CLUSTAL W (1.82) multiple sequence alignment O73778_Brachydanio_rerio ----------MLSSVKMESHE----------------------IPEWN-P O73843_Salmo_salar -------------------------------------------------- O42098_Oryzias_latipes ----------MLSSVKMEAHD----------------------ITDWNTT ENSMUST00000036018 ----------MLGSVKMEAHD----------------------LAEWS-- ENST00000302177 ----------MLGSVKMEAHD----------------------LAEWS-- Q98TD3_Colisa_lalia ---------MMLGAVKMEGHE----------------------HTDWS-T Q8UVZ8_Oreochromis_mossambicus ---------MMLGAVKMEGHE----------------------HTDWS-T SINFRUP00000134104 ---------IMLGAVKMEGHE----------------------HTDWS-T ENST00000245994 ----------MLGAVKMEGHE----------------------PSDWS-S ENSMUST00000047315 ----------MLGAVKMEGHE----------------------PSDWS-S ENST00000250448 ----------MLGTVKMEGHE----------------------TSDWN-S ENSMUST00000044380 ----------MLGTVKMEGHE----------------------SNDWN-S O73783_Brachydanio_rerio ----------MLGAVKMEGHE----------------------TPDWS-S SINFRUP00000139981 -------------------------------------------------- CG10002-RA MQKLYAEPPPSSAPVSMASSGGGGPPSGGGGGGGGGGGGGPPPPSNNNPN O73778_Brachydanio_rerio FYSEANEMYS-----SPSAM--NSVSSLNSYINLN--------SACSTSS O73843_Salmo_salar -------------------------------------------------- O42098_Oryzias_latipes FYSEASEMYS-----SPSATGLGSMGSINSYINLN--------AAASPTA ENSMUST00000036018 YYPEAGEVYS-----PVNPVP--TMAPLNSYMTLN--------PLSSP-- ENST00000302177 YYPEAGEVYS-----PVTPVP--TMAPLNSYMTLN--------PLSSP-- Q98TD3_Colisa_lalia YYGEPECYTS---VGNMNTGLGM--NSMNTYMSMSGMSTG---ANMTANS Q8UVZ8_Oreochromis_mossambicus YYGEPECYTS---VGNMNAGLGM--NSMNTYMSMSGMSTT---ANMTANS SINFRUP00000134104 YYAEPECYTS---VGNMNTGLGM--NSMNTYMSMSGMNTT---ANMTANS ENST00000245994 YYAEPEGYSS---VSNMNAGLGM--NGMNTYMSMSAAAMGSGSGNMSAGS ENSMUST00000047315 YYAEPEGYSS---VSNMNAGLGM--NGMNTYMSMSAAAMGGGSGNMSAGS ENST00000250448 YYADTQEAYSSVPVSNMNSGLGS-MNSMNTYMTMNTMTTS---GNMTPAS ENSMUST00000044380 YYADTQEAYSSVPVSNMNSGLGS-MNSMNTYMTMNTMTTS---GNMTPAS O73783_Brachydanio_rerio YYNDAQEVYSPMTNSSMNPGLSS-MNNMNSYMGMS---TS---GNMTSSS SINFRUP00000139981 --------------SSMATGMGSGLGSMTGYMSAN---------GTTSGS CG10002-RA PTSNGGSMSPLARSAYTMNSMGLPVGGMSSVSPQAAATFSSSVLDSAAAV : : O73778_Brachydanio_rerio MNMGYPSA-----GLNSSPLSSMGGGPNHMS-----------LSPVGSSL O73843_Salmo_salar -------------------------------------------------- O42098_Oryzias_latipes MNMPYPSS-----SLSSSSLAPMGSGPNHMS-----------LSPVASSL ENSMUST00000036018 ----YPPG-----GLQASPLP---TGP---------------LAPPAPTA ENST00000302177 ----YPPG-----GLPASPLP---SGP---------------LAPPAPAA