------------------------------------------------------- SINFRUP00000127562 TGVSLLVPPGTIPQGKFYEMYLIINKWDKM-TLPSEGSQTVLSPVVSCGPSGMLLNRPVV ENST00000261961 TGISLLIPPDAIPRGKIYEIYLTLHKPEDV-RLPLAGCQTLLSPIVSCGPPGVLLTRPVI ENSMUST00000026994 TGISLLIPPDAIPRGKIYEIYLTLHKPEDV-RLPLAGCQTLLSPIVSCGPPGVLLTRPVI ENST00000287272 TGVSLLIPHGAIPEENSWEIYMSINQGEP--SLQSDGSEVLLSPEVTCGPPDMIVTTPFA SINFRUP00000140701 VAEKCLIPGGYLT-----VLYLCVHS-----AVSDEESEIFLSPAVTYGPPGLDLSCPIA CG8166-RA GELLLFVPEHAIGKHVKKHVSLLLLSDECSRVSCATESSILCSSVVHSAPRNYSFVKPVI :: : : : : . : . . SINFRUP00000141797 LTIHHCADNVE----EDWLIQLRNQLAMGEWEDVVVVGEENFTTPCYVQMDSEACHILTE SINFRUP00000148078 ------------------------------------------------------------ SINFRUP00000127562 LTLPHCAQLDTPT--PDWTLTLKTQTHQGAWEEVLTVGEETLSSPCYLQLEEECCHVLME ENST00000261961 LAMDHCGEPSP----DSWSLRLKKQSCEGSWEDVLHLGEEAPSHLYYCQLEASACYVFTE ENSMUST00000026994 LAMDHCGEPSP----DSWSLRLKKQSCEGSWEDVLHLGEESPSHLYYCQLEAGACYVFTE ENST00000287272 LTIPHCADVSS----EHWNIHLKKRTQQGKWEEVMSVEDE--STSCYCLLDPFACHVLLD SINFRUP00000140701 MTVAHCAEVAA----DNWTIRLKRQAQDNKWEEVMSVDEE--STSCYCLLEANRCHLLLE CG8166-RA LKIPHCLVAPEQWHVHIYHADSEHDELSVNWRRAVSVGEETINTPMFVQLEATHVFIMTE : : : : : :: SINFRUP00000141797 TLGTYCLVGQSIC-KAAAKRLKLAVFGPVC-CTTLDYHIRVYCLDDNQDALKEVLQMETQ SINFRUP00000148078 -------------------------------------------------APNEVLQMEKQ SINFRUP00000127562 QLGTYGLVGQSCPPQPACKRLQLALFAPRAPCLSLDYSLRIYCIHDTPHALKDVLDLERS ENST00000261961 QLGRFALVGEALS-VAAAKRLKLLLFAPVA-CTSLEYNIRVYCLHDTHDALKEVVQLEKQ ENSMUST00000026994 QLGRFALVGEALS-VAATKRLRLLLFAPVA-CTSLEYNIRVYCLHDTHDALKEVVQLEKQ ENST00000287272 SFGTYALTGEPIT-DCAVKQLKVAVFGCMSCNS-LDYNLRVYCVDNTPCAFQEVVSDERH SINFRUP00000140701 HPGRYALFGAPMN-PDAAKRLRLAVFGCPDPSSPLGFSLRVYCVDDTPNAFQEVAVGEHS CG8166-RA QLGHFTVVAEPRI-QQPSIKMKLLAFSQHTPPSNANCSLRIYVVKDFPNSRDICANVEAK : : : : : : : : . * SINFRUP00000141797 MGGKLLDEPKTLNFKDSTHNLRLSIHDVPHTHWKSKLIAKYQEIPFYQVWAGSQRTLHCT SINFRUP00000148078 MGGKLLDEPKTLNFKDSTHNLRISIHDVPHALWKSKLLAKYQELSFQHVWSGSQRNLHCC SINFRUP00000127562 LGGVLLEDPKPLLFKDSYHNLRLSIHDIPHTHWRSKLLAKYQEIPFYHIWSGSQRPLHCT ENST00000261961 LGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQRYLHCT ENSMUST00000026994 LGGQLIQEPRVLHFKDSYHNLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQQYLHCT ENST00000287272 QGGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCA SINFRUP00000140701 RNGRLLEEPKTMLFRGTAFSLQVSIQDVPQLLWSIKPFTTCQEFSFSQVWASSRHPLQCA CG8166-RA LGGSFLGESQVFAFTLNSRNLNIRVRSA-----DVEAAAPYEHAIPYQHILSNNSILHCE .