CLUSTAL W (1.82) multiple sequence alignment ENST00000256172 -------------MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNR ENSMUST00000047330 -------------MADQRMDISSTISDFMSPGPTDLLSGSLGTSGVDCNR Q9I879_Brachydanio_rerio -------------MADQRMDISSTMNEFMSQSSADLISSSIGTTGMDYNR Q8JIG1_Brachydanio_rerio -------------MADQRMDISSTMNEFMSPSSTELISSSMGSTGMDFNR SINFRUP00000155305 ----------DDLMADQRMDISSTMTDFMSPGSTDLISSSISTPGMDYTR CG8727-RA ---------------MEVQEFCENMEEIEDENYDEEKSARTS----DENR Q9IAU1_Brachydanio_rerio -------------------------------------------------- SINFRUP00000143043 -------------------------------------------------- SINFRUP00000164327 -------------------------------------------------- ENST00000266503 MAAEEEAAAGGKVLREENQCIAPVVSSRVSPGTRPTAMGSFSSHMTEFPR :: : : ENST00000256172 KRKGSSTDYQES------MDTDKDDPHGRLEYTEHQG------------- ENSMUST00000047330 KRKGSATDYQ-------------------LEYAEHQG------------- Q9I879_Brachydanio_rerio KRKGSTTEYQIDG--FSFDDSMDTDKDKTLGRDEQQG------------- Q8JIG1_Brachydanio_rerio KRKGSITDYEIDG--FSFEDSMDTDKDKPLGRADQQ-------------- SINFRUP00000155305 KRKGSTTDYQRTEEKQDWGVESRTIYDTCLRRQSVTNGKFSVSPLISLHV CG8727-RA KQN----------------------------------------------- Q9IAU1_Brachydanio_rerio ---MDNLEMKSASNLDEDMEDDAGR-------SEDDQ------------- SINFRUP00000143043 -------------------------------------------------- SINFRUP00000164327 --------------VDPELLSDASS-------SRRER------------- ENST00000266503 KRKGSDSDPSQSGIMTEKVVEKLSQNPLTYLLSTRIE------------- : : :: : : ENST00000256172 -------------------RIKNAREAHSQIEKRRRDKMNSFIDELASLV ENSMUST00000047330 -------------------RIKNAREAHSQ-EKRRRDKMNSFIDELASLV Q9I879_Brachydanio_rerio -------------------RIKNAREAHSQIEKRRRDKMNSFIDELASLV Q8JIG1_Brachydanio_rerio --------------------MKNAREAHSQIEKRRRDKMNSFIDELASLV SINFRUP00000155305 ARPEECVTTYLCMFPLICHLCSSHREAHSQIEKRRRDKMNSFIDELASLV CG8727-RA ---------------------------HSEIEKRRRDKMNTYINELSSMI Q9IAU1_Brachydanio_rerio -----------------HLKIKCIREPHSQIEKRRRDKMNNLIDELAAMI SINFRUP00000143043 ------------------------REPHSQIEKRRRDKMNNLIDKLSAMI SINFRUP00000164327 -----------------FMSLCVCREPHSQIEKRRRDKMNTLIEELSAMI ENST00000266503 -----------------ISASSGSREAHSQTEKRRRDKMNNLIEELSAMI : : :: :: **: *********. *::*:::: ENST00000256172 PTCNAMSRKLDKLTVLRMAVQHMKTLRG--ATNPYTEANYKPTFLSDDEL ENSMUST00000047330 PTCNAMSRKLDKLTVLRMAVQHMKTLRG--ATNPYTEANYKPTFLSDDEL Q9I879_Brachydanio_rerio PTCNAMSRKLDKLTVLRMAVQHMKTLRG--ATNPYTEANYKPAFLSDDEL Q8JIG1_Brachydanio_rerio PTCNAMSRKLDKLTVLRMAVQHMKTLRG--AANPYTEANYKPAFLSDDEL SINFRUP00000155305 PTCNAMSRKLDKLTVLRMAVQHMKTLRG--AANPYTEANYKPSFLSDDEL CG8727-RA PMCFAMQRKLDKLTVLRMAVQHLRGIRGSGSLHPFNGSDYRPSFLSDQEL Q9IAU1_Brachydanio_rerio PTCNPMSRKLDKLTVLRMAVQHLKSLK--GATSSFAEANYKPAFLPDDEL SINFRUP00000143043 PTCNPMSRKLDKLTVLRMAVQHLKSLK--GSGSSFSEANYKPSFLPDEEL