CLUSTAL W (1.82) multiple sequence alignment ENST00000249471 MASSTPSSSATSSNAGADPNTTNLRP--TTYDTWCG-VAHGCTRKLGLKI ENSMUST00000028507 MASSTP-SPATSSNAGADPNTTNLRP--TTYDTWCG-VAHGCTRKLGLKI Q9DG86_Carassius_auratus MASSAP----SSSAPDMDPNTANLRQPATTGDAWYG-VAHGCTRKLGMKI Q9IAT3_Carassius_auratus MASSAP----SSSAPDMDPNTANLRQPATTGDAWYG-VAHGCTRKLGMKI SINFRUP00000149372 -------------------------------------------------- O93275_Brachydanio_rerio -------------------------------------------------- Q9DG87_Carassius_auratus MAS--HGFWFLGAENASGDGSQSPNT----PRAWCQAAAQKFSGGIGSKL SINFRUP00000129597 -------------------------------------------------- ENSMUST00000028123 MASPGSGFWSFGSEDGSAD-PENPGT----ARAWCQ-VAQKFTGGIGNKL ENST00000259271 MASPGSGFWSFGSEDGSGD-SENPGT----ARAWCQ-VAQKFTGGIGNKL ci0100141215 -------------------------------------------------- CG14994-RB -------------------------------------------------- : : : ENST00000249471 CGFLQRTNSLEEKSRLVSAFKERQSSKNLLSCENSDRDARFRRTETDFSN ENSMUST00000028507 CGFLQRTNSLEEKSRLVSAFRERQSSKNLLSCENSDQGARFRRTETDFSN Q9DG86_Carassius_auratus CGFLQKNNSLDEKSRMVGAFKE--SAKNQMTCDNSE---RFTRAETDFSN Q9IAT3_Carassius_auratus CGFLQKNNSLDEKSRMVGAFKE--SAKNQMTCDNSE---RFTRAETDFSN SINFRUP00000149372 -GFLQKNNSVDESGRILRSFKDG-AAKNLLSCDNGDP--RFRRTETDFSN O93275_Brachydanio_rerio -------------------------------------------------- Q9DG87_Carassius_auratus CALLNVGEAEKAAQA--PVKAE--DGSTAESCGCN-KPCNCPKAAVCFSD SINFRUP00000129597 -------------------------------------------------- ENSMUST00000028123 CALLY-GDSGKPAEGGGSVTSR--AATGKVACTCDQKPCNCPKGDVNYAF ENST00000259271 CALLY-GDAEKPAESGGSQPPR--AAARKAACACDQKPCSCSKVDVNYAF ci0100141215 ---MQKQSAWRFRSSSVGLIKVEPNNDD------------YSMNNGDFEN CG14994-RB --MSLNPNGYKLSERTG--------------------------------K : ENST00000249471 LFARDLLP-AKNGEEQTVQFLLEVVDILLNYVRKTFDRSTKVLDFHHPHQ ENSMUST00000028507 LFAQDLLP-AKNGEEQTAQFLLEVVDILLNYVRKTFDRSTKVLDFHHPHQ Q9DG86_Carassius_auratus LFARDLLP-AKNGEEPTIQFLLEVVEILTNYVRKTFDRSTKVLDFHHPHQ Q9IAT3_Carassius_auratus LFARDLLP-AKNGEEPTIQFLLEVVEILTNYVRKTFDRSTKVLDFHHPHQ SINFRUP00000149372 LFARDLLP-AKNGEEPSLQFLLEIVEILTNYVRKTFDRSTKVLDFHHPHQ O93275_Brachydanio_rerio -------------------------------------------------- Q9DG87_Carassius_auratus LYSTDLLP-ALDGDAKTMNFLQEVVDIMLAYIVESFDRSTKVIDFHYPNE SINFRUP00000129597 -------------------------------------------------- ENSMUST00000028123 LHATDLLP-ACDGERPTLAFLQDVMNILLQYVVKSFDRSTKVIDFHYPNE ENST00000259271 LHATDLLP-ACDGERPTLAFLQDVMNILLQYVVKSFDRSTKVIDFHYPNE ci0100141215 SSSADLLP-FGKSDEKTQLFLKEIFEILLKYISKSFDRKCKILDFHHPHQ CG14994-RB LTAYDLMPTTVTAGPETREFLLKVIDVLLDFVKATNDRNEKVLDFHHPED :: :: :. :: : :: : ENST00000249471 LLEGMEGFNLELSDHPESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLD ENSMUST00000028507 LLEGMEGFNLELSDHPESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLD Q9DG86_Carassius_auratus