CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000027766 MAAMLGDAIMVAKGLAKLTQAAVETHLQNLGLGGELLLAARALQSTAVEQFSMVFGKVQG ENST00000295188 MAAILGDTIMVAKGLVKLTQAAVETHLQHLGIGGELIMAARALQSTAVEQIGMFLGKVQG SINFRUP00000164971 ------------------------------------------------------------ SINFRUP00000143815 ------------------------------------------------------------ ENSMUST00000003860 ------------------------------------------------------------ ENST00000324451 ------------------------------------------------------------ SINFRUP00000157935 ------------------------------------------------------------ ci0100154511 -MQRVSDLIWMSRGVIKIGQTCAQNTCNEIGFALRASSVTGPLMEQCEKATGVCN----- ENSMUST00000021434 ------------------------------------------------------------ CG3608-RA ------------------------------------------------------------ ENSMUST00000027766 QDKHEDSYATENFEDLEAEVQFSTPQAAGTSLDFSAASSLDQSLSP----SHSQGPAPAY ENST00000295188 QDKHEEYFA-ENFGGPEGEFHFSVPHAAGASTDFSSASAPDQSAPPSLGHAHSEGPAPAY SINFRUP00000164971 ------------------------------------------------------------ SINFRUP00000143815 ------------------------------------------------------------ ENSMUST00000003860 -----------------------------------------------------------M ENST00000324451 ------------------------------------------------------------ SINFRUP00000157935 ------------------------------------------------------------ ci0100154511 ------------VSEFDETFDKNIFDEEEVFSELVGATEVNVASTTTEPLTGKGPTRQYH ENSMUST00000021434 ------------------------------------------------------------ CG3608-RA -----------------------------------------------------------M ENSMUST00000027766 ASSGPFREAGLPGQATSPMGRVNGRLFVDHRDLFLANGIQRRSFHQDQSSVGGLTAEDIE ENST00000295188 VASGPFREAGFPGQASSPLGRANGRLFANPRDSFSAMGFQRRFFHQDQSPVGGLTAEDIE SINFRUP00000164971 ------------------------------------------------------------ SINFRUP00000143815 ------------------------------------------------------------ ENSMUST00000003860 WLELGAMLRRTCGPLGRAVRLPCGGALGPRPHWWGPCRSCLAQSVHQDQPGRGLSEDDIR ENST00000324451 -EYWPRWLRSPCQEVVCSQRVVLG---------WTPAPSCR------------------- SINFRUP00000157935 ----PLLSEANAERIVDTLCKVRG-----------AALKIG------------------- ci0100154511 TSAHPFLRHNFMVHKTNPRTLGRRCLLSPHNRHLHTSNSLRAFTADELAAIAKVHRVRNV ENSMUST00000021434 MARKALKLASWTSVALAASGVYLYSNNYLDPNDFGAVRVGR------------------- CG3608-RA LLRRVLGYG-VVGAGLASAGWSLHTNDY-DPNSLGIVRLSR------------------- ENSMUST00000027766 