CLUSTAL W (1.82) multiple sequence alignment Q8QFL6_Brachydanio_rerio -------------------------WLNPLFSIGSKRRLEEDDMFNVLPE SINFRUP00000139356 -------------------------------------------------- ENST00000261295 -------------------------WLNPLFKIGHKRRLEEDDMYSVLPE ENSMUST00000036554 MLPVHTEVKPNPLQDANLCSRVFFWWLNPLFKTGHKRRLEEDDMFSVLPE SINFRUP00000139949 -------------------------------------------------- ci0100144289 -----------------------FRWMNGFFRNGSKHDLKDEDMYRLLPD CG7627-RA ---------------------------MPTFIKGRKRTLDTKDLYRALKE Q8QFL6_Brachydanio_rerio DRSKKLGEELQSYWDQEKEKAAKELKTPKLTKAIIRCY-WKSYAVLGVFT SINFRUP00000139356 -------------------------------------------------- ENST00000261295 DRSQHLGEELQGFWDKEVLRAENDAQKPSLTRAIIKCY-WKSYLVLGIFT ENSMUST00000036554 DRSKHLGEELQRYWDKELLRAKKDSRKPSLTKAIIKCY-WKSYLILGIFT SINFRUP00000139949 -------------------------------------------------- ci0100144289 DKSEKLCYDLECKWKAELQRFYSTGKKPSLFRAAVNTY-FSSWLFYVFIA CG7627-RA HKSETLGNKLCASWELELEKTKG---KPNLLRALLRVFGWYFALLGLVLF Q8QFL6_Brachydanio_rerio LIEESIKVIQPVFLGKLIKYFENYRHDDMAALSEAYGYATGVCLSTLGLA SINFRUP00000139356 -------------------------------------------------- ENST00000261295 LIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILA ENSMUST00000036554 LIEEGTRVVQPLFLGKIIEYFEKYDPDDSVALHTAYGYAAVLSMCTLILA SINFRUP00000139949 -------------------------------------------------- ci0100144289 VIEEVLRTFNPLLIRWLLGYFEVN---TNVPVSSAYLYATGIFAILVLLT CG7627-RA LLELGLRTLQPIFLLKLIAYYTHG----SESIESAYYYAAGVILCSALNV Q8QFL6_Brachydanio_rerio LLHHLYFYHVQRAGMKIRIAMCHMIYRKALCLSAAAMGQTTTGQIVNLLS SINFRUP00000139356 -------------------------------------------------- ENST00000261295 ILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLS ENSMUST00000036554 ILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNSAMGKTTTGQIVNLLS SINFRUP00000139949 -------------------------------------------------- ci0100144289 FLHHVLYYYTQRLGWHLRAATCALMYKKTLRLSQKALAATTTGQIVNLGA CG7627-RA IIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVVNLMS Q8QFL6_Brachydanio_rerio NDVNKFDELTIFLHFLWVGPLQAAAVIGLLWQEIGPSCLAGMAVLVFLMP SINFRUP00000139356 -------------------------------------------------- ENST00000261295 NDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLP ENSMUST00000036554 NDVNKFDQVTIFLHFLWAGPLQAIAVTVLLWVEIGISCLAGLAVLVILLP SINFRUP00000139949 -------------------------------------------------- ci0100144289 TDVIRFDWLGLFLHYLIIGPIQAVVVIYLLWADLGVSSLAGLVVIILAMI CG7627-RA NDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIP Q8QFL6_Brachydanio_rerio LQTMFGKLFSKYRSKTAALTDSRIRTMNEVVSGIRIIKMYAWEKPFAMLV SINFRUP00000139356 -------------------------------------------------- ENST00000261295 LQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLI ENSMUST00000036554 LQSCIGKLFSSLRSKTAAFTDARIRTMNEVITGMRIIKMYAWEKSFADLI SINFRUP00000139949 -------------------------------------------------- ci0100144289 