>ENSMUST00000023053/1-840 RIEWHLINSFKPERTGKSIGVKNADMHTVVESLTRTVCSRASALATIGSEVTARSSPGSE---------------------------------------------KIGETHTDIELSGLFPNTEYTVTVYASLRISNVGSNSARLTWDISGYRIVYTSADGTEINEVEVDPITFP-LKGLTPLTEYSIAIFSIYEEGQSLPLVGEFTTEEVPQYLEIDEVKTDSFRVTWHPLSAEEGQHKLMWIPVYGGKEQDSYVIEGLDPGTEYEVSLLAVLDDGSESEVVTAVGTTRNLVVDDETATSLRVSWSNVEQFRVTYGDPMEVPGVQNSLLLKALLPDTEYKVTVTPVYTV--GEGVSVSAPGKTLTRHCFYGLQPDSEYKISV >O93406_Brachydanio_rerio/1-2478 RIYLGSSRVGETYKGARGDTWQRPHMLECVCLGNGKGEWTNDQDTRTSSKTDSRGTGSHSTGMKWCGTTYNFDKEQRAAHEEVNEGVMYRVGDQRHDENCTCFGQTRVFYQIGESWDKLIQGIHYRCYCYGSISEAGNQPNSHPIQWNTQYILKWRPKNTHIQWMEVTIPGHNSYTIAGLKPGVTYEGQLISILRFGRRETTRFDFSTVHGSTSESVTEITSSSFVISWVSASDTVSGFRVEYELSEEGGSATSVNISELLPGRKYTVNVYEVTGEGEPNLILTTSQTTSDHEVEDVADTSIRISWAPITGYRVVYEGSSGLPEHSTSLTLGDLRPGVLYNISIFSVEENQESEPVFVQVTTAGETYHPSLNLQPDTEYSATL >ci0100149892/1-1923 NATTVTNNWVYQSYTAIKLEGNKPDYSNITSTSVNISWMETKYTVYITSVTERYAYTILVRETSKTIKGLKPFSLYLTKYGDGSATYLIYTMEDTSVNQPAEPNGTKETNKTFITLTNLKKYTEYIISISAGIFFHQHNSTSISLTWNNGIITLYSVHYRHGNKSLIRTTATPGITLNNLKKFTSYDVYIRASTKFGDGNQTSKIKSFKTLHHDVRVAAISSTSINVTWSPPTTPNGLIQFYTVYYQHNPKGMQVVIGNLRKFTNYLVWVTSSTALGDGNQMSDAIKVQSNLNCTAFNKSTMMVSWMEANGILLSYNEGET---NTNHYILTDLTPFTQYTASISAQTTVEGPISVCPTSLVTVTVQVQLTNLAPFTNYSLQL >ENST00000265131/1-2201 QLLAGVEQPVVFNNVLESTVDGENQFTHRINIPRRACGCAKELLSRLESLREQCTQPGEESNGQCVCDEGYTGEDCSDCHSRGEGKCVCEQGFKKDCKPSDCHGQDCGQHSCPSDCNNLGQCVSGRCICNECLVVTEVTEETVNLAWDTEYLVVYTPTHEGGLEMQFRVPGDTSTIIQELEPGVEYFIRVFAILENKKSIPVSARVATYLPAEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKRVTTTRSQIEVKDVTDTTALITWAEIDGIELTYDVPGDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKETFTTGLDTSYVLRGLEPGQEYNVLL >ENSMUST00000049074/1-1898 EPKPRISRVQRDEEGEINDMGPQLKRTATMLCAAGGNPDPFLPVDPAAQLRSGALSDYIGDSTRYSIGGLSPFSEYANSIGRGSEAVRARTGEQEPPENGLVRGYHNTDAGLLTTVGSLLPGITYSLRVLAGFQANAESDTRIQLSWL--YELVYWAAEDEGQQHKVTFDP-SSYTLEDLKPDTLYHFQLAARSDLGVGVFTPTVEARTAQSQKVTCVSTGSTTVRVSWVPPPADSRNGIITQYSVAYEAEHSSWDLLGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTRKVEVEPLNSTAVHVSWGQIRGYQVTYNGEPRMLAEAQETTISGLTPETTYSITVAAYTTKDGARSKPKVVTTTGAVHLTLLGLKPDTTYDIKV >ENSMUST00000060699/1-355 ---------------------------------------------------------------------------------------------------------TVGGRQNSVLLQKLKPDTPYTITVYSGLRVYDPSTSSLSVRWDPRQYKLFYAPTSGGPEELVPIPGNNYAILRNLQPDTPYTITVVPVYTEGDGGRTSDTGRTLVRGRNIQVYNPTPNSLDVRWDPAPGPVQQYRIVYSPVAGTRNTRTVHLERLIPDTPYSVNIVALYSDG-EGNPSPSQGRTRNIRVFGETTNSLSVAWGPVQQYRIIYGDPIDVPGRRNNVILQPLQPDTPYKITVIAIYED--GDGGHLTGNGRTV------------------ >ENST00000326996/1-1338 EDRLQMLKATVGGPLGSG-------IEDLKSSSLDRSSQREPTPSHTGSEP----SQVWDVNVFAVGVKNADEAELRSPPRDISVLDFLQLGALSSIRPAPRHPLVVEGPAASTELHNLASRTEYLVSVFPGLTLAAVTPRTVHLTWQTHYLVRCSPASPKGEEEEREVQVGPEVLLDGLEPGRDYEVSVQSLRGPEGSEARGIRARTPTLARHLGFSDVSHDAARVFWEGAPRPVRLVRVTYVSSEGGHNATSATLGPLSSSTTYTVRVTCLYPGGGSSTLTGRVTTKLSMTELPGDAVQLAWVAG-VLVYQITWEGKAHVPGNLGTAVLPGLGRHTEYDVTILAYYRDARSDPVSLRYTPSTVCALRPDGSLPGFDLMVAF >ENST00000261266/1-1990 TLGAALTRTVVLQLKTSTFDENNQKFFNLTAGSKYNIAITYTNGSTVPISTKANSGSDTEQNDSVVLLNITVGKEETTGLVPGEVEVIVESGNLTSLSTPVAEWESLSKDAKEFTFTDLVPGRKYMATVTSNHVANQGMTSSLFTNWTEFYQVLLIHENVVIKNESISSETS-RYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTVPSSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVTLSHDGKVVSVRECSFSSLTPGRLYTVTITTRSGKYENHSFSQERTVP-VSVSNSARSDYLRVSWGDFDHYEVTINFIQT---SENECVFVQLVPGRLYSVTVTTKSGQEANEQGNGRTIPEPVVEHTFHRLEAGEQYQIMI >ENST00000232377/1-2944 RTEFGLIHVFLPQRTGKSVGIKNADLRTLLPLVSRRVCTTRPPDDSTSSEPSSQSASETEGSWNLVPEARGYRLEWRPPQKVVDVTRYQLDGLQQRVRPVPGATQVLPGSQTAFDLDDVQAGLSYTVRVSAGPGLRVVVSDATRVRVAGASGFRISWSTGSGPESSQTLPPDTATDITGLQPGTTYQVAVSVLRGREEGPAAVIVARTDPLGRTVHVTQASSSSVTITWTRVPG-ATGYRVSWHSAHGPEEATVAELDGLEPDTEYTVHVRAHVAGVDGPPASVVVRTASRLQILNASSDVLRITWG-ATAYRLAWGGPMRLPGNTDSAEIRGLEGGVSYSVRVTALVGDREGTPVSIVVTTPPESSQRVTGLEPGVSYIFSL >ci0100133937/1-1652 