Q98TD3_Colisa_lalia MNMS-YVN----TGMSP-SMTGMSP-GTGAMNGMG-----AGMTAMGAAL Q8UVZ8_Oreochromis_mossambicus MNMS-YVN----TGMSP-SMTGMSP-GTGAMNGMG-----AGMTAMSAAL SINFRUP00000134104 MNMS-YVN----TGMSP-SMTGMSP-GTGAMNGMG-----AGMTAMSAAL ENST00000245994 MNMSSYVG----AGMSP-SLAGMSP-GAGAMAGMGGSAGAAGVAGMGPHL ENSMUST00000047315 MNMSSYVG----AGMSP-SLAGMSP-GAGAMAGMSGSAGAAGVAGMGPHL ENST00000250448 FNMSYANPG-LGAGLSPGAVAGMPGGSAGAMNSMTAA----GVTAMGTAL ENSMUST00000044380 FNMSYANTG-LGAGLSPGAVAGMPGASAGAMNSMTAA----GVTAMGTAL O73783_Brachydanio_rerio FNMSYANPA-LGAGLSPGTMAGMP--TGGAMNGMGG-----GVSSMGTAL SINFRUP00000139981 FNMSYG-----GAGLSPAPVTGMSSSTPVAMSGLGG-----GMTSMGGAL CG10002-RA ASMSASMSASMSASMNASMNGSMGAAAMNSMGGNCMTPSSMSYASMGSPL : : : O73778_Brachydanio_rerio NPSSLTQLGSSAS-TLGPLS-HYQSMGQPMSQISYPSPTSLNR---TKEM O73843_Salmo_salar -------------------------MGQPMSQLSYPSPTSLNR---AKEV O42098_Oryzias_latipes SSGSLTQLGPAAAGSLGPLS-HYQNMGQSMSQLGYPSTGSLSRSS-PKEI ENSMUST00000036018 PLGP----------TFPSLG-TGGSTGGSASGYVAPGPGLVHG----KEM ENST00000302177 PLGP----------TFPGLG-VSG--GSSSSGYGAPGPGLVHG----KEM Q98TD3_Colisa_lalia SPS-MSPMTAQPA-SMNALT-SYSN-MNAMSP--IYGQSNINRSR----- Q8UVZ8_Oreochromis_mossambicus SPS-MSPMTAQPA-SMNALT-SYSN-MNAMSP--IYGQSNINRSR----- SINFRUP00000134104 SPS-MSPMTAQPA-SMNALT-SYTN-MNAMSP--IYGQSNINRSR----- ENST00000245994 SPS-LSPLGGQAAGAMGGLA-PYAN-MNSMSP--MYGQAGLSRAR----- ENSMUST00000047315 SPS-LSPLGGQAAGAMGGLA-PYAN-MNSMSP--MYGQAGLSRAR----- ENST00000250448 SPSGMGAMGAQQAASMNGLG-PYAAAMNPCMSPMAYAPSNLGRSRAGGGG ENSMUST00000044380 SPGGMGSMGAQPATSMNGLG-PYAAAMNPCMSPMAYAPSNLGRSRAGGGG O73783_Brachydanio_rerio SPSNLNAMTAQHS-SMNALN-PYTS-MSPTMSSMTYVAANLNRAR----- SINFRUP00000139981 SPSHMNSVPAQQG--SMGLS-PYGG-MSPSSS-MAYGGNGINRAR----- CG10002-RA GNMGGCMAMSAASMSAAGLSGTYGAMPPGSREMETGSPNSLGRSR---VD : : O73778_Brachydanio_rerio P-KPYRRSLTHAKPPYSYISLITMAIQQSQSKMLTLNEIYQWIMDLFPYY O73843_Salmo_salar P-KPYRRSLTHAKPPYSYISLITMAIQQSGSKMLTLNEIYQWIMDLFPYY O42098_Oryzias_latipes PPKPYRRSLTHAKPPYSYISLITMAIQQSGSKMLTLNEIYQWIMDLFPYY ENSMUST00000036018 A-KGYRRPLAHAKPPYSYISLITMAIQQAPGKMLTLSEIYQWIMDLFPYY ENST00000302177 P-KGYRRPLAHAKPPYSYISLITMAIQQAPGKMLTLSEIYQWIMDLFPYY Q98TD3_Colisa_lalia DPKTYRRSYTHAKPPYSYISLITMAIQQSPSKMLTLAEIYQWIMDLFPFY Q8UVZ8_Oreochromis_mossambicus DPKTYRRSYTHAKPPYSYISLITMAIQQSPSKMLTLAEIYQWIMDLFPFY SINFRUP00000134104 DPKTYRRSYTHAKPPYSYISLITMAIQQSPSKMLTLAEIYQWIMDLFPFY ENST00000245994 DPKTYRRSYTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFY ENSMUST00000047315 DPKTYRRSYTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFY ENST00000250448 DAKTFKRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYY ENSMUST00000044380 DAKTFKRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYY O73783_Brachydanio_rerio DNKTFRRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYY SINFRUP00000139981 DNKAFRRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYY CG10002-RA KPTTYRRSYTHAKPPYSYISLITMAIQNNPTRMLTLSEIYQFIMDLFPFY . ::*. .*****************: :**** ****:******:* O73778_Brachydanio_rerio RENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPNSGNMFENG O73843_Salmo_salar RENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPNSGNMFENG O42098_Oryzias_latipes RENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWTLHPQSGNMFENG ENSMUST00000036018 RENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPSSGNMFENG ENST00000302177 RENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPSSGNMFENG Q98TD3_Colisa_lalia RQNQQRWQNSIRHSLSFNDCFVKVPRSPDKPGKGSFWTLHPDSGNMFENG Q8UVZ8_Oreochromis_mossambicus RQNQQRWQNSIRHSLSFNDCFVKVPRSPDKPGKGSFWTLHPDSGNMFENG SINFRUP00000134104 RQNQQRWQNSIRHSLSFNDCFVKVPRSPDKPGKGSF-DLHPDSGNMFENG ENST00000245994 RQNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWTLHPDSGNMFENG ENSMUST00000047315 RQNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWTLHPDSGNMFENG ENST00000250448 RQNQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWTLHPDSGNMFENG ENSMUST00000044380 RQNQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWTLHPDSGNMFENG O73783_Brachydanio_rerio RQNQQRWQNSIRHSLSFNDCFVKVSRSPDKPGKGSYWTLHPDSGNMFENG SINFRUP00000139981 RQNQQRWQNSIRHSLSFNDCFVKVSRSPDKPGKGSYWTLHPDSGNMFENG CG10002-RA RQNQQRWQNSIRHSLSFNDCFVKIPRTPDKPGKGSFWTLHPDSGNMFENG *:*******************:*:.*:********: ***.******** O73778_Brachydanio_rerio CYLRRQKRFKIEEKAGKKSSS-------KSQDGSSTKGTHSSEGMQEEHS O73843_Salmo_salar CYLRRQKRFKIDQEKAAKKSG-------KAQEGGSGKGGHG-DSLMEEHS O42098_Oryzias_latipes CYLRRQKRFKIEDKASKKGS--------KNQEGGSGKGSHSGDHLVENHS ENSMUST00000036018 CYLRRQKRFKLEEKAK---------------KGNS-ATSASRNGTAGSAT ENST00000302177 CYLRRQKRFKLEEKVK---------------KGGSGAATTTRNGTGSAAS Q98TD3_Colisa_lalia CYLRRQKRFKCDKKMG---------------MKDGGRKSGDG------GS Q8UVZ8_Oreochromis_mossambicus CYLRRQKRFKCDKKM-----------------KEPGRKSGDG------GS SINFRUP00000134104 CYLRRQKRFKCDKKM-----------------KDGGRKSGDG------GS ENST00000245994 CYLRRQKRFKCEKQLA---------------LKEAAGAAGSG-KKAAAGA ENSMUST00000047315 CYLRRQKRFKCEKQLA---------------LKEAAGAASSGGKKTAPGS ENST00000250448 CYLRRQKRFKCEKQPGAGGGGGSGSGGSGAKGGPESRKDPSG------AS ENSMUST00000044380 CYLRRQKRFKCEKQPGAGG----GSGGGGSKGGPESRKDPSG------PG O73783_Brachydanio_rerio CYLRRQKRFKCDKKLPDGK---------RSEGKRE--QSSAR------AL SINFRUP00000139981 CYLRRQKRFKCEKK---------------TSLKCDGRKDEGG------GA CG10002-RA CYLRRQKRFKDEKKEAIRQLHK-------SPSHSSLEATSPGKKDHEDSH ********** :.: O73778_Brachydanio_rerio PT--------TGSDGAESAHSDSSHAGSTSE-------EQQ-RSLVQLDC O73843_Salmo_salar PA--------GGSEGADSAHSDNSHPGSSSE-------EQQQRSMVQLDC O42098_Oryzias_latipes PA--------GGSEGPDSAHSDNSHPGSSDDQ------PHQRNSLVPLDC ENSMUST00000036018 SA--------TTTAATAVTSPAQPQPTPSEPE------AQSGDDVGGLDC ENST00000302177 ----------TTTPAATVTSPPQPPPPAPEPE------AQGGEDVGALDC Q98TD3_Colisa_lalia ----------SNSSSESCNGNESPHSNSS---------SGEHKR-SLSDM Q8UVZ8_Oreochromis_mossambicus ----------SNSSSESCNGNESPLSNSS---------SSDHKR-SLSDM SINFRUP00000134104 ----------SNSSSESCNGNESPHSNSS---------SSEHKR-SLSDM ENST00000245994 QASQAQLGEAAGPASETPAGTESPHSSASP--------CQEHKRGGLGEL ENSMUST00000047315 QASQAQLGEAAGSASETPAGTESPHSSASP--------CQEHKRGGLSEL ENST00000250448 N---------PSADSPLHRGVHGKTGQLEGAPAPGPAASPQTLDHSGATA ENSMUST00000044380 N---------PSAESPLHRGVHGKASQLEGAPAPGPAASPQTLDHSGATA O73783_Brachydanio_rerio R---------PATDQRQTR-AHG--LQLH-----------HLLKPVVQSA SINFRUP00000139981 S---------PSGDKPAGLLLASPLPSSS-----------QAASPPGLDL CG10002-RA HMH-------HHHHSRLDHHQHHKEAGGASIAGVNVLSAAHSKDAEALAM O73778_Brachydanio_rerio PSQAPNLLHSSPVPIPSSVS----ASMPPSSSHLHSQGMGNSPHLLGSPM O73843_Salmo_salar PPQHQSHVQSAPVAITS------------STPLLHSQVMGGSPHLLPSAM O42098_Oryzias_latipes PQLSSSHLHSPPVSLPPSSSSLSLSGTSSSNPLLHPQSLASSSHLLPSPM ENSMUST00000036018 ASPPS------------------------STPYFSGLELPG--------- ENST00000302177 GSPAS------------------------STPYFTGLELPG--------- Q98TD3_Colisa_lalia K--SSQALSPE----------------HAAASPVS--QGQ---HLMS-QH Q8UVZ8_Oreochromis_mossambicus K--TSQALSPE----------------HTAASPVT--QGQ---HLMS-QH SINFRUP00000134104 K--TSQALSPE----------------HAAASPVS--QGQ---HLMP-PH ENST00000245994 KGTPAAALSPP----------------EPAPSPGQ--QQQAAAHLLGPPH ENSMUST00000047315 KGAPASALSPP----------------EPAPSPGQ--QQQAAAHLLGPPH ENST00000250448 TGGASELKTPA----------------SSTAPPISSGPGALASVPASHPA ENSMUST00000044380 TGGASELKSPA----------------SSSAPPISSGPGALASVPPSHPA O73783_Brachydanio_rerio QFGPQEREPPK----------------LGTEERWP----QVHPVSTSCSR SINFRUP00000139981 HGGTSDLK-------------------VSSSQLLS---------SLSLPP CG10002-RA LHANAELCLSQ------------------QPQHVPTHHHHQHHQLQQEEL O73778_Brachydanio_rerio H-HLDLQNDPLKSMDPHFNFNHPFSITNLMSNEQKM------------DL