IQSCVGRQFGRIRAKMSVLTDQRIRIMNEVLTAMKIIKMYAWEKPFEKLV CG7627-RA LQAYLGKRTSVLRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMV Q8QFL6_Brachydanio_rerio NDVRRKEISKIMSSSYLRGLNMASFFTANKIILFVTFTVYVLVGNTMSAS SINFRUP00000139356 -------------------------------------------------- ENST00000261295 TNLRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITAS ENSMUST00000036554 ANLRKKEISKILGSSYLRGMNMASFFIANKVILFVTFTSYVLLGNEITAS SINFRUP00000139949 -------------------------------------------------- ci0100144289 SETRRKEVQKVLYSVILKACNFSMMFISSRLLNLFTFITFVLLGGHLTPS CG7627-RA AFARKKEINAIRHVSYIRGILLSFIIFLTRVSIFLSLVGYVLLGTFLTPE Q8QFL6_Brachydanio_rerio RVFVAVSLYSAVRLTVTLFFPAAIEKVSESAISIRRIKKFLLLD------ SINFRUP00000139356 -------------------------------------------------- ENST00000261295 RVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLD------ ENSMUST00000036554 HVFVAMTLYGAVRLTVTLFFPSAIERGSEAIVSIRRIKNFLLLD------ SINFRUP00000139949 -------------------------------------------------- ci0100144289 KVFSAIALYNVLRTSMGLFFPLAIEKLSESLISLKRIQNFLMLD------ CG7627-RA VAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKYMQSDETNVMD Q8QFL6_Brachydanio_rerio ---ELVKNHLPLSQE-----------------------------EKKEPS SINFRUP00000139356 -------------------------------------------------- ENST00000261295 ---EISQRNRQLPSD-----------------------------GKK--M ENSMUST00000036554 ---ELPQRKAHVPSD-----------------------------GKA--I SINFRUP00000139949 -------------------------------------------------- ci0100144289 ---EIDDDLQGLPPK-----------------------------SSKDCI CG7627-RA MSVDLTEDFQGSNQETVHADGDEERDEAEDKLLGPPIATVNENAKLSEAG Q8QFL6_Brachydanio_rerio VEMQDLICYWDKTLDA-PTLQNVCFTVKPGQLLAVIGPVGAGKSSLLSTV SINFRUP00000139356 -------------------------------------------------- ENST00000261295 VHVQDFTAFWDKASET-PTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAV ENSMUST00000036554 VHVQDFTAFWDKALDS-PTLQGLSFIARPGELLAVVGPVGAGKSSLLSAV SINFRUP00000139949 -------------------------------------------------- ci0100144289 VELTSFTAWWTEDSANRPTLEDITLKVKPGQLLAVIGPVGSGKSSFLSAI CG7627-RA ISISGLMAKWDVNSPD-YSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAI Q8QFL6_Brachydanio_rerio LGELPAEKGVIKVKGELTYASQQPWVFPGTIRSNILFGKELQPQRYERVL SINFRUP00000139356 -------------------------------------------------- ENST00000261295 LGELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVI ENSMUST00000036554 LGELPPASGLVSVHGRIAYVSQQPWVFSGTVRSNILFGKKYEKERYEKVI SINFRUP00000139949 -------------------------------------------------- ci0100144289 LRELPASTGQARVVGQVSYAGQTPWVFSGSIRENILFGEEYNEKRFKEVI CG7627-RA LGELPAESGEIKVNGSMSYASQEPWLFSGTVRQNILFGQPMDRRRYAKVV Q8QFL6_Brachydanio_rerio RACALKRDMELLPDGDLTVIGDRGATLSGGQKARVNLARAVYQD-ADIYL SINFRUP00000139356 -------------------------------------------------- ENST00000261295 KACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARAVYQD-ADIYL