KARQAKARPESKPHKQMLSERARERKVPVTRIGRLANFGGLAVGLGIGALAEVAKKS--L ENST00000295188 KARQAKARPENKQHKQTLSEHARERKVPVTRIGRLANFGGLAVGLGFGALAEVAKKS--L SINFRUP00000164971 ------------------------------------------------------------ SINFRUP00000143815 ------------------------------------------------------------ ENSMUST00000003860 RAREARLR---KAPRPQLSDRSRERKVPASRISRLASFGGLAVGLGLGALAEVTKKSL-P ENST00000324451 --------------RPMPSGLCRP------------------------------------ SINFRUP00000157935 -----------QMLSIQDNSFINP------------------------------------ ci0100154511 EKKTKKP----DSKMDNITSESKERRVPTSRLGRLASFGGLAASMAIGSLSDAAKKSIGV ENSMUST00000021434 -----------AVATTAVISYDYLTSLR-------------------------------- CG3608-RA -----------SAAAVVDVALTYKRELY-------------------------------- ENSMUST00000027766 RSENSTGKKAVLDSSPFLSEANAERIVSTLCKVRGAALKLGQMLSIQDDAFINPHLAKIF ENST00000295188 RSEDPSGKKAVLGSSPFLSEANAERIVRTLCKVRGAALKLGQMLSIQDDAFINPHLAKIF SINFRUP00000164971 -------KKGVLDSSPFLSEANAERIVRTLCKVRGAALKLGQMLSIQDDAFINPQLAKIF SINFRUP00000143815 -------KQSILDRSAFLSEANAERIVRTLCKVRGAALKIGQMLSIQDDAFINPQLAKIF ENSMUST00000003860 GGSLQHEGVSGLGSSPFLSEANAERIVQTLCTVRGAALKIGQMLSIQDNSFISPQLQRIF ENST00000324451 --YVQFE-----GPPSRLARCSASR----------------------------------- SINFRUP00000157935 --QLQKIFERVRQSADFMPSWQMKK----------------------------------- ci0100154511 SEQKSSGYKSSLAASVVLTEANMEKIVATLCKVRGAALKLGQMLSIQDVSVVDPKLIEVF ENSMUST00000021434 SVPYGSE--EYLQRRSQVHLRSARRLFELCCANRGTFIKVGQHLG-ALDYLLPEEYTSTL CG3608-RA YKEWDKETPEYKAEKSRVHKIAAEKLLQLICINKGVYIKVGQHIG-ALEYLLPKEFVQTM : ::. : : : : .: : ENSMUST00000027766 ERVRQSADFMPLKQMTKTLNSDLGPHWRDKLEYFEERPFAAASIGQVHLARMKGGREVAM ENST00000295188 ERVRQSADFMPLKQMMKTLNNDLGPNWRDKLEYFEERPFAAASIGQVHLARMKGGREVAM SINFRUP00000164971 DRVRQSADFMPIKQMMRALNSDLGPNWRDKLESFEERPFAAASIGQVHLARLKDGREVAM SINFRUP00000143815 ERVRQSADFMPSRQMMKAVSSDLGPDWRDKLEYFEEKPFAAASIGQVHLGRLKGGREVAM ENSMUST00000003860 ERVRQSADFMPRWQMMRVLEEELGKDWQDKVASLEEVPFAAASIGQVHQGLLKDGTEVAV ENST00000324451 ----------------RVLEEELGRDWQAKVASLEEVPFAAASIGQVHQGLLRDGTEVAV SINFRUP00000157935 -----------------VLEEDLGPGWQEKLLSFEEKPFAAASIGQVHHGVLKDGREIAV ci0100154511 DRVRQSADYMPASQMKKVLVEEFGSDWRSLVKEFDEKPFAAASIGQVHRAVLHNGKEVAM ENSMUST00000021434 KVLHSQAPQSSMQEVRQVIREDLGKEIHDLFLSFDDTPLGAASLAQVHKAVLHDGRTVAV CG3608-RA KVLHSDAPQNPIEDLYKVIRQDLHCNPEEIFDSFEREPLGTASLAQVHKARLKTGELVAV : : .: .:: . . :: *:.:**:.