SINFRUP00000164327 PACQHMARKLDKLTVLRKAVQHLNGLKA-GSSSTFPHPPHRPSILPHDEL ENST00000266503 PQCNPMARKLDKLTVLRMAVQHLRSLK--GLTNSYVGSNYRPSFLQDNEL * * * ********** ****:. :: .: . ::*::* .:** ENST00000256172 KHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLH ENSMUST00000047330 KHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLIGQSLFDYLH Q9I879_Brachydanio_rerio KHLILRAADGFLFVVGCDRGKILFVSESVYKILNYTQNDLIGQSLFDYLH Q8JIG1_Brachydanio_rerio KHLILKAADGFLFVVGCDRGKILFVSESVYKILNYSQNDLIGQSLFDYLH SINFRUP00000155305 KHLILRAADGFLFVVGCDRGKILFVSESVYKILNYSQNDLIGQSLFDYLH CG8727-RA KMIILQASEGFLFVVGCDRGRILYVSDSVSSVLNSTQADLLGQSWFDVLH Q9IAU1_Brachydanio_rerio KHLVLRAADGFLFVVGCDRGKIVFVSESVSKTLNYSRTELIGQSLFDYVH SINFRUP00000143043 KHLVLKAADGFLFVVGCDRGKIVFVSESVAKILNYSRTELIGQSLFDYVH SINFRUP00000164327 RQLLLRAADGFLLVVSCDRGKILFISESVSKILNFSPLELTGQSLFDFIH ENST00000266503 RHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLTGQSLFDFLH : ::*::::***:**.*:**:*:::*.** . ** .* *** ** :* ENST00000256172 PKDIAKVKEQLSSSDTAPRERLIDAKT-------------------GLPV ENSMUST00000047330 PKDIAKVKEQLSSSDTAPRERLIDAKT-------------------GLPV Q9I879_Brachydanio_rerio PKDIAKVKEQLSSSDTAPRERLIDAKT-------------------GLPV Q8JIG1_Brachydanio_rerio PKDIAKVKEQLSSSDTAPRERLIDAKT-------------------GLPV SINFRUP00000155305 PKDIAKVKEQLSSSDTAPRERLIDAKSNFDPGPCCTADGCHWCFAAGLPV CG8727-RA PKDIGKVKEQLSSLEQCPRERLIDAKT-------------------MLPV Q9IAU1_Brachydanio_rerio PKDIGKVKEQLSASELYPRERLIDAKT-------------------GLQV SINFRUP00000143043 PKDMGKVKEQLSSSELFPRERLIDAKT-------------------GVQV SINFRUP00000164327 PKDISKVKEQLASSELHN-HRLADAAA-------------------GVPV ENST00000266503 PKDVAKVKEQLSSFDISPREKLIDAKT-------------------GLQV ***:.******:: : .:* ** : : : : * ENST00000256172 KTDITPGPSRLCSGARRSFFCRMKCNRPS-VKVEDKDFPSTCSKKKADRK ENSMUST00000047330 KTDITPGPSRLCSGARRSFFCRMKCNRPS-VKVEDKDFASTCSKKKADRK Q9I879_Brachydanio_rerio KTDITPGPSRLCSGARRSFFCRMKCNRPS-VKMEDKDFPSTCSKKKADRK Q8JIG1_Brachydanio_rerio RTDIAPSPSRLCSGARRSFFCRMKCNRSM-VKMEDKDFPSTCSKKKADRK SINFRUP00000155305 KTDINPGPSRLCSGARRSFFCRMKCNRPS-VKVEDKDFPSTCSKKKADRK CG8727-RA KTDVPQSLCRLCPGARRSFFCRMKLRTASNNQIKEESDTSSSSRSSTKRK Q9IAU1_Brachydanio_rerio QAELPVGSARLCSGARRSFFCRMKYNKIT-VK-EEKDFQAGASKKKESQR SINFRUP00000143043 QTDLPVGATRLCSGARRSFFCRMKYNKIS-VKVEEKEFQASSSKKKESQK SINFRUP00000164327 QADAPLRPSVLTTGARRAFFCRMKHSRVM-GK-HDKHALPSTSKKKDAYR ENST00000266503 HSNLHAGRTRVYSGSRRSFFCRIKSCKIS-VK-EEHGCLPN-SKKKEHRK ::: : .*:**:****:* ::.:. . *:.. : ENST00000256172 S-------FCTIHSTGYLKSWPPTKMGLDEDNEPDN-EGCNLSCLVAIGR ENSMUST00000047330 S-------FCTIHSTGYLKSWPPTKMGLDEDNEPDN-EGCNLSCLVAIGR Q9I879_Brachydanio_rerio S-------FCTIHSTGYLKSWPPTKMGLDEDNEPDN-EGCNLSCLVAIGR Q8JIG1_Brachydanio_rerio S-------FCTIHSTGYLKSWPPTKMGLDEDNEPDN-EGCNLSCLVAIGR SINFRUP00000155305 S-------FCTIHSTGYLKSWPPTKMGLDEDNEPDN-EGCNLSCLVAIGR CG8727-RA SRLTTGHKYRVIQCTGYLKSWTPIKD-EDQDADSDE-QTTNLSCLVAIGR Q9IAU1_Brachydanio_rerio Y--------CTVHCTGYMRTWPTRQLATEGEAEADK-ESSHFSCLVAMGR SINFRUP00000143043 Y--------CTVHCTGYMRSWPTSQLGAEGEGEADKHDSSHFSCLVAVGR SINFRUP00000164327 Y--------CTLHCTGYMRSWLSSQLDAEGDA-ADK-DASSPTCLVTVCR ENST00000266503 F--------YTIHCTGYLRSWPPNIVGMEEERNSKK-DNSNFTCLVAIGR .::.