CLUSTAL W (1.82) multiple sequence alignment ENST00000298349 MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK ENSMUST00000029311 MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGDYASVKKSLEEAEIYFK SINFRUP00000152205 MSQLYYRKSNNSSYRDRIPLRIIRAESELSALERAYLGAVEKGDYSSVKQALEEAEIYFR ENSMUST00000040184 MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLSAVEKGDYATVKQALQEAEIYYN ENST00000262839 MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYN SINFRUP00000134312 ----------YSPYRDRIPLQIVRAEVELSAEERAYLTAVEKGDYAGVKHALREAEVYYN CG5996-RA ------------MMEEENTIRPHQEIRQLTLEEKKFLLAVERGDMAGTRRMLQKAQDTEY : : .:. .:: : :*: *: :* ***:** : .:: *.:*: ENST00000298349 ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHK- ENSMUST00000029311 ININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHK- SINFRUP00000152205 ININCIDPLGRTALLIAIENENLEIIELLLSYNVYVGDALLHAIRKQVVGAVELLLNHK- ENSMUST00000040184 VNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYR- ENST00000262839 VNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYR- SINFRUP00000134312 IDVNCLDPLGRSALLIAIENENLEIMELLLDHGIHTGDALLYAIRKEVVGAVELLLSHR- CG5996-RA INVNCVDPLGRTALLMAIDNENLEMVELLINYNVDTKDALLHSISEEFVEAVEVLLDHEN :::**:*****:***:**:*****::***:...: . ****::* ::.* ***:**.:. ENST00000298349 -KPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNC ENSMUST00000029311 -KPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKLLVQKGVSVPRPHEVRCNC SINFRUP00000152205 -KPRGEKQVLPVLLDRQFSDFTPDITPIILAAHTNNYEIIKLLLQRGVSIPQPHAVHCNC ENSMUST00000040184 -KPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNC ENST00000262839 -RPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNC SINFRUP00000134312 -RPSGEKQVPSLMMDSQFSEFTPDITPIMLAAHTNNYEIIKLLVQRKVTIPRPHQIRCDC CG5996-RA VTFHSEGNHSWESASEDTSTFTPDITPLILAAHRDNYEIIKILLDRGAVLPMPHDVRCGC .* : . : * *******::**** :******:*::: . :* ** ::*.* ENST00000298349 VECVSSS----------DVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQ ENSMUST00000029311 VECVSSS----------DVDSLRHSRSRLNIYKALASPSLIALSSEDPFLTAFQLSWELQ SINFRUP00000152205 VECVSCS----------DVDSLRHSRSHLNIYKALASPSLIALSSEDPFLTAFKLSWELK ENSMUST00000040184 VECVSSS----------EVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELK ENST00000262839 VECVSSS----------EVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELK SINFRUP00000134312 VECVSSSEVGKILLLLLKVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELK CG5996-RA DECVQSR----------QEDSLRHSRSRINAYRALASPSLIALSSKDPILTAFELSWELR ***.. . ********::* *:************:**:****.*.***: ENST00000298349 ELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNS-LIEEQSGNDLA ENSMUST00000029311 ELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNS-LIEEQSGNDLA SINFRUP00000152205 ELSTVENEFKSEYEELSRMCKQFAKDLLDQTRSSKELEIILNYRDDIN-PLMDENTNDLA ENSMUST00000040184 ELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLA ENST00000262839 ELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLA SINFRUP00000134312 ELSKVENEFRQEYEELSQQCKRFAKDLLDQARSSRELETILNHRDDQSEELDPRQCHNLA CG5996-RA RLSFLEHEFKNEYQELRKQCQDFATALLDHTRTSHELEILLNH-DPTGPVYEHGERMHLN .** :*:**: **:** : *: **. ***::*:*:*** :**: * . . .* ENST00000298349 RLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCY ENSMUST00000029311 RLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCFIIGLLFPVFSVCY SINFRUP00000152205 RLKLAIKYSQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKLLTCIFIGLIFPLLSIGY ENSMUST00000040184 KLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAY ENST00000262839 KLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAY SINFRUP00000134312 KLKLAIKYHQKEVPADIHN-------HFSSHSSGDNKHLIA---------------CQIY CG5996-RA RLKLAIKLRQKKFVAHSNVQQLLASIWYEGLPGFRRKNMALQAVDIIRIGIMFPIFSLAY :**:*** **:. *. : :: :. .. .:: : : : ::: ::. * ENST00000298349 LIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSD---------------- ENSMUST00000029311 LIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSD---------------- SINFRUP00000152205 