LLEGMEGFNLELSDQPESLEQILVDCRDTLKYGVRTGHPRFFNQLSSGLD Q9IAT3_Carassius_auratus LLEGMEGFNLELSDQPESLEQILVDCRDTLKYGVRTGHPRFFNQLSSGLD SINFRUP00000149372 LLEGMEGFNLELSDQPESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLD O93275_Brachydanio_rerio -------------------------------------------------- Q9DG87_Carassius_auratus LLQ---RNNWELSDEPETLDDILISCRATLKYAIKTAHPRYFNQLSTGLD SINFRUP00000129597 -------------------------------------------------- ENSMUST00000028123 LLQ---EYNWELADQPQNLEEILTHCQTTLKYAIKTGHPRYFNQLSTGLD ENST00000259271 LLQ---EYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFNQLSTGLD ci0100141215 LLEGIEGFSLNINGEAESLEQILVDCRDTLKYGVKTGHPRFFNQLSSGLD CG14994-RB MKR---LLDLDVPDRALPLQQLIEDCATTLKYQVKTGHPHFFNQLSNGLD : : : : :: : : : : : ENST00000249471 IIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVGWSSKDGDG ENSMUST00000028507 IIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVGWSNKDGDG Q9DG86_Carassius_auratus IIGLAGEWLTSTANTNMFTYEIAPVFVLMEQLTLKKMREIIGWTNGDGDG Q9IAT3_Carassius_auratus IIGLAGEWLTSTANTNMFTYEIAPVFVLMEQLTLKKMREIIGWTNGDGDG SINFRUP00000149372 IVGLAGEWLTSTANTNMFTYEIAPVFVLMEQLTLKKMREIVGWPDGEGDG O93275_Brachydanio_rerio -----------------FTYEVAPVFVLLEYVTLKKMREIIGWQDGRGDG Q9DG87_Carassius_auratus MVGLAADWLTSTANTNMFTYEVAPVFVLLEYVTLKKMREIIGWQDGRGDG SINFRUP00000129597 -----------------FTYEVAPVFVLLEYVTLKKMRDIIGWQDGRGDG ENSMUST00000028123 MVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDG ENST00000259271 MVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDG ci0100141215 IVSLAADWVTSTANTNMFTFEIAPVFILMEDVIIKRMMKIIGWEN--IDG CG14994-RB LISMAGEWLTATANTNMFTYEIAPVFILMENVVLTKMREIIGWSG--GDS :: : : :**:*:****:*:* : :.:* .*:** . *. ENST00000249471 IFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVP-KLVLFTSEQSHYSIK ENSMUST00000028507 IFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVP-KLVLFTSEHSHYSIK Q9DG86_Carassius_auratus LFSPGGAISNMYSVMVARYKYFPEVKTKGMSVAP-RLVLFTSEHSHYSIK Q9IAT3_Carassius_auratus LFSPGGAISNMYSVMVARYKYFPEVKTKGMSAAP-RLVLFTSEHSHYSIK SINFRUP00000149372 IFSPGGAISNMYSVMIARYKFFPVVKTXGXAAAP-RLILFTSEHSHYSIK O93275_Brachydanio_rerio IFSPGGAISNMYAMLLARYKMFPEVKEKGMSSVP-RLVAFTSEHSHFSIK Q9DG87_Carassius_auratus IFSPGGAISNMYAMLLARYKMFPEVKEKGMSSAP-RLVAFTSEHSHFSIK SINFRUP00000129597 IFSPGGAISNMYAMLLARFKMFPEVKEKGMSSVP-RLAAFTSEHSHFSIK ENSMUST00000028123 IFSPGGAISNMYAMLIARYKMFPEVKEKGMAAVP-RLIAFTSEHSHFSLK ENST00000259271 IFSPGGAISNMYAMMIARFKMFPEVKEKGMAALP-RLIAFTSEHSHFSLK ci0100141215 IFSPGGSINNLYSVMLARHKIMPDVKHSGLRGFP-QLVMFQSKHAHYSNK CG14994-RB ILAPGGSISNLYAFLAARHKMFPNYKEHGSVGLPGTLVMFTSDQCHYSIK :::***:*.*:*:.: **.* :* * * * * * *.:.