*** . :: * :*: ENSMUST00000027766 KIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRRELTLECDYQREAAYAKK ENST00000295188 KIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRRELALECDYQREAACARK SINFRUP00000164971 KIQYPGVAQSINSDVNNLMTVLNMSNALPEGLFPEHLIDVTRRELSLECDYIREARCAKK SINFRUP00000143815 KIQYPGVAKSINSDVNNIMTALSLSNVLPEGLFPEHLIEVMSRELALECDYIREAKCAKK ENSMUST00000003860 KIQYPGVAQSIQSDVENLLALLKMSVGLPEGLFAEQSLQTLQQELAWECDYCREAACAQT ENST00000324451 KIQYPGIAQSIQSDVQNLLAVLKMSAALPAGLFAEQSLQALQQELAWECDYRREAACAQN SINFRUP00000157935 KIQYPGVAESIHSDINNLMSVLKMSVILPEGLFADSSLEVLQRELAWECDYKREAECAKR ci0100154511 KIQYPGVADSINSDIDNLVSLLKLWNIFPEQLYIDKFIDVSRRELAWECDYQREAEFMKM ENSMUST00000021434 KVQHPKVQAQSSKDILLMEVLVLAVKQLFPDFEFMWLVDEAKKNLPLELDFLNEGRNAEK CG3608-RA KVQHPYVKGNSRVDMKTMELAVNVLARIFPDFKIHWLVEESKKNLPIELDFLNEGRNAEK *:*:* : . *: : : : : :: ::*. * *: .*. . ENSMUST00000027766 FRELLKDHPFFYVPEIVDELCSPHVLTTELISGFPLDQAEGLSQE--VRNEICYNILVLC ENST00000295188 FRDLLKGHPFFYVPEIVDELCSPHVLTTELVSGFPLDQAEGLSQE--IRNEICYNILVLC SINFRUP00000164971 FRELLKDHPFFYVPEVIDELSSRHVLTTELVPGFPLDQAESLSQE--LKNEICQNILLLC SINFRUP00000143815 FQELLKDHPFFYVPDVVDELSSQHVLTTTLVPGFPLDQATDLSQE--LRNEICEQILILC ENSMUST00000003860 FRKLLADDPFFRVPAVVQELCTTRVLGMELAGGIPLDQCQGLSQD--IRNQICFQLLRLC ENST00000324451 FRQLLANDPFFRVPAVVKELCTTRVLGMELAGGVPLDQCQGLSQD--LRNQICFQLLTLC SINFRUP00000157935 FRCLLEGDDFFQVPEVIDELSGTRVLAMELVQGVPLDRCVDLDQE--TRNQISFNILQLC ci0100154511 FREVLADEEMYGVPEITPQLSGKRVLTTELITGIPIDQVGNLSQD--ERNYVAAAVLRLV ENSMUST00000021434 VAHMLRHFDFLKVPQIHWELSTKRVLLMEFVEGGQVNDRAYMEKNQIDVNEISCHLGKMY CG3608-RA VAKQFKKYSWLRVPKIYWKYSSSRVLVMEYLEGGHVTDLDYIRRNKIDSFAVANRIGQLY . : ** : : . :** * : : :: :. : : ENSMUST00000027766 LRELFEFHVMQTDPNWSNFFYDPQQHK----VALLDFGATREYDRSFTDLYIQVIRAAAD ENST00000295188 LRELFEFHFMQTDPNWSNFFYDPQQHK----VALLDFGATREYDRSFTDLYIQIIRAAAD SINFRUP00000164971 LRELFEFRYMQTDPNWSNFFYDPQTHR----VALLDFGATRGFDQSFTDVYIEIIRSAAE SINFRUP00000143815 LRELFEFRYMQTDPNWSNFYFDPQAHK----IALLDFGATRGFDKSFTDMYIEIINAAAH ENSMUST00000003860 LRELFEFRFMQTDPNWANFLYDASSHQ----VTLLDFGASRAFGTEFTDHYIEVVKAAAD ENST00000324451 LRELFEFRFMQTDPNWANFLYDASSHQ----VTLLDFGASREFGTEFTDHYIEVVKAAAD SINFRUP00000157935 LRELFEFRFMQTDPNWANFFYNSETNK----VVLLDFGACRSYPESFTDDYIQVVHAASV ci0100154511 LREIFELRCMQTDPNWANFFYNEEQQK----LWLLDFGASRSYSKQFVDEYIDVVKGAAD ENSMUST00000021434 SEMIFVNGFVHCDPHPGNVLVRKRPDTGKAEIVLLDHGLYQVLTEEFRLDYCHLWQSLIW CG3608-RA SEMIFRTGFVHSDPHPGNILVRRTPEN-SLEIVLLDHGLYANLTDKFRYDYSNLWLSILK . :* :: **: .