* :: :.: : * . .*.: : . : . :. : ... *:* SINFRUP00000141797 FTLERLSSATAEISCKLCVR----QVEGEGQIFQLSNTLEEDVQCIDTSLMDPASNITTL SINFRUP00000148078 FTLERFSTATMDLACKICVR----QVEGEGQIFQLDTTLSEDSQSIDTSLLDPASNITTL SINFRUP00000127562 FSLERSSLAVSQLTCKICVR----QVEGEGQIFQLHTDIQETLPPHSPLPSGGSCPPSSQ ENST00000261961 FTLERVSPSTSDLACKLWVW----QVEGDGQSFSINFNITKDTRFAELLALESEAGVPAL ENSMUST00000026994 FTLERVNASTSDLACKVWVW----QVEGDGQSFNINFNITKDTRFAEMLALESEGGVPAL ENST00000287272 FSLERYTPTTTQLSCKICIR----QLKGHEQILQVQTSILESERETITFFAQEDSTFPAQ SINFRUP00000140701 FLLERYSHSSSQLSCKISVR----QVKGEEQILQVYTSVLENEKAVVPFFSQSDCTVTSQ CG8166-RA FSLRRQDQNSLCVDFGQGSEDDYYTFNIPAHSMSGSAEELASTTNTTISIDRQGNYVNES * *.* : .: : :. SINFRUP00000141797 VGPNAFRIPLSIRQKLCGSLDAPQTRGNDWRMLAHKLNLDRYLNYFATKSSPTGVILDLW SINFRUP00000148078 VGPNAFRIPVSIRQKLCGSLDAPQTRGNDWRMLAHKLNLDRYLNYFATKSSPTGVILDLW SINFRUP00000127562 VGPYAFRLPDSIRQKICASLDVPSARGCDWRLLARSLGFDRYLNYFATKPSPTGVLLDLW ENST00000261961 VGPSAFKIPFLIRQKIISSLDPPCRRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLW ENSMUST00000026994 VGPSAFKIPFLIRQKIITSLDPPCSRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLW ENST00000287272 TGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLW SINFRUP00000140701 TGSRAFKIPLSIRQRISATFDTANAKGKDWQLLAQKLHIDR------------------- CG8166-RA CVMDFVQLPHATKRLICGALDPPRADERDWRLLAKKLNTDRYIAYFATKASPTEQILNLW .::* :: : ::* . **: **:. : : : :: : SINFRUP00000141797 EAQHFPDG---------DLNELAAVLEEMGRSDS----------------------- SINFRUP00000148078 EAQHFPDG---------NLSRLAQVLEEMGRHDSLV--------------------- SINFRUP00000127562 EACHQADA---------DLVSLATALEDMGKSEVLVVMTTDGDC------------- ENST00000261961 EARHFPNG---------NLSQLAAAVAGLGQPDAGLFTVSEAEC------------- ENSMUST00000026994 EARHFPNG---------NLGQLAAAVAGLGQPDAGLFTVSEAEC------------- ENST00000287272 EARHQHDG---------DLDSLACALEEIGRTHTKLSNISESQLDEADFNYSRQNGL SINFRUP00000140701 --------------------------------------------------------- CG8166-RA ECRANSSPGSSSNSVSHTIMALLLTLKEMGRQDVLDIIVETIGPLWI---------- : : : :