CLUSTAL W (1.82) multiple sequence alignment ENST00000225916 MAEPSQAPTPAPAAQPRPLQSPAPAPTPTPAPSPASAPIPTPTPAPAPAPAAAPAGSTGT ENSMUST00000006973 MAEPSQAPNPVPAAQPRPLHSPAPAPTSTPAPSPASASTPAPTPAPAPAPAAAPAGSTGS SINFRUP00000141254 ----------AQALQPRLLQAQTGG------------------------SAGSSTGNTGS SINFRUP00000159173 ------------------------------------------------GAAGLVPAGPGA ENSMUST00000000724 ------------------------------------------------------------ CG4107-RA ---------MSGGPSITIKSQPIDGNNTGNAAAQQQQQAANGAATAGASGAAGSAQNPGH ENST00000225916 GGPGVGSGGAGSGGDPARPG-LSQQQRASQRKAQVRGLPRAKKLEKLGVFSACKANETCK ENSMUST00000006973 GGAGVG-----SGGDPARPG-LSQQQRASQRKAQVRGLPRAKKLEKLGVFSACKANETCK SINFRUP00000141254 GS---------GNSDPARPG-LSQQQRASQKKAQVRAFPRAKKLEKLGVFSACKAIDTCK SINFRUP00000159173 GG------------TEGSGT-AGGSARIAVKKAQLRSSPRPKKLEKLAVYSSCKAEGACK ENSMUST00000000724 ------------------------------------------------------AEESCK CG4107-RA GGAASG-----AGSVPAEGTRQNSLQRIQQRKQKVFNLPVPQKLAKLSMYSACQSEG-CR : : : : : *: ENST00000225916 CNGWKNPKP-PTAPRMDLQQPAANLSELCR--SCEHPLADHVSHLENVSEDEINRLLGMV ENSMUST00000006973 CNGWKNPKP-PTAPRMDLQQPAANLSELCR--SCEHPLADHVSHLENVSEDEINRLLGMV SINFRUP00000141254 CNGWKNPNP-PSAPRMDLQQQAASLSESCR--SCEHSLADHVSHLENVSEDEINRLLGMV SINFRUP00000159173 CNGWKSQNPPPTPPRTDQQSSAVNLQEPCR--SCSHTLGDHVTHLENISEEEMNRLLGIV ENSMUST00000000724 CNGWKNPNPSPTPPRGDLQQIIVSLTESCR--SCSHALAAHVSHLENVSEEEMDRLLGIV CG4107-RA CTGWKTPQE--NRHRDVESSYCPEFNEECRNTSCRHSLRSHIAHLDNISSSSMNELLGAI *.***. : . * .. .: * ** ** *.* *::**:*:*...::.*** : ENST00000225916 VDVENLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMTRPVVEGS-LGSPPFEKPNIEQGV ENSMUST00000006973 VDVENLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMTRPVVEGS-LGSPPFEKPNIEQGV SINFRUP00000141254 VDVENLFMSVHKEEDTDTKQVYFYLFKLLRKSILQMSQPVVEGS-LGSPPFEKPNIEQGV SINFRUP00000159173 LDVEYLYTCVHKEEDADTKQVYFSLFKLLRKSILQMGKPMLEA--QESPPFERPSIEQGV ENSMUST00000000724 LDVEYLFTCVHKEEDADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGV CG4107-RA IDMENLFMSMQRVEDEDTKKVYQYLFRLLRQCVLTRQQAVIRGP-LGDPPFETPCITKAV :*:* *: .::: ** ***:** **:***:.:* :.::.. .**** * * :.* ENST00000225916 LNFVQYKFSHLAPRERQTMFELSKMFLLCLNYWKLETPAQFRQRSQAEDVATYKVNYTRW ENSMUST00000006973 LNFVQYKFSHLAPRERQTMFELSKMFLLCLNYWKLETPAQFRQRSQSEDVATYKVNYTRW SINFRUP00000141254 LNFVQYKFSHLAPKERQTMFELSKMFLLCLNYWKLETPTQYRQRTQKDDGTAYKVDYTRW SINFRUP00000159173 NNFVQYKFSHLPSKERQTITELSKMFLNQINYWQLETPSQRRQRVSSDDAAGYKANYTRW ENSMUST00000000724 NNFVQYKFSHLPSKERQTTIELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRW CG4107-RA LSLVFYKYNHLSTPELQTMTEVAKTFLNFLNHYNFESPSTRRGDLTHEDASNYKINYTRW .:* **:.**.. * ** *::* ** :*::::*:*: * :* : ** :**** ENST00000225916 LCYCHVPQSCDSLPRYETTHVFGRSLLRSIFTVTRRQLLEKFRVEKDKLVPEKRTLILTH ENSMUST00000006973 LCYCHVPQSCDSLPRYETTHVFGRSLLRSIFTVTRRQLLEKFRVEKDKLVPEKRTLILTH SINFRUP00000141254 LCYCHVPQSNDSLPRYETTQVFGRSLLKSIFIVTRRQLLEKFRVEKDKLLPEKRTLILTH SINFRUP00000159173 LCYCNVPQFCDSLPRYQTTQIFGRTLLRSVFTVMRKQLLEQARQEKDKLPPEKRTLILTH ENSMUST00000000724 LCYCNVPQFCDSLPRYETTKVFGRTLLRSVFTIMRRQLLEQARQEKDKLPLEKRTLILTH CG4107-RA LVFCHVPAFCNSLRQCETSLVFGRTLLRTVFQCMSQQLKKKCISERDRFPEDKRS-IITL * :*:** :** : :*: :***:**:::* :** :: *:*:: :**::*:* ENST00000225916 FPKFLSMLEEEIYGANSPIWESGFTMPPSEGTQLVPRPASVSAAVVPSTPI-----FSPS ENSMUST00000006973 FPKFLSMLEEEIYGANSPIWESGFTMPPSEGTQLVPRPATVSATVVPS--------FSPS