CLUSTAL W (1.82) multiple sequence alignment ENST00000323186 ------------------------------------MRLLLLREIVINES ENSMUST00000001386 -------------------------------------------------- Q90409_Brachydanio_rerio -------------------------------------------------- SINFRUP00000147729 -------------------------------------------------- Q8UV16_Sphoeroides_nephelus -------------------------------------------------- P79736_Brachydanio_rerio -------------------------------------------------- ENST00000312052 -------------------------------------------------- ENSMUST00000003501 -------------------------------------------------- ENST00000264073 -------------------------------------------------- ENSMUST00000042830 -------------------------------------------------- Q9PTK5_Brachydanio_rerio -------------------------------------------------- SINFRUP00000143488 -------------------------------------------------- Q9PTK4_Brachydanio_rerio -------------------------------------------------- SINFRUP00000129669 -------------------------------------------------- ci0100137398 -------------------------------------------------- CG3151-RD MVEGQTAVQQQQQQPSGAGGASGVGSTTGSAGGPATANNVTNSQAQTNGG ENST00000223951 -------------------------------------------------- ENSMUST00000008633 -------------------------------------------------- SINFRUP00000129727 -------------------------------------------------- ENST00000323186 RNCSFMIISTMEPQVSNGPTSNTSNGPSSNNRNCPSPMQTGATTD----- ENSMUST00000001386 ----------MEPQVSNGPTSNTSNGPSSNNRNCPSPMQTGAATD----- Q90409_Brachydanio_rerio -----MIISNMEPQVTNGPNSATANGPSSNSRSCPSPMQTGGSND----- SINFRUP00000147729 --------------IISTMETQVSNGPSGTSLPNGPVISTNGSTD----- Q8UV16_Sphoeroides_nephelus -------------QIISTMETQVSNGPSGTSLPNGPVISTNGSTD----- P79736_Brachydanio_rerio -----------MVTIISTMETQVSNGPSGTSLPNGPVISTNGATD----- ENST00000312052 -------------QILGAMESQVGGGPAGPALPNGPLLGTNGATD----- ENSMUST00000003501 -------------QILGAMESQVGGGPAGPALPNGPLLGTNGATD----- ENST00000264073 ----------------------------MSNGYEDHMAEDCRGD------ ENSMUST00000042830 ----------------------------MSNGYEDHMAEDCRDD------ Q9PTK5_Brachydanio_rerio ----------------------------MSNGYEDHMADELID------- SINFRUP00000143488 ----------------------------MSNGYEDHMGGGEGKD------ Q9PTK4_Brachydanio_rerio ----------------------------MPNGYEDPMGDEPSD------- SINFRUP00000129669 -----------------------------NNGFEDQLME---DE------ ci0100137398 ---------------------------NSSTNVNNNLTNSNLNTLPSMD- CG3151-RD TTATTTAAAGAGSTTNAAVGQATANNAASNNNNNNNNTNNNNNNNATANN ENST00000223951 ------------METQLSNGPTCNNTANGPTTINNNCSSPVDSGNTE--- ENSMUST00000008633 ------------METQLSNGPTCNNTANGPTTVNNNCSSPVDSGNTE--- SINFRUP00000129727 ---QIISNMEAPVTNGPSGGGTTANGPTTNNHGCPSPMQTGPTND----- ENST00000323186 ------DSKTNLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQS ENSMUST00000001386 ------DSKTNLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQS Q90409_Brachydanio_rerio ------DSKTNLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQS SINFRUP00000147729 ------DSKTNLIVNYLPQNMTQEEFKSLFGSIGEIESCKLVRDKITGQS Q8UV16_Sphoeroides_nephelus ------DSKTNLIVNYLPQNMTQEEFKSLFGSIGEIESCKLVRDKITGQS P79736_Brachydanio_rerio ------DSKTNLIVNYLPQNMTQEEFKSLFGSIGEIESCKLVRDKITGQS ENST00000312052 ------DSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQS ENSMUST00000003501 ------DSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQS ENST00000264073 ------IGRTNLIVNYLPQNMTQDELRSLFSSIGEVESAKLIRDKVAGHS ENSMUST00000042830 ------IGRTNLIVNYLPQNMTQEELRSLFSSIGEVESAKLIRDKVAGHS Q9PTK5_Brachydanio_rerio -------SKTNLIVNYLPQNMSQDELRSLFSSIGEVESAKLIRDKVAGHS SINFRUP00000143488 -------AKTNLIVNYLPQNMSQEELRSLFSSIGEVESAKLIRDKIAGHS Q9PTK4_Brachydanio_rerio -------AKTNLIINYLPQNMSQEELRSLFSSIGEVESAKLIRDKMAGHS SINFRUP00000129669 ------DARTNLIVNYLPQSMSQEELRSLFSSVGDVESAKLIRDKVAGHS ci0100137398 ------ESKTNLIINYLPQAMTQEDLRNLFSSIGELESCKLIRDKLTGQS CG3151-RD NNNNEPDPKTNLIVNYLPQTMSQDEIRSLFVSFGEVESCKLIRDKVTGQS ENST00000223951 ------DSKTNLIVNYLPQNMTQEELKSLFGSIGEIESCKLVRDKITGQS ENSMUST00000008633 ------DSKTNLIVNYLPQNMTQEELKSLFGSIGEIESCKLVRDKITGQS SINFRUP00000129727 ------DSKTNLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGTD :****:***** *:*::::.** *.*::**.**:***::* . ENST00000323186 LGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYV ENSMUST00000001386 LGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYV Q90409_Brachydanio_rerio LGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYV SINFRUP00000147729 LGYGFVNYVDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYV Q8UV16_Sphoeroides_nephelus LGYGFVNYVDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYV P79736_Brachydanio_rerio LGYGFVNYVDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYV ENST00000312052 LGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYV ENSMUST00000003501 LGYGFVNYSDPNDADKAINTLNGLKLQTKTIKVSYARPSSASIRDANLYV ENST00000264073 LGYGFVNYVTAKDAERAINTLNGLRLQSKTIKVSYARPSSEVIKDANLYI ENSMUST00000042830 LGYGFVNYVTAKDAERAISTLNGLRLQSKTIKVSYARPSSEVIKDANLYI Q9PTK5_Brachydanio_rerio LGYGFVNYVNPNDAERAISTLNGLRLQSKTIKVSYARPSSDSIKDANLYI SINFRUP00000143488 LGYGFVNYVTPSDAERAINTLNGLRLQSKNIKVMCNKVS-DTIKDANLYI Q9PTK4_Brachydanio_rerio LGYGFVNYVNPSDAERAINTLNGLRLQSKTIKVSYARPSSDGIKDANLYI SINFRUP00000129669 LGYGFVNFVNPSDAVRAINTLNGLRLQSKTLKVSYARPSSEMIKDANLYI ci0100137398 LGYGFVNYVKAADAEKAINSLNGLRMQQKTIKVSFARPSTPLIKDANLYV CG3151-RD LGYGFVNYVKQEDAEKAINALNGLRLQNKTIKVSIARPSSESIKGANLYV ENST00000223951 LGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYV ENSMUST00000008633 LGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYV SINFRUP00000129727 CTKSHLSLFDLR-CIRKTLTIKSIHFPTWSSSVCFSSFSSVLIRKTG-KT ..:. . : :::.::: . .