*:* * ENST00000249471 KAGAALGFGTDNVILIKCNERGKIIPADFEAKILEAKQKGYVPFYVNATA ENSMUST00000028507 KAGAALGFGTDNVILIKCNERGKIIPADLEAKILDAKQKGYVPLYVNATA Q9DG86_Carassius_auratus KAGAVLGFGKENVILLKTDERGRVIPADLEAKIIDAKQKGYVPLFVNATA Q9IAT3_Carassius_auratus KAGAVLGFGRENVILLKTDERGRVIPADLEAKIIDAKQKGYVPLFVNATA SINFRUP00000149372 KTSAALGFGTENLILLNTDERGRVIPADLEAKVIEAKQKGYVPMYVNATA O93275_Brachydanio_rerio KGAAALGIGTESVICIKADERGKMIPSDLERRIIEAKQKGYVPFFVSATA Q9DG87_Carassius_auratus KGAAALGIGTESVICIKADERGKMIPSDLERRIIEAKQKGYVPFFVSATA SINFRUP00000129597 KGAAALGIGTESVICIKADESGKLIPADLERRILEAKQKGFVPFFVSATA ENSMUST00000028123 KGAAALGIGTDSVILIKCDERGKMIPSDLERRILEVKQKGFVPFLVSATA ENST00000259271 KGAAALGIGTDSVILIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATA ci0100141215 RPAAILGIGLNNCIDIEVDERGHMKPEDLELKILQSKLDGKVPFYVTATA CG14994-RB SCAAVCGLGTDHCIVVPSDEHGKMITSELERLILERKAKGDIPFFVNATA .* *:* : * : :* *:: . ::* ::: * .* :*: *.*** ENST00000249471 GTTVYGAFDPIQEIADICEKYNLWLHVDAAWGGGLLMSRKHRH-KLNGIE ENSMUST00000028507 GTTVYGAFDPIQEIADICEKYNLWLHVDAAWGGGLLMSRKHRH-KLSGIE Q9DG86_Carassius_auratus GTTVYGAFDPINDIADICEKYNLWLHVDGAWGGGLLMSRKHRH-KLSGIE Q9IAT3_Carassius_auratus GTTVYGAFDPINDIADICEKYNLWLHVDGAWGGGLLMSRKHRH-KLSGIE SINFRUP00000149372 GTTVYGAFDPINEIADICEKHNMWLHVDGAWGGGLLMSRKHRH-KLNGVE O93275_Brachydanio_rerio GTTVYGAFDPLIAIADICKKHDVWMHVDGAWGGSLLMSRKHRW-KLNGVE Q9DG87_Carassius_auratus GTTVYGAFDPLMAIADICKKHDVWMHVDGAWGGSLLMSRKHRW-KLNGVE SINFRUP00000129597 GTTVYGAFDPLIAISDICRKYGVWMHVDGAWGGSLLMSRKHRW-KLDGVE ENSMUST00000028123 GTTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRKHKW-KLSGVE ENST00000259271 GTTVYGAFDPLLAVADICKKYKIWMHVDAAWGGGLLMSRKHKW-KLSGVE ci0100141215 GTTVRGAFDEIVKISEVCKKYKIWLHVDAAWGGAVMMSQKHRH-LVAGIE CG14994-RB GTTVLGAFDDINTIADICQKYNCWMHIDAAWGGGLLMSRKHRHPRFTGVE **** **** : ::::*.*: *:*:*.****.::**:**: . *:* ENST00000249471 R----ANSVTWNPHKMMGVLLQCSAILVKEKGILQGCNQMCAGYLFQPDK ENSMUST00000028507 R----ANSVTWNPHKMMGVLLQCSAILVKEKGILQGCNQMCAGYLFQPDK Q9DG86_Carassius_auratus R----ANSVTWNPHKMMGAPLQCSAILVREKGILQGCNSMCAGYLFQPDK Q9IAT3_Carassius_auratus R----ANSVTWNPHKMMGAPLQCSAILVREKGILQGCNSMCAGYLFQPDK SINFRUP00000149372 R----ANSVTWNPHKMMGVPLQCSAILVRERGLLQGCNSMCAGYLFQQDK O93275_Brachydanio_rerio R----ANSMTWNPHKMMAVPLQCSALLVREEGLMQSCNQMQACYLFQQDK Q9DG87_Carassius_auratus R----ANSMTWNPHKMMAVPLQCSALLVREEGLMQSCNQMQACYLFQQDK SINFRUP00000129597 RQDLVANSVTWNPHKMMSVPLQCSALLVREEGLMQNCNQMHACYLFQQDK ENSMUST00000028123 R----ANSVTWNPHKMMGVPLQCSALLVREEGLMQSCNQMHASYLFQQDK ENST00000259271 R----ANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQMHASYLFQQDK ci0100141215 M----SDSVTWNPHKMVGVVLQCSMFLTKHKRLLESCNNMRADYLFQQDK CG14994-RB R----ADSVTWNPHKLMGALLQCSTIHFKEDGLLISCNQMSAEYLFMTDK ::*:******::.. **** : :. :: .**.