CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000018909 ------------------------------MGGLASGGDVEPGLPVEVRG ENST00000250113 ------------------------------MGGLASGGDVEPGLPVEVRG ENSMUST00000001620 ----------------------------------------MAELTVEVRG ENST00000305586 ----------------------------------------MAELTVEVRG Q9PUN3_Brachydanio_rerio -----------------------------------------EELTVEVRG SINFRUP00000154584 -------------------------------------------------- ENSMUST00000000857 AAAGGRAVTRRRRRRRRRLGLKRLQPTSRRRAPGARTDEKMEELVVEVRG ENST00000218200 ----------------------------------------MEELVVEVRG Q9DF20_Brachydanio_rerio ----------------------------------------MDELAVEVRG CG6203-RA ----------------------------------------MEDLLVEVRL : : : ENSMUST00000018909 SNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPP--PADYNKE ENST00000250113 SNGAFYKGFVKDVHEDSVTIFFENNWQSERQIPFGDVRLPP--PADYNKE ENSMUST00000001620 SNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPP--PPDIKKE ENST00000305586 SNGAFYKGFIKDVHEDSLTVVFENNWQPERQVPFNEVRLPP--PPDIKKE Q9PUN3_Brachydanio_rerio SNGAYYKGFVRDVHDDSLSISFENNWQPERQVPFSDVRLPP--SADTKKE SINFRUP00000154584 ------------------------SWQPERQLPFSDVRLPP--PADYHKD ENSMUST00000000857 SNGAFYKAFVKDVHEDSITVAFENNWQPERQIPFHDVRFPP--PVGYNKD ENST00000218200 SNGAFYKAFVKDVHEDSITVAFENNWQPDRQIPFHDVRFPP--PVGYNKD Q9DF20_Brachydanio_rerio ASGAFYKAYIKDVHESTVTVAFENNWQPERQISFQDVRFPP--PTGFQKE CG6203-RA DNGAYYKGQVTAVADDGIFVDVDG-VPESMKYPFVNVRLPPEETVEVAAP : : : : . . : .* :**:** . ENSMUST00000018909 ITEG-DEVEVYSRANEQEPCGWWLARVRMMKG--------DFYVIEYAAC ENST00000250113 ITEG-DEVEVYSRANEQEPCGWWLARVRMMKG--------DFYVIEYAAC ENSMUST00000001620 ISEG-DEVEVYSRANDQEPCGWWLAKVRMMKG--------EFYVIEYAAC ENST00000305586 ISEG-DEVEVYSRANDQEPCGWWLAKVRMMKG--------EFYVIEYAAC Q9PUN3_Brachydanio_rerio IGEG-EEVEIFSRANEQEPCGWWLAKVRMMKG--------DFYVIEYAAC SINFRUP00000154584 IIEG-EEVEVYSRANEQEPCGWWLARVKMIKGESLFLLLHQFYVIEYAAC ENSMUST00000000857 INES-DEVEVYSRANEKEPCCWWLAKVRMIKG--------EFYVIEYAAC ENST00000218200 INES-DEVEVYSRANEKEPCCWWLAKVRMIKG--------EFYVIEYAAC Q9DF20_Brachydanio_rerio INES-DEVEVYSRANDKEPCGWWLAKVRMVKG--------EFYVIEYAAC CG6203-RA IFEEGMEVEVFTRTNDRETCGWWVGIIKMRKA--------EIYAVAYIGF * * ***:::*:*::*.