* * *: :.: ENST00000323186 SGLPKTMTQKELEQLFSQYGRIITSRILVDQVTG---VSRGVGFIRFDKR ENSMUST00000001386 SGLPKTMTQKELEQLFSQYGRIITSRILVDQVTG---VSRGVGFIRFDKR Q90409_Brachydanio_rerio SGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGPTGGSRGVGFIRFDKR SINFRUP00000147729 SGLPKTMSQKDMEQLFSQYGRIITSRILVDQVTG---ISRGVGFIRFDKR Q8UV16_Sphoeroides_nephelus SGLPKTMSQKDMEQLFSQYGRIITSRILVDQVTG---ISRGVGFIRFDKR P79736_Brachydanio_rerio SGLPKTMSQKDMEQLFSQYGRIITSRILVNQVTG---ISRGVGFIRFDKR ENST00000312052 SGLPKTMSQKEMEQLFSQYGRIITSRILVDQVTG---VSRGVGFIRFDKR ENSMUST00000003501 SGLPKTMSQKEMEQLFSQYGRIITSRILLDQATG---VSRGVGFIRFDKR ENST00000264073 SGLPRTMTQKDVEDMFSRFGRIINSRVLVDQTTG---LSRGVAFIRFDKR ENSMUST00000042830 SGLPRTMTQKDVEDMFSRFGRIINSRVLVDQTTG---LSRGVAFIRFDKR Q9PTK5_Brachydanio_rerio SGLPKTMTQKDVEEMFGRYGRIINSRVLVDQASG---LSRGVAFIRFDKR SINFRUP00000143488 SGLPKSMTQKDVEDMFSRFGRIINSRVLVDQATG---ASRGVAFIRFDKR Q9PTK4_Brachydanio_rerio SGLPKTMTQKNVEDMFTQYGRIINSRILVDQASG---LSRGVAFIRFDKR SINFRUP00000129669 SGLPRTASQQDLEDMFSHYGRIINSRVLVDQASG---VSRGVAFIRFDKR ci0100137398 SGLPKSMTQEDLQRIFHPFGRIITSRILVEPSTG---MSRGVGFVRFDKR CG3151-RD SGLPKNMTQSDLESLFSPYGKIITSRILCDNITG---LSKGVGFIRFDQR ENST00000223951 SGLPKTMTQKELEQLFSQYGRIITSRILVDQVTG---ISRGVGFIRFDKR ENSMUST00000008633 SGLPKTMTQKELEQLFSQYGRIITSRILVDQVTG---ISRGVGFIRFDKR SINFRUP00000129727 SQLTSKHQSEEQTQTLSTIS-ILRQGPCLFMSSGPAGGSRGVGFIRFDKR * *. . ..: : . *: . :* *:**.*:***:* ENST00000323186 IEAEEAIKGLNGQKPSGATEPITVKFANNPSQ-KSSQALLSQLYQSPNRR ENSMUST00000001386 IEAEEAIKGLNGQKPSGATEPITVKFANNPSQ-KSSQALLSQLYQSPNRR Q90409_Brachydanio_rerio IEAEEAIKGLNGQKPSGAAEPITVKFANNPSQ-KTSQALLSQLYQSPNRR SINFRUP00000147729 NEAEEAIKGLNGQKPLGAAEPITVKFANNPSQ-KTGQALLTQLYQTAARR Q8UV16_Sphoeroides_nephelus NEAEEAIKGLNGQKPLGAAEPITVKFANNPSQ-KTGQALLTQLYQTAARR P79736_Brachydanio_rerio NEAEEAIKGLNGQKPLGAAEPITVKFANNPSQ-KTGQALLTQLYQTAARR ENST00000312052 IEAEEAIKGLNGQKPLGAAEPITVKFANNPSQ-KTGQALLTHLYQSSARR ENSMUST00000003501 IEAEEAIKGLNGQKPLGAAEPITVKFANNPSQ-KTGQALLTHLYQSSARR ENST00000264073 SEAEEAITSFNGHKPPGSSEPITVKFAANPNQ-NKNVALLSQLYHSPARR ENSMUST00000042830 SEAEEAITSFNGHKPPGSSEPITVKFAANPNQ-NKNMALLSQLYHSPARR Q9PTK5_Brachydanio_rerio AEAEDAIKDLNGQKPPGAAEQMTVKFAASPNQ-VKNTQVIPQVYHQQSRR SINFRUP00000143488 AEAEDAVNNLNGQKPSGVVEPITVKFAANPNQ-TKNTQVISQLFHNQSRR Q9PTK4_Brachydanio_rerio SEAEEAIKDLNGSKPSGASEPITVKFAANPNQ-SKNSQLLSQLYHTQSRR