LISPKSRYGLFIRKPFIKFICHTASYLTFLFLLFLASQHIASPL---------------- ENSMUST00000040184 LISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTD---------------- ENST00000262839 LISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTD---------------- SINFRUP00000134312 LLAPKSALGNFIKKPFIKFICHTASYLTFLFLLLLASQHIARTN---------------- CG5996-RA ILAPYSSIGQTMRKPFIKFICHSASYFTFLFLLMLASQRIETFIGGWFFADSSGMLNTME :::* * * ::*********:***:****:*:****:* ENST00000298349 --LNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATI ENSMUST00000029311 --LNRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATI SINFRUP00000152205 --PNLQGPPPTTVEWMILPWVLGFIWNEIKQMWDSGFQGYIDDWWNLMDFIMNSLYIATI ENSMUST00000040184 --LHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATI ENST00000262839 --LHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATI SINFRUP00000134312 --LHMQGPPPTVVEWMILPWVLGFIWAEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATI CG5996-RA ELPTKRGAKPTFIEWLILAWVSGLIWSEVKQLWDVGLQEYLNDMWNVIDFVTNSLYVATV :*. ** :**:**.** *:** *:*::** *: *:.* **::** ****:**: ENST00000298349 SLKIVAFVKYS---------ALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANS ENSMUST00000029311 SLKIVAFVKYS---------ALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANS SINFRUP00000152205 SLKILAYVKYS---------VQKPRCNWEMWHPTLVAESLFAIANIFSSLRLICLFTANS ENSMUST00000040184 SLKIVAYVKYN---------GSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANS ENST00000262839 SLKIVAYVKYN---------GSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANS SINFRUP00000134312 SLKIVAYVKYN---------SSRPREEWEMWHPTLIAEALFAIANIFSSLRLISLFTANS CG5996-RA ALRVVSFFQVQKEMIYNSHATDLPRERWDAWDPMLISEGLFSAANIFSSLKLVYIFSVNP :*:::::.: . ** *: *.* *::*.**: :**:***:*: :*:.*. ENST00000298349 HLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKG---LTCKGIRCEKQ ENSMUST00000029311 HLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKG---LSCKGIRCEKQ SINFRUP00000152205 HLGPLQISLGRMLLDILKFLFIYWLVLLAFANGLNQLYFYYETEGS---NNCKGIRCNQQ ENSMUST00000040184 HLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQ ENST00000262839 HLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQ SINFRUP00000134312 HLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETKASEEHNNCKGIRCERQ CG5996-RA HLGPLQVSLSRMVMDIMKFFFLYVLVLFAFGSGLNQLLWYYADLEKKRCPEVSPMSALLN ******:**.**::**:**:*:* ***:**..***** :** . : . : ENST00000298349 NN------------AFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYN ENSMUST00000029311 NN------------AFSTLFETLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYN SINFRUP00000152205 NN------------AFSTLFETLQSLFWSIFGLISLYVTNVEPEHEFTEFVGSTMFGTYN ENSMUST00000040184 NN------------AFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYN ENST00000262839 NN------------AFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYN SINFRUP00000134312 NN------------AFSTLFETLQSLFWSIFGLLNLYVTNVKARHEFTEFIGATMFGTYN CG5996-RA MNGTNDPNACIVWRRFSNLFETTQTLFWAVFGLIDLDSFELDGIKIFTRFWGMLMFGTYS * **.**** *:***::***:.* ::. : **.* * *****. ENST00000298349 VISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKS ENSMUST00000029311 VISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKS SINFRUP00000152205 IISLVVLLNMLIAMMNNSYQHIADHADIEWKFARTKLWMSYFEEGGTLPSPFNIIPSPKS ENSMUST00000040184 VISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKS ENST00000262839 VISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKS SINFRUP00000134312 VISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIVPSPKS CG5996-RA VINIVVLLNLLIAMMNHSYQLISERADVEWKFARSKLWISYFEEGGTCPPPFNIIPTPKS :*.:*****:******:*** *:::**:******:***:***:**** *.