SINFRUP00000141254 FPKFLSMLEEEIYGENSPIWEADFTVPASDGTQLGHQTVISPAAVSGSP-------ALPK SINFRUP00000159173 FPKFLSMLEEEVYSHNSPIWSQDFLAGVS-GGQIPVHTVISAPPVVIPLYYSPSPVSVDP ENSMUST00000000724 FPKFLSMLEEEVYSQNSPIWDQDFLSASSRTSPLGIQTVIS-PPVTGTALFSSNSTSHEQ CG4107-RA MPKFLETLRAELLKDDSPIWDTSYRPSNSFVIQQRKRNQEVANVPIGP------------ :****. *. *: :****. .: * : . ENST00000225916 MGGGSNSSLSLDSAGAEPMP-GEKRTLPENLTLEDAKRLRVMGDIPMELVNEVMLTITDP ENSMUST00000006973 MGGGSNSSLSLDSAGTEPMPAGEKRKLPENLTLEDAKRLRVMGDIPMELVNEVMLTITDP SINFRUP00000141254 GLSGVSAVGSVESGGAEPHT-GEKRKISEALTLEDAKRIRVMGDIPMELVNEVMMTITDP SINFRUP00000159173 SMCGSVSPARKAASVLEPSPVGEKRKPTEPLHHEENKRPRVLGDIPMDLINEVMATIADP ENSMUST00000000724 INGGRTSPGCRGSSGLEANP-GEKRKMNNSHAPEEAKRSRVMGDIPVELINEVMSTITDP CG4107-RA --SAASIGGNKRTSVGEPLHKRIKKEPTDRPSSEN------LDDLPADVVMRAMKSVSE- . :. *. *: : *: ::.*:* ::: ..* :::: ENST00000225916 AAMLGPETSLLSANAARDETARLEERRGIIEFHVIGNSLTPKANRRVLLWLVGLQNVFSH ENSMUST00000006973 AAMLGPETSLLSANAARDETARLEERRGIIEFHVIGNSLTPKANRRVLLWLVGLQNVFSH SINFRUP00000141254 AAMLGPETNLLTPNAARDETARLEERRGIIEFHVIGNSLSQKSNKKILMWLVGLQNVFSH SINFRUP00000159173 AAIP--ETSLLSAHSARDEAARLEERRGVIEFHVIGNSLNQKPNKRILMWLVGLQNVFSH ENSMUST00000000724 AGMLGPETNFLSAHSARDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSH CG4107-RA SKTTNKAEILFPVNVSRDENVKAEEQKRAIEFHVVGNSLTKPVDKQTVLWLLGLQLVFAY : ::. : :*** .: **:: *****:****. ::: ::**:*** **:: ENST00000225916 QLPRMPKEYIARLVFDPKHKTLALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKG ENSMUST00000006973 QLPRMPKEYIARLVFDPKHKTLALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKG SINFRUP00000141254 QLPRMPKEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKG SINFRUP00000159173 QLPRMPKEYITRLVFDPKHKTLSLIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKG ENSMUST00000000724 QLPRMPKEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKG CG4107-RA QLPEMPREYISQLVFDTKHKTLALIKENQPIGGICFRPFPSQGFTEIVFCAVTMSEQVKG ***.**:***::****.*****:***:.: ******* **:************ .***** ENST00000225916 YGTHLMNHLKEYHIKHNILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGAT ENSMUST00000006973 YGTHLMNHLKEYHIKHSILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGAT SINFRUP00000141254 YGTHLMNHLKEYHIKHNILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGAT SINFRUP00000159173 YGTHLMNHLKEYHIKHEILNFLTYADEYAIGYFKKQGFSKDIKVPKAKYVGYIKDYEGAT ENSMUST00000000724 YGTHLMNHLKEYHIKHEILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIKDYEGAT CG4107-RA YGTHLMNHLKDYSIQRGIKHLLTFADCDAIGYFKKQGFSKDIKLARPVYAGYIKEYDSAT **********:* *:: * :**:** ************:**:.:. * ****:*:.** ENST00000225916 LMECELNPRIPYTELSHIIKKQKEVIIKKLIERKQAQIRKVYPGLSCFKEGVRQIPVESV ENSMUST00000006973 LMECELNPRIPYTELSHIIKKQKE-IIKKLIERKQAQIRKVYPGLSCFKEGVRQIPVESV SINFRUP00000141254 LMECELNPRIPYTELSHIIKRQKE-VDKKLIERKQSQIRKVYPGLTCFKEGVRQIPVESI SINFRUP00000159173 LMGCELNPSIPYTEFSVIIKKQKE-IIKKLIERKQAQIRKVYPGLSCFKEGVRQIPIESI ENSMUST00000000724 LMGCELNPQIPYTEFSVIIKKQKE-IIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESI CG4107-RA LMHCELHPSIVNTQFIAVIRSQSE-ILKELIAQRHNEVQKVRPGLTCFKEGLPVIPVESI ** ***:* * *:: :*: *.