CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000041393 ------------------------------------------------------------ ENST00000298992 ------------------------------------------------------------ SINFRUP00000148474 ------------------------------------------------------------ SINFRUP00000135200 ------------------------------------------------------------ SINFRUP00000149518 ------------------------------------------------------------ CG11250-RB MQSPHQVQSQLPPSQTPLSSQKGLAVAMATPAPRVFKELAQQPNKGMPHKMVASSSSCSG ENSMUST00000041393 ------------------------------------------------------------ ENST00000298992 ------------------------------------------------------------ SINFRUP00000148474 ------------------------------------------------------------ SINFRUP00000135200 ------------------------------------------------------------ SINFRUP00000149518 ------------------------------------------------------------ CG11250-RB GQANSSCKMPSPGTASKALIPQRAVAGPARLTVQSTPVKSQPPQLSGSLSQSQVSPNRPI ENSMUST00000041393 ----------------------------MAGTYSSTLKTLEDLTLDSGYG-AGDSCRSLS ENST00000298992 ------------------------------------------------------------ SINFRUP00000148474 ----------------------------MAGLSNVHMKTLEDLTLDSGYG-AGDSCKSLS SINFRUP00000135200 ----------------------------MARSSKTAARTLEDLTLDSGYGGAADSFRSSS SINFRUP00000149518 ------------------------------------------------------------ CG11250-RB LGIPTTAANPTPPRIHQHDQFRALQRVQECHSSSDENRSSGHASMSDTGGHSSSPAGGMT : ENSMUST00000041393 LSSSKSNSQALNSSAQQHRGAAWWCYSGS-----------------MNSRHNSWDTVNTV ENST00000298992 ------------------------------------------------------------ SINFRUP00000148474 LSSSKSNSQALMTAPHRGN---WWYYSGS-----------------MNSRNNSWDTVNTV SINFRUP00000135200 ASLCCSEAHGAN----------HWHLTDS-----------------MHSRHNSLDTVNTV SINFRUP00000149518 ------------------------------------------------------------ CG11250-RB LGPLPEDRLAAGVTNRSTRSRRHRGIMPGGKAPWSGTGLEDIKLAMLTLRSQTSSSTYSS : ENSMUST00000041393 LPEDPEVADLFSRCP------------------------RLPELEEFPWTEGDVARVLRK ENST00000298992 ----------------------------------------------------------RK SINFRUP00000148474 LPEDPE--DIFSKCP------------------------RLPELEEFPWAEEDVAKILRK SINFRUP00000135200 LVEDAEILESTGRLA------------------------KLPELEDVPWSLGEVACALSR SINFRUP00000149518 ------------------------------------------------------------ CG11250-RB LSAGSESSEPARRLGRYSSLETVVTSTSADEFVWVDSHNRLVELQHPPWSQQCILKVLRN : : : : : ENSMUST00000041393 SVG-----GRRLPSFSAEAVRRLAGLLRRALIRVAREAQRLSVLHAKCTRFEVQSAVRLV ENST00000298992 GAG-----GRRLPQFSAEAVRRLAGLLRRALIRVAREAQRLSVLHAKCTRFEVQSAVRLV SINFRUP00000148474 VAETGAGKGGSAPVFSAEAVRRLSALLRRALIRISREAQRLSVMHCRCTRFEVQSAMRLV SINFRUP00000135200 DEE------VRLPTLPQDVLLRLSVMVSRALVRVAREAQRLSLRYAKCTKYEIQSAIRIV SINFRUP00000149518 ------------------------------------------------------------ CG11250-RB GRC-----QQQAEHLAVEAVSRLGYLLQRALVRIAREIQRFSAGVGLCSKQEVVGALRVV : : : :: :: : : : : :: ENSMUST00000041393 HSWALAESCALAAVKALSLYSMSAG-DGLRRGKSARCGLTFSVGRFFRWMVDTRISVRIH ENST00000298992 HSWALAESCALAAVKALSLYSMSAG-DGLRRGKSARCGLTFSVGRFFRWMVDTRISVRIH SINFRUP00000148474 LSWALADHCVSATVKAISMYSMSAG-ELLRKGKSARCGLSFSVGRFFRWMVDTRISVRIH SINFRUP00000135200 LSWTVSINCISAALSALSMYNMSTEEEKFSRGKSVRCGLIFNVGKFFRWMVDSRVAVRIH SINFRUP00000149518 ------------------------------------------------------------ CG11250-RB LSSSLADSCTKACLRSAAMFAVPGE-SALKQSKSARAGLQLSVGRFYRWMTDARLGKFIH : : : : : : : : : : : : ENSMUST00000041393 EYAAISLTACMENLVEEIRARVLASQSPDGG---GAGGGEVSAEALEMVINNDAELWGVL ENST00000298992 EYAAISLTACMENLVEEIRARVMASHSPDGG---GAGGGEVSAEALEMVINNDAELWGVL SINFRUP00000148474 EYAAICLTACMEALVEEIGSRVLMAERGHVGSESGSAGAPVTAEALEVVVNNDAELWGVL SINFRUP00000135200 EHAAIYLAACMESLFREC-ARVLRSAPLERD----NGIPKFTVETLEQAVSSDAEVWGSL SINFRUP00000149518 ------------------------------------------------------------ CG11250-RB EYAAVYLCAGIENLLEEIALQCNG----------------TTAAALDQSIASSGDVWGLL : : : :. : : : : ENSMUST00000041393 QPYEHLICGKNANGVLSLPAYFSPYN-GGSLGHDERADAYAQLELRTLEQSLLATCVGSI ENST00000298992 QPYEHLICGKNANGVLSLPAYFSPYN-GGSLGHDERADAYAQLELRTLEQSLLATCVGSI SINFRUP00000148474 QHYEHLICGKNANGVLSLPAHFSPYTENQQTSVDSREDAYAQLELRTLEQSLLATCVGSI SINFRUP00000135200 LPWQHLICGKNANVILKSWG--------------------LILGLRSSCP-LFSHCSSAL SINFRUP00000149518 ------------------------------------------------------------ CG11250-RB QPFAHLNAGRIASGALALPRWANSLD--------------QVIASSGDFRGHLATCVGSI : : : : : ENSMUST00000041393 SELSDLVSRAMHHMQGRHPLCPGTSPARQARQPPQPITWSPDALHTLYYFLRCPQMESME ENST00000298992 SELSDLVSRAMHHMQGRHPLCPGASPARQARQPPQPITWSPDALHTLYYFLRCPQMESME SINFRUP00000148474 SELSDLVSRAMHHMQRLSSMRPGLSPARHVR-PQQPVSWSPDALHTLYYFLRCPQMESME SINFRUP00000135200 CVSGDLVSRAMHYLQPLHTKNHNNGTPMHQK--STVIHWQPEAIYTLCYFMHCPQME-WE SINFRUP00000149518 ----DLVSRAMHHLQPLHIKNPSNGTPVHQK-SSTTVHWEPEALYTLCYFMHCPQME-WE CG11250-RB RELKEKALRTQQEFQLAAALSGSALAALFYFMRCSQLEHTELLAASGCHAGQAQSAAPGG : . *: : :* . .. : : : :. . ENSMUST00000041393 NPNLDPPRMTLNNE--------------RPFMLLPPLMEWMRVAITYAEHRRSPTVDSGD ENST00000298992 NPNLDPPRMTLNNE--------------RPFMLLPPLMEWMRVAITYAEHRRSLTVDSGD SINFRUP00000148474 NPNLDPPRMALSKE--------------RPFLLLPPLMEWMRVAIVHAEHRKSLLVDSDD SINFRUP00000135200 NPNVEPSKVTLQNE--------------RPFMVLPPLMEWVRVAVVHTEHRRSFTVDSDD SINFRUP00000149518 NPNVEPSKVTLQTESHHVLTCMVRLAPHRPFLVLPPLMEWIRVAVAHTEHRRSFSVDSDD CG11250-RB GTSSAGHHVQELCY-------------ERAYVVLPPLAEWLRVAAAHAEHRNAMMIDKDD ... :: *.:::**** **:*** .::***.: :*..