DCSESIANDCSGNDSADCQCRCHGSCSAQRCLRDCSGNGDQCDEPWTGKCPNQCSGTGTMQEGTANAVYQSVGPNVTLDSGTQYVYAMIDESLSTFAEPPKAKIDVVQSNKTSVLIKDLSPGETYSVALYASVEFIDVTSTSATAWWVTGYKFALVQFDGQNIVEDQVTSTSRMFTFTNLKPRTRYNFTIHSIRGEEHSVPLHANLITGLEPVNFSLTKVLPNMVSFKWDSPNARIKRFRISIFQELSYNHTYKGTFNDLIPGTKYVVEVVSVEHGVESGPLVKHIMTGTNLRIASTTPTSVSVTWADVEGYSVECRGARQGGMYEWSATFTSLRPATEYNITIQAELDDSSTKVWRLTYTTLPQAYVSITNLIDDTSYVINV >ENST00000322880/1-4288 RSNVTLGKQVVFTNPTEPVKGLKEQLHGVFDLSRCTCSCETDAEIPPSSCPDDCNGRGRSRSGRCMCWPGYTGRDCGDCRGRGDGRCVCNPGFTEDCSPSNCHGRTCATRMCPADCRGRGRCVQGVCLCHVCFRGPDCAIQTCPGDCRHDGSCVCKDGYAGEDCGEARVPSSSAYDQRGLAPGQEYQVTVRALRGTSWGLPASKTITTMIDGQDLRVVAVTPTTLELGWLRPQAEVDRFVVSYVSAGNQR---GTLLTDLMPGVEYVVTVTAERGRAVSYPASVRANTEQRQVLGSSADGALLVSLGQFERVVLRWPAEGPVPGTTRTVSLPDLRPGTTYHVEVHGVRAGQTSKSYAFITTTGPSSSAVITSLDPGRKYKFVL >ENSMUST00000027389/1-854 RTYLGNSKVGDTYKGGRGDKWRRPHMLECLCLGNGKGEWTNDQDTRTSSKKDNRGTGSQHTNMKWCGTTQNYDADQKAAHEEINEGVMYRIGDQRHEENCTCFGQTRTFYQIGDSWEKFVHGVRYQCYCYGHITETPSQPNSHPIQWNTKYILRWRPKTSTGRWKEATIPGHNSYTIKGLTPGVIYEGQLISIQQYGHREVTRFDFTTSASTTSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDTATSVNIPDLLPGRKYIVNVYQISEEGKQSLILSTSQTTPDPTVDQVDDTSIVVRWAPITGYRIVYEGSS-LPETANSVTLSDLQPGVQYNITIYAVEENQESTPVFIQQETTGT------------------ >ENST00000239462/1-1115 RFPMGLSQQVTVSKVADPEAREEQNFRHNIRLQTPQKDCEQDLLARVKEMKEQCSVTSEASDGRCLCHEPYVGADCGNCSGHGRGVCQCHEDFMEDCSPGDCSGHDCAQVVTP-------------------LQLLKNTEDSLLVSWEDHYLLSYYPLGKELSGKQIQVPKEHSYEILGLLPGTKYIVTLRNVKNEVSSSPQHLLATTDLAVGTAWVTDETENSLDVEWENPSTEVDYYKLRYGPMTGQEPKSRYDITGLHPGTEYKITVVPMRGELEGKPILLNGRTETNVVTDRVTEDTATVSWAVIDKYVVRYSADGDVHKDESSTVLTGLKPGEAYKVYVWAERGNQGSKKADTN------TSTVLTGLRPGVEYTVHV >ENSMUST00000026740/1-2853 QTEFGLIRVFLPRRTGKSVGIKNADLRTLLPLISRRVCTTLPSDDTPSSEPSSQSASETDSSWNLVPEARGYRLEWRTPQKVEDVTRHQLDGLQQRVRPVPGATELLPGSQTTFDLDDVRAGLSYTVRVSAGPGLRVVASDATRIRVAGASGFRISWRTGSGPESSRTLTPDTVTDILGLQPSTSYQVAVSALRGREEGPPVVIVARTDPLGRRVHLTQAGSSSVSITWTGVPG-ATGYRVSWHSGHGPEDATVAEIDGLEPDTEYIVRVRTHVAGVDGAPASVVVRTASKLQILNASSDVLRVTWG-ATSYKLAWGGPMKLPGNKESAEIRDLEGGVSYSVRVTALVGDREGAPVSIVITTPPAPSHRVTGLEPGISYVFSL >Q90484_Brachydanio_rerio/1-614 ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- >ENST00000316893/1-1894 VPPPSIVDTG---Q----TRGPLDSMSVVLACETSGAPRPERILASGSPLESGSLSDV-TLATSVTVKGLVPARSYQNDVGKGKDTERVSLPEEQPPPNGILKGYITDADVNNLLLEDLIIWTNYEIEVAAGVHAEATNSTTIRFTWNQGYKLIAWEPEQEEEVTMVTARPNHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDGHLSFSEILDTSLKVSWQEP--GEKNGILTGYRISWEEVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGTNLGISNIGPRSVTLQFSISRWLVEAQGEGEENEPDARSMEVPDLNPFTCYSFRMRQVNIVTSPPSQPSRKIQTLQVSAQLTGLGKYVLYEVQV >ENSMUST00000030056/1-2019 WLLPGIEQPVVFNNVLESTVDGENQFTHRINIPRRACGCAKELLSRLESLREQCTQPGEDSNGQCVCDEGYTGEDCSDCHNRGQGKCICEQGFKKDCKPSDCHGQDCGQRSCPNDCSNQGQCVSGRCICNECLIVTEVTEETVNLAWDTEYLIMYTPTHADGLEMQFRVPGDTSTTIRELEPGVEYFIRVFAILENKRSIPVSARVATYLPAEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDPETSYRQTGLAPGQEYEISLHIVKNNTRGPGLKKVTTTRSHIEVKDVTDTTALITWAEIDSIELSYDVPGDLTHEDNQYSIGNLRPDTEYEVSLISRRVDMASNPAKETFITGLDTSHVLTDLEPGQEYTVLL >ENSMUST00000027385/1-783 SAPISDTTNLLVRVSSPSSVYEQHEGRQKTGLDSPTG---SSDITANSPRAPITGEHNV-TTATIN--NIKPGADYTTGRGDSSKPVSINYKTE---------GL----------IEGLQPTVEYVVSVYAELKFSQVTPTSFTAQWITGYRVRVNPKEKTGPMKEINLSPDSSVIVSGLMVATKYEVSVYALKDTLTSRPAQGVITTLENV-RARVTDATETTITISWRTKTETITGFQVDAIPANGQTDVRSYTITGLQPGTDYKIHLYTLNDNARSSPVIIDAS-TSNLRFLTTTPNSLLVSWARITGYIIKYSPPRERPG-VTEATITGLEPGTEYTIYVIALKNNQKSEPLIGRKKTVQKEEEPLQFQVPGTSTSATL >O57587_Brachydanio_rerio/1-932 RLKRGLSKEVTFS-QSQVTVNGENDFKHSIRLQPAGCGCAKALLYRVNYLKSQCAGGSNSNDGRCVCYEGYTGHDCSDCKDKGDGKCVCFSGFSEDCSPNDCIGNDCSMVLGP-------------------LRLIKVTDVSLLVEWEEYYILSYHPKGNKGAIKEVQVENTNSYLITGLKPGVTYIVQVYAVIRGINSESDQITATTEVSGEGIKVLSQTEDSIQVDWKNPGIIVDYFKLTHASHDGQGARTKHTIVGLNPGTEYQIGVQAIKGENEGKASFATGVTDTNLATREVTENSATVTWAEIDGYMLTYSAEGTVAAGATSYQLTSLKPGVLYTVFLWAYKGSRSSRKS---------TSYRFTGLKPGVLYTVYV >ci0100133765/1-17232 NAGVGEANSIRLFRKEGKSTRNDSGPSAPTALAAKDVTKESYYFRVMAAACETPGPSDIQTETEYRASGLDQGLEYENAAGISRPSELAHCRDPLCRDPSLEYDQDGRDIDQSPRVKFDHSTTHTTLTIGDGLAVEDITATKCTVTWDGGSNITNYIVEKRQTSRITWTQIARYIKVGHLMKDNEYIFRVRAENKFGLGDVTESTPIVTKNPSNLQISNVNRKSLILTWDRPTEDGGSEVTNYVVEKREKEECRLKITGLQEGQEYEFQVMAENAEGVSQPSASSESVVRTVKVTDTTRSSISLSWSDITGYTVEIAETEDSGSISTQYTITGLQGEKLYKIRVRAVNAGSSEPAQLATAVQPKDDSFKITGLVEGDSYFFRV >CG10443-RA/1-2029 DPPPSISRAGRDDEGAVSTQGPGTRHTVLMTCKAIGNPTPQTKVDMSNSLKDGFLEDYRSSTMYYVVRALSPYTEYENNIGRGSAPATCTTGETEPPENGQVTGYQMVDNSELTTVSELTPHAIYTVRVQAGFRATDIGETAVTLQWT--YEL-YWNDTYANQAHHKRISN-EAYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQYRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVENMTSIVLDELKRWTEYKIWVLAGTSVGDGPRSHPIILRTQDVKATPLNSTSIHVSWGIIRGYHIHADEGKGDVVDTLEFNVTGLQPDTKYSIQVAALTRKDGDRSAAIVVKTPGGTKAVFTNLEENTEYIFRV >ENSMUST00000041627/1-1424 -------------------------------------------------------------ATSVMVKGLVPARSYQNDVGKGKDTERVSLPEEQPPPNGILKGYITDADVNNLLLEDLIIWTNYEIEVAAGVHAEATNSTTIRFTWNQGYKLIAWEPAQEEEVTMVTARPNHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSSPQLVRTHEDGHLSFNDILDTSLKVSWQEP--GEKNGILTGYRISWEEVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGTNLGISNIGPRSVTLQFSISRWVVEAQGEGEENEPDARSMEVPDLNPFTYYSFRMRQVNIVTSPPSQPSRKIQTLQVSAQLTGLGKYVLYEVQV >ENST00000322519/1-1874 RTEWQLLQNFRTQRTGKSIGIKNADLSRIVDDLTINLCNS--GPGDLESERTHRSPSGTELTMNVFWEPVPGKVRKYPEEDVKVDRSETSTSLKEGFRHGASDVSTIGGRQNSVVLQKLKPDTPYTITVSSGLRVYDPSTSTLNVRWDPRQYKLFYAPAAGGPEELVPIPGNNYAILRNLQPDTSYTVTVVPVYTEGDGGRTSDTGRTLMRGRNVQVYNPTPNSLDVRWDPAPGPVLQYRVVYSPVDGTRNTRMVHLERLIPDTLYSVNLVALYSDG-EGNPSPAQGRTRNLRVFGETTNSLSVAWGPVQQYRIIYGDPIDVPGRRNNVILQPLQPDTPYKITVIAVYED--GDGGHLTGNGRTVTSHCFTGLSPDTDYGVTV >O93405_Brachydanio_rerio/1-922 RIYLGSSRVGETYKGARGDTWQRPHMLECVCLGNGKGEWTNDQDTRTSSKTDSRGTGSHSTGMKWCGTTYNFDKEQRAAHEEVNEGVMYRVGDQRHDENCTCFGQTRVFYQIGESWDKLIQGIHYRCYCYGSISEAGNQPNSHPIQWNTQYILKWRPKNTHIQWMEVTIPGHNSYTIAGLKPGVTYEGQLISILRFGRRETTRFDFSTVHGSTSESVTEITSSSFVISWVSASDTVSGFRVEYELSEEGGSATSVNISELLPGRKYTVNVYEVTGEGEPNLILTTSQTTSDHEVEDVADTSIRISWAPITGYRVVYEGSSGLPEHSTSLTLGDLRPGVLYNISIFSVEENQESEPVFVQVTTAGE------------------ >SINFRUP00000139900/1-2154 