CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000022217 MDSYFKAAVSGLDKLLDDFEQNPDKQDYLP---DAYAFNQCSVSSESASPQ-LALLSKDQ ENST00000313202 MDSYFKAAVSDLDKLLDDFEQNPDEQDYLQDVQNAYDSNHCSVSSELASSQRTSLLPKDQ SINFRUP00000145372 ------------------------------------------------------------ SINFRUP00000149172 ------------------------------------------------------------ CG15667-RA ------------------------------------------------------------ ENSMUST00000022217 RCISTCASSEACCEDANETFLEGKIHEGLTSRPNEKNVAGLDLLSSVDASTSDEIQPSCM ENST00000313202 ECVNSCASSETSYG-TNESSLNEKTLKGLTSIQNEKNVTGLDLLSSVDGGTSDEIQPLYM SINFRUP00000145372 ------------------------------------------------------------ SINFRUP00000149172 ------------------------------------------------------------ CG15667-RA ------------------------------------------------------------ ENSMUST00000022217 RRCSKPVCDLISDMGNLVHATNSEEDIKQLLPDDPKSSADTLITLDSSSVSEALTVSSVD ENST00000313202 GRCSKPICDLISDMGNLVHATNSEEDIKKLLPDDFKSNADSLIGLDLSSVSDTPCVSSTD SINFRUP00000145372 ------------------------------------------------------------ SINFRUP00000149172 ------------------------------------------------------------ CG15667-RA ---------------------MDLVDIDQVLDNLELSIAADEQLSRNAAAAAAAGANPGR ENSMUST00000022217 CGSNAVREEQNNINAGIKNRDIS-IKELGVKVDMALFDSCKYNRTENLKDKIISNELET- ENST00000313202 HDSDTVREQQNDISSELQNREIGGIKELGIKVDTTLSDSYNYSGTENLKDKKIFNQLESI SINFRUP00000145372 ------------------------------------------------------------ SINFRUP00000149172 ------------------------------------------------------------ CG15667-RA FLGDGASASISGVGAGAGVSGAAGVTPTPASGKSFVGVSQVFNSLDDYRENVKSLQVDAQ ENSMUST00000022217 VDFDMPSVLMEQSSEMSNTKDNPQYKRLPCELLKDDGCLAEEKVAVAVNNTECLEEGGGS ENST00000313202 VDFNMSSALTRQSSKMFHAKDKLQHKSQPCGLLKDVGLVKEEVDVAVITAAECLKEEG-- SINFRUP00000145372 ------------------------------------------------------------ SINFRUP00000149172 ------------------------------------------------------------ CG15667-RA LPSYDWQTEAEHEDDIHKFSEQASKNNGQTIVSSSESLTTSSCSTFSSG----------- ENSMUST00000022217 NTIAMPCKLPENEGISPSDPASKDENFKLPDFPLQENRTSVFMKQTVKEDSRNLDLKDN- ENST00000313202 KTSALTCSLPKNEDLCLNDSNSRDENFKLPDFSFQEDKT--VIKQSAQEDSKSLDLKDND SINFRUP00000145372 ------------------------------------------------------------ SINFRUP00000149172 ------------------------------------------------------------ CG15667-RA -----------------PSPVSNGSHSEELATPPEDEKTSEVQVEPKEQDQQPEQVKHED ENSMUST00000022217 -----NDIVHVSGDDVPPSLSCLSLSGSLCGSLIHNNEHSDILPPNESEGQNNDAVTIHE ENST00000313202 VIQDSSSALHVSSKDVPSSLSCLPASGSMCGSLIESKARGDFLPQHEHKDNIQDAVTIHE SINFRUP00000145372 ------------------------------------------------------------ SINFRUP00000149172 ------------------------------------------------------------ CG15667-RA QHQDQAVPPPTQSKQTVEELAVGLSSISITASGTES------------------------ ENSMUST00000022217 EIQKSDVLDG----ETDLSKKETCRSIFLQPVNEKKGEGKVEVEEMVISGESLESPEDAS ENST00000313202 EIQNSVVLGGEPFKENDLLKQEKCKSILLQSLIEGMEDRKIDPDQTVIRAESLDGGD--T SINFRUP00000145372 ------------------------------------------------------------ SINFRUP00000149172 ------------------------------------------------------------ CG15667-RA --------------QSLLPEEVTASSVLGQVLEELSEESSPSREPETEMTNGIDVPLANL ENSMUST00000022217 SAAAAGSPVALSAASVPEAPGPCEGLT--FPSSDMDGQELDYFNIDESMRSGILISDAEL ENST00000313202 SSTVVESQEGLSGTHVPESSDCCEGFINTFSSNDMDGQDLDYFNIDEGAKSGPLISDAEL SINFRUP00000145372 ------------------------------------------------------------ SINFRUP00000149172 ------------------------------------------------------------ CG15667-RA PASVAEVPVPKEMEQPVQTEE----------------EDVELPQEQHPRRSQPLTFCSTM ENSMUST00000022217 DAFLKEQCLSNSNTMSAGENVNDSQLQMNQITMKGLHDENAGDIYFNAEAGAAGENGGVG ENST00000313202 DAFLTEQYLQTTNIKSFEENVNDSKSQMNQIDMKGLDDGNINNIYFNAEAGAIGESHGIN SINFRUP00000145372 ------------------------------------------------------------ SINFRUP00000149172 ------------------------------------------------------------ CG15667-RA DEISDTELDSMLQEMDADDNQADDQQMPDDEKSCSASPVTEEESVRILSDEQETTSNDQM ENSMUST00000022217 -NCETSDKENTENNGLSIGEKGAIPTERELSACQPDIRDELPVPSIKTQAVGGARPKQLL ENST00000313202 IICEIVDKQNTIENGLSLGEKSTIPVQQGLPTSKSEITNQLSVSDINSQSVGGARPKQLF SINFRUP00000145372 ------------------------------------------------------------ SINFRUP00000149172 ------------------------------------------------------------ CG15667-RA NVDNFSQASTVEFADLKQPESTPVTAMGEDVASSFSSTESDSLSGRKLDGEVEVDREHED ENSMUST00000022217 SLPPGTRSSKELNKPDVVDVPESEPCTANATAVSTCSADHIPDSQVSFNSNYIDIESNFE ENST00000313202 SLPSRTRSSKDLNKPDVPDTIESEPSTADTVVPITCAIDSTADPQVSFNSNYIDIESNSE SINFRUP00000145372 ------------------------------------------------------------ SINFRUP00000149172 ----------------------------------------------------PDNEGEQT CG15667-RA ASLATDALETQEQRPQRPQTLNLNGCQAESSTPSQDENPEIQQETLQPTEVREGAAGVGV ENSMUST00000022217 DGSSFVTANKDSLPENKRKESLVLGQKQPTWVPDSEAPNCMNCQVKFTFTKRRHHCRACG ENST00000313202 GGSSFVTANEDSVPENTCKEGLVLGQKQPTWVPDSEAPNCMNCQVKFTFTKRRHHCRACG SINFRUP00000145372 -----------------------LGSRQPSWVPDSEAPNCMNCSQRFTFTKRRHHCRACG SINFRUP00000149172 SGGILS-----------KNRGTILGEVAPVWVPDAQAQVCMKCGVKFTFTKRRHHCRACG CG15667-RA IPGEDDEESPIYEAVGYSDPHANLGKVPPIWVPDNMAGQCMQCQQKFTMIKRRHHCRACG **. * **** * **:* :**: ********** ENSMUST00000022217 KVFCGVCCNRKCKLQYLE-KEARVCVICYETINKAQAFERMMSPGG---------SCLKS ENST00000313202 KVFCGVCCNRKCKLQYLE-KEARVCVVCYETISKAQAFERMMSPTG---------SNLKS SINFRUP00000145372 KVYCAVCCNRKCKLKYLE-KEARVCLICFDSINRAQALERMMSPVG---------PSPNP SINFRUP00000149172 KVFCGLCSSLKFKLSHLDGKEGRVCVSCHSALMKR---ERGLLTID---------IVPKA CG15667-RA KVLCSVCCSQRFRLEFATEPESRVCVQCYMILSERQANGLNSESAPGSALPPTPIRSPNP ** *.:*.. : :*.. *.