CLUSTAL W (1.82) multiple sequence alignment SINFRUP00000145254 ------------------EIELSTKCVVDMEDNQTVLHPPPSNAK-GESRPE-ICLHNRM ENSMUST00000057087 MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERVPSPPCAHHFL ENST00000265613 ------------------ETDLHTKCVVDVDANKVILNPVNTNLSKGDARNVEVFLTHTY CG8566-RD --MSSVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDSVKRFNFDYSYW * :**:::: . : . .: SINFRUP00000145254 FYLFT-IISMEVLCRK---------GQEVVFKCLGEGILENAFQGYNACIFAYGQTGSGK ENSMUST00000057087 SPLIQSDVSQAGNPGQ---------SQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGK ENST00000265613 VHFQQVFAYDHCFWSMDESVKEKYAGQDIVFKCLGENILQNAFDGYNACIFAYGQTGSGK CG8566-RD SHDHHDADFST---------------QSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGK *.:*:* :** :*:::*:***.*********:** SINFRUP00000145254 SFSMMGNGE--QPGLIPRLCCSLFERVHKEENEAHTFKVEVSYMEIYNEKVRDLLDPKGS ENSMUST00000057087 SFSMMGHAE--QLGLIPRLCCALFQRIALEQNESQTFKVEVSYMEIYNEKVRDLLDPKGS ENST00000265613 SYTMMGTAD--QPGLIPRLCSGLFERTQKEENEEQSFKVEVSYMEIYNEKVRDLLDPKGS CG8566-RD SYTMMGRQEEQQEGIIPMICKDLFTRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPK-N *::*** : * *:** :* ** * :.: .:.********* *:*****:** . SINFRUP00000145254 RQSLKVREHKVLGPYVDGLSQLAVMSFEDIEVLMSEGNKSRTVAATNMNEESSRSHGVFS ENSMUST00000057087 RQSLKVREHKVLGPYVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFN ENST00000265613 RQTLKVREHSVLGPYVDGLSKLAVTSYKDIESLMSEGNKSRTVAATNMNEESSRSHAVFK CG8566-RD KGNLRVREHPLLGPYVEDLSKLAVTDYQDIHDLIDEGNKARTVAATNMNETSSRSHAVFT : .*:**** :*****:.**:*** .::**. *:.****:********** *****.**. SINFRUP00000145254 IIVTQTLYDLRSGNSGEKVSKMSLVDLAGSERVSKTGAAGERLKEGSNINKSLTTLGCVI ENSMUST00000057087 IIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVSKTGAAGERLKEGSNINKSLTTLGLVI ENST00000265613 ITLTHTLYDVKSGTSGEKVGKLSLVDLAGSERATKTGAAGDRLKEGSNINKSLTTLGLVI CG8566-RD IFFTQRRHDLMTNLTTEKVSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVI * .*: :*: :. : ***.*:**********. .*** * *****:********** ** SINFRUP00000145254 SALADQSAGKG---KAKFVPYRDSVLTWLLKDNLGGNSKTAMIATVSPAADNYEETLSTL ENSMUST00000057087 SSLADQAAGKG---KNKFVPYRDSVLTWLLKDNLGGNSQTSMIATISPAADNYEETLSTL ENST00000265613 SALADQSAGKN---KNKFVPYRDSVLTWLLKDSLGGNSKTAMVATVSPAADNYDETLSTL CG8566-RD SALAEVASKKKNTKKADFIPYRDSALTWLLRENLGGNSKTAMIAAISPADINYDETLSTL *:**: :: * * .