SINFRUP00000129669 SEAEDAIKHLNGHTPPGSAEPITVKFATNPNQ-ARGSQVMSQMYHGQSRR ci0100137398 PEAENAISALNGTIPAGAKDPVTVKFANNPSQKNQQVLQSLYAAASPTRR CG3151-RD FEADRAIKELNGTTPKNSTEPITVKFANNPSS-NKNSMQPLAAYIAPQNT ENST00000223951 IEAEEAIKGLNGQKPPGATEPITVKFANNPSQ-KTNQAILSQLYQSPNRR ENSMUST00000008633 IEAEEAIKGLNGQKPPGATEPITVKFANNPSQ-KTNQAILSQLYQSPNRR SINFRUP00000129727 VEAEEAIKGLNGQKPSGAAEPITVKFANNPSQ-KTSQALLSQLYQSPNRR **: *:. :** * . : :***** .*.. . ENST00000323186 YP----GPLHHQAQRFRLDNLLNMAYGVK-------RFSPITIDGMTSLV ENSMUST00000001386 YP----GPLHHQAQRF--------------------RFSPITIDGMTSLV Q90409_Brachydanio_rerio YP----GPLHHQAQRFRLDNLLNMAYGVK-------RFSPITIDSMTSLV SINFRUP00000147729 YT----GPLHHQTQRFRLDNLLNASYGVK-------RFSPITIDSMTSLA Q8UV16_Sphoeroides_nephelus YT----GPLHHQTQRFRLDNLLNASYGVK-------RFSPITIDSMTSLA P79736_Brachydanio_rerio YT----GPLHHQTQRF--------------------RFSPITIDSMTSLA ENST00000312052 YA----GPLHHQTQRFRLDNLLNMAYGVK-------RFSPIAIDGMSGLA ENSMUST00000003501 YA----GPLHHQTQRFRLDNLLNMAYGVKSPLSLIARFSPIAIDGMSGLA ENST00000264073 FG----GPVHHQAQRF--------------------RFSPMGVDHMSGLS ENSMUST00000042830 FG----GPVHHQAQRF--------------------RFSPMGVDHMSGIS Q9PTK5_Brachydanio_rerio FG----GPVHHQAQRF--------------------RFSPMSVDHMSGMS SINFRUP00000143488 FG----GPLHHQAQRF--------------------RFSPMSVDHMGGVG Q9PTK4_Brachydanio_rerio FG----GPVHHQPQRF--------------------RFSPMSVDHS--VS SINFRUP00000129669 FG----GPVHHQAQRF--------------------RFSPMSVDHVS--- ci0100137398 LATPAAGPLYHQARNFSDLLSNVNMGLGVKS-PNESRYSPITPELLTSMG CG3151-RD RGGRAFPANAAAGAAAAAAAAAIHPNAGRYS-SVISRYSPLTSDLITN-G ENST00000223951 YP----GPLAQQAQRFRLDNLLNMAYGVK-------RFSPMTIDGMTSLA ENSMUST00000008633 YP----GPLAQQAQRFRLDNLLNMAYGVKS------RFSPMTIDGMTSLA SINFRUP00000129727 YP----GPLHHQAQRF--------------------RFSPITIDSMTSLV . *:**: : : ENST00000323186 GMNIPGHTGT-------GWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKV ENSMUST00000001386 GMNIPGHTGT-------GWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKV Q90409_Brachydanio_rerio GMNIPGHTGT-------GWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKV SINFRUP00000147729 GVNLTG-PTG------AGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKV Q8UV16_Sphoeroides_nephelus GVNLTG-PTG------AGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKV P79736_Brachydanio_rerio GVNLTG-PTG------AGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKV ENST00000312052 GVGLSGGAAG------AGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKV ENSMUST00000003501 GVGLSGGAAG------AGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKV ENST00000264073 GVNVPGNASS-------GWCIFIYNLGQDADEGILWQMFGPFGAVTNVKV ENSMUST00000042830 