CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000002318 -------------------------------------------------- ENST00000229405 -------------------------------------------------- ENST00000299606 ------------------------------MTEFPGGGMEAQHVTLCLTE ENSMUST00000061729 VSCPGAWWSDEGIVGKFSRRLAQINRDSQGMTEFPGGGMEAQHVTLCLTE ci0100153818 -------------------------------------------------- ENST00000264291 ------------------------------------MGEHSP-DNNIIYF ENSMUST00000030723 ------------------------------------MGEHSP-DDNIIFF Q8QGH4_Brachydanio_rerio ------------------------------------MGENGPLSETAMLF ci0100133743 -------------------------------------------------- CG10270-RA ------MNEESQYSIHTVCRTCLSTVDDSAAYDLFRVPGLAKKLCVCTSL : ENSMUST00000002318 ------------MESLGLQTVRLSDGTTAYVQQAVKGEKLLEGQVIQLED ENST00000229405 ------------MESLGLHTVTLSDGTTAYVQQAVKGEKLLEGQVIQLED ENST00000299606 AVTVADGDNLENMEGVSLQAVTLADGSTAYIQHNSKDAKLIDGQVIQLED ENSMUST00000061729 AVTVADGDNLENMEGVSLQAVTLADGSTAYIQHNSKDGRLIDGQVIQLED ci0100153818 RQLKFVQSTHSRMNCAVEPDLERDELQIDVSVSGESVVSFQDGQEVQLDD ENST00000264291 EAEEDELT-------PDDKMLRFVDKNGLVP---SSSGTVYDRTTVLIEQ ENSMUST00000030723 KGEEDDLT-------PHDKMLRFVDDNGLVP---SSSGTVYDRTTVLIEQ Q8QGH4_Brachydanio_rerio EDEEEDVDKLGREEEDEDKMANFDKDGNMISGPSSSSGTVYDRTTVLIEQ ci0100133743 -------------------------------------------------- CG10270-RA SVEQADGFPKNLCNVCFSKLNDLHDFQKQCVDSVQKFQDLVASNAFACQT . . ENSMUST00000002318 GTTAYIHQVTIQKES---FSFEDGQPVQLEDGSMAYIHHTPKEGCDPSAL ENST00000229405 GTTAYIHQVTVQKE-----------------------------GYDPSTL ENST00000299606 GSAAYVQHVPIPKSTGDSLRLEDGQAVQLEDGTTAFIHHTSKDSYDQSAL ENSMUST00000061729 GSAAYVQHVPIPKSN----------------------------SYDQSSL ci0100153818 GSTALIFHQAKDSYP-------------------------------LELG ENST00000264291 DPGTLEDEDDDGQCG-----------------------------EHLPFL ENSMUST00000030723 DPGTLEDDEDDGQCG-----------------------------EPLPFL Q8QGH4_Brachydanio_rerio DPIRLDEEGEE---------------------------------DGMTFL ci0100133743 -------------------------------------------------- CG10270-RA NFDVLDTSAAVADLPG---------------------EEEDNVHFDPLLN ENSMUST00000002318 EAVQLEDGSTAYIHHPVPVPSDSAILAVQTEAGLEDLAAEDEEGFGTDTV ENST00000229405 EAVQLEDGSTAYIHHPVAVPSESTILAVQTEVGLEDLAAEDDEGFSADAV ENST00000299606 QAVQLEDGTTAYIHHAVQVPQSDTILAIQADGTVAGLHTG-DATIDPDTI ENSMUST00000061729 QAVQLEDGTTAYIHHAVQVPQSDTILAIQADGTVAGLHTG-DATIDPDTI ci0100153818 QPIQLENGSTAYLYHTKANTVNDVEQTSEENK--------------TEGE ENST00000264291 VGGE--EGFH--LIDHEAMSQGYVQHIISPDQIHLTINP-------GSTP ENSMUST00000030723 VEGE--EGF---LIDQEAMSQGYVQHIISPDQIHLTINP-------GSTP Q8QGH4_Brachydanio_rerio PEGEGDEGSLAFMGDPDGMSQGYIHHTISPDQIQFIINP-------GSTP ci0100133743 --------------------QVFMTFSPSVD---------------VCMP