*:*****.*****::.*****:*:*:*::*** **:****** SINFRUP00000145254 RYADRAKRIVNHAVVNEDPNARIIRELREEVEKLK-------------VQLSQAESMKAP ENSMUST00000057087 RYADRAKRIVNHAVVNEDPNAKVIRELREEVEKLR-------------EQLSQAEAMKAP ENST00000265613 RYADRAKHIVNHAVVNEDPNARIIRDLREEVEKLR-------------EQLTKAEAMKSP CG8566-RD RYADRAKQIVCKAVVNEDANAKLIRELKEEIQKLRDLLKAEGIEVQEEDELTKSTVIKSP *******:** :******.**::**:*:**::**: :*::: :*:* SINFRUP00000145254 E------------LKEKLHESEKLIQEMTVTWEEKLRKTEEIATERQKQLESMGISLETS ENSMUST00000057087 E------------LKEKLEESEKLIKELTVTWEEKLRKTEAIAQERQRQLESMGISLETS ENST00000265613 E------------LKDRLEESEKLIQEMTVTWEEKLRKTEEIAQERQKQLESLGISLQSS CG8566-RD TKSRNRNGSTTEMAVDQLQASEKLIAELNETWEEKLKRTEEIRVQREAVFAEMGVAVKED ::*. ***** *:. ******::** * :*: : .:*:::: . SINFRUP00000145254 GIKVKDD----KCFLVNLNADPALNELLVYYLKEHTRVG----ADTSQDIQLFGIGIQPE ENSMUST00000057087 GIKVGDD----KCYLVNLNADPALNELLVYYLKDHTRVG----ADTSQDIQLFGIGIQPE ENST00000265613 GIKVGDD----KCFLVNLNADPALNELLVYYLKEHTLIG----SANSQDIQLCGMGILPE CG8566-RD GITVGVFSPKKTPHLVNLNEDPNLSECLLYYIKEGLTRLGTHEANVPQDIQLSGSHILKE **.* . .***** ** *.* *:**:*: : .***** * * * SINFRUP00000145254 HCVLELCQDGDVTLTPVGISRTCVNGTMIDSLVHLWHGDRILWGNNHFFRINLPNRKRRD ENSMUST00000057087 HCEIDIAADGDITLTPKENARSCVNGTLVCSTTQLWHGDRILWGNNHFFRINLPKRKRRD ENST00000265613 HCIIDITSEGQVMLTPQKNTRTFVNGSSVSSPIQLHHGDRILWGNNHFFRLNLPKKKKKA CG8566-RD HCTFENK-NSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQAREL ** :: :. : * * : *** : . * *.*:: *:**.**:. *:: :. SINFRUP00000145254 RLKELERASPRE-----SFIEADVETASEASSEQDYSYEFAQMEVMMKT-LGNNDPMQNV ENSMUST00000057087 WLKDFERET--------SSAEHDLDAASEASSEPDYNYEFAQMEVIMKT-LNSNDPVQNV ENST00000265613 EREDEDQDPSMKNENSSEQLDVDGDSSSEVSSEVNFNYEYAQMEVTMKA-LGSNDPMQSI CG8566-RD RDK--------------IETENEAENEVEKTDTQQVDWNFAQCELLEKQGIDLKAEMKKR : : : : * :. : .:::** *: * :. : ::. SINFRUP00000145254 VQVLEKQYLEE---KRTALEEQRMMYERELESLRQQLSPEKTAAPHH-HSGGERLTYPVA ENSMUST00000057087 VQVLEKQYLEE---KRTALEEQRLMYERELEQLRQQLSPERQPP----SSASDRLAY-SS ENST00000265613 LNSLEQQHEEE---KRSALERQRLMYEHELEQLRRRLSPEKQNCR-----SMDRFSF-HS CG8566-RD LDNLEEQYKREKLQADQQFEEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPEDFHQEED :: **:*: .* :*.