* ENSMUST00000041393 IRQAARLLLPGLDCEPRQLKPECCFSSFR-RLDARAATERFNQDLG-------------- ENST00000298992 IRQAARLLLPGLDCEPRQLKPEHCFSSFR-RLDARAATEKFNQDLG-------------- SINFRUP00000148474 VRQTARLLLPGLDCEPRQLKPECCFSSFK-RLDSKAATDKFHLDLG-------------- SINFRUP00000135200 VRQAARLLLPGVDCEPRQLRTDDCVCASR-RLDAASTEAKFLQDLG-------------- SINFRUP00000149518 VRQAARLLLPGVDCEPRQIKAEDCFCATR-KLDAASTEAKFLQDLG-------------- CG11250-RB VMQAARLLLPGVDCPIRPVAHDEELPTKKTHFNTAPTVSSTGTGTGSSSCSSPVVSGIGI : *:*******:** * : : . : : :::: .: . * ENSMUST00000041393 ------------------FRMLNCGRTDLISQAIEALGPDG-VNTMDDQGMTPLMYACAA ENST00000298992 ------------------FRMLNCGRTDLINQAIEALGPDG-VNTMDDQGMTPLMYACAA SINFRUP00000148474 ------------------FRMLNCGRTDLIGQAIDLLGPDG-VNSMDDQGMTPLMYACAA SINFRUP00000135200 ------------------FRMLSCGRTDLVKQAVNLLGPDG-INSMSEQGMTPLMYACVR SINFRUP00000149518 ------------------FRMLNCGRTDLVKQAVNLLGPDG-INSMSEQGMTPLMYACVR CG11250-RB GIGEDTSELGRRATIGVAFKLLLTGRAELLAQAAQLLPPTTRYDTQNSAGLTALMIASIR *::* **::*: ** : * * :: .. *:*.** *. ENSMUST00000041393 GDEAMVQMLIDAGANLDIQVPSHSPRHP-SVHPDSRHWTSLTFAVLHGHISVVQLLLDAG ENST00000298992 GDEAMVQMLIDAGANLDIQVPSNSPRHP-SIHPDSRHWTSLTFAVLHGHISVVQLLLDAG SINFRUP00000148474 GDEALVQMLIDAGANLDVAVPPCSPKHP-SVHPDSRCWAALTFAVLHGHISVVQLLLDAG SINFRUP00000135200 GDEAMVQMLLDAGADINTHLWNLLLESTGQDLVQDNLIYSKILHILPLPPSQLQLLLDAK SINFRUP00000149518 GDEAMVQMLLDAGADINRDL---------------------------------------- CG11250-RB NDEVALHALLDAGCDPNVEVPPAGSAGYPAIQPDTQHWTALSFAASRANYVALRILLERG .**. :: *:***.: : : : : ::: ENSMUST00000041393 AHVEGSAVNSGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEANGMA---SSLH ENST00000298992 AHVEGSAVNGGEDSYAETPLQLASAAGNYELVSLLLSRGADPLLSMLEAHGMG---SSLH SINFRUP00000148474 ANVEGAAVRNGQESTADTPLQLASSAGNYEMVSLLLARGADPLSKTHSGNALT---SSLY SINFRUP00000135200 ANVEG-SLQDGMENYTETPLQLAAAAGNFELVSLLLERGADPMVGTMYRNGIS---TAPQ SINFRUP00000149518 -----------------MLMVAALFSGNFELVSLLLERGADPMIGTMCRNGIS---SAPL CG11250-RB GKVEG-GARSSEEKCTLTPLQLAAGTGNLEIVALLLAHGANAFLSTQQKDSLCFAGSAQK : : * :** *:*:*** :**:.: ..: :: ENSMUST00000041393 EEMNCFSHSAAHGHRNVLRKLLTQPQQ-AKADVLSLEEILAEGVEESDT--------SSQ ENST00000298992 EDMNCFSHSAAHGHRNVLRKLLTQPQQ-AKADVLSLEEILAEGVEESDA--------SSQ SINFRUP00000148474 EDMNCFSHAAAHGHRNVLRKLLTQPQQ-VKEDVLSLEEILAEGVEGEEAGICPFVPLSPL SINFRUP00000135200 GDMNSYSLAAAHGHRNVFRKLLSHTEK-GKGDVLSLEEILAEGSELEGR----------- SINFRUP00000149518 GDMNSFSLAASHGHRNVFRKLMAQSDK-EKGDVLSLEEILAEGSDHAEKR-------LAP CG11250-RB GCFCAISVAAAHGHRSCLRKLLTHPVSPGTRDVLSLEEMLAEGDVGGVRGSGGPTGAGGP : . * :*:****. :***:::. . . *******:**** ENSMUST00000041393 GS-SEGP--------VRLSRTRTKALQEAMYYSAEHGYLDITMELRALGVPWKLHIWIES ENST00000298992 GSGSEGP--------VRLSRTRTKALQEAMYYSAEHGYVDITMELRALGVPWKLHIWIES SINFRUP00000148474 RTPSPAPGALPEVGILRLCKARMKALQEASYYSAEHGYLDVTMELRALGVPWKLHVWLES SINFRUP00000135200 -SPSQID-------LIRTGKAKLKALKEAMYHSSEHGHVDITIDIRSLGVPWTLHTWLES SINFRUP00000149518 QANSGGT--------LRTGKAKLRALREAMYHSAEHGHVDITIDIRSLGVPWTLHTWLET CG11250-RB NSASASGNN--EDILPLLNKTQIKRLQEAMYHSAENNHLDITIELRKLGVPWTLHCWMHA : * : : ::: : *:** *:*:*:.::*:*:::* *****.