CLUSTAL W (1.82) multiple sequence alignment ENST00000246672 ---MTTLDSNNNTGGVITYIGSSGSSPSRTSPESLYSDNSNGSFQSLTQG ENSMUST00000017381 ---MTTLDSNNNTGGVITYIGSSGSSPSRTSPESLYSDSSNGSFQSLTQG SINFRUP00000148390 -------------------------------------------------- Q90Z63_Oncorhynchus_mykiss -------------------------------------------------- Q90Z65_Brachydanio_rerio -------------------------------------------------- CG8127-RB MEAVQAAAAATSSGGSSGSVPGSGSGSASKLIKTEPIDFEMLHLEENERQ : : : ENST00000246672 CPTYFPPSPTGSLTQDPARSFG---------SIPPSLSDDGSPSSSSSSS ENSMUST00000017381 CPTYFPPSPTGSLTQDPARSFG---------SAPPSLSDDSSPSSASSSS SINFRUP00000148390 -------------------------------------------------- Q90Z63_Oncorhynchus_mykiss -------------------------------------------------- Q90Z65_Brachydanio_rerio -------------------------------------------------- CG8127-RB QDIEREPSSSNSNSNSNSLTPQRYTHVQVQTVPPRQPTGLTTPGGTQKVI ENST00000246672 SSSSS-FYNGSPPGSLQVAMEDSSRVSPSKSTSNITKLNGMVLLCKVCGD ENSMUST00000017381 SSSSSSFYNGSPPGSLQVAMEDSSRVSPSKGTSNITKLNGMVLLCKVCGD SINFRUP00000148390 -------------------------------------------------- Q90Z63_Oncorhynchus_mykiss -------------------------------------------------- Q90Z65_Brachydanio_rerio -------------------------------------------LCKVCGD CG8127-RB LTPRVEYVQQRATSSTGGGMKHVYSQQQGTAASRSAPPETTALLTTTSGT : :: ENST00000246672 VASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQ ENSMUST00000017381 VASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQ SINFRUP00000148390 -------------------------------------------------- Q90Z63_Oncorhynchus_mykiss ------------------FRRSIQHSTRYKKCLKMENCTVIRINRNRCQQ Q90Z65_Brachydanio_rerio VASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKTESCTIVRINRNRCQQ CG8127-RB PQIIITRTLPSNQHLSRRHSASPSALHHYQQQQPQRQQSPPPLHHQQQQQ : : : ENST00000246672 CRFKKCLSVGMSRDAVRFGRIPKRE------------------------- ENSMUST00000017381 CRFKKCLSVGMSRDAVRFGRIPKRE------------------------- SINFRUP00000148390 --------------AVRFGRIPKRE------------------------- Q90Z63_Oncorhynchus_mykiss CRFKKCLAVGMSRDSVRFGRIPKRE------------------------- Q90Z65_Brachydanio_rerio CRFKKCLSVGMSRDAVRFGRIPKRE------------------------- CG8127-RB QQHVRVIRDGRLYDEATVVVAARRHSVSPPPLHHHSRSAPVSPVIARRGG : . . .:*. ENST00000246672 -------------------------------------------------- ENSMUST00000017381 -------------------------------------------------- SINFRUP00000148390 -------------------------------------------------- Q90Z63_Oncorhynchus_mykiss -------------------------------------------------- Q90Z65_Brachydanio_rerio -------------------------------------------------- CG8127-RB AAAYMDQQYQQRQTPPLAPPPPPPPPPPPPPPPQQQQQQYISTGVPPPTA ENST00000246672 ----------KQRMLAEMQSAMN--LANN--QLSSQCPLETSP------- ENSMUST00000017381 ----------KQRMLAEMQSAMN--LANN--QLSSLCPLETSP------- SINFRUP00000148390 ----------KQRMLLEMQNAMNNMMSNN-SQLHTMLHSHQSPSPPMEAS Q90Z63_Oncorhynchus_mykiss ----------KQRMLLEMQNAMNNMMMNNNSQHHSMLHGTQSPPCPMEGL Q90Z65_Brachydanio_rerio ----------KQRMLLEMQTAMNNMMNNS--QLQHMLHVSPS-------- CG8127-RB AARKFVVSTSTRHVNVIASNHFQQQQQQHQAQQHQQQHQQHQQHQQHVIA .::: .. :: : * . ENST00000246672 --TQHPTPGPMGPSPPPAP----VPSPLVGFSQFPQQLTPPRSPSPEPTV ENSMUST00000017381 --TPHPTSGSMGPSPPPAP----APTPLVGFSQFPQQLTPPRSPSPEPTM SINFRUP00000148390 --DASSAPSASDSSSCSSPSSPQCPQDSESVISMDTNSSSASSCASDSGE Q90Z63_Oncorhynchus_mykiss PNDGSSSSSASSSSSISSSSGSNPSSPCSAQDSMETSSSSASSCSSDSGD Q90Z65_Brachydanio_rerio --DSSSSSSASPPDSPRSS--------TESLVPMDT----ASSCSSDSGE CG8127-RB SVSSSSSSSAIGSGGSSSSHIFRTPVVSSSSSSNMHHQQQQQQQQSSLGN .:... .. :. . . .. ENST00000246672 EDVISQVARAHREIFTYAHDKLG-------SSPGNFNANHASGSPPATTP ENSMUST00000017381 EDVISQVARAHREIFTYAHDKLG-------TSPGNFNANHASGSPSATTP SINFRUP00000148390 DEAVVTGSGQRQNAFAYRQQSQ--------ASYSLVTVPTEAGCMEVPAE Q90Z63_Oncorhynchus_mykiss DEVPPSRVCH-QGTFTYRREQQQSIKEEPEESPSPVARETVKDRRDSRME Q90Z65_Brachydanio_rerio E----------DGRFSYS------------ASVSPAASETLSREEE---- CG8127-RB SVMRPPPPPPPPKVKHASSSSSGNSSSSNTNNSSSSSNGEEPSSSIPDLE . . . ENST00000246672 HRWENQGCPPAPNDNNTLAAQRHN---EALNGLRQAPSSYPPT---WPPG ENSMUST00000017381 HRWESQGCPSAPNDNNLLAAQRHN---EALNGLRQGPSSYPPT---WPSG SINFRUP00000148390 --QENWNCWNKNTGVEAYQYRSHS-PHVSNAAYREERGDYQQQ---CHSA Q90Z63_Oncorhynchus_mykiss ELQESWKRCDQDT--RGYQPSCNSHQHVTNGPYREERVVYQQQPAQLSGA Q90Z65_Brachydanio_rerio --EPQMHCWRRSD--------CPN----TTGPYREQT---AQQ---CIRS CG8127-RB FDGTTVLCRVCGDKASGFHYGVHS--CEGCKGFFRRSIQQKIQYRPCTKN . . ENST00000246672 PAHHSCHQSNSNGHRLCPTHVYAAPEGKAPANSPRQGNSKNVLLACPMNM ENSMUST00000017381 PTHHSCHQPNSNGHRLCPTHVYSAPEGEAPANSLRQGNTKNVLLACPMNM SINFRUP00000148390 PSRKPAEDATSWREFKR------LPSCRGPQEPNSCLHN-RTRLVCPMNT Q90Z63_Oncorhynchus_mykiss PSGRMPEDSYSLHHRSHNIMHNIQTVSNGYSRPSYSLRDHKTNMVTP--- Q90Z65_Brachydanio_rerio PTEN-----------------------RTYCRRNMNEGGNRAHLVCPMSA CG8127-RB QQCSILRINRNRCQYCRLKKCIAVGMSRDAVRFGRVPKREKARILAAMQQ . . .. : .: ENST00000246672 YPHGRSGR------------------------------------------ ENSMUST00000017381 YPHGRSGR------------------------------------------ SINFRUP00000148390 SPYVGPNK------------------------------------------ Q90Z63_Oncorhynchus_mykiss SLYVDPSQ------------------------------------------ Q90Z65_Brachydanio_rerio SQFVDATR------------------------------------------ CG8127-RB STQNRGQQRALATELDDQPRLLAAVLRAHLETCEFTKEKVSAMRQRARDC : ENST00000246672 ----------------TVQEIWEDFSMSFTPAVREVVEFAKHIPGFRDLS ENSMUST00000017381 ----------------TVQEIWEDFSMSFTPAVREVVEFAKHIPGFRDLS SINFRUP00000148390 ----------------SSQEIWEEFSMSFTPAVQEVVDFAKRIPGFRDLP Q90Z63_Oncorhynchus_mykiss ----------------RSQEIWEEFSLSFIPAVREVVGFAKRIPGFRDLS Q90Z65_Brachydanio_rerio ----------------PGHEVWEEFSRSFIPAVREVVEFAKRIPGFQELS CG8127-RB PSYSMPTLLACPLNPAPELQSEQEFSQRFAHVIRGVIDFAGMIPGFQLLT : ::** * .:: *: ** ****: *. ENST00000246672 QHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQELGAMG-M ENSMUST00000017381 QHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQELGAMG-M SINFRUP00000148390 KNDQVSLLKAGTFEVLMVRFASLFNAAERTVTFLSGKRYSLDTLCSLG-A Q90Z63_Oncorhynchus_mykiss EYDQVSLLKNGTFEVLMVCFASLFDVAERTVTFLTGKCYSLELLHSLR-A Q90Z65_Brachydanio_rerio QHDQVNLLKAGTFEVLMVRFVPLFDVQQRTVSFMSGRRYSVDLLRSMG-A CG8127-RB QDDKFTLLKAGLFDALFVRLICMFDSSINSIICLNGQVMRRDAIQNGANA : *:..*** * *:.