CLUSTAL W (1.82) multiple sequence alignment ENST00000323135 -------------------------MPPGVDCPMEFWTKE----ENQSVVVDFLLPTGVY ENST00000289153 -------------------MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIY ENST00000263967 -------------------------MPP-RPSSGELWGIH---LMPPRILVECLLPNGMI ENSMUST00000029201 -------------------------MPP-RPSSGELWGIH---LMPPRILVECLLPNGMI SINFRUP00000141882 -------------------------MPP-RPSSGELWGMH---LMPPSILVECLLPNGMI SINFRUP00000144436 -----------------------------------------------RILVDCLLPNGMI SINFRUP00000133771 -------------------------MAP-RPSSGELWGLH---LMPPRILVDCCLPNGMM CG4141-RA MNMMDNRALAYVAHQPKYETPPEEAEPPCMRFSVNLWKNE----MLNWVDLICLLPNGFL : : **.*. ENST00000323135 LNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCD ENST00000289153 IQLEVPREATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCD ENST00000263967 VTLECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAEREEFFDETRRLCD ENSMUST00000029201 VTLECLREATLVTIKHELFREARKYPLHQLLQDETSYIFVSVTQEAEREEFFDETRRLCD SINFRUP00000141882 LTLECLREATLITVKHELFKEARKYPLYHLLQEESSYIFVSVTQEAEREEFYDETRRLCD SINFRUP00000144436 LTLECLREATLITIKHELFKEARKYPLHHLLQEETSYIFVSVTQEAEREEFYDETRRLCD SINFRUP00000133771 VSLECLRETPLISIKQQLFTEARKYPLYHLLQEESCYIFVGVTQEAEREEFYDETRRLCD CG4141-RA LELRVNPANTIQVIKVEMVNQAKQMPLGYVIKEACEYQVYGISTFN-IEPYTDETKRLSE : : : :* : ..: *: :: * . :. : ** :**.: ENST00000323135 VQPFLPVLRLVAREGDR---VKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCE ENST00000289153 VRPFLPVLKLVTRSCDP---GEK-LDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSE ENST00000263967 LRLFQPFLKVIEPVGNR---EEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCK ENSMUST00000029201 LRLFQPFLKVIEPVGNR---EEKILNREIGFVIGMPVCEFDMVKDPEVQDFRRNILNVCK SINFRUP00000141882 LRLFQAFLKVIEPVGNR---EEKILNREIGFAIGMPICEFDLVKDPEVQDFRRNILNVCK SINFRUP00000144436 LRLFQPFLKVIEPVGNR---EEKILNREIGFAIGMPVCEFDLVKDPEVQDFRRNILNVCK SINFRUP00000133771 LRLFHPILKVIEPLGNR---EEKILNREIGFAIGMPVCEFEMLKDPEVQDFRRSILSVCR CG4141-RA VQPYFGILSLGERTDTTSFSSDYELTKMVNGMIGTTFDHNRTHGSPEIDDFRLYMTQTCD :: : .* : . : :. ** . . .**:::** : . . ENST00000323135 EAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGS----EESFT ENST00000289153 EKILSLVGLSWMDWLKQTYPPEHEPSIPEN--LEDKLYGGKLIVAVHFENC----QDVFS ENST00000263967 EAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYT ENSMUST00000029201 EAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYT SINFRUP00000141882 EAVDLRDCNGPHSRALYVYPPNVESSPELPRHIYNKLDKGQIIVVIWVIVSPTNDKQKYT SINFRUP00000144436 DSVELRDASGPHSRALYVYPPNVESSQELPKHIYSKLDKGQIIVVIWVIVSPNNDKQKYT SINFRUP00000133771 EAMEEREGGGAHSQALYVYPPNVESSPQLPQHIYSKLDKGRLIVTIWVIVSPSNSKQKYT CG4141-RA NIELERSAYTWQQRLLYEHPLRLANSTKMPELIRERHPTRTFLIVVKNEND----QSTFT : .* . * : ::: : :. :: ENST00000323135 FQVSTKDVPLALMACALRKK-----ATVFRQPLVEQPED--YTLQVNGRHEYLYGSYPLC ENST00000289153 FQVSPNMNPIKVNELAIQKR-----LTIHGKEDEVSPYD--YVLQVSGRVEYVFGDHPLI ENST00000263967 LKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLS ENSMUST00000029201 LKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLS SINFRUP00000141882 LKINHDYVPEQVIAEAIRKKTRSMLLSQEQLKMCVQEYQGKYILKVCGCDEYLLEKYPLS SINFRUP00000144436 LKINHDCVPEQVIAEAIRKKTRSMLLSPEQLKMCVQEYQGKYILKVCGCDEYLLEKHPIS SINFRUP00000133771 LKVSHDSLPEQLIAESIRKKSRSMHLSPQQLRLCVQEYQGQYILKVCGCDEYLLEKYPLS CG4141-RA LSVNEQDTPFSLTESTLQKMN--------RSQMKMNDRTSDYILKVSGRDEYLLGDYPLI :.:. . * : :::* : * *:* * **. .:*: ENST00000323135 QFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAK--PPPIPAKKPSSVS ENST00000289153 QFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKTRIIS ENST00000263967 QYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRRISTATPYMNG--ETSTKS ENSMUST00000029201 QYKYIRSCIMLGRMPNLMLMAKESLYSQLPIDSFTMPSYSRRISTATPYMNG--ETSTKS SINFRUP00000141882 QYKYVRSCIMLGRMPNLMLMAKDSLYSQLPMDIFTIPSYARRISTATPYMNG--ETATKA SINFRUP00000144436 QYKYIRSCIMLGRMPNLMLMAKDSLYSQLPTDNFVMPSYSRRISTATSYMNG--EVAAKS SINFRUP00000133771 QYKYIRSCIIVGRLPHLMLVSKDSLYSQLPASGFVTPSYSRRTPQPSPCPGGGDGSPPRS CG4141-RA QFLYIQEMLSDSAVPNVVLQSVYRLESYINHHNEQAMVTKRPLPKKRTVHLH----KSIS *: *: . : *:. : : . . . : ENST00000323135 -LWSLEQPFRIELIQG--SKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSV--CSEPV ENST00000289153 HVWENNNPFQIVLVKG--NKLNTEETVKVHVRAGLFHGTELLCKTIVSSEVSG--KNDHI ENST00000263967 -LWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPC--SNPR- ENSMUST00000029201 -LWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPC--SNPR- SINFRUP00000141882 -LWTINGTLRIKILCATYVNVNIRDIDKIYVRTGIYHGGEQLCDNVNTQRVPC--SNPR- SINFRUP00000144436 -LWTINGTLRIRILCATYVNVNIRDIDKIYVRTGIYHGGEQMCDNVNTQRVPC--SNPR- SINFRUP00000133771 -LWAFNTPLRVRXLAX-YVNVNIRDXEKIYVRTGIYHGGEPLCDXVNTQRVPX--SNPRQ CG4141-RA SLWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCLYHGDKKLCAQRSTDSPNGNFDTFLF :* ::: :.: *: *:. ::** : :* :. . ENST00000323135 WKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTK----------KKSKKADCPIAW ENST00000289153 WNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAW ENST00000263967 WNEWLNYDIYIPDLPRAARLCLSICSVKGR------------------KGAKEEHCPLAW ENSMUST00000029201 WNEWLNYDIYIPDLPRAARLCLSICSVKGR------------------KGAKEEHCPLAW SINFRUP00000141882 WNEWLSYDMYIPDIPRAARLCLSICSVKGR------------------KGAKEEHCPLAW SINFRUP00000144436 WNEWLTYDMYISDIPRAARLCLSICSVKGR------------------KGAKEEHCPLAW SINFRUP00000133771 WNEWLTYDIYLADLPRSARLCLSICSVKGR------------------KGAKEEHCPLAW CG4141-RA NDLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSN----NKDIALKDVPYNKNPLAW . : :*: : ::** :***: : * : . *:** ENST00000323135 ANLMLFDYKDQLKTGERCLYMWPSVPDEK-GELLNPTGTVRSNPNTDSAAALLICLPEVA ENST00000289153 VNTMVFDFKGQLRTGDIILHSWSSFPDEL-EEMLNPMGTVQTNPYTENATALHVKFPENK ENST00000263967 GNINLFDYTDTLVSGKMALNLWP-VPHGL-EDLLNPIGVTGSNPNKE-TPCLELEFDWFS ENSMUST00000029201 GNINLFDYTDTLVSGKMALNLWP-VPHGL-EDLLNPIGVTGSNPNKE-TPCLELEFDWFS SINFRUP00000141882 GNINMFDYTHTLVAGKMALNLWP-VPHGL-EDLLNPIGVTGSNPNKE-TPCLELEFEHFG SINFRUP00000144436 GNINLFDYTHTLVANKMALNLWP-VPHGL-EDLLNPIGVTGSNPNKE-TPCLELEFDHFS SINFRUP00000133771 GNVNLFDYKDILVSGKVALSLWP-VPHGL-EDLLNPIGVAGSNPNKE-TPCVGLEFSWFN CG4141-RA VNTTIFDHKDILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSSG * :**.. * :. * *. . ::::* *. .** .: . : : : ENST00000323135 PHPVYYPALEKILELG---RHSEC------------VHVTEEE----QLQLREILERRGS ENST00000289153 KQPYYYPPFDKIIEKAAEIASSDS------------ANVSSRGGKKFLPVLKEILDRDPL ENST00000263967 -SVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPL ENSMUST00000029201 -SVVKFPDMSVIEEHANWSVSREAGFSYSHTGLSNRLARDNELRENDKEQLRALCTRDPL SINFRUP00000141882 -CPVKYPDMTIIEEHANWNISRELGFNYCHTGLSSRLARDNPVTDADNDQLRQVCTRDPL SINFRUP00000144436 -SSVKYPDMNAVEDHASRTISREVGLNYTLSGQSNRAARDHILTEGDSEQLRQLTNRDPL SINFRUP00000133771 -QTVVFPDEQQIEEHANWTISRELGYNYCH-GLSTRLACDSSVSTSDAEQLRSLCSKDPL