CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000061101 MGRGLLRGLWPLHIVLWTRIASTIPPHVPKSDVEMEAQKDASIHLSCNRT ENST00000295754 MGRGLLRGLWPLHIVLWTRIASTIPPHVQKS------------------- SINFRUP00000139089 -------------------------------------------------- SINFRUP00000148320 -------------------------------------------------- ENSMUST00000035093 -------------------------------------------------M ENST00000302400 -------------------------------------------------- O13102_Carassius_auratus -------------------------------------------------M Q9YGU4_Brachydanio_rerio -------------------------------------------------M ENSMUST00000028096 -----------------------FVSEEDPGNWISSENFLRLLRRLGKMG ENST00000241416 -------------------------------------------------- CG7904-RA ------------------------------------------MSKYDLLY ci0100135103 -------------------------------------------------- ENSMUST00000061101 IHPLKHFNSDVMASDNGGAVKLPQLCKFCDVRLSTCDNQKSCMSNCSITA ENST00000295754 ------VNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITS SINFRUP00000139089 -----------------------QLCKFCDVESSNCSGTGTCTSNCSITA SINFRUP00000148320 -------------------------------------------------- ENSMUST00000035093 TAPWAALALLWGSLCAGSGRGEAETRECIYYNANWE-LERTNQSGLERCE ENST00000302400 -------------------------------------------------- O13102_Carassius_auratus FASWPTFALLLGTFSAGPSHAEVETHECLYFNINWE-VEKTNRSGVERCE Q9YGU4_Brachydanio_rerio FASLLTLALLLATFAADPSHGEVETRECLYYNVNWE-VEKTNRSGVERCE ENSMUST00000028096 AAAKLAFAVFLISCSSGAILGRSETQECLFFNANWE-RDRTNQTGVEPCY ENST00000241416 ----------------GAILGRSETQECLFFNANWE-KDRTNQTGVEPCY CG7904-RA LTAQLTLVCCLIGIHGSILPGSHGIIECEHFDEKMCNTTQQCETRIEHCK ci0100135103 -----MKCLILISLLSYLHTGSSIHCRQCSAEIDANDCNSTSCTIPCSTV ENSMUST00000061101 ICEKPHEVCVAVWRKNDKNITLETVCHDPKLTYHGFTLEDAASPKCVMKE ENST00000295754 ICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKE SINFRUP00000139089 ICSSAEEICVALWRKNETGFSIETLCHDPSKSLYGMMLDDFNSSACLMKE SINFRUP00000148320 -------------------------------------------------- ENSMUST00000035093 GEQDKRLHCYASWRN--SSGTIELVKKG----CWLDDFNCYDRQECVATE ENST00000302400 -------------------------------------------------- O13102_Carassius_auratus GEKDKRSHCYASWRN--SSGSIQLVKKG----CWLDDFNCYDRQECVATE Q9YGU4_Brachydanio_rerio GEKDKRSHCYASWRN--NSGSIQLVKKG----CWLDDFNCYDRQECVATE ENSMUST00000028096 GDKDKRRHCFATWKN--ISGSIEIVKQG----CWLDDINCYDRTDCIEKK ENST00000241416 GDKDKRRHCFATWKN--ISGSIEIVKQG----CWLDDINCYDRTDCVEKK CG7904-RA MEADKFPSCYVLWSVNETTGILRIKMKG----CFTDMHECN-QTECVTSA ci0100135103 DCSCLGLCYTNVILNFSGKHSVQAACIQQLCPTRASYLNLYTKRQIEGYC ENSMUST00000061101 KKRAGETFFMCACNMEECNDYIIFSE------EYTTSSPDLLLVIIQVTG ENST00000295754 KKKPGETFFMCSCSSDECNDNIIFSE------EYNTSNPDLLLVIFQVTG SINFRUP00000139089 KNTTGGMVQVCSCTGDECNNFLIFSP------VVDPSPDDPLVSVVLVS- SINFRUP00000148320 -----------------------------------------VLPVVGVS- ENSMUST00000035093 ENPQ---VYFCCCEGNFCNERFTHLP-EPGGPEVTYEPPPTAPTLLTVLA ENST00000302400 GEPQ---VYFCCCEGNFCNERFTHLP-EAGGPEVTYEPPPTAPTLLTVLA O13102_Carassius_auratus