***::*:*** ENST00000298349 LWYLIKWIWTHLCKKKMR----RKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAM ENSMUST00000029311 LWYLVKWIWTHLCKKKMR----RKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAM SINFRUP00000152205 VYYLFAWIKKHLLKRQSV----KRLETFETLGRRAAENVRLNHEYQEVLKNLVKRYVAAM ENSMUST00000040184 FLYLGNWFNNTFCPKRDP-DGRRRRHNLRSFTERHADSLIQNQHYQEVIRNLVKRYVAAM ENST00000262839 FLYLGNWFNNTFCPKRDP-DGRRRRRNLRSFTERNADSLIQNQHYQEVIRNLVKRYVAAM SINFRUP00000134312 VWYLLMWLHNKLCRRGPLGDDTHKCENLREFTE--------------VIRNLVKRYVAAM CG5996-RA IWYAIKWMRRVFCSGSSA----ARREHLKTIRRKAQQASDRDFKYQQIMRNLVRRYVTVE . * *: : : . : : . :::***:***:. ENST00000298349 IRDAKTEEGLTEENFKELKQDISSFRFEVLGLLRGS------------------------ ENSMUST00000029311 IREAKTEEGLTEENVKELKQDISSFRFEVLGLLRGS------------------------ SINFRUP00000152205 IRDGKTERSLTEENFKELKQDISSFRYEVLGMMKSK------------------------ ENSMUST00000040184 IRNSKTNEGLTEENFKELKQDISSFRYEVLDLLGNR------------------------ ENST00000262839 IRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNR------------------------ SINFRUP00000134312 IRSAKTDEGLTEENFK-------------------------------------------- CG5996-RA QRKAES-QGVTEDDVNEIKQDISAFRCELVEILKNSGMDTNVTAGQGGGGGGKKNRQKER *..:: ..:**::.: : : : :: :: ENST00000298349 -------------------------------KLSTIQSANASKESSNSADSDEKSDSEGN ENSMUST00000029311 -------------------------------KLSTIQSANAAS----SADSDEKSQSEGN SINFRUP00000152205 -------------------------------RRGGVSSKVASST---------------- ENSMUST00000040184 -------------------------------KHPRRSLSTSSAD---FSQRDDTNDGSGG ENST00000262839 -------------------------------KHPR-SFSTSSTE---LSQRDDNNDGSGG SINFRUP00000134312 ------------------------------------------------------------ CG5996-RA RLMKGFNIAPPGSTGSLAPVAEFSTSLDNYDNQHEILSSTLSTLFTPNFMHKRQQSQAGS ENST00000298349 SKDKKKNFSLFDLTTLIHPRSAAIASERHNISNGSALVVQEPPREKQRKVNFVTDIKNFG ENSMUST00000029311 GKDKRKNLSLFDLTTLIHPRSAAIASERHNLSNGSALVVQEPPREKQRKVNFVADIKNFG SINFRUP00000152205 ------------------------------------------------------------ ENSMUST00000040184 ARAKSKSVSFN---VGCKKKACHGAPLIRTVPRASGAQGKPKSESSSKRSFMGPSFKKLG ENST00000262839 ARAKSKSVSFN---LGCKKKTCHGPPLIRTMPRSSGAQGKSKAESSSKRSFMGPSLKKLG SINFRUP00000134312 ------------------------------------------------------------ CG5996-RA GGGGSESPTTPTAPQGTQGAAMTASSQVTKYNKSALKPYNKRIAGHKKRWGTLIEAAKVG ENST00000298349 LFHRRSKQNAAEQNANQIFSVSEEVARQQAAGPLERNIQLESRGLASRGDLSIPGLSEQC ENSMUST00000029311 LFHRRSKQNAAEQNANQIFSVSEEITRQQAAGALERNIELESKGLASRGDRSIPGLNEQC SINFRUP00000152205 ------------------------------------------------------------ ENSMUST00000040184 LFFSKFNGQTSEPTSEPMYTISDGIAQQHCMWQDIRYSQMEKGKAEACSQSQMN----LG ENST00000262839 LLFSKFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYSQMEKGKAEACSQSEIN----LS SINFRUP00000134312 ------------------------------------------------------------ CG5996-RA NVSKMLGRSKSEDSVCNSSHTSTPVHGQMRVTYAQNSPQQEYGYHGETSSTTISTPTPTI ENST00000298349 VLVDH----------------------------------------------RERNTDTLG ENSMUST00000029311 VLVDH----------------------------------------------RERNTDTLG SINFRUP00000152205 ------------------------------------------------------------ ENSMUST00000040184 EVELG----------------------------------------------EIRGAAARS ENST00000262839 EVELG----------------------------------------------EVQGAAQ-S SINFRUP00000134312 ------------------------------------------------------------ CG5996-RA SVVSNSPAAHAGVGSHFFHTTSGLTAIAALKRKRKKFSSSKNICPVTESVAAANAAEILN ENST00000298349 LQVGKRVCP-FKSEKVVVEDTVPIIP--------KEKHAKEEDSSIDYDLNLPDT--VTH ENSMUST00000029311 LQVGKRVCSTFKSEKVVVEDTVPIIP--------KEKHAHEEDSSIDYDLSPTDT--AAH SINFRUP00000152205 ------------------------------------------------------------ ENSMUST00000040184 SECPLACSSSLHCASGICSSNSKLLD--------SSEDVFETWGEACDLLMHKWG--DGQ ENST00000262839 SECPLACSSSLHCASSICSSNSKLLD--------SSEDVFETWGEACDLLMHKWG--DGQ SINFRUP00000134312 ------------------------------------------------------------ CG5996-RA DKTLKRVSSYPAAEAGVQHNPAQLVKPRRHEQTQSQHDSVETNSTFTLSIDPSNTSVNSR ENST00000298349 EDYVTTRL-------- ENSMUST00000029311 EDYVTTRL-------- SINFRUP00000152205 ---------------- ENSMUST00000040184 EEQVTTRL-------- ENST00000262839 EEQVTTRL-------- SINFRUP00000134312 ---------------- CG5996-RA EPLISTSCVSTTGAIG