* : *:** ::: :::** ***:***:*: **:**: ENST00000225916 PGIRETGWKPLGK-----EKGKELKDPDQLYTTLKNLLAQIKSHPSAWPFMEPVKKSEAP ENSMUST00000006973 PGIRETGWKPLGK-----EKGKELKDPDQLYTTLKNLLAQIKSHPSAWPFMEPVKKSEAP SINFRUP00000141254 PGIRETGWKPSNK-----DKGKEVKDPDVLYNMLKNLLAQIKSHPDAWPFMEPVKKSEAP SINFRUP00000159173 PGIRETGWKPVG-------KGKELKDPDQLYSTLKTILQHVKMHQNAWPFMEPVKKTEP- ENSMUST00000000724 PGIRETGWKPSGK-----EKSKEPKDPEQLYSTLKNILQQVKNHPNAWPFMEPVKRTEAP CG4107-RA PGLREIGWKPQNRPARSSRPLEESTDPEKLATSFASVLQSVRQHTTAWPFLRPVTAAEVP **:** **** . :* .**: * . : .:* :: * ****:.**. :* ENST00000225916 DYYEVIRFPIDLKTMTERLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASALEK ENSMUST00000006973 DYYEVIRFPIDLKTMTERLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASALEK SINFRUP00000141254 DYYEIIRFPIDLKTMTERLKNRYYVTKKLFIADLQRIISNCREYNHPDSEYCKCANTLEK SINFRUP00000159173 WYYQSIRFPMDLKTMSERLKSRYYTTRKLFMADMQRIFTNCREYNPPESEYYKCANLLEK ENSMUST00000000724 GYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCASILEK CG4107-RA DYYDHIKYPMDLKTMGERLKKGYYQTRRLFMADMARIFSNCRFYNSPDTEYYRCANSLER **: *::*:***** ***:. ** :::**:**: *:::**: ** *::** :**. **: ENST00000225916 FFYFKLKEGGLIDK---------------------------------------------- ENSMUST00000006973 FFYFKLKEGGLIDK---------------------------------------------- SINFRUP00000141254 FFYFKLKDGGLIEKYFRLYSYQQEVVRRALLGENIIIWLPTGAGKTRAAVYVAKRHLETT SINFRUP00000159173 FFYTKIKEAGLIEK---------------------------------------------- ENSMUST00000000724 FFFSKIKEAGLIDK---------------------------------------------- CG4107-RA YFQTKMRELGLWDK---------------------------------------------- :* *::: ** :* : : :: :: ::: : : : : ENST00000225916 ------------------------------------------------------------ ENSMUST00000006973 ------------------------------------------------------------ SINFRUP00000141254 AKAKVVVLVNKIHLVDQHYTKEFQPHLDRSYRVVPISGDSEERDFFGQVVKDSDVVICTA SINFRUP00000159173 ------------------------------------------------------------ ENSMUST00000000724 ------------------------------------------------------------ CG4107-RA ------------------------------------------------------------ ::::: : :: : : :: : :: :: ::: ENST00000225916 ------------------------------------------------------------ ENSMUST00000006973 ------------------------------------------------------------ SINFRUP00000141254 QILYNAMINTDKAKHVELSDITLLIIDECHHTKKQAVYNQIMSCYVEKKLNGERALPQVL SINFRUP00000159173 ------------------------------------------------------------ ENSMUST00000000724 ------------------------------------------------------------ CG4107-RA ------------------------------------------------------------ :: :: : : : :::: : :: : : : :: ENST00000225916 ------------------------------------------------------------ ENSMUST00000006973 ------------------------------------------------------------ SINFRUP00000141254 GLTASLGTGGEKILERAVEYVLQICANLDSDIVSTKDYMPDLEERVPKPVKTFDIVDERP SINFRUP00000159173 ------------------------------------------------------------ ENSMUST00000000724 ------------------------------------------------------------ CG4107-RA ------------------------------------------------------------ : : :: : :: : : :: : : : : : :: ENST00000225916 ------------------------------------------------------------ ENSMUST00000006973 ------------------------------------------------------------ SINFRUP00000141254 EDPFGDHLKWMMQRIHDFMDLPNNITLRECGTQEYEADVVILERHGVKEDNRVWAQCALH SINFRUP00000159173 ------------------------------------------------------------ ENSMUST00000000724 ------------------------------------------------------------ CG4107-RA ------------------------------------------------------------ : : :: : :: : : : :::: : : : ENST00000225916 ------------------------------------------------------------ ENSMUST00000006973 ------------------------------------------------------------ SINFRUP00000141254 LRKYNDALLINDTLRMLDAYRSLKDFYRSKVDTEIDGTDFFLMGLYRDSRYENPKMSKLE SINFRUP00000159173 ------------------------------------------------------------ ENSMUST00000000724 ------------------------------------------------------------ CG4107-RA ------------------------------------------------------------ : ::: : :: : : : : :::: : : : ENST00000225916 ------------------------------------------------------------ ENSMUST00000006973 ------------------------------------------------------------ SINFRUP00000141254 SVLLNQFRPGGESRGILFSKTRKSTHCLCDWVSTSSTLQQAGIKAAILTGAGNGIDTMTH SINFRUP00000159173 ------------------------------------------------------------ ENSMUST00000000724 ------------------------------------------------------------ CG4107-RA ------------------------------------------------------------ ::: : ::: : : : : :: : : ENST00000225916 ------------------------------------------------------------ ENSMUST00000006973 ------------------------------------------------------------ SINFRUP00000141254 VKQKDTIRSFRQGDLNLLISTSVAEEGLDIPECNLVVRYGLLTNEIAQKQASGRARARDS SINFRUP00000159173 ------------------------------------------------------------ ENSMUST00000000724 ------------------------------------------------------------ CG4107-RA ------------------------------------------------------------ : : : : ::: : : : ::: :: : ENST00000225916 ------------------------------------------------------------ ENSMUST00000006973 ------------------------------------------------------------ SINFRUP00000141254 QYSVIAQKGGREERREHINEYLDELTGDAIAVIQAMRPPEFRSKIAQMQREAIMKRKVQE SINFRUP00000159173 ------------------------------------------------------------ ENSMUST00000000724 ------------------------------------------------------------ CG4107-RA ------------------------------------------------------------ :: : : : : :: : : : : :: : ENST00000225916 ------------------------------------------------------------ ENSMUST00000006973 ------------------------------------------------------------ SINFRUP00000141254 SQKAKRRSQHTPASVQLLCRNCFKQVASGSDIRLLDKAHYVNINPDFKKHYKTGGQVFLN SINFRUP00000159173 ------------------------------------------------------------ ENSMUST00000000724 ------------------------------------------------------------ CG4107-RA ------------------------------------------------------------ : :: : : : :: : : : ::: ENST00000225916 ------------------------------------------------------------ ENSMUST00000006973 ------------------------------------------------------------ SINFRUP00000141254 RTFEDWEPGCTISCNNGSCNKAWGSEIKYKKVALLPNLSIESFALETPQGRTTPRRWRDI SINFRUP00000159173 ------------------------------------------------------------ ENSMUST00000000724 ------------------------------------------------------------ CG4107-RA ------------------------------------------------------------ : : : : :: : : : : : ENST00000225916 ------------------- ENSMUST00000006973 ------------------- SINFRUP00000141254 TFTVDDFSFEEYCQEHMPD SINFRUP00000159173 ------------------- ENSMUST00000000724 ------------------- CG4107-RA ------------------- : : : : :