CG10270-RA SKIEIIENEEDVFKMLESVEKEVEEVEMEMEQPFGRVSQDDSFESGNDND : . : : ENSMUST00000002318 VALEQYASKVLHDSPASHNG--------------------------KGQQ ENST00000229405 VALEQYASKVLHDSQIPRNG--------------------------KGQQ ENST00000299606 SALEQYAAKVSIDGSESVAGTGMIGENEQEKKMQIVLQGHATRVTAKSQQ ENSMUST00000061729 SALEQYAAKVSIDGSDGVTSTGMIGENEQEKKMQIVLQGHATRVTPKSQQ ci0100153818 EEVDMQLTDVSWVSSSSTES------------------------------ ENST00000264291 MPRNIEGATLTLQSECPETKR----------------------------- ENSMUST00000030723 MPRNIEGATLTLQSECPETKR----------------------------- Q8QGH4_Brachydanio_rerio MPRNIEGATLTLHSECPETKQ----------------------------- ci0100133743 QENDIDGATLTFTSTDNHMK------------------------------ CG10270-RA LDADFQISSDDDIPLAQRSRRGATRGSKAK--------GKPKSAAKRQEE : : ENSMUST00000002318 VGDRAFRCGYKGCGRLYTTAHHLKVHERAHTGDRPYRCDFPSCGKAFATG ENST00000229405 VGDRAFRCGYKGCGRLYTTAHHLKVHERAHTGDRPYRCDFPSCGKAFATG ENST00000299606 SGEKAFRCEYDGCGKLYTTAHHLKVHERSHTGDRPYQCEHAGCGKAFATG ENSMUST00000061729 SGEKAFRCKYDGCGKLYTTAHHLKVHERSHTGDRPYQCEHSGCGKAFATG ci0100153818 ---KVFKCDFGTCNKVYTTAHHLKVHKRVHTGEKPYKCNWKNCEKVFMTS ENST00000264291 KEVKRYQCTFEGCPRTYSTAGNLRTHQKTHRGEYTFVCNQEGCGKAFLTS ENSMUST00000030723 KEVKRYQCTFEGCPRTYSTAGNLRTHQKTHRGEYTFVCNQEGCGKAFLTS Q8QGH4_Brachydanio_rerio REVKRYQCLFEGCTRTYSTAGNLRTHQKTHRGEYTFVCNQQGCGKAFLTS ci0100133743 KEIKRFKCLYTGCKRVYTTAGNLKSHQKTHRGEYYFICDQDGCGKAFLTS CG10270-RA ESEESEETSSSDDSDGNPKDKPKRKRIPATERDRHRLIDCHICHQKFKKA . . .. : : : : * : * .. ENSMUST00000002318 YGLKSHVRTHTGEKPYKCPEELCSKAFKTSGDLQKHVRTHTGE--RPFRC ENST00000229405 YGLKSHVRTHTGEKPYKCPEELCSKAFKTSGDLQKHVRTHTGE--RPFQC ENST00000299606 YGLKSHVRTHTGEKPYRCSEDNCTKSFKTSGDLQKHIRTHTGE--RPFKC ENSMUST00000061729 YGLKSHFRTHTGEKPYRCSEDNCTKSFKTSGDLQKHIRTHTGE--RPFKC ci0100153818 YSLKSHHRVHTGEKPYPCPHTSCSKAFKTAGDLQKHIRTHTGE--KPFKC ENST00000264291 YSLRIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTG---KTFNC ENSMUST00000030723 YSLRIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTG---KTFNC Q8QGH4_Brachydanio_rerio YSLKIHVRVHTKEKPFECDVQGCEKAFNTLYRLKAHQRLHTG---KTFNC ci0100133743 YSLKVHVRVHTKERPYRCSDQDCEKSFNTLYRLKAHQRIHNG---KTFNC CG10270-RA IRYEEHMKHHNDLLPFQCTVESCRKGFTTANGLRVHVEHAHTETSAMHPC . * : *. *: * * *.*.* *: * . . * ENSMUST00000002318 PFEGCGRSFTTSNIRKVHVR-THTGERPYT-CPEPHCGRGFTSATNYKNH ENST00000229405 PFEGCGRSFTTSNIRKVHVR-THTGERPYT-CPEPHCGRGFTSATNYKNH ENST00000299606 PFEGCGRSFTTSNIRKVHVR-THTGERPYY-CTEPGCGRAFASATNYKNH ENSMUST00000061729 PIEGCGRSFTTSNIRKVHIR-THTGERPYY-CTEPGCGRAFASATNYKNH ci0100153818 PFEGCEKAFTTSNICKVHIR-THTGERPYT-CPYEDCKKSFSNITNYRNH ENST00000264291 ESEGCSKYFTTLSDLRKHIR-THTGEKPFR-CDHDGCGKAFAASHHLKTH ENSMUST00000030723 ESQGCSKYFTTLSDLRKHIR-THTGEKPFR-CDHDGCGKAFAASHHLKTH Q8QGH4_Brachydanio_rerio ESEGCTKYFTTLSDLRKHIR-THTGEKPFR-CDHDGCGKAFAASHHLKTH ci0100133743 SSEGCTKFFTTLSDLKKHYR-THTGERPFK-CNIPECSKSFTVSHHLKSH CG10270-RA TYEGCNKSFARPVLLSFHMKRVHKVDTPQRDFPCTECEKVFRCPTALKKH :** : *: * : .