ENSMUST00000036554 KACALKKDLQLLEDGDLTVIGDRGATLSGGQKARVNLARAVYQD-ADIYL SINFRUP00000139949 -------------------------------------------------- ci0100144289 DICCLEKDLLSFEFGDLTLVGQRGVTLSGGQKARVNLARAVYRRGTNIFL CG7627-RA KKCALERDFELLPFKDKTIVGERGASLSGGQKARISLARAVYRE-TSIYL Q8QFL6_Brachydanio_rerio LDDPLSAVDAEVSRHLFEQCVCGILKDKPRILVTHQLQYLKAANQILVLK SINFRUP00000139356 -------------------------------------------------- ENST00000261295 LDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILK ENSMUST00000036554 LDDPLSAVDAEVGKHLFQLCICQALHEKITILVTHQLQYLKAASHILILK SINFRUP00000139949 -------------------------------------------------- ci0100144289 MDDPLSAVDASVAHKMFEGCICRYLRKTIRILVTHQLQFLQKADQIMILK CG7627-RA LDDPLSAVDTHVARHLFEQCMRGYLRERIVILATHQLQFLQHADQIVIMD Q8QFL6_Brachydanio_rerio EGHMVARGSYSELQQSGLDFTSLLKKDEEEESGSEKGEAPRSPRSRTVSQ SINFRUP00000139356 -------------------------------------------------- ENST00000261295 DGKMVQKGTYTEFLKSGIDFGSLLKKDNEESEQPPVPGTP-TLRNRTFSE ENSMUST00000036554 DGEMVQKGTYTEFLKSGVDFGSLLKKENEEAEPSTAPGTP-TLRKRTFSE SINFRUP00000139949 -------------------------------------------------- ci0100144289 EGKIAGLGTYSELQADGTDFAALLKKKEE----PPLSPGPGGFRNRLLSG CG7627-RA KGRVSAVGTYESLRESGLDFASMLADPERDEQSEERSRSRSGSYTHSHSD Q8QFL6_Brachydanio_rerio NSVRSHSSSVLSVKDDSDQLPAEP--VHTMAEESRSEGNIGIRMYWKYFR SINFRUP00000139356 -------------------------------EESRSEGNISLHLYVKYFR ENST00000261295 SSVWSQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGFQAYKNYFR ENSMUST00000036554 ASIWSQQSSRPSLKDGAPEGQDAENTQAVQPEESRSEGRIGFKAYKNYFS SINFRUP00000139949 -------------------------------------------------- ci0100144289 D----RQRTYSFIEDN---LQCEYFVAPVEEEEINAQGSVKFQVYKNYFI CG7627-RA Q----RRNSEQSLLSMADSCMDDLEAEQANNQERQEAGQIGLRLYSKYFK Q8QFL6_Brachydanio_rerio AGANVVMLVLLVLLNLLAQTFYILQDWWLSYWATEQEKLDHNTNNTNTNN SINFRUP00000139356 AGANFLVLLILICINALAHIAFVLQDWWLAYWASEQK----RVNVTEHFN ENST00000261295 AGAHWIVFIFLILLNTAAQVAYVLQDWWLSYWANKQS----MLNVTVNGG ENSMUST00000036554 AGASWFFIIFLVLLNMVGQVFYVLQDWWLSHWANKQG----ALNNTRNAN SINFRUP00000139949 -------------------------------------------------- ci0100144289 Y--NVYFFTLLTILALCDHTVFILCDWWIAMCPWAWG-----LNGSFFNP CG7627-RA AGGGFFAFFVMMGFCVLSQGLASLGDYFLSYWVTKKG----NVAYRADNN Q8QFL6_Brachydanio_rerio TSAGNTTQQLDLNFYLG--------------IYAGLTGATIVFGFMRCLI SINFRUP00000139356 SSFP---QQLDLDLYLG--------------VYAGLTATSVVFGFLRCLL ENST00000261295 GNVT---EKLDLNWYLG--------------IYSGLTVATVLFGIARSLL ENSMUST00000036554 GNIT---ETLDLSWYLG--------------IYAGLTAVTVLFGIARSLL SINFRUP00000139949 -------------------------------------------------- ci0100144289 VVIN-----RLSKLSLL--------------FYTGLIGLLTVLLYTRSIA CG7627-RA DTTRSEELEPRLSTWLRDIGLSVDAEMLDTYIFTVITVLTILVTVARSFL Q8QFL6_Brachydanio_rerio MFNALVSSAETLHNRMFNSILRTPVRFFDINPIGRILNRFSKDIGHLDSL SINFRUP00000139356 FFNVLVNSAQNLHDSMFNAILQTPVQFFDVNPIGRILNRFSKDIGYLDSL ENST00000261295 VFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDL ENSMUST00000036554 VFYILVNASQTLHNRMFESILKAPVLFFDRNPIGRILNRFSKDIGHMDDL SINFRUP00000139949 ----------------------------------RILNRFSKDIGQLDSK ci0100144289 QFYYCVKSGILMHDKMFHAILHAPMRFFDVNPVGRILNRFSKDLGQVDEL CG7627-RA FFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEI *********:* :*. Q8QFL6_Brachydanio_rerio LPWTFVDFIQVFLQIVGVIAVASSVIPWILIPVLPLLICFLFLRRYFLRT SINFRUP00000139356 LPWSFVDFIQVFLQVIGVIAVAAVIIPWILIPVAPLLAIFLYLRCYFLQT ENST00000261295 LPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLET ENSMUST00000036554 LPLTFLDFIQTLLLVVSVIAVAAAVIPWILIPLVPLSVVFLVLRRYFLET SINFRUP00000139949 MPWIFVDFIQLFLQILGVIAVSASVIPWILIPVLPLLLVFIYLRRYFLQT ci0100144289 LPQTFMDFIYIFCMIFSILILSVTINYFVIVIVIPLSIYFIWLRQYYIKT CG7627-RA LPAVMMDVIQIFLALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKT :* ::*.* : : .:: : : . : * * ** :::.* Q8QFL6_Brachydanio_rerio SRDVKRIESTTRSPVFSHLSSSLQGLWTIRAFKAEERFQQTFDAHQDLHS SINFRUP00000139356 SRDIKRLESTTRSPVFSHLSSTLHGLSTIRAFKVQQAFQQMFDEFQDIHS ENST00000261295 SRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHS ENSMUST00000036554 SRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHS SINFRUP00000139949 SRDVKRLESTTRSPVFSHLSSSLQGLWTIRAFQAEDRFQKTFDDYQDLHS ci0100144289 SRDIKRMEGASRSPVFTHVSNTIQGLTTVRAFNMQDRFEEEFNNRQDLHS CG7627-RA SRDVKRMEAITRSPVYSHLAASLTGLSTIRAFGAQRVLEAEFDNYQDMHS ***:**:*. :****::*:: :: ** *:**: : : *: **:** Q8QFL6_Brachydanio_rerio EAWFLFLTTSRWFAVRLDGMCSVFVTITAFGCLLLK--DTMNAGDVGLAL SINFRUP00000139356 EAWFLFLTTSRWLAVRVDGICSVFVTTTAFACLYFR--DELEPGSVGLAL ENST00000261295 EAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILA--KTLDAGQVGLAL ENSMUST00000036554 EAWFLFLTTSRWFAVRLDAICAIFVIVVAFGSLVLA--KTLNAGQVGLAL SINFRUP00000139949 QAWFLFLTTSRWFALRLDGICSIFVTVTTFGCLLLR--DQLDAGSVGLAL ci0100144289 SAWFLFITGSRWLAVRLDAICAIFIGCVAYFSILTSSINAVDAGKVGLTL CG7627-RA SAFYMFISTSRAFGYWLDCFCVIYIAIITLSFFIFP---PANGGDVGLAI .*:::*:: ** :. :* :* ::: : : : *.***:: Q8QFL6_Brachydanio_rerio SYAVTLMGMFQWGVRQSAEVENMMTSVERVVEYTELESEAPWETQ--KRP SINFRUP00000139356 SYAMTLTGMFQWGVRQSAEIENMMTSVERVVEYAELESEAPWETD--VRP ENST00000261295 SYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQ--KRP ENSMUST00000036554 SYALTLMGMFQWSVRQSAEVENMMISVERVIEYTDLEKEAPWECK--KRP SINFRUP00000139949 TYAVTLMGMFQWAVRQSAEVENLMTSVERVIEYTELEGEAPWQTQ--KRP ci0100144289 TYAIMLMGMFQWGTRQSAEVENLMTSVERIQQYYAIEPEAPHEVEG-SSL CG7627-RA TQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIEPEGALEAPADKKP : *: : **.** *****:** * :***: :* :* *.. : Q8QFL6_Brachydanio_rerio SPDWPNRGLITFDRVNFSYSSD--GPVVLKNISAMFRPREKVGIVGRTGA SINFRUP00000139356 PYDWPTRGCITFDRVNFSHGSS--EPLVLKNLSVVFKPREKVGIVGRTGA ENST00000261295 PPAWPHEGVIIFDNVNFMYSPG--GPLVLKHLTALIKSQEKVGIVGRTGA ENSMUST00000036554 PPGWPHEGVIVFDNVNFTYSLD--GPLVLKHLTALIKSREKVGIVGRTGA SINFRUP00000139949 PPDWPSKGLVTFDQVSFSYSDD--SPPVLHSLKAMFLPQEKVGIVGRTGA ci0100144289 PRGWPQYGIVTFDNLSYAHYKG--GPDILHDIRANIRAHEKVGIVGRTGA CG7627-RA PKSWPEQGKIVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGA . ** * : **.:. : . :*: : : .:*********** Q8QFL6_Brachydanio_rerio GKSSLISALFRLSE-PEGKILVDGVLTSEIGLHDLRQKMSIIPQDPVLFT SINFRUP00000139356 GKS-LISALFRLAE-PEGRILIDGFLTSEIGLHTLRQRMSIIPQDPVLFT ENST00000261295 GKSSLISALFRLSE-PEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFT ENSMUST00000036554 GKSSLISALFRLSE-PEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFT SINFRUP00000139949 GKSSLVSALFRLAE-PKGNIYIDGILTSEIGLHDLRQKMSIIPQDPVLFT ci0100144289 GKSSLISTLFRLNEYSKGSVMIDGINVSELGLTDLRSAISIIPQDPILFA CG7627-RA GKSSLINALFRLSY-NDGSVLIDKRDTSEMGLHDLRSKISIIPQEPVLFS *** *:.:**** .* : :* .:*:** **. :*****:*:**: Q8QFL6_Brachydanio_rerio GTMRKNLDPFNQHSDHDLWKALEEVQLKAAVEELPGKLETELAESGSNFS SINFRUP00000139356 GTVRKNLDPFRQHTDEDLWNALQEVQLKAVVEDLPNKLETVLAESGSNFS ENST00000261295 GTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFS ENSMUST00000036554 GTMRKNLDPFNEHTDEELWRALEEVQLKEAIEDLPGKMDTELAESGSNFS SINFRUP00000139949 GSMRKNLDPFNQHTDEELWNALEEVQLRSVVEDLPGKLETVLAESGSNFS ci0100144289 GTMRKNLDPFQLYTDDEVWTALEQVQLKPVVEQLPLRLFTELAESGSNFS CG7627-RA GTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQSKITEGGTNFS *::* ***** ::*..:* :*::*:*: .: :** : : ::*.*:*** Q8QFL6_Brachydanio_rerio VGQRQLVCLARAILRKNRVLIIDEATANVDPRTDELIQKTIRDKFKECTV SINFRUP00000139356 VGQRQLVCLARAILRKNRILIIDEATANVDPRTDSLIQQTIRDKFRECTV ENST00000261295 VGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTV ENSMUST00000036554 VGQRQLVCLARAILKNNRILIIDEATANVDPRTDELIQQKIREKFAQCTV SINFRUP00000139949 VGQRQLVCLARALLRKNRILIIDEATANVDPRTDELIQKTIRDKFRECTV ci0100144289 VGQRQLVCLARAVLRKNRVLIIDEATANVDLRTDFLIQETIRNSFKHCTV CG7627-RA VGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTV ************:*::*::*::******** :** *** .**:.* .*** Q8QFL6_Brachydanio_rerio LTIAHRLNTIIDSDRILVLDAGRIHEYDAPHVLLQNQSG-IFYKMVQQTG SINFRUP00000139356 LTIAHRLNTIIDCDRILVLAAGRIQEYDRPYVLLQNRDG-FFHQMVQQTG ENST00000261295 LTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKES-LFYKMVQQLG ENSMUST00000036554 LTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNPES-LFYKMVQQLG SINFRUP00000139949 LTIAHRLNTIIDSDRIL--------------------------------- ci0100144289 LTIAHRLHTIIDSDRVMILDQGRLIEFDEPHVLLGKEDG-IFTQMVDATG CG7627-RA LTIAHRLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVKQTG *******:**:*.*::: Q8QFL6_Brachydanio_rerio KAEATSLLQTAKQ----------------------------------- SINFRUP00000139356 RAEAASLLHAAKQV---------------------------------- ENST00000261295 KAEAAALTETAKQVYFKRNYPHIGHTDHMVTNTSNGQPSTLTIFETAL ENSMUST00000036554 KGEAAALTETAKQVYFRRNYPDITFTSPAVMNTSNGQPSALTIFETAL SINFRUP00000139949 ------------------------------------------------ ci0100144289 RSEAKALREIAAKVF--------------------------------- CG7627-RA HATYESLLKIAQKAFENRQNHSLSS-----------------------