** ** .:: *::::. : . : : SINFRUP00000145254 HAAHSKLRLWTEERDE---------LFRQSLSRLREQVVKANTLVREANFLAEEMSTLTD ENSMUST00000057087 QTAQQKVTQWAEERDE---------LFRQSLAKLREQLVKANTLVREANFLAEEMSKLTD ENST00000265613 PSAQQRLRQWAEEREA---------TLNNSLMRLREQIVKANLLVREANYIAEELDKRTE CG8566-RD VYTNPMYESCWTAREAGLAAWAFRKWRYHQFTSLRDDLWGNAIFLKEANAISVELKKKVQ :: *: :.: **::: :::*** :: *:.. .: SINFRUP00000145254 YQVTLQIPAANLSANRKRGVIVS-----------------EPAIQVRRKGRGTQVWTIEK ENSMUST00000057087 YQVTLQIPAANLSANRKRGAIVS-----------------EPAIQARRKGKGTQVWTIEK ENST00000265613 YKVTLQIPASSLDANRKRGSLLS-----------------EPAIQVRRKGKGKQIWSLEK CG8566-RD FQFTLLTDTLYSPLPPELASTVAPVHQEDEFGAPPVSKTLVAVEVTDTKNGATHHWSLEK ::.** : : . :: .. . *. ..: *::** SINFRUP00000145254 LENKLVDMREHYADWKEDS-AEMCKRTNSNCC-DPFYEAQENHNLIGVANIFLECLFHDV ENSMUST00000057087 LENKLIDMRDLYQEWKEN--VPEAKRLYGKRG-DPFYEAQENHNLIGVANVFLECLFCDV ENST00000265613 LDNRLLDMRDLYQEWKECEEDNPVIRSYFKRA-DPFYDEQENHSLIGVANVFLESLFYDV CG8566-RD LRQRLELMREMYHNEAEMSPTSPDYNVESLTGGDPFYDRFPWFRMVGRSFIYLSNLLYPV * ::* **: * : * . ****: . ::* : ::*. *: * SINFRUP00000145254 KLQYAVPIISQQGEVAGRLHIEMMRVSGAVPERLCGGDDSSENSSESSCYEVMDTNGEIV ENSMUST00000057087 KLQYAVPIISQQGEVAGRLHVEVTRITGTIPERMAE-DDSSENSSESGSLEVVDSSGEVI ENST00000265613 KLQYAVPIINQKGEVAGRLHVEVMRLSGDVGERIAGGDEVAEVSFEKETQE--------- CG8566-RD PLVHKVAIVNERGDVRGYLRIAVQPVLDEESIDFNNGVKQSARLVFNEDDAKPKYR---- * : *.*:.::*:* * *:: : : . : . : . :: SINFRUP00000145254 HMAKRLTCRVRIREATGLPLNLSNFVFCQYS--FWEQGEPAVAPPMVSPDRPSPRSPDAQ ENSMUST00000057087 HRVKKLTCRVIIKEATGLPISLSNFVFCQYT--FWDQCESTVAAPVVDPDVPSPQSKDAQ ENST00000265613 ---NKLVCMVKILQATGLPQHLSHFVFCKYS--FWDQQEPVIVAPEVDTS-SSSVSKEPH CG8566-RD -ALNEKDDVQRYIDNGGLDSKLEELEDVDSGRGIDSNSASECHENSEEPGEHLQVGKEFT :. : ** *..: . : .: . ... . : SINFRUP00000145254 FTVQFDHCKKPLVLISVSFQE----------------------------EDLNCVRERWS ENSMUST00000057087 YTVTFSHCKDYVVTVTEEFLEFISDGALAIEVWGHRC--AGNGSPIWEVDSLHAKTRTLH ENST00000265613 CMVVFDHCNEFSVNITEDFIEHLSEGALAIEVYGHKINDPRKNPALWDLGIIQAKTRSLR CG8566-RD FRVTVLQATGIGAEYADIFCQFNFLHRHEEAFSTEPVKNSASGAPLGFYHVQNITVPVTK * . :.. . : * : : SINFRUP00000145254 E--ALIKRR--------------------------------------------------- ENSMUST00000057087 D--REMRRMAVIWIVIR------------------------------------------- ENST00000265613 DRWSEVTRKLEFWVQILEQNENGEYCPVEVISAKDVPTGGIFQLRQGQSRRVQVEVKSVQ CG8566-RD SFIEYLKTQP-------------------------------------------------- . : SINFRUP00000145254 ------------------------------------------------------------ ENSMUST00000057087 ----------------------------------------------------YCHRCQSR ENST00000265613 ESGTLPLMEECILSVGIGCVKVRPLRAPRTHETFHEEEEDMDSYQDRDLERLRRKWLNAL CG8566-RD ------------------------------------------------------------ SINFRUP00000145254 ----EYLDEQIKKIINKHEKTEEDIEREARLVEQWVGLAEERNAVLVPAPGSGIPGAPAD ENSMUST00000057087 AWGTALANHQPSQSRGQGEKTEDDMEREARLVEQWVGLTEERNAVLVPAPGSGIPGAPAD ENST00000265613 TKRQEYLDQQLQKLVSKRDKTEDDADREAQLLEMRLTLTEERNAVMVPSAGSGIPGAPAE CG8566-RD -----IMFKIFGHYQTHPLHKDAKQDFVSRPPPRRMLPPSIPISQPVRSPKFGPLPCAPT . : : :.: . : :: : .. : * :. * ... SINFRUP00000145254 WTPPAGMEAHIPVLFLDLNADNLTLNEQLTGPHAAGVNSILPKEHGSQFFYLPIIRHSEE ENSMUST00000057087 WVPPPGMETHIPVLFLDLNADDLSANEQLVGPHASGVNSILPKEHGSQFFYLPIIKHSDD ENST00000265613 WTPVPGMETHIPVIFLDLNADDFSSQDNLDDPEAGGWDATLTGEEEEEFFELQIVKQHDG CG8566-RD STVLAKHDVLVWFEICELAPNGEYVPSVVEHSDDLPCRGLFLLHQG---IQRRIRITIVH . . :. : . : :* .:. . : .. . : .. :: * SINFRUP00000145254 ELSAVCSWDSSIHDSVHLNRVTSSNERIYLIVKATVQLSHPASLELVLRKRIAVNIYNKQ ENSMUST00000057087 EVSATASWDSSVHDSLHLNRVTPQNERIYLIVKTTVQLSHPAAMELVLRKRIAANIYNKQ ENST00000265613 EVKAEASWDSAVHGCPQLSRGTPVDERLFLIVRVTVQLSHPADMQLVLRKRICVNVHGRQ CG8566-RD EPTTEVKWKDINELVVGRIRNTPESSDEQDEDACVLSLGLFPGEALEVPGDDRSFYRFEA * .: .*.. . * *. .. .:.*. . * : . SINFRUP00000145254 SFTQSLKRRMSLKNTLHACGVTYEIVSNIPKASEEPEERETLALMAARGDSEETQDGETY ENSMUST00000057087 SFTQSLKRRISLINICYSCGVTYEIVSNIPKATEEIEDRETLALLAARSENEGTLDGETY ENST00000265613 GFAQSLLKKMSHRSSIPGCGVTFEIVSNIPEDAQGVEEREALARMAANVENPASADSEAY CG8566-RD AWDSSLHNSALLNRVSQGGETIYITLSAYLELENCARPAIITKDLSMVIYGRDARTGPRS .: .** . . . : :* : : . :: . : . SINFRUP00000145254 IEKYTRGVLEVENILSLEKLRQAVTVKEALTVKGRHLRRSVSTPNVQ----HVMIICPDL ENSMUST00000057087 IEKYTRGVLQVENILSLERLRQMIIRYVRHVGKMRLSQVSSSRPDLSGFD-EDDKGWPEN ENST00000265613 IEKYLRSVLAVENLLTLDRLRQEVAVKEQLTGKGKLSRRSISSPNVNRLSGSRQDLIPSY CG8566-RD LKHLFSGQYRNPEANRLTGVYELALRRASEAGSPGVQRRQRRVLDTSSTYVRGEENLHGW ::: . : * : : . . : . : . SINFRUP00000145254 TVETQGSIPEMINAIQVGNDKE---------QSITNNMSAGLAADGATFFNSSPFKVLSP ENSMUST00000057087 QLDVSDYSSSYQDVACYGTLPR---------DSPRRSK-EGCPSENPHALTVSPFKAFSP