*. : * * : * :.* ENSMUST00000002318 VRIHT-------------------------------------------GE ENST00000229405 VRIHTESQVSVPLPPSGSPFTNPVPHPCPLSFPLASPSSHPPHSPVSPGE ENST00000299606 VRIHT-------------------------------------------GE ENSMUST00000061729 VRIHT-------------------------------------------GE ci0100153818 TRIHT-------------------------------------------GE ENST00000264291 VRTHT-------------------------------------------GE ENSMUST00000030723 VRTHT-------------------------------------------GE Q8QGH4_Brachydanio_rerio VRTHT-------------------------------------------GE ci0100133743 IRTHT-------------------------------------------GE CG10270-RA MYKHTG------------------------------------------EE ** * ENSMUST00000002318 KPYVCTVPGCGKRFTEYSSLYKHHVVHTHCKPYTCSSCGKTYRQTS---- ENST00000229405 KPYVCTVPGCGKRFTEYSSLYKHHVVHTHCKPYTCSTCGKTYRQTS---- ENST00000299606 KPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYNCNHCGKTYKQIS---- ENSMUST00000061729 KPYVCTVPGCDKRFTEYSSLYKHHVVHTHSKPYNCNHCGKTYKQIS---- ci0100153818 KPYVCAVGNCKKQFTEYSSLYKHQIVHSIAKPYACHYCGKLYRQTS---- ENST00000264291 RPFFCPSNGCEKTFSTQYSLKSHMKGHDNKGHSYNALPQHNGSEDTNH-- ENSMUST00000030723 RPFFCPSNGCEKTFSTQYSLKSHMKGHDNKGTAYSALPQHNGSEDTNH-- Q8QGH4_Brachydanio_rerio KPFFCPSDGCEKTFSSQYSLKSHIRGHD-KGPSFTVS-GHPLSEDANH-- ci0100133743 KPFVCEEGGCTKAYAAQHSLKQHK------------------SKDHSN-- CG10270-RA LPFACEI--CGKRFPINSVLRDHLLRHAGIKNHVCPYCGVGKTTRQEWNK *: * * * :. * .* ENSMUST00000002318 ---TLAMHKRSAHGELEATEESEQALYEQQQLEAASAAEES--------- ENST00000229405 ---TLAMHKRSAHGELEATEESEQALYEQQQLEAASAAEES--------- ENST00000299606 ---TLAMHKRTAHNDTEPIEEEQEAFFE------PPPGQGE--------- ENSMUST00000061729 ---TLAMHKRTAHNDTEPIEEEQEAFFE------PPPGQGD--------- ci0100153818 ---TLVIHKRKVHKDDSGVTEEDFVQIPNNIGKEGSAKSYENTRMDHMHS ENST00000264291 ---SLCLSDLSLLSTDSELRENSSTTQGQDLSTISPAIIFESMFQN---- ENSMUST00000030723 ---SLYLSELGLLSTDSELQENSSSTQDQDLSTISPAIIFESMFQN---- Q8QGH4_Brachydanio_rerio ---SLCLSDLSLISTDSELQEN-HNSQGLDLNSVTPIRIFELMFQS---- ci0100133743 -------------------------------------------------- CG10270-RA HILTHTKEKKYECRQCDHASHNKQALANHVKVVHEKRKDFACQYCGKTFG :: ENSMUST00000002318 ------PPPKPTHIAYLSEVKEESSAIPTQVAMVTEEDGPPQVALITQDG ENST00000229405 ------PPPKRPRIAYLSEVKEERDDIPAQVAMVTEEDGAPQVALITQDG ENST00000299606 ------DVLKGSQITYVTGVEGD-DVVSTQVATVTQSGLSQQVTLISQDG ENSMUST00000061729 ------DVLKGSQITYVTGVDGE-DIVSTQVATVTQSGLSQQVTLISQDG ci0100153818 MNNANNKVESPVASVVVLPMNNTQNPVIINPSTPTQSQLPTSITTMSSNN ENST00000264291 -SDDTAIQEDPQQTASLTESFNGDAESVSDVPPSTGNSASLSLPLVLQPG