* **:. ::* *. ::*.: * . ENSMUST00000018909 DATYNEIVTLERLRPVNPSPLATKGSFFKVTMAVPEDLREACSNENVHKE ENST00000250113 DATYNEIVTLERLRPVNPNPLATKGSFFKVTMAVPEDLREACSNENVHKE ENSMUST00000001620 DATYNEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKD ENST00000305586 DATYNEIVTFERLRPVNQNKTVKKNTFFKCTVDVPEDLREACANENAHKD Q9PUN3_Brachydanio_rerio DATYNEIVTFERLRPVNRNKAVTESTFFRCSVPVPEDLRAACESEQAHKE SINFRUP00000154584 DATYNEIVTAERIRPLNPNCPCTSNSFHKIQIPVPEDLRDICSNDNIHKD ENSMUST00000000857 DATYNEIVTIERLRSVNPNKPATKDTFHKIKLEVPEDLRQMCAKESAHKD ENST00000218200 DATYNEIVTIERLRSVNPNKPATKDTFHKIKLDVPEDLRQMCAKEAAHKD Q9DF20_Brachydanio_rerio DATLNEIVTLERLRPVNPNKAATKNTFLKTRLDVPEDLRQMCAKDSAHKD CG6203-RA ETSYTEICELGRLRAKNSNPPITAKTFYQFTLPVPEELREEAQKDGIHKE ::: .** *:*. * . . :* : : ***:** . .: **: ENSMUST00000018909 FKKALGANCIFLNITNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLM ENST00000250113 FKKALGANCIFLNITNSELFILSTTEAPVKRASLLGDMHFRSLRTKLLLM ENSMUST00000001620 FKKAVGACRIFYHPETTQLMILSASEATVKRVNILSDMHLRSIRTKLMLM ENST00000305586 FKKAVGACRIFYHPETTQLMILSASEATVKRVNILSDMHLRSIRTKLMLM Q9PUN3_Brachydanio_rerio FKKAVGAIRIVYSPEKSELVVLSLSEATVKRVSLLSDIHLRSIRTKLMLM SINFRUP00000154584 LRKAIGANSISYSAQSHELIVLSTNGATVKRATLLSDMHFRSIRTKLMLM ENSMUST00000000857 FKKAVGAFSVTYDPENYQLVILSINEVTSKRAHMLIDMHFRSLRTKLSLI ENST00000218200 FKKAVGAFSVTYDPENYQLVILSINEVTSKRAHMLIDMHFRSLRTKLSLI Q9DF20_Brachydanio_rerio FKKAIGAFNVTYDSEEKQLVILSVNEVTAKRISMLSDMHFRSLRTKLALI CG6203-RA FQRTIDAGVCNYSRDLDALIVISKFEHTQKRASMLKDMHFRNLSQKVMLL :::::.* *.::* . ** :* *:*:*.: *: *: ENSMUST00000018909 SRNEEATKHLETSKQLAA-AFQEEFTVREDLMGLAIGTHGANIQQARKVP ENST00000250113 SRNEEATKHLETSKQLAA-AFQEEFTVREDLMGLAIGTHGANIQQARKVP ENSMUST00000001620 SRNEEATKHLECTKQLAA-AFHEEFVVREDLMGLAIGTHGSNIQQARKVP ENST00000305586 SRNEEATKHLECTKQLAA-AFHEEFVVREDLMGLAIGTHGSNIQQARKVP Q9PUN3_Brachydanio_rerio SRNQEATKHLESTKQLAS-AFQEEFTVREDLMGLAIGSHGSNIQQARKVP SINFRUP00000154584 SRNEEASKHLETSKQLAS-AYQEEVKVSEDLMGLAIGSHGANIQQARKVP ENSMUST00000000857 LRNEEASKQLESSRQLAS-RFHEQFIVREDLMGLAIGTHGANIQQARKVP ENST00000218200 MRNEEASKQLESSRQLAS-RFHEQFIVREDLMGLAIGTHGANIQQARKVP Q9DF20_Brachydanio_rerio LRNEEATRQLESSRQLAS-RFHEQFVERDDLMGLAIGTHGANIQQARKIS CG6203-RA KRTEEAARQLETTKLMSRGNYVEEFRVRDDLMGLAIGSHGSNIQAARTVD *.:**:::** :: :: : *:. :********:**:*** **.: ENSMUST00000018909 GVTAIELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNLVGKVIG ENST00000250113 GVTAIELGEETCTFRIYGETPEACRQARSYLEFSEDSVQVPRNLVGKVIG ENSMUST00000001620 GVTAIELDEDTGTFRIYGESAEAVKKARGFLEFVEDFIQVPRNLVGKVIG ENST00000305586 GVTAIELDEDTGTFRIYGESADAVKKARGFLEFVEDFIQVPRNLVGKVIG