CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000027760 ------------------------------------------------------------ ENST00000304685 ------------------------------------------------------------ SINFRUP00000130037 ------------------------------------------------------------ ENST00000303548 ------------------------------------------------------------ ENSMUST00000028170 ------------------------------------------------------------ SINFRUP00000148457 ------------------------------------------------------------ ENSMUST00000045726 ------------------------------------------------------------ CG8865-RA MNFTSRANCKCPHSQKHQQKPALIKSHTCAYQLQDLTGYNRALMPPLDNTDFSNAWRQVN ENSMUST00000027760 ------------------------------------------------------------ ENST00000304685 ------------------------------------------------------------ SINFRUP00000130037 ------------------------------------------------------------ ENST00000303548 ------------------------------------------------------------ ENSMUST00000028170 --------------------------------------------------TRRGEARRGA SINFRUP00000148457 ------------------------------------------------------------ ENSMUST00000045726 ------------------------------------------------------------ CG8865-RA NNTTSQSCAYHQQRQQQQQQQDAKDSKRHYHHHTCPRQRKKSMTPVEPTHLCQKHQEAKQ ENSMUST00000027760 -------------------------ARGKRGDPEPGQRDAPTASEQGAPCSVRVPERKLR ENST00000304685 -------------------------MEVKPVGEPTQEVSKFKLSTKVESTGHWLVEDHVR SINFRUP00000130037 ------------------------------------------------------------ ENST00000303548 ----MVQRMWAEAAGPAGGAEPLFPGSRRSRSVWDAVR----LEVGVPDSCPVVLHSFTQ ENSMUST00000028170 ARRRQWKRHWRRPRSSGPGEDRRPRHEPRSRTPRCAARGPRRAASASPGPRPGAGDELPR SINFRUP00000148457 ------------------------------------------------------------ ENSMUST00000045726 ----------------------------------------------------------ME CG8865-RA RRSRSASAKPRRNSSYHSYDDLDVSSAVLNAERKVVASLKYLCACTGATLRNLSKKTKDL ENSMUST00000027760 MKLLWQAKMSSIQDWGEEVEEGAVYHVTLKRVQIQQAANKGARWLGVEGDQLPPGHTVSQ ENST00000304685 IWEVLKTEESSIQDWGEEVEEGAVYHVTLKRVQIQQAANKGARWLGVEGDQLPPGHTVSQ SINFRUP00000130037 ---------SSVQDWGEEVEEGAIYNVTLKRVQIQQAANKGARWLGAEGDRLPPGHTVSQ ENST00000303548 LDPDLPRPESSTQEIGEELINGVIYSISLRKVQLHHGGNKGQRWLGYENE-----SALNL ENSMUST00000028170 LR-MMVDCQSSTQEIGEELINGVIYSISLRKVQLHQGATKGQRWLGCENE-----SALNL SINFRUP00000148457 --------QSSTQEIGEEAEDDAIFTITLRKMQLHQSASKGQRWLGVETD-----SALSL ENSMUST00000045726 RTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRSTPERS---GEGQTPIPATDTFLH