ENSMUST00000030723 -SDDPGIQDDPLQTAALIDSFNGDAESVIDVPPPAGNSASLSLPLVLQSG Q8QGH4_Brachydanio_rerio -PENSVSEDDPKPTESLAESFG------LEPSPQSAPADASTHPAFPQP- ci0100133743 -------------------------------------------------- CG10270-RA KSHACKIHERSHTGEKCCECKICGKVFLFEKGLTKHLKTHEKRDLPKTQG ENSMUST00000002318 TQQVS-------------------LSPEDLQALGS--------------- ENST00000229405 AQQVS-------------------LSPEDLQALGS--------------- ENST00000299606 TQHVN-------------------ISQADMQAIGN--------------- ENSMUST00000061729 TQHVN-------------------ISQADMQAIGN--------------- ci0100153818 TNRDQQLVVTLNDNVTLATAASDKVTNQFLQDFASNKKDEGELFISEDPD ENST00000264291 LSEPPQPLLP----------ASAPSAPPPAPSLGPG---------SQQAA ENSMUST00000030723 ISEPPQPLLP----------ATAPSAPPPAPSLGPG---------SQPAA Q8QGH4_Brachydanio_rerio ---PPSTCSS----------SCSITAPAQDAQTPPT---------TQQAP ci0100133743 -------------------------------------------------- CG10270-RA TNALMGDGAS----------GSSTIAKPSPHLRGR--------------- ENSMUST00000002318 --AISVVTQHGSTTLTIPGHHEELAT--------------SGTHTVTMVS ENST00000229405 --AISMVTQHGSTTLTIPSPDADLAT--------------SGTHTVTMVS ENST00000299606 --TITMVTQDG-TPITVPAHDAVISS--------------AGTHSVAMVT ENSMUST00000061729 --TITMVTQDG-TPITVPTHDAVISS--------------AGTHSVAMVT ci0100153818 NVAVDISSNAGISEAATSSFNSDIWVNYSTENQDINKQVEEDQYSVATLV ENST00000264291 FGNPPALLQPPEVPVPHSTQFAANHQEFLPHPQAP-QPIVPGLSVVAGAS ENSMUST00000030723 FGSPPALLQPPEVPVPHSTQFAANHQEFLPHPQAPPQTIVPGLSVVAGAP Q8QGH4_Brachydanio_rerio ---PPAVSSSSQTSSFPSAPPSSSQPAEVSSPSAP----SATQHYMMAQS ci0100133743 -------------------------------------------------- CG10270-RA VERVDIAQLAGTVANPIPSVNLPSWSPQVNFTKKEGQHICPDCGKGFNHV : ENSMUST00000002318 ADGTQTQPVTIITS--GALVTEDSSVASLHH------------------- ENST00000229405 ADGTQTQPVTIITS--GAVVAEDSSVASLRH------------------- ENST00000299606 AEGTEGEQVAIVAQDLAAFHTASSEMGHQQHSHHLVTTE----------- ENSMUST00000061729 AEGTEGQQVAIVAQDLAAFHTASSEMGHQQHSHHLVTTE----------- ci0100153818 IDGTNYLVQVVNEPDQSQCSVDQESIVNALTSSVLTTPLGGSKGPDVELP ENST00000264291 ASAAAVASAVAAPAPPQSTTEPLPAMVQTLPLGANSVLTN---------- ENSMUST00000030723 ASAATVASAVAAPAPPQSTTEPLPAMVQTLPLGANSVLTN---------- Q8QGH4_Brachydanio_rerio VSSPSAASVSSVPAG---TAEVTAAVTHTVPLAAP--------------- ci0100133743 -------------------------------------------------- CG10270-RA SNMKLHYKVVHQKVKDFCCRFCPKRFAKKQYLRHHEYIHT---------- . ENSMUST00000002318 -------QQVALLATANGTHIAVQLEDQQT--------LEEAISVATAAM ENST00000229405 -------QQVALLATANGTHIAVQLEEQQT--------LEEAINVATAAM ENST00000299606 ------TRPLTLVATSNGTQIAVQLGEQPS--------LEEAIRIASRIQ ENSMUST00000061729 ------TRPLTLVATSNGTQIAVQLGEQPS--------LEEAIRIASRIQ ci0100153818 LVGNLILHTQPSGEISTGNDISIDLNSSTTSCATGSRLISDMIQDVSQIN ENST00000264291 ------NPTITITPTPNTAILQSSLVMGEQN-------LQWILNGATSSP