* * *** ** ENST00000249471 QYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQINKCLELAEYL ENSMUST00000028507 QYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQINKCLELADYL Q9DG86_Carassius_auratus QYDVTYDTGDKAIQCGRHVDIFKFWLMWKAKGTIGFEQHIDRCLELSEYL Q9IAT3_Carassius_auratus QYDVTYDTGDKAIQCGRHVDIFKFWLMWKAKGTIGFEQHIDRCLELSEYL SINFRUP00000149372 QYDVTYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFEQHIDKCLELSAYL O93275_Brachydanio_rerio HYDLQ--------------------------------------------- Q9DG87_Carassius_auratus QYDLSYDTGDKALQCGRHVDIFKLWLMWRAKGTIGFEAQIEKCLELSEYL SINFRUP00000129597 HYDLSYDTGDKALQCGRHVDIFKLWLMWRAKGTIGFEAQIDKCLELSEYL ENSMUST00000028123 HYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHIDKCLELAEYL ENST00000259271 HYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEYL ci0100141215 HYDITYDTGDKTIQCGRHVDVFKLWLSWRAKGDKGFCHHVERCIELARYL CG14994-RB QYDISYDTGDKVIQCGRHNDIFKLWLQWRAKGTEGFEQQQDRLMELVQYQ :**: : :: : : : : : ENST00000249471 YAKIKNREEFEMVFNGEPEHTNVCFWYIPQSLRGVPDSPQRREKLHKVAP ENSMUST00000028507 YAKIKNREEFEMVFDGEPEHTNVCFWYIPQSLRGVPDSPERREKLHRVAP Q9DG86_Carassius_auratus YNKIKNREGYEMVFEGQPQHTNVCFWYIPPSLRGMPHGDERREKLHRVAP Q9IAT3_Carassius_auratus YNKIKNREGYEMVFEGQPQHTNVCFWYIPPSLRGMPHGDERREKLHRVAP SINFRUP00000149372 YHKIKNREGFEMVFNGEPQHTNVCFWYLPPSLRNLPDGKERRERLHKVAP O93275_Brachydanio_rerio -------------------------------------------------- Q9DG87_Carassius_auratus YNKIKDREGYEMVFDGKPQHTNVCFWYLPPGVRYLEDKVEKMKRLHKVAP SINFRUP00000129597 YNKIKDREGYEMVFNGKPQHTNVCFWYLPPGIRYMEDTEERKKRLHKVAP ENSMUST00000028123 YTIIKNREGYEMVFDGKPQHTNVCFWFVPPSLRTLEDNEERMSRLSKVAP ENST00000259271 YNIIKNREGYEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAP ci0100141215 VRKIKKTPGFQLVFQ-EPEYSNVCFWYYPPSIRNICDEVIKNEKLGKVAP CG14994-RB LKRIREQSD-RFHLILEPECVNVSFWYVPKRLRGVPHDAKKEVELGKICP : : : : : : : : : ENST00000249471 KIKALMMESGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERL ENSMUST00000028507 KIKALMMESGTTMVGYQPQGDKANFFRMVISNPAATQSDIDFLIEEIERL Q9DG86_Carassius_auratus KIKAMMMECGTTMVGYQPQGDKVNFFRMVVSNHAVTKSDIDFLIDEIERL Q9IAT3_Carassius_auratus KIKAMMMECGTTMVGYQPQGDKVNFFRMVVSNHAVTKSDIDFLIDEIERL SINFRUP00000149372 KIKALMMESGTTMVGYQPQGNKVNFFRMVISNPAATRSDIDFLVDEIERL O93275_Brachydanio_rerio -------------------------------------------------- Q9DG87_Carassius_auratus VIKARMMEYGTTMVSYQPQGDKVNFFRMVISNPAATFEDIDFLIEEIERL SINFRUP00000129597 VIKARMMEYGTTMVSYQPQGDKVNFFRMVISNPAATFEDIDFLIEEIERL ENSMUST00000028123 VIKARMMEYGTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERL ENST00000259271 VIKARMMEYGTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERL ci0100141215 IIKSRMMERGSIMIGYQPLGSKVNFFRCVISNCAVNYDDIDFMVGEIERL CG14994-RB IIKGRMMQKGTLMVGYQPDDRRPNFFRSIISSAAVNEADVDFMLDEIHRL : :: :: :: :: : ::: : : ENST00000249471 GQDL-- ENSMUST00000028507 GQDL-- Q9DG86_Carassius_auratus GHDL-- Q9IAT3_Carassius_auratus GHDL-- SINFRUP00000149372 GNDL-- O93275_Brachydanio_rerio ------ Q9DG87_Carassius_auratus GQDL-- SINFRUP00000129597 GQDL-- ENSMUST00000028123 GQDL-- ENST00000259271 GQDL-- ci0100141215 GHDIDM CG14994-RB GDDL-- :