CLUSTAL W (1.82) multiple sequence alignment


ENST00000321068         MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACL------
ENSMUST00000042498      MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEENDPPTYKDAFPPLPEKAACL------
SINFRUP00000137357      MSSVAVLTQEIFNEHRSGLLPEQSNGTSVG-EEEDALPTYKEAFPPLPEKAASP------
SINFRUP00000158862      MSSVAVLTPESFAEHRSGLKDQEIP--GCVPEDEAYIPTYLEAFPPLPEKGAPG------
ci0100149712            MNSVDSAQTSGANDVGN--------------NDTEVIPTYSEAFPPLAGDHENV------
CG5170-RC               MQAAAVMEETNNATTIEQQPIALINGQEQVANEQQPSSPTSVATPTSTTSGGTGNATPAF
                        *.:.            .              ::    ..   * *. . .          

ENST00000321068         ------------ESAQEPAGAWGNKIRPIKASVITQVFHVPLEERKYKDMNQFGEG--EQ
ENSMUST00000042498      ------------ESAQEPAGAWSNKIRPIKASVITQVFHVPLEERKYKDMNQFGEG--EQ
SINFRUP00000137357      ------------EGTQETANAWTSKIRSLKSSIITQVFHVPLEERKYKDISQFGEG--DQ
SINFRUP00000158862      ------------EKAGEPAPAWGSKIRPIKASVITQVFHVPLEERRYKDNSQFGEG--EE
ci0100149712            ------------PTTSSENQWLNPKVQRIRSTVVTQIFHIPMEERAFKQ-SEFGQSQKDQ
CG5170-RC               SYDDLFPALPANTSAQSQSGASGSTLARVTSSQKTHIVHVPCKERKSTESEKFGEG--ES
                                      : .       .:  : ::  *::.*:* :**  .: .:**:.  :.

ENST00000321068         AKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKE
ENSMUST00000042498      AKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVPIPKE
SINFRUP00000137357      AKVCVDIMQKTGAHLELSLAKDQGLSIMVSGKMDAVMKARKEIVSRLQTQASTTVAIPKE
SINFRUP00000158862      AKVCLDIMQRTGAHIELSLAKDQGLSIMVTGKLDNVMKARKEIVARLQTQASATVAIPKE
ci0100149712            SKVCIDIMRITDTMIEMSTCRDGSLSLLVSGKAENVLKARREIFNKLQTQACVTVNIPKE
CG5170-RC               KRICQQITKETGAQIEIVSGKNQSLTFLIKGKQSELLDARRKILMGFSTQASRQVTVPRE
                         ::* :* : *.: :*:   :: .*::::.** . ::.**:.*.  :.***.  * :*:*

ENST00000321068         HHRFVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQD
ENSMUST00000042498      HHRFVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQD
SINFRUP00000137357      HHRFVIGKNGEKLQELELKTATKIQIPRPDDLSNQIKISGTKEGLEKAKHEILLISAEQD
SINFRUP00000158862      HHRFVIGKNGEKLQELELKTATKIAIPRPDDPSANIRITGTKEGIEKARHEILLISAEQD
ci0100149712            HHRVILGKAGSRLQKLELETATKINIPRSEKQSTEITIVGTQEGIHRARQEIQMISDEQA
CG5170-RC               HFRVILGKGGQRLREIERVTATRINIPSQSDESEFITIAGTKEGIAQAEQEIRQLSAEQY
                        *.*.::** *.:*:.:*  ***:* **  .. *  * * **:**: :*.:*:  :* ** 

ENST00000321068         KRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQA
ENSMUST00000042498      KRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQA
SINFRUP00000137357      KRAVERVNIDKVYHPFITGAYNKLVGELMQETGARINVPPPSVNKTEVVITGEKEQVALA
SINFRUP00000158862      KRAVERLSLEKVFHPFIAGAHNRLVQELGQETGARISVPPPSLPKDEIVITGEKEAVALA
ci0100149712            KLAMERLPIEKMYHPFINGPRNEFASKLSKEHGVRIHIPPPSVQKDEVVVSGERDGVAAA
CG5170-RC               KKSSDRITVPKVYHPFIVGPYSENLNKLQEETGARINVPPQQVQKDEIVISGEKDAVAAA
                        * : :*: : * :**** *. ..   :: :* *.** :** .: : *:*.:**:: :* *