GVNVPGNASS-------GWCIFIYNLGQDADEGILWQMFGPFGAVTNVKV Q9PTK5_Brachydanio_rerio GVNVPGNSSS-------GWCIFIYNLGQDADEGILWQMFGPFGAVTNVKV SINFRUP00000143488 GVSVPTNSNN-------GWCIFIYNLGQEADETILWQMFGPFGAVTNVKV Q9PTK4_Brachydanio_rerio SMNVASSSSS-------GWCIFVYNLGQDADEGILWQMFGPFGAVTNVKV SINFRUP00000129669 SSSASGNSPN-------GWCIFIYNLGQEADEAILWQLFGPFGAVVNVKV ci0100137398 MPSTAPSASSSTVAPNFGICIFVYNLAPETDENILWQLFGPFGAVTSVKV CG3151-RD MIQGNTIASS-------GWCIFVYNLAPDTEENVLWQLFGPFGAVQSVKV ENST00000223951 GINIPGHPGT-------GWCIFVYNLAPDADESILWQMFGPFGAVTNVKV ENSMUST00000008633 GINIPGHPGT-------GWCIFVYNLAPDADESILWQMFGPFGAVTNVKV SINFRUP00000129727 GMNIPGHTGT-------GWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKV . * ***:***. :::* :***:******* .*** ENST00000323186 IRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKAH ENSMUST00000001386 IRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKAH Q90409_Brachydanio_rerio IRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKTH SINFRUP00000147729 IRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTSKQH Q8UV16_Sphoeroides_nephelus IRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTSKQH P79736_Brachydanio_rerio IRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTSKQH ENST00000312052 IRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGERVLQVSFKTSKQH ENSMUST00000003501 IRDFTTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGERVLQVSFKTSKQH ENST00000264073 IRDFNTNKCKGFGFVTMTNYEEAAMAIASLNGYRLGDKILQVSFKTNKSH ENSMUST00000042830 IRDFNTNKCKGFGFVTMTNYEEAAMAIASLNGYRLGDKILQVSFKTNKSH Q9PTK5_Brachydanio_rerio IRDFNTNKCKGFGFVTMTHYEEAAMAIASLNGYRLGDKILQVSFKTSKSH SINFRUP00000143488 IRDFTTNKCKGFGFVTMSNYEDAAMAIASLNGYRLGEKILQVSFKTSKGH Q9PTK4_Brachydanio_rerio IRDFNTSKCKGFGFVTMTNYEEAAMAISSLNGYRLGDKVLQVSFKSSKSH SINFRUP00000129669 IRDFNTSKCKGFGFVTMSNYEEAAMAIHSLNGYRLGDKVLQVSFKTSKGH ci0100137398 IRDYQTQKCKGYGFVTMTNYEEAFIAVCSLNGYKLGDRVLQVSM------ CG3151-RD IRDLQSNKCKGFGFVTMTNYEEAVLAIQSLNGYTLGNRVLQVSFKTNKNK ENST00000223951 IRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKTH ENSMUST00000008633 IRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKTH SINFRUP00000129727 IRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKTH *** :.****:*****::*::* :*: ***** **:::****: ENST00000323186 KS ENSMUST00000001386 KS Q90409_Brachydanio_rerio KS SINFRUP00000147729 KA Q8UV16_Sphoeroides_nephelus KA P79736_Brachydanio_rerio KA ENST00000312052 KA ENSMUST00000003501 KA ENST00000264073 K- ENSMUST00000042830 K- Q9PTK5_Brachydanio_rerio K- SINFRUP00000143488 K- Q9PTK4_Brachydanio_rerio K- SINFRUP00000129669 K- ci0100137398 -- CG3151-RD QT ENST00000223951 KA ENSMUST00000008633 KA SINFRUP00000129727 KS