ENST00000265613 SLGSNKGRWESQQDVSQTTVSRGIAPAPALSVSPQNNHSPDPGLSNLAASYLNPVKSFVP CG8566-RD RPRGDSLIFDHQWELEKLTRLEEVG-----RMRHLLLLRERLGMDTNPNPTTKTEKDVCN . . . . . .. * . SINFRUP00000145254 QPAKFLKSLLPVKEESKAR----KALEARPLLGQE------------------------- ENSMUST00000057087 QPPKFFKPLMPVKEEHKKR----LALEARPLLSQESMPPSQAHNPGCIVTPGSNGSSMPV ENST00000265613 QMPKLLKSLFPVRDEKRGKRPSPLAHQPVPRIMVQSASP-----------------DIRV CG8566-RD LAARAATSPVHMVIPQSPQ--------------------------------------TPV .: .. . : : : SINFRUP00000145254 -DSEDEETDVDAN---LSLDPTLHDHSGFKPYIPEDFANFEIYNAALESLPFSRSDSKRG ENSMUST00000057087 EHSSKPEKKIDSEEEENELEALSRKLMLTQPYVPVEFADFSVYNASLENREWS--SSKAD ENST00000265613 TRMEEAQPEMGPDVLVQTMGAPALKICDKPAKVPSPPPVIAVTAVTPAPEAQDGPPSPLS CG8566-RD KDPQQIIPEREYNQREQDLMLKCLKLVQGRYTKSEANDTQTQSDVSPSDEGCADMTVSCI .. . : : . . .: SINFRUP00000145254 RCGGGSGDREVPRSPTVSSCTSGYFSHSASN-----------ATLSDMPFSTSESCD--- ENSMUST00000057087 LTDSRALEKAVSRSPTTSSLTSGYFSHSASN-----------ATLSDMAVPSSDSSD--- ENST00000265613 EASSGYFSHSVSTATLSDALGPGLDAAAPPGSMPTAPEAEPEAPISHPPPPTAVPAEEPP CG8566-RD SSNSMENNKFVIRRRLCSPDRADAPNGWEAP-----------APATQPALPLR------- .. .: * .. .. . *. :. . . SINFRUP00000145254 ---HLSGTSRD------------------------------------------------- ENSMUST00000057087 ---QLAVSTKEVECAEPPGPSLAPDVRPASNQELTEVGRGSGKDETIAVPLEENSALP-K ENST00000265613 GPQQLVSPGRERPDLEAPAPGSPFRVRRVRASELRSFSRMLAGDPGCSPGAEGNAPAPGA CG8566-RD ----LYVPELEEIRVSPVVARKGLLNVLEHGGSGWKKRWVIVRRPYVFIYRSEKDPVERA * . : SINFRUP00000145254 ------------------------------------------------------------ ENSMUST00000057087 GTPSPQSIPEESSRMPCRTASCSELDVGPSKDGHQAREFCPGEVTIEHTTNILEDHSFTE ENST00000265613 GGQALASDSEEADEVPEWLREGEFVTVGAHKTG-VVRYVGPADFQEGTWVGVELDLPSGK CG8566-RD VLNLATAHVECSEDQAAMVKIPNTFSVVTKHRGYLLQTLGDKEVHDWLYAINPLLAG--- SINFRUP00000145254 ------------------------------------------------------------ ENSMUST00000057087 FMGVSDGKDFDGLADCS------------------------VGEPSRRRALTN---ETDH ENST00000265613 NDGSIGGKQYFRCNPGYGLLVRPSRVRRATGPVRRRSTGLRLGAPEARRSATLSGSATNL CG8566-RD ----------------------------------------QIKSRLARRTLEPASQTASQ SINFRUP00000145254 ------------------------- ENSMUST00000057087 KGIPERPPDADRLHPKIENDQVITP ENST00000265613 ASLTAALAKADRSHKNPENRKSWAS CG8566-RD IQATNAANANSASK-----------