** *:.: ENSMUST00000041393 LRTSFSQSRYSVVQSLLKDFSSIKEEEYNEELVTEGLQLMFDILKTSK-----NDSVLQQ ENST00000298992 LRTSFSQSRYSVVQSLLRDFSSIREEEYNEELVTEGLQLMFDILKTSK-----NDSVIQQ SINFRUP00000148474 LRCAQQQSRTGITMSLLREFTTIREEDYCEELVSVGLPLMFNILRTSK-----NDAVVQQ SINFRUP00000135200 LRTCFCQHRRPLIQGLLKEFSCIEEEEYTEELVTHGLPLMFQILRASK------------ SINFRUP00000149518 LRTCFVQHRRPLIQGLLKDFSCIHEDEYTEELLTHGLPLMFQILRVCKSVCLQNEAISQH CG11250-RB LSAAHDLRLDAVIDQLLQDFLQVCPDDYSAQFVSECLPLLFNIFRNKN------EGTTLL * . : **::* : ::* :::: * *:*:*:: : ENSMUST00000041393 LATIFTHCYGTSPIP---SIPEIRKTLPARLDP---------------HFLNNKEMSDVT ENST00000298992 LATIFTHCYGSSPIP---SIPEIRKTLPARLGEGAPPAPCITTRPPPLPFPASSPLCHLS SINFRUP00000148474 LAAIFSHCFGPAPLP---AIPEIKAALSAQLDP---------------HFLNNKEMSDVT SINFRUP00000135200 ------------------------------------------------------------ SINFRUP00000149518 LSVIFTHCYGPFPIP---KLTEIKRKQTSRLDP---------------HFLNNKEMSDVT CG11250-RB LADIFATCFGWETLPPVKEQPPMQPVQGSRIDP---------------KFVNNPELSDVT : :: : : : : : : ENSMUST00000041393 FLVEGKLFYAHKVLLVTASNRFKTLMTNKSEQDGDSSKTIEISDIKYHIFQMLMQYLYYG ENST00000298992 PFPSAKAPASVSLFLTSVSHPQPQTRTSQHTQANPSRGSRGIH-MGLFPPQMMMQYLYYG SINFRUP00000148474 FVVDGKPFYGHRVLLVTASDRFKSLLASFGPDGNP-KKEVEISDVKYNIFQMMMSYLYCG SINFRUP00000135200 ------------------------------------------------------------ SINFRUP00000149518 FLVEGKPFYAHKVLLFTASARFKSLLQNRPAAENT---CIEISHVKYNIFHLVMQYLYCG CG11250-RB FRVEGKIFYGHKIVLVTASPRFQSMLSSKLSEGSS-TPTVQINDIRYHIFQLVMQFLYCG :.: : : ::: : ENSMUST00000041393 GTESMEIPTADILQLLSAANLFQLDALQRHCEILCSQTLSVESAVNTYKYAKIHNAPELA ENST00000298992 GTESMEIPTTDILELLSAASLFQLDALQRHCEILCSQTLSMESAVNTYKYAKIHNAPELA SINFRUP00000148474 GTESLKTNVPDLLELLSAASMFQLGVLQRHCELICSQHINLENAVSIYKTAKV------- SINFRUP00000135200 ------------------------------------------------------------ SINFRUP00000149518 GTESLHIRNTEVMELLSAAKFFQLEALQRHCEIICSKNITTETCVDLYKHARFLGASELT CG11250-RB GCSSLDVAHGDVLELMAAASFFQLEGLLRYTEARCSEMVDVDNVVAMYIHAKVYNANRLL : :: :: :: : : : : . ENSMUST00000041393 LFCEGFFLKHMKALLEMPSGSSSMAEAAKSRAWTHCRICRAP------------------ ENST00000298992 LFCEGFFLKHMKALL--------------------------------------------- SINFRUP00000148474 ------------------------------------------------------------ SINFRUP00000135200 ------------------------------------------------------------ SINFRUP00000149518 AFIEGYFLKNMVLLIELDSFKQLLYEPPPPESPVSSPGIYSDILHDLEKTLAMRIRSIHL CG11250-RB EFCQCFLLQNMVALLTYDDSVKRLLFAKKIPNHDVLAGLLQTLQNRLKARKPNSGGGLVN ENSMUST00000041393 ------------ ENST00000298992 ------------ SINFRUP00000148474 ------------ SINFRUP00000135200 ------------ SINFRUP00000149518 STSKGSV----- CG11250-RB SYRSPPVTPVKK