Q9PUN3_Brachydanio_rerio GVTAIELEEETGTFRIYGESTETLQKARNYLEFLEDSVQIPRNLVGKVIG SINFRUP00000154584 GVTAIELEEESCTFRIYGESPEAVRQAREYLEFREEYFQVPRNLVGKVIG ENSMUST00000000857 GVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIG ENST00000218200 GVTAIDLDEDTCTFHIYGEDQDAVKKARSFLEFAEDVIQVPRNLVGKVIG Q9DF20_Brachydanio_rerio GVTTIDLDEETCTFHIYGEDQEAVRKARSYLEFSEDVIKVPRNLVGKVIG CG6203-RA GVTNIELEEKSCTFKISGETEESVQRARAMLEYAEEFFQVPRELVGKVIG *** *:* *.: **:* ** :: ::** **: *: .::**:******* ENSMUST00000018909 KNGKVIQEIVDKSGVVRVRV-----EGDNDKKNPRE-------------- ENST00000250113 KNGKVIQEIVDKSGVVRVRV-----EGDNDKKNPRE-------------- ENSMUST00000001620 KNGKVIQEIVDKSGVVRVRI-----EGDNENKLPRE-------------- ENST00000305586 KNGKVIQEIVDKSGVVRVRI-----EGDNENKLPRE-------------- Q9PUN3_Brachydanio_rerio KSGKVIQEIVDKSGVVRVRI-----EGDNDNKLPRQ-------------- SINFRUP00000154584 KSGKVIQEIVDKSGVVRVRI-----EGDNDKKLPRV-------------- ENSMUST00000000857 KNGKLIQEIVDKSGVVRVRI-----EAENEKSVPQEEEIMPPSSLPSNNS ENST00000218200 KNGKLIQEIVDKSGVVRVRI-----EAENEKNVPQEEEIMPPNSLPSNNS Q9DF20_Brachydanio_rerio KSGKLIQEVVDKSGVVRVRV-----EPENDK------------------- CG6203-RA KNGRIIQEIVDKSGVFRIKVSAIAGDDEQDQNIPRE-------------- *.*::***:******.*::: : : :::: ENSMUST00000018909 -------------------------------------------------- ENST00000250113 -------------------------------------------------- ENSMUST00000001620 -------------------------------------------------- ENST00000305586 -------------------------------------------------- Q9PUN3_Brachydanio_rerio -------------------------------------------------- SINFRUP00000154584 -------------------------------------------------- ENSMUST00000000857 RVGPNSSEEKKHLDTKEN-THFSQPNSTKVQRVLVVSSIVAGGPQKPEPK ENST00000218200 RVGPNAPEEKKHLDIKENSTHFSQPNSTKVQRVLVASSVVAGESQKPELK Q9DF20_Brachydanio_rerio ---------------------------------------------KPSP- CG6203-RA -------------------------------------------------- ENSMUST00000018909 --EGMVPFIFVGTRENISNAQALLEYHLSYLQEVEQLRLERLQIDEQLRQ ENST00000250113 --EGMVPFIFVGTRENISNAQALLEYHLSYLQEVEQLRLERLQIDEQLRQ ENSMUST00000001620 --DGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQ ENST00000305586 --DGMVPFVFVGTKESIGNVQVLLEYHIAYLKEVEQLRMERLQIDEQLRQ Q9PUN3_Brachydanio_rerio --EGMVPFTFVGTKESISNVQVLLEYHIAYLNEVEQLRLERLQIDEQLRQ SINFRUP00000154584 --EGMVPFVFVGTKENIKTAWALLEYHMSYLQ------------------ ENSMUST00000000857 AWQGMVPFVFVGTKDSIANATVLLDYHLNYLKEVDQLRLERLQIDEQLRQ ENST00000218200 AWQGMVPFVFVGTKDSIANATVLLDYHLNYLKEVDQLRLERLQIDEQLRQ Q9DF20_Brachydanio_rerio LEEGMVPFVFVGTKESISNARILLDYHLNYLKEVDQLRMERLQIDEQLRQ CG6203-RA --LAHVPFVFIGTVESIANAKVLLEYHLSHLKEVEQLRQEKMEIDQQLRA . *** *:** :.