CG8865-RA HAKNYTYTKPTWRLWGEEHEKNAIFTVYLKKVRYHRPTPTASNDSDDEIS-------HLE .. : *** ...:: : *:: : :: . : ENSMUST00000027760 YETCKIRTIKAGTLEKLVENLLTAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNL ENST00000304685 YETCKIRTIKAGTLEKLVENLLTAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNL SINFRUP00000130037 LETCKIRSIRAGTLARLVETLLTAFDDNDLTYTSIFLSTYRAFTSTQTVLHLLLDSYGSP ENST00000303548 YETCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRC ENSMUST00000028170 YETCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTVFLCTYRAFTTTQQVLDLLFKRYGRC SINFRUP00000148457 YETCKVRTIKAGTLERLVEYMVSSFRGKDSTYVTIFLCTYRSFASTKQVLDLLLNRYAKL ENSMUST00000045726 YRTSKVRALRAARLERLVHELVSGDREQDPGFVPAFLATHRAFVPTARVLGFLLPPPPPP CG8865-RA WETVRVRFVKAATLARLVEALATDDGELESTFINVFLSTYRTFSTPKQVLSLLTQRYDAL .* ::* ::*. * :**. : . : : **.*:* * .. ** :* ENSMUST00000027760 TG------PNCEDDG------SQSSPESKAVIRNAIASILRAWLDQCAEDFREPPHFPCL ENST00000304685 TS------PNCEEDG------SQSSSESKMVIRNAIASILRAWLDQCAEDFREPPHFPCL SINFRUP00000130037 EE------NGRDTAG------HQSS-ETNAAIRNALASFLRAWLDQCPEDFQEPPDYPCL ENST00000303548 DA------LTASSRYGCILPYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCL ENSMUST00000028170 DA------LTASSRYGCILPYSSEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCL SINFRUP00000148457 QN------VPAATAH----RVSQDD---CTELRNTVSSILGAWLDQYSEDFWSPPNYDCL ENSMUST00000045726 PP------PPAGVDS----KRTEGQDLNFSKNLRAVVSVLGSWLRNHPQDFRDPPDHQNL CG8865-RA HEKHLEELEQAQQNGQVMDPAYDPHASIHEQHKKTLVSALHVWLDGFPEDWHEDNLQQIL . .:: * * ** .:*: . * ENSMUST00000027760 QKLLEYLKQMMPGSDPERRAQNLLEQFQKQD--VDSDNGLLNT----------------- ENST00000304685 QKLLDYLTRMMPGSDPERRAQNLLEQFQKQE--VETDNGLPNT----------------- SINFRUP00000130037 HRLMDYLRQALPGSEALRRAEGLLEQLQTQASLDDTDGGFHGN----------------- ENST00000303548 KQLVAYVQLNMPGSDLERRAHLLLAQLEHSEPIEAEPEALSPVPALKPTPELELALTPAR ENSMUST00000028170 KQLVAYVQLNMPGSDLERRAHLLLAQLEDLEPSEAESEALSPAPVLSLKPASQLEPALLL SINFRUP00000148457 HQLLSYLHRHFLGSDLERRARNLLAHFHRRQQCEPDPDGMKAG----------------- ENSMUST00000045726 GNVRIFLGWAAPGGAEAREAEKLLEDFLKEAKGEQTEEEKRLA----------------- CG8865-RA AFATKRLKRSDLHIKVLNRLERLIKQSLYGNGGGSGGSENNGHSWLSAAR---------- : .. . *: . ENSMUST00000027760 ------------------------------------------------------------ ENST00000304685 ------------------------------------------------------------ SINFRUP00000130037 ------------------------------------------------------------ ENST00000303548 APSPVPAPAPEPEPAPTPAPGSELEVAPAPAPELQQAPEPAVGLESAPAPALELEPAPEQ ENSMUST00000028170 TPSQVVTSTPVREPAAAPVPVLASSPVVAPAPELEPVPEPPQ------EPEPSLALAPEL SINFRUP00000148457 ---------QERDYRAGTYDAERVGPCGRICTEVN-------------------FVAKGR ENSMUST00000045726 ------------------------------------------------------------ CG8865-RA ------------------------------------------------------SQQMQQ ENSMUST00000027760 ---SSFSLEEEEELESGGSAEFTN---------------------FSEDLVAEQLTYMDA ENST00000304685 ---ISFSLEEEEELEGGESAEFTC---------------------FSEDLVAEQLTYMDA SINFRUP00000130037 ---GLLCLGEENEVEPEAQDEFLS---------------------FETDLVAEQLTYMDA ENST00000303548 DPAPSQTLELEPAPAPVPSLQPSWPSPVVAENGLSEEKPHL--LVFPPDLVAEQFTLMDA ENSMUST00000028170 EPAVSQSLELESAPVPTPALEPSWSLPEATENGLT-EKPHL--LLFPPDLVAEQFTLMDA SINFRUP00000148457 IKSAGSVLGVEMKISLSAGEHIGCPFATQEESGFEDELPAFSFLSFDPIMVAEQFTLMDA ENSMUST00000045726 ---WSAPLSGSDHVPASWSLHLTNVEPLALASKQWTWVPTLLGRTSNKITHISPAFSPTQ CG8865-RA FMIPTHYGSSYDLTDQFNGMYLSPMGHGPIYRGPTHFLQAFRFPHVPVRHFAEQLTRMDT . ENSMUST00000027760 QLFKKVVPHHCLGCIWSQRDKKENKHLAPTIRATISQFNTLTKCVVSTVLGSKELKTQQR ENST00000304685 QLFKKVVPHHCLGCIWSRRDKKENKHLAPTIRATISQFNTLTKCVVSTILGGKELKTQQR SINFRUP00000130037 LLFKRVIPHHCLGSIWSQRDKKDSKHSAPTIRATIAQFNAVTACVVSTILRHRRLRPHVR ENST00000303548 ELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANCVITTCLGNRSTKAPDR ENSMUST00000028170 ELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVAQFNNVANCVITTCLGDQSMKAPDR SINFRUP00000148457 DLFKKVVPYHCLGGIWSQRDKKGKEHLAPTIRATVAQFNSVTNCVITTCLSNPTLKPNQR ENSMUST00000045726 ELFLRVRSCECLGSMWSQRDRPGAAGISPTVRATVAQFNTVTGCVLGSVLAAPGLAASQR CG8865-RA ELFKRLIPHQCLGHTWARRDSGG----SETVVATINQFNAVLFRVVSSILIDR-LKPQER ** :: . .*** *::** : *: **: *** : *: : * . * ENSMUST00000027760 ARVIEKWINIAHECRILKNFSSLRAIVSALQSNSIYRLKKAWAAVPKDRMLMFEELSDIF ENST00000304685 AKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVPRDRMLMFEELSDIF SINFRUP00000130037 ARVIQRWIEIAQECRIRKNFSSLRAIVSALQSNPLYRLKRVWACVHKDSVQTFEELSDIF ENST00000303548 ARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWEDVSRDSFRIFQKLSEIF ENSMUST00000028170 ARVVEHWIEVARECRALKNFSSLYAILSALQSNAIHRLKKTWEEVSRDSFRVFQKLSEIF SINFRUP00000148457 ARLLERWIDVARECRILKNFSSLRAILSALQCNAIHRLKRTWEEVSRESFRTFRELSEIF ENSMUST00000045726 AQRIEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSVFRKLSQIF CG8865-RA ALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLPKERMEVFTELANIC * :.:** :*:. * :***** **:***:.