ENST00000321068         VARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISET
ENSMUST00000042498      VARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISET
SINFRUP00000137357      IVMIKKIFEEKKKNTTTIAVEVKKSQHKYVIGPKGNTLQKILDKTGVSVEIPPSDSSSET
SINFRUP00000158862      LNRIRAIYEDKKRKTTTISVEVKKSQHKYIIGPKGNTLQEILEATGVSVEMPPLDSSSET
ci0100149712            VNKIMMVYQQKSRNCKTISVEINKSQHKYIIGPRGQTLQDILAEADVSVELPPTDSLSET
CG5170-RC               KAKVEAIYKDMEKKCSTVSVEVAKPKHRYVIGPKGSTIAEILQLTGVSVEMPPNDSPSET
                           :  :::: .:: .*::**: *.:*:*:***:*.:: .**  :.****:** ** ***

ENST00000321068         VILRGEPEKLGQALTEVYAKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIE
ENSMUST00000042498      VILRGEPEKLGQALTEVYAKANSFTVSSVSAPSWLHRFIIGKKGQNLAKITQQMPKVHIE
SINFRUP00000137357      IILRGEPDRLGQALTEVYAKANSYTIGMVSAPSWLHRFIIGKKGQNLAKITQQMPKVHIE
SINFRUP00000158862      IILRGEPDKLGPALTQVYAKAKSVMVVEVTAPAWLHRFIIGKKGQNIGRITQQLPRVHIE
ci0100149712            VVLRGEPGKLGQGLTIVYAKANSVVIREVSAAAWLHRFIIGKKGANIRAITSNLPRVNVE
CG5170-RC               ITLRGPQVALGNALTVVYQKSNSVKSVEINAAHWIHKYVIGRKGANMKQLEEDCPNVNVN
                        : ***    ** .** ** *::*     : *. *:*:::**:** *:  : .: *.*:::

ENST00000321068         FTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINR
ENSMUST00000042498      FTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINR
SINFRUP00000137357      FTEGEDRITLEGPTKDVQMVQSQIEVTVADLISRMDYTEITVDPKFHRHLIGKGGVNINR
SINFRUP00000158862      FTDGEERICLEGPTEEVEQAQAQIQEIIKDLLVRMDYTEVIIDQRFHRHLIGKNGTNINR
ci0100149712            FQDEGNKIVIEGPPEEADPAQQQLELQVKELKARMDFAEVHIDPKFHKNIIGKGGQSINK
CG5170-RC               CLED--KIKLEGDPENVDRAVAYLSEIIKNYEENFTFEVMTVNPSYYKHIIGKAGANVNR
                          :   :* :** .::.: .   :.  : :   .: :  : ::  :::::*** * .:*:

ENST00000321068         IKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHR
ENSMUST00000042498      IKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHR
SINFRUP00000137357      IKELHKVTVRIPPDNEKSNLIRIEGDPQGVQEAKKELLELASRMENERTKDLIIEQRFHR
SINFRUP00000158862      IKEQYKVSVRIPQDSERSNLVRIEGDPKGVQLARRELSEMVQRMENERTKDLIVDQKFHR
ci0100149712            LRDQYNVNIQIPTDTDKSSLIRIEGDPEGVKEAKKELEQMGQRLENEKSKDVLIEHRFHR
CG5170-RC               LKDELKVNINIE-EREGQNNIRIEGPKEGVRQAQLELQEKIDKLENEKSKDVIIDRRLHR
                        :::  :*.:.*  : : .. :****  :**: *: ** :  .::***::**:::::::**

ENST00000321068         TIIGQKGERIREIRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVEN
ENSMUST00000042498      TIIGQKGERIREIRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVEN
SINFRUP00000137357      AIIGQKGEKIKEVRDKFPEVIINFPDPAQKSDIVQLRGPRNEVEKCAKFMQKIVAEMVEN
SINFRUP00000158862      TIIGQKGEKIKEVRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCAKFLQKIIADLIEN
ci0100149712            NIIGQKGEKVKAIRDLFPKVNISFPDAKKKSDVVNLRGPKNDVEKCYKYLKQLNDDMVEK
CG5170-RC               SIIGAKGEKIREVKDRYRQVTITIPTPQENTDIVKLRGPKEDVDKCHKDLLKLVKEIQES
                         *** ***::: ::* : :* *.:* . :::*:*:****:::*:** * : ::  :: *.