***: *. : . . :. ENSMUST00000022217 NH-SNECATDQPLQETQTS----STPSPTTLPISALKQPNVEGP---------CSKEQKR ENST00000313202 NH-SDECTTVQPPQENQTS----SIPSPATLPVSALKQPGVEGL---------CSKEQKR SINFRUP00000145372 NIPSEYCSTIPPLQQARAAGTLNSPPPTVMVPVSVLKHPNDS-----------CPREQKR SINFRUP00000149172 CF----DDISPPLFLSGTP-----------------------------------PRGKRR CG15667-RA NNPMEYCSTIPPHRQVANSP--GAPPPSVIVPVGVLKKTDGSSSNSSSSDGQKGQRKRKS * . : :: ENSMUST00000022217 VWFADGILPNGEVADTTKLSSGSKRCSDDFSPVLPDVPTMIN--KVDRTHSPTVEKPNNG ENST00000313202 VWFADGILPNGEVADTTKLSSGSKRCSEDFSPLSPDVPMTVN--TVDHSHSTTVEKPNNE SINFRUP00000145372 VWFADGILPNGEVADTSKLSVTSRRDSQEFSSVTPDQPAVRAPIRTPQPHTHKVQKIN-- SINFRUP00000149172 VWFADEILNR-----RSESAPASPVGGPPFSPLMTRAADGLG---KSPAASP-------- CG15667-RA VMFSDGIAPGSELASTMEQQWGESKHSRRGLSRSGSGAGQKPPTPATEEPPRSIDTSSTL * *:* * : . . . . . ENSMUST00000022217 LGDIIRSEISQSPTCHTAPVERLPGNTGTEGLPMPGPFTLEDDVFVDSEEPSTPTVVPAN ENST00000313202 TGDITRNEIIQSPISQVPSVEKLSMNTGNEGLPTSGSFTLDDDVFAETEEPSSPTGVLVN SINFRUP00000145372 ---------YINPLIPPSSAELEGVDGGS----------------SCPEGPGAAEVVRP- SINFRUP00000149172 ----------------------------------------------QIRRALRPHGTAVN CG15667-RA GLVAQLFRGSIPPSAAAATLS-------------------------ATETSAGRSSSQSQ . . ENSMUST00000022217 SGLPVASISDYRLLCSVAKCVCNNISLLPDDDIGLPPLLATSGEDGS-VPVVQERPSHEQ ENST00000313202 SNLPIASISDYRLLCDINKYVCNKISLLPNDEDSLPPLLVASGEKGS-VPVVEEHPSHEQ SINFRUP00000145372 ---PLSGPWDYALLCGLGSSVEKVPSLLPNNEEELPPLLIITGEDEAGDVLVEENPAPCQ SINFRUP00000149172 EACGLYGWGTTTLLSSSS-------NLIPLDG--LPPILTSTGVKGD--YTVDEQPSETV CG15667-RA AQTSPRRKAESSRNRKLPPNGDAQGCYLPPEENGLPPICISSKEGGEVDYKVVRNDG--- :* : ***: : * .. . ENSMUST00000022217 IILLLEGEGFPPATFVLNANLLVNVKLVLYSSEK---YWYFSTNGLHGLGQAEIIVLLQC ENST00000313202 IILLLEGESFHPVTFVLNANLLVNVKFIFYSSDK---YWYFSTNGLHGLGQAEIIILLLC SINFRUP00000145372 ILHLLAEGGPRPLTFALNANLLVNVKLVTCSGRQ---CWCFGSTGLQALGQKELVFLLEC SINFRUP00000149172 LIQELEGSRAKPLVFVLNANLLAMVKLVNYVNRK---CWCLTTKGMHAVGQVEVVVLLQC CG15667-RA --SLLDRLQNETLKFIIKNNFFVLVKIVNMSCCMNRWVLNFTTSGLHHMGSDELIILLEI :: * . * :: *::. **:: : :.*:: :*. *::.** ENSMUST00000022217 LP--------NEDTVPKDIFRLFITIYKDALKGKYIENLDNLTFT--ESFLNSKDHGGFL ENST00000313202 LP--------NEDTIPKDIFRLFITIYKDALKGKYIENLDNITFT--ESFLSSKDHGGFL SINFRUP00000145372 LP--------DEKVLPKDLFSLYLNIYQEAQKGKFLEELDNVTFT--STFLGSKDHAGML SINFRUP00000149172 LP--------EEKSFPKDIFSHFVHVYRESLTG-VLKHLSLSLFD--SGFLGSEEHAGFL CG15667-RA KQPKQEEYVKGEVAIPKDLFQHLYEIYVEAEHARSGTHELAFTSPRNANFLGSREHGGFI * .***:* :* :: . . **.*.:*.*:: ENSMUST00000022217 FITPTFQNLDGLPVPRSPFLCGILIQKLEIPWAKVFPMRLMLRLGAEYKAYPAPLTSVRG ENST00000313202 FITPTFQKLDDLSLPSNPFLCGILIQKLEIPWAKVFPMRLMLRLGAEYKAYPAPLTSIRG SINFRUP00000145372 FFSPTYQPLDGLTLPSQPFLFGLLIQKLEVPWAKVFPIRLLLRLGAEYNVYPTPLISVRF SINFRUP00000149172 YVHSTLQSLQGLPLPNQPYLFGLLVHRAEVAWAKAFPLRLMLRLGAEYRFYPCPLYSVRF CG15667-RA FIRPTYQCLQGVIVPDNPYLVGVLIHRHEVPWAKVLPLRLILRLGAQYRYYPCPLISVRG :. .