O73843_Salmo_salar H-NLDLQNDPLKAMDPHYNFNHPFSITNLMSNEQKM------------DL O42098_Oryzias_latipes QQHMDLQSD-LKSLDPHYNFNHPFSITNLMSNEQKM------------DL ENSMUST00000036018 ----------ELKLDAPYNFNHPFSINNLMSEQ----------------- ENST00000302177 ----------ELKLDAPYNFNHPFSINNLMSEQ----------------- Q98TD3_Colisa_lalia HSVLAHEAHLKP--EHHYSFNHPFSINNLMSSEQQ---------HHKMDL Q8UVZ8_Oreochromis_mossambicus HSVLAHEAHLKP--EHHYSFNHPFSINNLMSSEQQ---------HHKMDL SINFRUP00000134104 HSVLAHEAHLKP--EHHYSFNHPFSINNLMSSEQQH--------HHKMDL ENST00000245994 HPGLPPEAHLKP--EHHYAFNHPFSINNLMSSEQQHHHSHHHHQPHKMDL ENSMUST00000047315 HPGLPPEAHLKP--EHHYAFNHPFSINNLMSSEQQHHHSHHHHQPHKMDL ENST00000250448 HGLAPHESQLHLKGDPHYSFNHPFSINNLMSSSEQQ---------HKLDF ENSMUST00000044380 HGLAPHESQLHLKGDPHYSFNHPFSINNLMSSSEQQ---------HKLDF O73783_Brachydanio_rerio CTLWPTESQLDLKGDPHYSFNHPFSINNLMS-LQSQ---------HKLEL SINFRUP00000139981 HSMA-HESQLHLKGDPHYSFNHPFSINNLMSSSEQQ---------HKLDL CG10002-RA SAMMANRCHPSLITDYHSSMHPLKQEPSGYTPSSHP-------------F : :: . . : : : O73778_Brachydanio_rerio KSYQDQVMAYNSYATSSPVAAKQIYDNAGP-----SAIDSGAYYQTLYSR O73843_Salmo_salar KTYQDQVMAYNGYAASSPIAAKQIYDSAGP-----SVMDSGAYYQTLYSR O42098_Oryzias_latipes KSYQDQVMAYNSYTAGSPVGAKQIYDSPGP-----AAMDSGAYYQTLYSR ENSMUST00000036018 --------------TSTPSKLDVGFGGYGA-----ESGEPGVYYQSLYSR ENST00000302177 --------------TPAPPKLDVGFGGYGA-----EGGEPGVYYQGLYSR Q98TD3_Colisa_lalia RTYEQVMHYSG-YGSPVTGALSMGSMTGKAGLDSSSIP-DTTYYQGVYSR Q8UVZ8_Oreochromis_mossambicus KTYEQVMHYSG-YGSPMAGPLSMGSMAGKAGLDSSSIP-DTTYYQGVYSR SINFRUP00000134104 KTYEQVMHYSG-YGSPMAGALSMGAMAGKHGLDSASIP-DAAYYQGVYSR ENST00000245994 KAYEQVMHYPG-YGSPMPGSLAMGPVTNKTGLDASPLAADTSYYQGVYSR ENSMUST00000047315 KAYEQVMHYPGGYGSPMPGSLAMGPVTNKAGLDASPLAADTSYYQGVYSR ENST00000250448 KAYEQALQYSP-YGSTLPASLPLGSASVTTRSPIEPSALEPAYYQGVYSR ENSMUST00000044380 KAYEQALQYSP-YGATLPASLPLGSASVATRSPIEPSALEPAYYQGVYSR O73783_Brachydanio_rerio KT-RTTLQYSS-YGSGMSSNLPMAGRASMDPS----AALEASYYQGVYSR SINFRUP00000139981 KA-YEALQYSS-YSTGGPS--GLGGRS--------MESLEATYYQGVYPR CG10002-RA SINRLLPTESKADIKMYDMSQYAGYNALSPLTNSHAALGQDSYYQSLGYH *** : : O73778_Brachydanio_rerio SVLNAS-- O73843_Salmo_salar SVLNAS-- O42098_Oryzias_latipes SVLNAS-- ENSMUST00000036018 SLLNAS-- ENST00000302177 SLLNAS-- Q98TD3_Colisa_lalia PIMNSS-- Q8UVZ8_Oreochromis_mossambicus PIMNSS-- SINFRUP00000134104 PIMNSS-- ENST00000245994 PIMNSS-- ENSMUST00000047315 PIMNSS-- ENST00000250448 PVLNTS-- ENSMUST00000044380 PVLNTS-- O73783_Brachydanio_rerio PVLNTS-- SINFRUP00000139981 PLLNTS-- CG10002-RA APAGTTSL . .::