*.::**.: * : :: . * :*::* ENSMUST00000027760 SDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMGVMQGTVPYLGTFLT ENST00000304685 SDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMGVMQGTVPYLGTFLT SINFRUP00000130037 SDHNNYLTSRELLMREGTSKFASLESCAKEHQKRTHKRLQLQKEMGAMQGTIPYLGTFLT ENST00000303548 SDENNYSLSRELLIKEGTSKFATLEMNPKRAQK-------RPKETGIIQGTVPYLGTFLT ENSMUST00000028170 SDENNYSLSRELLIKEGTSKFATLEMNPRRAQR-------RQKETGVIQGTVPYLGTFLT SINFRUP00000148457 SDDNNYSLSRELLVKVG--REFSLFLSLERFWR-------YLN--GVMQGTIPYLGTFLT ENSMUST00000045726 SDEDNHLSSRAILSQEETTEDDDCPSGSLPSKLP--------------PGPVPYLGTFLT CG8865-RA SEDNNAWTLREVLKREGTAKNPDPGSDHSDRHLQK---LILNLGTQTSHGTIPYLGTFLT *:.:* * :* : . : *.:******** ENSMUST00000027760 DLTMLDTALQDYIEG-GLINFEKRRREFEVIAQIKLLQSACNSYCMGPDQKFIQWFQRQQ ENST00000304685 DLTMLDTALQDYIEG-GLINFEKRRREFEVIAQIKLLQSACNSYCMTPDQKFIQWFQRQQ SINFRUP00000130037 DLTMLDTALPDFVES-GLINFEKRRREFEVIAQIKLLQSACNSYCLTPEPSFLRWFKSQT ENST00000303548 DLVMLDTAMKDYLYG-RLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAWFRAVE ENSMUST00000028170 DLVMLDTAMKDYLYG-RLINFEKRRKEFEVIAQIKLLQSACNNYSIAPEEHFGTWFRAME SINFRUP00000148457 DLVMMDTAMKDYTEG-GLINFEKRRKEFEVIAQIKLLQLASNNYSFTPDSHFREWFTGVE ENSMUST00000045726 DLVMLDTALPDTLKG-NLINFEKRRKEWEILARIQQLQQRCQRYSLSPRPPILAALRAQR CG8865-RA DLTMIHTANPDYLTENKLINFDKKRKEFEVLAQIKLLQGAANTYNLQADALFDHWFNSMP **.*:.** * ****:*:*:*:*::*:*: ** .: * : . : : ENSMUST00000027760 LLSEEESYALSCEIEAAADANTTSPKPRKS--MVKRLSLLFLGSDIIPGS----TPTKEQ ENST00000304685 LLTEEESYALSCEIEAAADASTTSPKPRKS--MVKRLSLLFLGSDMITSP----TPTKEQ SINFRUP00000130037 WLSDEESYALSCEIEGLGDSSPTSPKPRKS--MVKRLSLLFHGADSSASS----SPVRET ENST00000303548 RLSETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAPSTELSTSGSSHSKSCDQ ENSMUST00000028170 RLSEAESYTLSCELEPPSESASNTLRSKKSTAIVKRWSDRQAPSTELSTSSSAHSKSCDQ SINFRUP00000148457 KLSEAESYNLSCEIEPLSESASNTLRAKKNGGIMKRWSDRQLTEPSCSGPAGSHSKSFDH ENSMUST00000045726 QLSEEQSYRVSRVIEPPAASCPSSPRIRRRISLTKRLS----------------AKLSRE CG8865-RA VFDEREAFELSCRLEPPPPAPRKS--------VVSTNTSLTNTTASSTASIMGHRKTDSI : : ::: :* :* : .: : . : ENSMUST00000027760 PKSAASGSSG-ESMDSVSVSSCESNHSEAEEGPVTPMD-TPDEPQKKLSESSSSCSSIHS ENST00000304685 PKSTASGSSG-ESMDSVSVSSCESNHSEAEEGSITPMD-TPDEPQKKLSESSSSCSSIHS SINFRUP00000130037 PRSPPNGSSG-ESMDSVSVSSSDSSSPSDSEG-LTPTH-SSDSQQNKLSESSS-YTSLHS ENST00000303548 LRCGPYLSSG-DIADALSVHSAGSSSSDVEEINISFVPESPDGQEKKFWESASQSSPETS ENSMUST00000028170 LRCSPYLGSG-DITDALSVHSAGSSSSDVEEINMSFVPESPDGQEKKFWESASQSSPETS SINFRUP00000148457 THFRPYQGGGGDSGDALSVTSVSSSGSDLEDVNASFLSDSPDGHERKFWECTSLSSLDTS ENSMUST00000045726 KNSSPGGSPG----DPSSPTSSVSPG-------------SPPSSPRNREPPPPGSPPASP