* .. **:**: :*: : : : : : ENSMUST00000018909 IGLGFRPPGSGRGGSGGGSDKAGYTTDESSSSSLHTTRTYGGSYGGRGRG ENST00000250113 IGLGFRPPGSGRG--SGGSDKAGYSTDESSSSSLHATRTYGGSYGGRGRG ENSMUST00000001620 IGS------------------------RSYSG------------RGRGRR ENST00000305586 IGS------------------------RSYSG------------RGRGRR Q9PUN3_Brachydanio_rerio IGMGFRSVPNRPA-----DKEKGFGPDESSSGSIHTQRSY----RGRGRR SINFRUP00000154584 -------------------------------------------------- ENSMUST00000000857 IGASSRPPPNRTD------KEKGYVTDDGQGMGRGS-RPYRN--RGHGRR ENST00000218200 IGASSRPPPNRTD------KEKSYVTDDGQGMGRGS-RPYRN--RGHGRR Q9DF20_Brachydanio_rerio IGGGPRALPGRPE------KEKSFMADNGMGPSRGGGKPFGR--GGRGRR CG6203-RA IQESSMGSTQSFP-VTRRSERGYSSDIESVRSMRGGGGGQRGRVRGRGGG : ENSMUST00000018909 RRTGGPAYGPSSDPSTASETESEKREES---NRAGPGDRDP--PSRGEES ENST00000250113 RRTGGPAYGPSSDVSTASETESEKREEP---NRAGPGDRDP--PTRGEES ENSMUST00000001620 GPNYTSGYGTNSELSNPSETESERKDELSDWSLAG-EDDRE--TRHQRDS ENST00000305586 GPNYTSGYGTNSELSNPSETESERKDELSDWSLAG-EDDRD--SRHQRDS Q9PUN3_Brachydanio_rerio GPAHTSAYGTNSEHSYTSETDSERKAELSDWSLAADESERN--PRPQRDS SINFRUP00000154584 -------------------------------------------------- ENSMUST00000000857 GPGYTS--GTNSEASNASETESDHRDELSDWSLAPTEEERESFLRRG-DG ENST00000218200 GPGYTS--GTNSEASNASETESDHRDELSDWSLAPTEEERESFLRRG-DG Q9DF20_Brachydanio_rerio GPTLAS--GTNSEASNASETESDHRDELSDWSLAPTDEESMGYPKRAPDG CG6203-RA GPGGGNGLNQRYHNNRRDEDDYNSRGDHQRDQQRGYNDRGGGDNTGSYRG ENSMUST00000018909 RRRPIGGRGRG-PPPVPRPTSRYNSSSISSVLKDPDSNPYSLLDTSEPEP ENST00000250113 RRRPTGGRGRG-PPPAPRPTSRYNSSSISSVLKDPDSNPYSLLDTSEPEP ENSMUST00000001620 RRR-PGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQ ENST00000305586 RRR-PGGRGRSVSGGRGRGGPRGGKSSISSVLKDPDSNPYSLLDNTESDQ Q9PUN3_Brachydanio_rerio RRRDMRGRGR---GSRGRGS--GASNSISSVLKDPDGNPYSLLDNTETDQ SINFRUP00000154584 -------------------------------------------------- ENSMUST00000000857 RRRGGGGRGQG---GRGR------------------GGGFKGNDDHSRTD ENST00000218200 RRHSVVGLNRG---CGNKELPVSISESVT---VEPFENILIGNDDHSRTD Q9DF20_Brachydanio_rerio RKRGGGPRGRG---GRGR-------------------GGYK-TEDMHWND CG6203-RA GGGGAGGPGNNRRGGINRRPPRNDQQNG----RDYQHHNHTTEEVRETRE ENSMUST00000018909 PVDSEPGEPPPASARRRRSRRRRTDEDRTVMDGGLESDGPNMTENGLEDE