*. . : ***.* .* * .: . ENSMUST00000027766 QDREAVLKKSI-------EMKFLTGYEVKAMEDAHLDAILILGEAFASEEPFDFGTQSTT ENST00000295188 RDRETVRAKSI-------EMKFLTGYEVKVMEDAHLDAILILGEAFASDEPFDFGTQSTT SINFRUP00000164971 GNREGVLQKSI-------EMKFLTGYESKAMINAHVDAVMILGEAFASKEDFRFGCQSTT SINFRUP00000143815 QNREGVLQKSR-------EMKFLTGYESKAMENAHVDAVMILGEAFSSQEPFDFGSQSTT ENSMUST00000003860 GDRDRVLQKSQ-------DLKFLTGFETKAFSDAHVEAVMILGEPFAASGPYDFGAGETA ENST00000324451 GDRDCVLQKSR-------DLKFLTGFETKAFSDAHVEAVMILGEPFATQGPYDFGSGETA SINFRUP00000157935 GDRATVLSKSK-------DLKFLT------------------------------------ ci0100154511 GDRELVLEKSK-------KLGFLTGYEPQVMNDAHVDAIMILGEPFASDDVFDFSTQNTS ENSMUST00000021434 TDMDGLKQYSQRLGAA-DLYPLFACMLTARSWDSVKQGIGQAPVSATEDSEIRNNAACYL CG3608-RA VDRKAMRQHSEQLGIKGDLYGLFACMVTGRPWETVMQGLTKVKYSKEEKNTLQNNTSLVL : : * ::: : ENSMUST00000027766 EKIHNLIPVMLKHRLIPPPE-------ETYSLHRKMGGSFLICSKLKARFPCKAMFEEAY ENST00000295188 EKIHNLIPVMLRHRLVPPPE-------ETYSLHRKMGGSFLICSKLKARFPCKAMFEEAY SINFRUP00000164971 KRIHNLIPVMLKHRLTPPPE-------ETYSLHRKMGGSFLICSRLDAKLRCKDMFQTAY SINFRUP00000143815 ERIHNLIPVMLRERLTPPPE-------ETYSLHRKMGGSFLICSKLKAKIACNNMFQETY ENSMUST00000003860 RRIQGLIPVLLRHRLRPPPE-------ETYALHRKLAGAFLACARLHAHIACRDLFQDTY ENST00000324451 RRIQDLIPVLLRHRLCPPPE-------ETYALHRKLAGAFLACAHLRAHIACRDLFQDTY SINFRUP00000157935 ------------------------------------------------------------ ci0100154511 SRIMNIIPVFMKHRLSPPPE-------ETYSLHRKLSGAFLIATKLKAKFACQKMFFDIY ENSMUST00000021434 PEISQLLNHVPRQMLLILKTNDLLRSIETTLGTRSSASSFLNMSRCCIR-ALAEHKKRDA CG3608-RA PHISDVLEQVDRQMLLILKTNDLIRGIESTLRTQNRMTAFWVMSKCCVQSSYAEQRAKQS : :: . : : ENSMUST00000027766 SNYCRMKSGLQ------------------------------------------ ENST00000295188 SNYCKRQAQQ------------------------------------------- SINFRUP00000164971 EKY-------------------------------------------------- SINFRUP00000143815 KNYWK------------------------------------------------ ENSMUST00000003860 HRYWASRQTLPLPAAS------------------------------------- ENST00000324451 HRYWASRQPDAATAGSLPTKGDSWVDPS------------------------- SINFRUP00000157935 ----------------------------------------------------- ci0100154511 EKYWQENVKTS------------------------------------------ ENSMUST00000021434 GS-FFRRTQISFSEAFSLWQINLHELLLRVRALRLACWVSALLGWLTRAPHRM CG3608-RA DSGSSRILWLRVRERWELFKLNCYYLYLGLIN----------FGFLEALKQVI