***:::* . : : ..: : :***:: * ENST00000256172 LHS----HVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLP ENSMUST00000047330 LHS----HMVPQPANGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAYLP Q9I879_Brachydanio_rerio LHP----HIVPQPMNGDIRVKPTEYVSRHAIDGKFVFVDQRATAILAYLP Q8JIG1_Brachydanio_rerio LHP----HIVPQPVNGDIRVKPTEYVSRHAIDGKFVFVDQRATAILAYLP SINFRUP00000155305 LHP----HIVPQPSLADIRVKPTEYVSRHAIDGKFVFVDQRATAILGYLP CG8727-RA IPPNVRNSTVPASLDNHPNIRHVLFISRHSGEGKFLFIDQRATLVIGFLP Q9IAU1_Brachydanio_rerio VHP----HTLPQA-NGEIKVKPTEFVTRYAMDGKFTFVDQRATTILGYLP SINFRUP00000143043 VHS----HSSLQV-NGEVQVKPTEFITRYAMDGKFTFVDQRATTILGYLP SINFRUP00000164327 LLP----PGSHHP-PRDVPVKPAEFMTRCAIDGKFTFVDHRATALLGYLP ENST00000266503 LQP----YIVPQN-SGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLP : . . :: :::* : :*** ::*:*** ::.:** ENST00000256172 QELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFIT ENSMUST00000047330 QELLGTSCYEYFHQDDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFIT Q9I879_Brachydanio_rerio QELLGTSFYEYFHQDDIGHLAECHRQVLQMREKISTNCYKFKIKDGSFIT Q8JIG1_Brachydanio_rerio QELLGTSFYEYFHQDDIGHLAECHRQVLQMREKINTHCYKFKIKDGSFIT SINFRUP00000155305 QELLGTSFYEYFHQDDIGHLAECHRQVLQMREKINTNCYKFKIKDGSFIT CG8727-RA QEILGTSFYEYFHNEDIAALMESHKMVMQVPEKVTTQVYRFRCKDNSYIQ Q9IAU1_Brachydanio_rerio QELLGTSCYEYFHLDDLPHLAERHRKVLRSKEKIETNCYKFKTKSGSFVN SINFRUP00000143043 QELLGTSCYEYFHQDDLPQLADRHRKVLRSKEKIETNSYKFKTKHGSFVT SINFRUP00000164327 QEILGTSCYEYFHQDDLQHLADKHRQVLRSKEKIETSCYKFKTKQGSYAS ENST00000266503 QELLGTSCYEYFHQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVT **:**** ***** :* * : *: *:: **: * *:*: * .*: ENST00000256172 LRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTASPHSMDS ENSMUST00000047330 LRSRWFSFMNPWTKEVEYIVSTNTVVLANVLEGGDPTFPQLTAPPHSMDS Q9I879_Brachydanio_rerio LRSRWFSFMNPWTKEVEYIVSTNTVVSGSMLEGADPSYSQTASSPQSMDS Q8JIG1_Brachydanio_rerio LRSRWFSFMNPWTKEVEYIVSTNTVVSGSSVDGAEPGFPQLSASPQSMDS SINFRUP00000155305 LRSRWFSFMNPWTKEVEYIVSTNTVVSCPMMEGSD--YPQSAASPQSMDC CG8727-RA LQSEWRAFKNPWTSEIDYIIAKNSVFL----------------------- Q9IAU1_Brachydanio_rerio LQSQWFSFINPWTKEVEYIVSTNTVVSGKSNPGGSGDKAEQPSSSKASED SINFRUP00000143043 LQSQWFSFINPWTKEVEYIVSTNTVIS----------RLIKFSYRMARHD SINFRUP00000164327 LQSQWFSFVNPWTKEVEFIVSLNRVIPGSNQP-----RDEEPGSSRSFQE ENST00000266503 LKSQWFSFTNPWTKELEYIVSVNTLVLGHSEPG---EASFLPCSSQSSEE *:*.* :* ****.