KAYLGSEQVGETYKGGRGETWKRRHMLECVCLGNGKGEWTNDQDTRASTKLDSSGLG-TTTTMRWCGTTYDYDSDQLAAHEELSDGVMHRVGDKRHNENCTCYGETRAFYQIGESWDKVLHNKQYHCYCYGSITEAGKQPNSHPIQWNTQYILKWRIKNSMKAWREATIPGHNSYTISGLRPGLTYEGQLISILRYGNREVTRFEFTTTDGSTSESVTEITSNSFVVSWTSASSTISGFRVEYELSEDGTTASSVNIGDLLPGRRYDVRVYELPTQGEPHLILTTSPTTAQHSIVDVRESSIQISWAPITGYRVVYEGSS-LQGSDTSVNLVDLKPGLLYNISIYAVKLNQESKPIFLQVSTAGSTQYPLKNLRPDTEYTITL >ENSMUST00000040785/1-911 -------QPMVFNNSLEATSDHESQFTHKINLPKKACPCAQELLSRIELLRDQCNSAGNYSDGQCICDSEYSGDDCSDCSSRGDGECVCEEPYTEDCRPGDCSGKDCSQRRCLNACK---------------LRVAGISDRSIELEWDTEYVISYQPTALGGLQLQQRVPGDSGVTIMELEPGLTYNISVYAVISNILSLPITAKVATRTS-WGTDVVCFLISSLHNFSNHISVPVTPLISLFRPTLQNNDVTSFNQTGLKPGEEYIVNVVALKEQARSPPTSASVSTVTQILVRDVSDTVAFVEWAKVDFILLKYGGEGGLQPPLSQYSVQALRPGSRYEVSISAVRGTNESEASSTQFT----TSYTLTDLEPGAEYIISI >ENST00000299669/1-2557 RSNVTLGKQVVFTNPTEPVKGLKEQLHGVFDLSRCTCSCETDAEIPPSSCPDDCNGRGRSRSGRCMCWPGYTGRDCGDCRGRGDGRCVCNPGFTEDCSPSNCHGRTCATRMCPADCRGRGRCVQGVCLCHVCFRGPDCAIQTCPGDCRHDGSCVCKDGYAGEDCGEARVPSSSAYDQRGLAPGQEYQVTVRALRGTSWGLPASKTITTMIDGQDLRVVAVTPTTLELGWLRPQAEVDRFVVSYVSAGNQR---GTLLTDLMPGVEYVVTVTAERGRAVSYPASVRANTEQRQVLGSSADGALLVSLGQFERVVLRWPAEGPVPGTTRTVSLPDLRPGTTYHVEVHGVRAGQTSKSYAFITTTGPSSSAVITSLDPGRKYKFVL >SINFRUP00000155994/1-2169 RPYLGSAAVGETYKGSRGDTWRRPHMLECVCLGNGKGEWTNDQDTLTSTKTDSQGTGSQPVSSTLIYLAVHFD----VAHEEVSEGVMYRVGDQQHEENCTCFGQTRGFYQIGESWDKVIHGIMYKCICYGSITESGNQPNSHPIQWNNQYILKWRVKNTQSLWKEVLIPGHNSYTISGLKPGLTYEGQLISLLQFGRQEVTRFEFTTTYGSISESVTEITSSSFVISWVSASDTVSGFRVEYELTEEGQTTTSVNINELLPGRKYTVKVYEVTEGGEDNIILSTSQTTSDHEVEDVGETSILISWAPITGYRVIYEGES-LPDTATSVTLSDLLPGKLYNISIYAVEDTLESEPVFVQVHTAGDTQYTLLNLKPDTVYTATL >ENST00000263525/1-1358 LLGSMITQPVVFNNSLEATSDHESQFTHRINFPKKACPCAQELLSRIEVLRDQCNSAGNYSDGQCICDSEYSGDDCSDCSSRGDGECVCEEPYTEDCRPGDCSGKDCGQRQCLNACSGRGQCEEGLCVCEECLRVAGISDRSIELEWDTEYVISYQPTALGGLQLQQRVPGDSGVTITELEPGLTYNISVYAVISNILSLPITAKVATHLSTQGLQFKTITETTVEVQWEPFSFSFDGWEISFIP--KNNDVTSFNQTGLKPGEEYIVNVVALKEQARSPPTSASVSTVTQILVRDVSDTVAFVEWAKVDFILLKYGGEGGLQPPLSQYSVQALRPGSRYEVSVSAVRGTNESDSATTQFTTEIDTSYTLTDLEPGAEYIISV