CG8865-RA HSNSSSGAGSQFYCELNSSTSSRHNSLDRDVHHQHASLMSASSSVSNLSLDSSNSGGRQS . . . : * * :. : .. . ENSMUST00000027760 MDTNSSGMSSLINPLSS----PPTCNNNPKIHKRSVSVTSIT--STVLPPVYNQQNEDTC ENST00000304685 MDTNSSGMSSLINPLSS----PPSCNNNPKIHKRSVSVTSIT--STVLPPVYNQQNEDTC SINFRUP00000130037 MDTGSSTASVSVTPV------IPSLQGPPCTHRRSLSLTPLTPSSPGQTPAYNTQAQDAC ENST00000303548 GISSASSSTS-SSSAS------TTPVAATRTHKR--SVSGLCNSSS-ALPLYNQQVGDCC ENSMUST00000028170 GISSASSSTS-SSSAS------TTPVSTTRTHKR--SVSGVCSYSS-SLPLYNQQVGDCC SINFRUP00000148457 GTGSSSGSASGSSSASSSSVSCSTPLSASRSHKR--SVSAVSNYSTLSLPLYNQQIDDCC ENSMUST00000045726 GPQSPSTKLSLTMDPPG-----PWPVTLTPSSSR--------------VPLLGQQTSEAR CG8865-RA GKLTHSQSMGNGLKSHG--------NGTTNGGSPHINAQLVQPSSGTPHSAPDFYIIRVT * . : : . . ENSMUST00000027760 IIRISVEDNNGNMYKSIMLTSQDKTPAVIQRAMSKHNLESDPAEEYELVQVISEDKE--- ENST00000304685 IIRISVEDNNGNMYKSIMLTSQDKTPAVIQRAMLKHNLDSDPAEEYELVQVISEDKE--- SINFRUP00000130037 IIRVSLEHGNGNLYKSILLTNQDKTPAVISRAMAKHNLEVEPDEGYELVQVISEERE--- ENST00000303548 IIRVSLDVDNGNMYKSILVTSQDKAPAVIRKAMDKHNLEEEEPEDYELLQILSDDRK--- ENSMUST00000028170 IIRVSLDVDNGNMYKSILVTSQDKAPTVIRKAMDKHNLDEDEPEDYELVQIISEDHK--- SINFRUP00000148457 IIRVSLDVENGNMYKSILVTSQDKTPAVIRKAMIKHNLEREKTEDYELMQKISEDKVRSE ENSMUST00000045726 VIRVSINNNHGNLYRSILLTCQDKAPSVVQRALEKHNVPQPWARDYQLFQVLPGDRE--- CG8865-RA YETDNIELDGIVLYKSIMLGNNERTPQVIRNAMLKLGLEDD-PDRFTLAQVLPDKE---- .:: :*:**:: ::::* *: .*: * .: : * * :. .. ENSMUST00000027760 --------------------------------LVIPDSANVFYAMNSQVNFDFILRKKNS ENST00000304685 --------------------------------LVIPDSANVFYAMNSQVNFDFILRKKNS SINFRUP00000130037 --------------------------------LVIPDNANVFYAMNTSANFDFLLRVRGS ENST00000303548 --------------------------------LKIPENANVFYAMNSTANYDFVLKKR-T ENSMUST00000028170 --------------------------------LKIPENANVFYAMNSTANYDFILKKR-T SINFRUP00000148457 ITAAKLWHSTLNVFHLYADTLLSPRHSLVSVELRIPDNANVFYAMNSTANYDFVLKKR-G ENSMUST00000045726 --------------------------------LLIPDGANVFYAMSPAAPGDFLLRRK-- CG8865-RA --------------------------------LVMPKNANVYYAVNTNYNLNFILRPR-- * :*..***:**:.. :*:*: : ENSMUST00000027760 VEEQVKLRSRTSLTLPRTAKRGCWSNRHSKITL ENST00000304685 MEEQVKLRSRTSLTLPRTAKRGCWSNRHSKITL SINFRUP00000130037 AGRAIQLRSRCSSTLPRAQHRSSLSIRLSKVAL ENST00000303548 FTKGVKVKHGASSTLPRMKQKG---LKIAKGIF ENSMUST00000028170 FTKGAKVKHGASSTLPRMKQKG---LRIAKGIF SINFRUP00000148457 LGRPVRAKNVASSTLPRMKQKG---LKIAKGIF ENSMUST00000045726 --------EGTGHTLSASPT------------- CG8865-RA ------KEEGVAGS------------------- . :: :