*:* : :*: .:: :. : : ENST00000246672 GDLLSAMFDFSEKLNSLALTEEELGLFTAVVLVSXHRSGMENSASVEQLQ ENSMUST00000017381 GDLLNAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQ SINFRUP00000148390 GELLLSMCEFSEKLAALRLDSDEMSLFAAVVLVSADRSGIQDLNAVEALQ Q90Z63_Oncorhynchus_mykiss GQLLTSMCDFSEKLAALQLDKDEMSLFIAVVLVSADRSGIQDLKSVEALQ Q90Z65_Brachydanio_rerio GELLNCMFEFSEKLAALQLNDEEMSLFSAVVLVSADRSAIEDVVGVEALQ CG8127-RB RFLVDSTFNFAERMNSMNLTDAEIGLFCAIVLITPDRPGLRNLELIEKMY *: . :*:*:: :: * . *:.** *:**:: .*..:.: :* : ENST00000246672 ETLLRALRALVLKNRPLET-SRFTKLLLKLPDLRTLNNMHSEKLLSFRVD ENSMUST00000017381 ETLLRALRALVLKNRPSET-SRFTKLLLKLPDLRTLNNMHSEKLLSFRVD SINFRUP00000148390 DQLIRALRNLIGEKHGDESATTFTKLLLKLPELRS--------------- Q90Z63_Oncorhynchus_mykiss DTLIRALRSLIMTNHANET-TTFTKLLLKL-------------------- Q90Z65_Brachydanio_rerio ESLIRALRNLIMKNHSNES-SVFTKLLLKLPDLRT--------------- CG8127-RB SRLKGCLQYIVAQNRPDQP-EFLAKLLETMPDLRTLSTLHTEKLVVFRTE . * .*: :: :: :. ::*** .: : : : :: : ENST00000246672 AQ------------------------------------------------ ENSMUST00000017381 AQ------------------------------------------------ SINFRUP00000148390 -------------------------------------------------- Q90Z63_Oncorhynchus_mykiss -------------------------------------------------- Q90Z65_Brachydanio_rerio -------------------------------------------------- CG8127-RB HKELLRQQMWSMEDGNNSDGQQNKSPSGSWADAMDVEAAKSPLGSVSSTE ENST00000246672 -------------------------------------------------- ENSMUST00000017381 -------------------------------------------------- SINFRUP00000148390 -------------------------------------------------- Q90Z63_Oncorhynchus_mykiss -------------------------------------------------- Q90Z65_Brachydanio_rerio -------------------------------------------------- CG8127-RB SADLDYGSPSSSQPQGVSLPSPPQQQPSALASSAPLLAATLSGGCPLRNR ENST00000246672 -------------------------------------------------- ENSMUST00000017381 -------------------------------------------------- SINFRUP00000148390 -------------------------------------------------- Q90Z63_Oncorhynchus_mykiss -------------------------------------------------- Q90Z65_Brachydanio_rerio -------------------------------------------------- CG8127-RB ANSGSSGDSGAAEMDIVGSHAHLTQNGLTITPIVRHQQQQQQQQQIGILN ENST00000246672 -------------------------------------------------- ENSMUST00000017381 -------------------------------------------------- SINFRUP00000148390 -------------------------------------------------- Q90Z63_Oncorhynchus_mykiss -------------------------------------------------- Q90Z65_Brachydanio_rerio -------------------------------------------------- CG8127-RB NAHSRNLNGGHAMCQQQQQHPQLHHHLTAGAARYRKLDSPTDSGIESGNE ENST00000246672 -------------------------------------------------- ENSMUST00000017381 -------------------------------------------------- SINFRUP00000148390 -------------------------------------------------- Q90Z63_Oncorhynchus_mykiss -------------------------------------------------- Q90Z65_Brachydanio_rerio -------------------------------------------------- CG8127-RB KNECKAVSSGGSSSCSSPRSSVDDALDCSDAAANHNQVVQHPQLSVVSVS ENST00000246672 -------------------------------------------------- ENSMUST00000017381 -------------------------------------------------- SINFRUP00000148390 -------------------------------------------------- Q90Z63_Oncorhynchus_mykiss -------------------------------------------------- Q90Z65_Brachydanio_rerio -------------------------------------------------- CG8127-RB PVRSPQPSTSSHLKRQIVEDMPVLKRVLQAPPLYDTNSLMDEAYKPHKKF ENST00000246672 -------------------------------------------------- ENSMUST00000017381 -------------------------------------------------- SINFRUP00000148390 -------------------------------------------------- Q90Z63_Oncorhynchus_mykiss -------------------------------------------------- Q90Z65_Brachydanio_rerio -------------------------------------------------- CG8127-RB RALRHREFETAEADASSSTSGSNSLSAGSPRQSPVPNSVATPPPSAASAA ENST00000246672 -------------------------------------------------- ENSMUST00000017381 -------------------------------------------------- SINFRUP00000148390 -------------------------------------------------- Q90Z63_Oncorhynchus_mykiss -------------------------------------------------- Q90Z65_Brachydanio_rerio -------------------------------------------------- CG8127-RB AGNPAQSQLHMHLTRSSPKASMASSHSVLAKSLMAEPRMTPEQMKRSDII ENST00000246672 -------------------------------------------------- ENSMUST00000017381 -------------------------------------------------- SINFRUP00000148390 -------------------------------------------------- Q90Z63_Oncorhynchus_mykiss -------------------------------------------------- Q90Z65_Brachydanio_rerio -------------------------------------------------- CG8127-RB QNYLKRENSTAASSTTNGVGNRSPSSSSTPPPSAVQNQQRWGSSSVITTT ENST00000246672 -------------------------------------------------- ENSMUST00000017381 -------------------------------------------------- SINFRUP00000148390 -------------------------------------------------- Q90Z63_Oncorhynchus_mykiss -------------------------------------------------- Q90Z65_Brachydanio_rerio -------------------------------------------------- CG8127-RB CQQRQQSVSPHSNGSSSSSSSSSSSSSSSSSTSSNCSSSSASSCQYFQSP ENST00000246672 -------------------------------------------------- ENSMUST00000017381 -------------------------------------------------- SINFRUP00000148390 -------------------------------------------------- Q90Z63_Oncorhynchus_mykiss -------------------------------------------------- Q90Z65_Brachydanio_rerio -------------------------------------------------- CG8127-RB HSTSNGTSAPASSSSGSNSATPLLELQVDIADSAQPLNLSKKSPTPPPSK ENST00000246672 -------------------------------------------------- ENSMUST00000017381 -------------------------------------------------- SINFRUP00000148390 -------------------------------------------------- Q90Z63_Oncorhynchus_mykiss -------------------------------------------------- Q90Z65_Brachydanio_rerio -------------------------------------------------- CG8127-RB LHALVAAANAVQRYPTLSADVTVTASNGGPPSAAASPAPSSSPPASVGSP ENST00000246672 --------------- ENSMUST00000017381 --------------- SINFRUP00000148390 --------------- Q90Z63_Oncorhynchus_mykiss --------------- Q90Z65_Brachydanio_rerio --------------- CG8127-RB NPGLSAAVHKVMLEA