CG4141-RA TGTVRYPSEEVVLQYAADREQVNR--------LQRQLAGPEKPIKELKELMANYTGLDKI :* : : . : : ENST00000323135 GELYEHEKDLVWKLR--HEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLS ENST00000289153 SQLCENEMDLIWTLR--QDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPRE ENST00000263967 SEITEQEKDFLWSHR---HYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQ ENSMUST00000029201 SEITEQEKDFLWSHRQVVHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQ SINFRUP00000141882 SEITEQEKDFLWRHR---QDCLNMPEILPKILLAVKWNSRDEIAQMYCLLKDWPAIRPEQ SINFRUP00000144436 SEITEQEKDFLWRNR---YYCMNIPEILPKILLAVKWNSRDEVAKMYCLLKEWPSIRPEQ SINFRUP00000133771 YELSEQEKDFLWRHR---HYCVNIPESLPKLLLSVKWNSRDEVSHLPSEMRLLYISGDEL CG4141-RA YEMVDQDRNAIWERR--NDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPLISIER :: ::: : :* * :*: *. :* *:. ::::.: : ENST00000323135 A--LELLDFSFPDCHVG-SFAIKSLRK-LTDDELFQYLLQLVQVLKYESYLDCELTKFLL ENST00000289153 A--LELLDFNYPDQYVR-EYAVGCLRQ-MSDEELSQYLLQLVQVLKYEPFLDCALSRFLL ENST00000263967 A--MELLDCNYPDPMVR-GFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLL ENSMUST00000029201 A--MELLDCNYPDPMVR-SFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLL SINFRUP00000141882 A--MELLDCNFPDPMIR-EFAVKCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNPLARFLL SINFRUP00000144436 A--MELLDCNYPDPMVR-HFAVRCLDKYLTDDKLSQYLIQLVQVLKYEQYLDNPLVRFLL SINFRUP00000133771 FGNHGNSDCNYKVNNFRGAVCPLASVNYIVEFALSQYLLQLVQVLKYEMYLDNPLARFLI CG4141-RA S--LELLDYAYPDPAVR-RFAIRCLHF-LKDEDLLLYLLQLVQAIKHESYLESDLVVFLL * : . . . : : * **:****.:*:* :*: * **: ENST00000323135 DRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKA ENST00000289153 ERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLKT ENST00000263967 KKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLIN ENSMUST00000029201 KKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLIN SINFRUP00000141882 KRALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLSRQVEAMEKLIN SINFRUP00000144436 KKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLEAYCRACGMYLKHLSRQVEAMEKLIN SINFRUP00000133771 KKSLTNQRIGHFFFWHLKSEMHNKTVSRRFGLLLEAFCRACGMYLKHLNRQVEAMDKLVN CG4141-RA ERALRNQRIGHYFFWHLRSEMQTPSMQTRFGLLLEVYLKGCKHHVAPLRKQLHVLEKLKQ .::* *::**:::****:**:: :: :**::** : :.. :: * :* ..:.** ENST00000323135 LNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDS ENST00000289153 LNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDS ENST00000263967 LTDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSS ENSMUST00000029201 LTDILKQEKKDETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSS SINFRUP00000141882 LTDLLKQEKKDEAQKVQMKFLVEQMRRPDYMDALQSFTSPLNPAHQLGNLRLEECRMMSS SINFRUP00000144436 LTDILKQEKKDETQKVQMRFLVDQMKRPDYMDALQNFTSPLNPAHQLGNLRLDECRIMSS SINFRUP00000133771 LTDTLKQEKKDETQKTQMKFLVEHMSRPDYMEALQGFVSPLNP-HQLGNLRLEECRIMSS CG4141-RA GSLIAKKGSKEKVKTMLQDFLRDQRNS----AVFQNIQNPLNPSFRCSGVTPDRCKVMDS . * . : : .:. : .**:* . : :.* *.* ENST00000323135 KMKPLWIMYSNEEAGSGG---SVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMT ENST00000289153 KMKPLWLVYNNKVFGED----SVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRML ENST00000263967 AKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRML ENSMUST00000029201 AKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRML SINFRUP00000141882 AKRPLWLNWENPDMMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRML SINFRUP00000144436 AKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIKIMENIWQNQGLDLRML SINFRUP00000133771 AKRPLWLNWENPDIMSELLFTNNEIIFKNGDDLRQDMLTLQIIKIMENIWQNQGLDLRML CG4141-RA KMRPLWVVFENADVNAS----DVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMN :***: :.