ENPQ---VFFCCCEGDFCNERFTHLP-DITGP--VLESPPSAPLLLIVLV Q9YGU4_Brachydanio_rerio ENPQ---VFFCCCEGNFCNERFTHLP-DISGP--VISPPPVSPSLLNVLV ENSMUST00000028096 DSPE---VYFCCCEGNMCNEKFSYFP-EMEVTQPTSNPVTPKPPYYNILL ENST00000241416 DSPE---VYFCCCEGNMCNEKFSYFP-EMEVTQPTSNPVTPKPPYYNILL CG7904-RA EPRQG-NIHFCCCKGSRCNSNQKYIKSTTEATTQVPKEKTQDGSNLIYIY ci0100135103 DVSKG--VVTCECASDDCNHMISFEPITIDDEDIIIEDKYDLSSIIVGVL ENSMUST00000061101 VSLLPPLGIAIAVIIIFYCYRVHRQQKLSPSWESSKPRK-----LMDFSD ENST00000295754 ISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRK-----LMEFSE SINFRUP00000139089 --LLPLLVMGIAG--MFYWYRVHRPRLRSQEWKSSIKKRKPKSGGLDCSD SINFRUP00000148320 --LVPPLLVAVAATVAFYIYRTRHLDKPDSPARPDWTPKQTTDLYLASDL ENSMUST00000035093 YSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHEVRQCQRWAGRRDGCAD ENST00000302400 YSLLPIGGLSLIVLLAFWMYRHRKPPYGHVDIHE---------------- O13102_Carassius_auratus YSLLPVTMLSMLLLLGFWMYRHRKPPYGHVDLSE---------------- Q9YGU4_Brachydanio_rerio YSLLPLSMLSMAVLLAFWMYRHRKPPYGHVDVNE---------------- ENSMUST00000028096 YSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQ--------------- ENST00000241416 YSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQ--------------- CG7904-RA IGTSVFSVLMVIVGMGLLLYRRRKQAHFNEIPTH---------------- ci0100135103 VGFLLLCLLVXKLTSGSRLSSDDASLIDGWDDSGKHSYS---------AY : ENSMUST00000061101 NCAIILEDDRSDISSTCANNIN-------HNTELLPIELDTLVGKGRFAE ENST00000295754 HCAIILEDDRSDISSTCANNIN-------HNTELLPIELDTLVGKGRFAE SINFRUP00000139089 VCVIMMDDDRSDSSSTDANNLN-------HNTEPLPIELDQLVGKGRFAQ SINFRUP00000148320 PCGGGVDREASQAKNSHSDVINNMTDCPGQGKELLPIKLEVLVGKGRFAE ENSMUST00000035093 SFKPLPFQDPGPPPPSPLVGLK-------------PLQLLEIKARGRFGC ENST00000302400 --------DPGPPPPSPLVGLK-------------PLQLLEIKARGRFGC O13102_Carassius_auratus --------DPSPSPPSPLLTLK-------------PLQLLEVKARGRFGQ Q9YGU4_Brachydanio_rerio --------DPGPSPPSPLVGLK-------------PLQLLEVKARGRFGC ENSMUST00000028096 --------DPGPPPPSPLLGLK-------------PLQLLEVKARGRFGC ENST00000241416 --------DPGPPPPSPLLGLK-------------PLQLLEVKARGRFGC CG7904-RA --------EAEITNSSPLLSNR-------------PIQLLEQKASGRFGD ci0100135103 RYSSSVATQYSRGSRGNVLNHN---------DQHLPIELQKIIGKGRFAE : . : :*::* . ***. ENSMUST00000061101 VYKAKLKQN---TSEQFETVAVKIFPYEEYSSWKTEKDIFSDINLKHENI ENST00000295754 VYKAKLKQN---TSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENI SINFRUP00000139089 VYKAKLKQA---ASDQFETVAVKIFPYEEYASWKNEKDIFSNSDLRHENV SINFRUP00000148320 VWSGRLLRGGKGGSNSHETVAVKVFPAVEYASWRNECSIFSDPNMAHDNI ENSMUST00000035093 VWKAQLMND---------FVAVKIFPLQDKQSWQSEREIFSTPGMKHENL ENST00000302400 VWKAQLMND---------FVAVKIFPLQDKQSWQSGREIFSTPGMKHENL O13102_Carassius_auratus VWRAQMMNE---------CVAVKIFPIQDKQSWQNERDMFSTPGMKHENL Q9YGU4_Brachydanio_rerio VWKAQMINE---------YVAVKIFPIQDKLSWQNEREMFSTPGMKHDNL ENSMUST00000028096 VWKAQLLNE---------YVAVKIFPIQDKQSWQNEYEVYSLPGMKHENI ENST00000241416 VWKAQLLNE---------YVAVKIFPIQDKQSWQNEYEVYSLPGMKHENI CG7904-RA VWQAKLNNQ---------DVAVKIFRMQEKESWTTEHDIYKLPRMRHPNI ci0100135103 VWKANLQQDAS----PPQVVSVKVFRLHNYGAWRQEKDMLTESWMRHENI *: ..: . *:**:* : :* .: . : * *: ENSMUST00000061101 LQFLTAEER--KTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGS ENST00000295754 LQFLTAEER--KTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGS SINFRUP00000139089 LHFLTAEEK--KAQR--QYWLITAFHTRGNLQEHLTHNITSWEELKILGS SINFRUP00000148320 VRFHAAEDRGPPGHALTQHWLILAYHSLGNLQDFLTANILGWEELVAMAG ENSMUST00000035093 LQFIAAEKR--GSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAE ENST00000302400 LQFIAAEKR--GSNLEVELWLITAFHDKGSLTDYLKGNIITWNELCHVAE O13102_Carassius_auratus LRYIGAERR--GANLETEFWLITEFHERGSLTDHLKGNVLSWTDLCHIAE Q9YGU4_Brachydanio_rerio LRFIAAEKR--GSNLEMEFWLITEFHERGSLTDYLKGNAVSWADLCVIAE ENSMUST00000028096 LQFIGAEKR--GTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAE ENST00000241416 LQFIGAEKR--GTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAE CG7904-RA LEFLGVEKH--MD--KPEYWLISTYQHNGSLCDYLKSHTISWPELCRIAE ci0100135103 IEFYASEQH--TVRGRLQYWLITSYYQEKSLADFLGSNILDWDQFCDMAT :.: * : : *** : .* :.* : * :: :. ENSMUST00000061101 SLARGIAHLHSDHTPCG--RPKMPIVHRDLKSSNILVKN-DLTCCLCDFG ENST00000295754 SLARGIAHLHSDHTPCG--RPKMPIVHRDLKSSNILVKN-DLTCCLCDFG SINFRUP00000139089 SLARGVSHLHSDRLPCG--RPKVAIVHRDLKSSNILVKN-DLTCCLCDFG SINFRUP00000148320 SIAKGLAHLHSDTTQEG--LPKVPVAHRDLKSSNIVMKS-RTECALCDFG ENSMUST00000035093 TMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKS-DLTAVLADFG ENST00000302400 TMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKS-DLTAVLADFG O13102_Carassius_auratus TMACGLAYLHEDVPRSK-----PAIAHRDFKSRNVLLKS-DLSAVLGDLG Q9YGU4_Brachydanio_rerio SMACGLAYLHEDVPRSKGEGPKPAIAHRDFKSKNVMLKM-DLTAVIGDFG ENSMUST00000028096 TMARGLAYLHEDIPGLK-DGHKPAISHRDIKSKNVLLKN-NLTACIADFG ENST00000241416 TMARGLAYLHEDIPGLK-DGHKPAISHRDIKSKNVLLKN-NLTACIADFG CG7904-RA SMANGLAHLHEEIPASKTDGLKPSIAHRDFKSKNVLLKS-DLTACIADFG ci0100135103 SIAKGLSYLHAERDDVG--RPKIPIAHRDVKSCNILVKDGRRECVLADFG ::: *:::** : .: ***.** *:::* . : *:* ENSMUST00000061101 LSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYS ENST00000295754 LSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYS SINFRUP00000139089 LGLQLDSSLSVDDLANSGQVGTARYMAPEVLEARLNLENIESFKQADIYS SINFRUP00000148320 LALRLDVSLTVDDYANSGQVGTARYMAPEVLESRVNLEDLEAFKQMDVYS ENSMUST00000035093 LAVRFEPGKPPGD--THGQVGTRRYMAPEVLEGAINFQ-RDAFLRIDMYA ENST00000302400 LAVRFEPGKPPGD--THGQVGTRRYMAPEVLEGAINFQ-RDAFLRIDMYA O13102_Carassius_auratus LAVRFEPGTPPGD--THGQVGTRRYMAPEVLEGAINFQ-RDSFLRIDMYA Q9YGU4_Brachydanio_rerio LAVRFEPGKPPGD--THGQVGTRRYMAPEVLEGAINFQ-RDSFLRIDMYA ENSMUST00000028096 LALKFEAGKSAGD--THGQVGTRRYMAPEVLEGAINFQ-RDAFLRIDMYA ENST00000241416 LALKFEAGKSAGD--THGQVGTRRYMAPEVLEGAINFQ-RDAFLRIDMYA CG7904-RA LAMIFQPGKPCGD--THGQVGTRRYMAPEVLEGAINFN-RDAFLRIDVYA ci0100135103 LSLKLDPKLSRDELANAGQVGTSRYMAPELLERLVNLTDIEMFKRVDVYA *.: :: . .: . ***** ******:** :*: : * : *:*: ENSMUST00000061101 MALVLWEMTSRCNAVG---------------------------------- ENST00000295754 MALVLWEMTSRCNAVG---------------------------------- SINFRUP00000139089 MALVLWEMTSRCEAVGGQCSCQISAQMSPLAGDDVVLSKHLLPSRGASLC