* * *:.: :* .*:* *:*::: *:.***.:*:**:*****:*. ** ** *:* ENSMUST00000022217 RKPLFGEIGHTIMNLLVDLRNYQYTLHNIDQLLIHMEMGKSCIKIPRKKYSDVMKVIHSS ENST00000313202 RKPLFGEIGHTIMNLLVDLRNYQYTLHNIDQLLIHMEMGKSCIKIPRKKYSDVMKVLNSS SINFRUP00000145372 RESVFRETGHTIMNLLADLRNYQYSLS-VVEGLRHMEMGHIYIDIPKSSYSDMQRVVNVS SINFRUP00000149172 RKPLFGEIGHTIMRLLVDFRNYRYSLPMVPGLTVDLEAQRTCIKIPITRYNELIKAINKS CG15667-RA RESVYGEIAQTIINFLVDFRNYSYSLPAIRGLYIHMEDRQTTVIIPKYRQQDVIKAINNA *:.:: * .:**:.:*.*:*** *:* : .:* : : ** .:: :.:: : ENSMUST00000022217 NEHVISIGASFSTEADSHLVCVQSD-------GVYQTQANSATGQPRKVTGASFVVFNGA ENST00000313202 NEHVISIGASFSTEADSHLVCIQND-------GIYETQANSATGHPRKVTGASFVVFNGA SINFRUP00000145372 NEHVISIGAHFSTEADSHLVCFQNEE------GNYQTQASSMPGKTRTVTGASFVVFNGA SINFRUP00000149172 NEHVLAFGACFNEAADSHLICVQGED------GQYQTQAISIHNQPRKVTGSCFFIFSSA CG15667-RA SDHILAFAGNFSKVADGHLVCMQNINDDRSEMYSYSTQAINIQGQPRKITGASFFVLNEA .:*::::.. *. **.**:*.*. *.*** . .:.*.:**:.*.::. * ENSMUST00000022217 LKTSSGFLAKSSIVEDGLMVQITPETMEGLRLALREQKDFRIQCGKVDAVDLR-EYVDIC ENST00000313202 LKTSSGFLAKSSIVEDGLMVQITPETMNGLRLALREQKDFKITCGKVDAVDLR-EYVDIC SINFRUP00000145372 LKASSGFIAKSSIVEDGLMVQIPPETMESLRTALREQTDFHIPCGRNDGGEVR-ENVTVR SINFRUP00000149172 LKASAGYFAKSSIVEDGLMVQITVETMAELRRSLREMKEYTVTCGRLGQSESQ-ELVCVQ CG15667-RA LKSSSGLSGKCSIVEDGLMVQIMPAKMEEVRQALRNQNDIDIVCGPIDATDDQSEIVSIK **:*:* .*.*********** .* :* :**: .: : ** . : : * * : ENSMUST00000022217 WVDSEERKNKG------VISSVDGMSVEGFPSEKIKLETDFETEEK--TVKCTEVFYFLK ENST00000313202 WVDAEEKGNKG------VISSVDGISLQGFPSEKIKLEADFETDEK--IVKCTEVFYFLK SINFRUP00000145372 WVDWSSPVNRG------KTSGVDGRPLDGVRSVRVLQDTDFESDGR--TIRCTEVFYQLK SINFRUP00000149172 WVEEKCTVNKGRVCPLNVISSIDGKSMESISSTKMFQKSEYKENGK--IIRWTEVFFLQR CG15667-RA WVDNNRDINVG------VKSPIDDQPMDGISNMRVLKWASFNYSNTNYAIRLSDIYIIKC **: . * * : : * :*. .::.. . :: :.:: . :: :::: ENSMUST00000022217 -DQD---ISILSSSYQFAKEIAVACSAALCPHLRTLKSNRMNKIGLRVSIDTDMVEFQAG ENST00000313202 -DQD---LSILSTSYQFAKEIAMACSAALCPHLKTLKSNGMNKIGLRVSIDTDMVEFQAG SINFRUP00000145372 -TLDRSLESVLSSCSGFQKEIALAACSALTPHLAVLASAGINSLSLRISTQADMVEYQAG SINFRUP00000149172 GDRPKEGTSDSAEHNRLIERIARAFCLALCPHLKLLKEDGMAKLGLRVTFESQEVGFVAG CG15667-RA EDWYATNGGNCEEITRIAEQLARSASMALLPLLDLLAAAGINKLGLRATLDQDNVGYEAG . : :.:* : . ** * * * : .:.** : : : * : ** ENSMUST00000022217 CEGQLLPQHYLNDLDSALIPVIHGG-TSNSSLPLEIELAFFILENLSE ENST00000313202 SEGQLLPQHYLNDLDSALIPVIHGG-TSNSSLPLEIELVFFIIEHLF- SINFRUP00000145372 CGGRLLPQ-YMNELDGALIPVIHGGSASVPQTAMDMEFTFYI------ SINFRUP00000149172 SNGQPLPAQYLDALDNMLAPVMSSRGRKRGDEPLVMELVFYILENI-- CG15667-RA ARGSKLPPLYMNALDNHLIATLHGE-SSGIQEPIILELIFYILNA--- . * ** *:: **. * ..: . . . .: :*: *:*: :