*:::*:: * :. ENST00000256172 MLP--------SGEGGPKRTHPTVPGIP--GGTRAGAGKIGRMIAEEIME ENSMUST00000047330 MLP--------SGEGGPKRTHPTVPGIP--GGTRAGAGKIGRMIAEEIME Q9I879_Brachydanio_rerio VLT--------SGDGGGKRPLQIVPGIP--GGTRAGAGKIGRMIAEEVME Q8JIG1_Brachydanio_rerio VLT--------AADGSGK----TVPGLP--GGTRAGAGKIGRMIAEEVME SINFRUP00000155305 VLTSEEVKYEFSGPTFAKQMHLRIFNET--GCVNVLSGETNRALEKVTGA CG8727-RA -------------------------------------------------- Q9IAU1_Brachydanio_rerio -DA------------KKSQQVPIIPGISSASG-MIYAGCIGTQIANEIMD SINFRUP00000143043 KDG------------KKS--LPIIPGISTTPGTMIYAGSIGTQIANEMLD SINFRUP00000164327 ----------------DTKHIPEIPGLSTGSGPMIYAGSIGTQIANELTD ENST00000266503 ---------------SSRQSCMSVPGMS--TGTVLGAGSIGTDIANEILD : : : : ENST00000256172 IHR-----------------------QIRGSSPSSCGSSPLNIT-STPPP ENSMUST00000047330 IHRQ------------------LFSNRIRGSSPSSCGSSPLNIT-STPPP Q9I879_Brachydanio_rerio IQR------------------------IRGSSPSSCGSSPLNIT-ATPPP Q8JIG1_Brachydanio_rerio IHR------------------------IRGSSPSSCGSSPLNISNSTPPP SINFRUP00000155305 LCAQPMVALSGRGEVSVSDCSVFFSIRIRGSSPSSCGSSPLNIT-STPPP CG8727-RA -------------------------------------------------- Q9IAU1_Brachydanio_rerio FNR-------------------------MNSSPSSGNTSPFSLLQDKSPL SINFRUP00000143043 FNR-------------------------MNSSPSSGSVSPFSLPQEKCQQ SINFRUP00000164327 SYR-------------------------MNSSPSSGAASPLGPPQDKCPL ENST00000266503 LQR-------------------------LQSSSYLDDSSPTGLMKDTHTV :: : : : ::: : ENST00000256172 DASSPGGKKILNGGTPDIPSSGLLSGQAQENPGYPYSDSSSILGENPHIG ENSMUST00000047330 DASSPGGKKILNGGTPDIPSTGLLPGQAQETPGYPYSDSSSILGENPHIG Q9I879_Brachydanio_rerio DTCSPGGKKIQNGGTPDLPSAGIVPGPD--SIGYPYSNNS-LMSDNSHLS Q8JIG1_Brachydanio_rerio DTSSPAARKMSNGGTPDIPSAGLGSGQD--SIGYPYSNSS-ILSDNSHIG SINFRUP00000155305 DTCSPGGKKIQNGGTPELPSAGIIPGPD--SVGYPYSNQS-IMSDNSHLS CG8727-RA -------------------------------------------------- Q9IAU1_Brachydanio_rerio ALAQASSNVPNGEATDVEMPGKSSSEEEARGGPFSTGDNLMEASS----- SINFRUP00000143043 SHNQASNNVPNGEATN-EMPGRSSSENEPQGAAFSEEETPMAHMSSGENS SINFRUP00000164327 TSPQPVQSASSREETT---GGSSESKSDSATTASAASESAGEPSQG---- ENST00000266503 NCRSMSNKELFPPSPS-EMGELEATRQNQSTVAVHSHEPLLSDGA----- ENST00000256172 IDMIDNDQG--SSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL ENSMUST00000047330 IDMIDNDQG--SSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL Q9I879_Brachydanio_rerio I-DIMEEPG--SSSPSNDEAAMAVIMSLLEADAGLGGPVDFSDLPWPL Q8JIG1_Brachydanio_rerio IGDIMDEPG--SSSPSSDEAAMAIIMSLLEADAGLGGPVDFSDLPWPL SINFRUP00000155305 I-DIMDDPG--SSSPSNDEAAMAVIMSLLEADAGLGGPVDF------- CG8727-RA ------------------------------------------------ Q9IAU1_Brachydanio_rerio QLDLEGVPG--LGALSTDEAAMAVIMSLLETDANLGEAVNFDEMHWSL SINFRUP00000143043 QLDLDSVVGPGLSSLSNDEAAMAVIMSLLETDTNLGEAMDFEQMHWSL SINFRUP00000164327 VLDNMVVPG--LSTFSSDEAAMAVIMSLLEADVNMGQSVDFEDLHW-- ENST00000266503 QLDFDALCD-------NDDTAMAAFMNYLEAEGGLGDPGDFSDIQWTL : :: : : :