SINFRUP00000148320 MALVLWEMASRCQATG---------------------------------- ENSMUST00000035093 MGLVLWELVSRCKAADG--------------------------------- ENST00000302400 MGLVLWELVSRCKAADG--------------------------------- O13102_Carassius_auratus MGLVLWELVSRCRAADG--------------------------------- Q9YGU4_Brachydanio_rerio MGLVLWELVSRCKAADG--------------------------------- ENSMUST00000028096 MGLVLWELASRCTAADG--------------------------------- ENST00000241416 MGLVLWELASRCTAADG--------------------------------- CG7904-RA CGLVLWEMVSRCDFAG---------------------------------- ci0100135103 MALVLWEMANRCETSEG--------------------------------- .*****:..** ENSMUST00000061101 ------------EVKDYEPPFGSKVREHPCVESMKDSVLRDRGRPEIPSF ENST00000295754 ------------EVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSF SINFRUP00000139089 CSPSYPDEPGLCEVKDYEPAYGSKVREHPCVESMKDNVLRDRGRPEIPDT SINFRUP00000148320 ------------EVKSYEPAFGSQVCEQPCVDSMRDLVLRDRGRPDIPAL ENSMUST00000035093 ------------PVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDH ENST00000302400 ------------PVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDH O13102_Carassius_auratus ------------PVDEYMLPFEEEIGQHPSLEDLQDAVVHKKMRPAFKDC Q9YGU4_Brachydanio_rerio ------------PVDEYMLPFEEEIGQHPSLEDLQDAVVHKKLRPAFKDC ENSMUST00000028096 ------------PVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDY ENST00000241416 ------------PVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDY CG7904-RA ------------PVGEFQLPFEAELGLRPSLDEVQESVVMKKLRPRLLNS ci0100135103 ------------MASPYKPPFGDKINDRPTKDQMLLLVCKERQLPSIPEK . : .: :: :* :.: * .: * : ENSMUST00000061101 WLNHQGIQIVCETLT-ECWDHDPEARLTAQCVAERFSELE---------H ENST00000295754 WLNHQGIQMVCETLT-ECWDHDPEARLTAQCVAERFSELE---------H SINFRUP00000139089 WLRHQGVAMMCGTIM-ECWDHDPEARLTAHCVAERISEMED--------E SINFRUP00000148320 WSQHKGLSIFCSTII-ECWDHDPEARLTAHCVVERFKALQ---------- ENSMUST00000035093 WLKHPGLAQLCVTIE-ECWDHDAEARLSAGCVEERVSLIRRSVNGTTSDC ENST00000302400 WLKHPGLAQLCVTIE-DCWDHDAEARLSAGCVEERVSLIRRSVNGTTSDC O13102_Carassius_auratus WLKHSGLAQMCETIE-ECWDHDAEARLSAGCVEERISQIRR-LTSITTSD Q9YGU4_Brachydanio_rerio WLKHSGLCQMCETME-ECWDHDAEARLSAGCVQERISQIRR-VSSSTSDC ENSMUST00000028096 WQKHAGMAMLCETIE-ECWDHDAEARLSAGCVGERITQMQRLTNIITTED ENST00000241416 WQKHAGMAMLCETIE-ECWDHDAEARLSAGCVGERITQMQRLTNIITTED CG7904-RA WRAHPGLNVFCDTME-ECWDHDAEARLSSSCVMERFAQLNKYPSTQ---- ci0100135103 WKKHQGLSEFVDTILNETWEYDAEARITASCVLERFKVLRHHGDVIGSDG * * *: . *: : *::*.***::: ** **. :. ENSMUST00000061101 PERLSGRSCSQEKIPEDGSLNTTK-- ENST00000295754 LDRLSGRSCSEEKIPEDGSLNTTK-- SINFRUP00000139089 MDKLSSHSSSTEKIPEE--------- SINFRUP00000148320 ---------NEE-------------- ENSMUST00000035093 LVSLVTSVTNVDLLPKESSI------ ENST00000302400 LVSLVTSVTNVDLPPKESSI------ O13102_Carassius_auratus LLSTVTSLTNVDLSPKESRI------ Q9YGU4_Brachydanio_rerio LFSMVTSLTNVDLPPKESSI------ ENSMUST00000028096 IVTVVTMVTNVDFPPKESSL------ ENST00000241416 IVTVVTMVTNVDFPPKESSL------ CG7904-RA --LLIKNHTNIDDAKESTNCL----- ci0100135103 SDVEDKIRVKAKNESNRISEVISTVV . .