ENSMUST00000030723 ------NPTITITPTPNTAILQSSLVMGEQN-------LQWILNGATSSP Q8QGH4_Brachydanio_rerio -------PTISIAPTLG---LQPSLVMSDQN-------LQWILSSAASAQ ci0100133743 -------------------------------------------------- CG10270-RA -------GEKPYECKVCGKHFRQEQVLKTHMKVHDKPPRPPGKPKEPAGP : ENSMUST00000002318 QQGAVTLET--TESGC---------------------------------- ENST00000229405 QQGAVTLETTVSESGC---------------------------------- ENST00000299606 QGETPGLDD----------------------------------------- ENSMUST00000061729 QGETPGLDD----------------------------------------- ci0100153818 SQCDVNFQQATTTFLCNQPTNPILTFTNQNSVTSSMLTTPVTTDQQIKLD ENST00000264291 QNQEQIQQASKVEKVFFTTAVPVASSPGSSVQQIGLSVPVIIIKQEEACQ ENSMUST00000030723 QNQEQIQQASKVEQVYFATAVPVASGTGSSVQQIGLSVPVIIIKQEEACQ Q8QGH4_Brachydanio_rerio QNPE--QQGPKVEKVFFTTAIPVGGNSG----MIGY-------------- ci0100133743 -------------------------------------------------- CG10270-RA KAESSTAVKRQQPKNFEQYQDPAAERAAATAELLAYQIEENEAKRKAEAE ENSMUST00000002318 -------------------------------------------------- ENST00000229405 -------------------------------------------------- ENST00000299606 -------------------------------------------------- ENSMUST00000061729 -------------------------------------------------- ci0100153818 TDKSYSKVVKKRGLHAKGQRLPSSTSKSKITVKLPISSSSRQRHHVTQ-- ENST00000264291 CQCACRDSAKERASSRRKGCSSPPPPEPSPQAPDGPSLQLPAQTFSSAPV ENSMUST00000030723 CQCACRDSAKERAAGRRKGCSSPPPPEPNPQPPDGPSLQLPP-------- Q8QGH4_Brachydanio_rerio -------------------------------------------------- ci0100133743 -------------------------------------------------- CG10270-RA LRKIQEAAFEQLNKLQKQSNTYDGFYAQKAEAEGTSVDALKLDHV----- ENSMUST00000002318 -------------------------------------------------- ENST00000229405 -------------------------------------------------- ENST00000299606 -------------------------------------------------- ENSMUST00000061729 -------------------------------------------------- ci0100153818 -------------------------------------------------- ENST00000264291 PGSSSSTLPSSCEQSRQAETPSDPQTETLSAMDVSEFLSLQSLDTPSNLI ENSMUST00000030723 -------------------------------------------------- Q8QGH4_Brachydanio_rerio -------------------------------------------------- ci0100133743 -------------------------------------------------- CG10270-RA -------------------------------------------------- ENSMUST00000002318 -------------------- ENST00000229405 -------------------- ENST00000299606 -------------------- ENSMUST00000061729 -------------------- ci0100153818 -------------------- ENST00000264291 PIEALLQGEEEMGLTSSFSK ENSMUST00000030723 -------------------- Q8QGH4_Brachydanio_rerio -------------------- ci0100133743 -------------------- CG10270-RA --------------------