ENST00000250113 PVDSEPGEPPPASARRR-SRRRRTDEDRTVMDGGLESDGPNMTENGLEDE ENSMUST00000001620 TADTDASESHHSTNRRRRSRRRRTDEDAVLMDGLTESDTASVNENGL--- ENST00000305586 TADTDASESHHSTNRRRRSRRRRTDEDAVLMDGMTESDTASVNENGL--- Q9PUN3_Brachydanio_rerio TADTDGSESQMNTSRRRRSRRRRTDEDTTVMDGMSESDNASLSENGL--- SINFRUP00000154584 -------------------------------------------------- ENSMUST00000000857 NRPRNPREAKGRTADG-----------------SLQSASS---------- ENST00000218200 NRPRNPREAKGRTTDGSLQIRVDCNNERSVHTKTLQNTSS---------- Q9DF20_Brachydanio_rerio SRSRSSRDSKLRPQEESRQIRIDSNNERSIHTSRSSQAMAGAR------- CG6203-RA MSSVERADSNSSYEGSSRRRRRQKNNNGPSNTNGAVANNNNKPQSAQQPQ ENSMUST00000018909 SRPQRRNRSRRRRNRGNRTDGSISGDRQPVTVADYISRAESQSRQRP-LE ENST00000250113 SRPQRRNRSRRRRNRGNRTDGSISGDRQPVTVADYISRAESQSRQRPPLE ENSMUST00000001620 -----------------------------GKRCD---------------- ENST00000305586 -----------------------------VTVADYISRAESQSRQRNLPR Q9PUN3_Brachydanio_rerio -----------------------------VTVADYISRAESQSRQTN-PR SINFRUP00000154584 -------------------------------------------------- ENSMUST00000000857 ----------------------------------------EGSRLRTGKD ENST00000218200 ----------------------------------------EGSRLRTGKD Q9DF20_Brachydanio_rerio ----------------------------------------GGNRQRPIKE CG6203-RA QQQPPAPGNKAALNAGDASKQNSGNANAAGGASKPKDASRNGDKQQAGTQ ENSMUST00000018909 RTKPSEDSLSG----QKGDSVSKLPKGPSE------------------NG ENST00000250113 RTKPSEDSLSG----QKGDSVSKLPKGPSE------------------NG ENSMUST00000001620 -------------------------------------------------- ENST00000305586 ETLAKNKKEMAKDVIEEHGPSEKAINGPTSASGDDISKLQRTPGEEKINT Q9PUN3_Brachydanio_rerio DTRKSKKDMTRGDFISEHSAAESVSNGP--------------------NN SINFRUP00000154584 -------------------------------------------------- ENSMUST00000000857 RNQKKEK------------------------------------------- ENST00000218200 RNQKKEK------------------------------------------- Q9DF20_Brachydanio_rerio RVMKKEK------------------------------------------- CG6203-RA QQQPSQVQQQQAAQQQQPKPRRNKNRSNNHTD------------QPSGQQ ENSMUST00000018909 ELSAPLELGSLVNGVS ENST00000250113 ELSAPLELGSMVNGVS ENSMUST00000001620 ---------------- ENST00000305586 LKEENTQEAAVLNGVS Q9PUN3_Brachydanio_rerio ADEPSESAKAVVNGVS SINFRUP00000154584 ---------------- ENSMUST00000000857 -PDSVDGLQPLVNGVP ENST00000218200 -PDSVDGQQPLVNGVP Q9DF20_Brachydanio_rerio -QDGSDS-QAVVNGVS CG6203-RA QLAENVKKEGLVNGTS ::