* :: . :****************::::*: :*:. *:*:** ENST00000323135 PYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGE-ALDR ENST00000289153 PYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGD-DLDR ENST00000263967 PYGCLSIGDCVGLIEVVRNSHTIMQIQCKGG-LKGALQFNSHTLHQWLKDKNKGE-IYDA ENSMUST00000029201 PYGCLSIGDCVGLIEVVRNSHTIMQIQCKGG-LKGALQFNSHTLHQWLKDKNKGE-IYDA SINFRUP00000141882 PYGCLSIGDCVGLIEVVRNSHTIMQIQCKGG-LKGALQFNSHTLHQWLKDKNKGE-MYDQ SINFRUP00000144436 PYGCLSLGDCVGLIEVVRSSHTIMQIQCKGG-LKGALQFNSNTLHQWLRDKNKGE-MYDM SINFRUP00000133771 PYGCL-IGDCVGLIEVVKNSFTIMQIQCKGG-LKGALQFNSNTLHHWLKDNNVGRRQYDR CG4141-RA IYNCISMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSWLKEHNKPADKLNK *.*: . *:**** : ** :** : . . .: *:. :* **:. * : ENST00000323135 AIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERV ENST00000289153 AIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERV ENST00000263967 AIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERV ENSMUST00000029201 AIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERV SINFRUP00000141882 AIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERV SINFRUP00000144436 AVDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERV SINFRUP00000133771 AIDLFTRSCAGYCVATFILGIGDRHNSNIMVKENGQLFHIDFGHFLDHKKKKFGYKRERV CG4141-RA AINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERV *:: ** ********:::**:.***..***:: **********:*.: * *:* .**** ENST00000323135 PFILTYDFVHVIQQG--KTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPE ENST00000289153 PFILTYDFIHVIQQG--KTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPE ENST00000263967 PFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPE ENSMUST00000029201 PFVLTQDFLIVISKGAQEYTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPE SINFRUP00000141882 PFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPE SINFRUP00000144436 PFVLTQDFLIVISKGSQECVKTKEFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPE SINFRUP00000133771 PFVLTQDFLIVISKGVQESTKTKEFERF-EMCYKAYLAIRQHASLFINLFSLLLGCGMPE CG4141-RA PFVLTHDFVYVINKG-FNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPE **:** **: **.:* : ::.:* :* * *: :*:*. *:: **::: *:** ENST00000323135 LSCSKDIQYLKDSLALGKTEE-------------EALKHFRVKFNEALRESWKTKVNWLA ENST00000289153 LTSVKDIQYLKDSLALGKSEE-------------EALKQFKQKFDEALRESWTTKVNWMA ENST00000263967 LQSFDDIAYIRKTLALDKTEQ-------------EALEYFMKQMNDAHHGGWTTKMDWIF ENSMUST00000029201 LQSFDDIAYIRKTLALDKTEQ-------------EALEYFTKQMNDAHHGGWTTKMDWIF SINFRUP00000141882 LQSFDDIAYIRKTLALDKSEQ-------------EALDYFMKQMNDAHHGGWTTKMDWIF SINFRUP00000144436 LQSFDDIAYIRKTLALEKTEQAMMLFSFLISTHPEALDYFMKQMNDAHHGGWTTKMDWIF SINFRUP00000133771 LQSFDDIAYLRKTLALEKSQQ-------------EALEYFTKQMNDAHHGGWSTKMDWIF CG4141-RA LSSEKDLDYLRETLVLDYTEE-------------KAREHFRAKFSEALANSWKTSLNWAS * . .*: *::.:*.* ::: :::: ::: :* . * ::.:* .*.*.::* ENST00000323135 HNVSKDNRQ ENST00000289153 HTVRKDYRS ENST00000263967 HTIKQHALN ENSMUST00000029201 HTIKQHALN SINFRUP00000141882 HTIRQHAMN SINFRUP00000144436 HTIRQHALN SINFRUP00000133771 HTIR----- CG4141-RA HNFSKNNKQ *..