ENST00000321068         SYSISVPIFKQFHKNIIGKGGANIKKIREESNTKIDLPAENSNSETIIITGKRANCEAAR
ENSMUST00000042498      SYSISVPIFKQFHKNIIGKGGANIKKIREESNTKIDLPAENSNSETIIITGKRANCEAAR
SINFRUP00000137357      SYSVSVPIFKQFHRNIIGKGGSNIKKIREETNTKIDLPAENSNSEMIVITGKKANCEAAR
SINFRUP00000158862      SFSLSVPIFKQFHKNIIGKGGANIKKIREETNTKIDLPTENSNSEMIVITGKKGNCEAAR
ci0100149712            NYCIDVPIFKQYHKNIIGKGGANIRKIREETNTQIELPKEDSDNEVIVITGKKADCEKAR
CG5170-RC               SHIIEVPIFKQFHKFVIGKGGANIKKIRDETQTKIDLPAEGDTNEVIVITGKKENVLEAK
                        .. :.******:*: :*****:**:***:*::*:*:** *.. .* *:****: :   *:

ENST00000321068         SRILSIQKDLANIAEVEVSIPAKLHNSLIGTKGRLIRSIMEECGG-VHIHFPVEGSGSDT
ENSMUST00000042498      SRILSIQKDLANIAEVEVSIPAKLHNSLIGTKGRLIRSIMEECGG-VHIHFPVEGSGSDT
SINFRUP00000137357      NRVLAIQKELANITEMEVSIPSKLHNSLIGSKGRFVRSIMEECGG-VHIHFPTEGSGNDK
SINFRUP00000158862      ERILGIQRELANIKEAEVVIPARLHNSLIGSKGCLVRSIMDDCGG-VHIHFPSEGSGSDR
ci0100149712            KLIRAIEREQANIVEESVTINPQLHNQLIGAKGRLVRSLMDDYGGNVQIHFPMGSSGSDK
CG5170-RC               ERIQKIQNELSDIVTEEVQIPPKYYNSIIGTGGKLISSIMEECGG-VSIKFPNSDSKSDK
                        . :  *:.: ::*   .* * .: :*.:**: * :: *:*:: ** * *:**  .* .* 

ENST00000321068         VVIRGPSSDVEKAKKQLLHLAEEKQTKSFTVDIRAKPEYHKFLIGKGGGKIRKVRDSTGA
ENSMUST00000042498      VVIRGPSSDVEKAKKQLLHLAEEKQTKSFTVDIRAKPEYHKFLIGKGGGKIRKVRDSTGA
SINFRUP00000137357      VTIRGPVEEVAKAKQQLLALAEEKQTKNFTAELQAKPEYHKFLIGKGGGNIRKVRDSTGA
SINFRUP00000158862      VTIRGPLGEVEKAKKQLLQLAEEKQVNNFTAELQAKPEYHKFLIGRGGANIRRVRDRTGA
ci0100149712            VTIRGPKEEVEKAKDQLMQIAKQKELSSYTKELKCKAELHRFLIGRGGTTIKKVRDETGA
CG5170-RC               VTIRGPKDDVEKAKVQLLELANERQLASFTAEVRAKQQHHKFLIGKNGASIRKIRDATGA
                        *.****  :* *** **: :*::::  .:* :::.* : *:****:.* .*:::** ***

ENST00000321068         RVIFPAAEDKDQDLITIIGKEDAVREAQKELEALIQNLDNVVEDSMLVDPKHHRHFVIRR
ENSMUST00000042498      RIIFPAAEDKDQDLITIIGKEDAVREAQKELEALIQNLENVVEDYMLVDPKHHRHFVIRR
SINFRUP00000137357      RIIFPTADDKDQELITVIGTEEAVQEAQKELEELIK------------------------
SINFRUP00000158862      RIIFPSPDDTEQELITIVGKEEAVRQAQKELENLVKNLDDVVEDGMEVDVRHHRHFVCRR
ci0100149712            RIMFPASNDTDKETITVMGKQADVDTACKILEERIKSMENIVEIEMEIEQKHHKYFVARR
CG5170-RC               RIIFPSNEDTDKEVITIIGKEESVKKAREQLEAIIKECDEVTEGEVSVDPKHHKHFVAKR
                        *::**: :*.::: **::*.:  *  * : **  ::    :    : :       ::   

ENST00000321068         GQVLREIAEEYGGVMVSFPRSGTQSDKVTLKGAKDCVEAAKKRIQEIIEDLEAQVTLECA
ENSMUST00000042498      GQVLREIAEEYGGVMVSFPRSGTQSDKVTLKGAKDCVEAAKKRIQEIIEDLEAQVTVECA
SINFRUP00000137357      -------------------------GLVSLRTTTGGGGGTKKRMQEIVEDLDAQVTVECV
SINFRUP00000158862      GQVLRELAEEYGGVAVSFPRTGVNSQRVTLKGAKECVEAAKKRIQEIIEDLESQVTVEVA
ci0100149712            GAVLRDIADEFGGVAVSFPRIGDESSTVRIKGPSECVEGAKSKLAELVDDLDNQVTIECL
CG5170-RC               GFILHRISEECGGVMISFPRVGINSDKVTIKGAKDCIEAARQRIEEIVADLEAQTTIEVV
                          ::  :      : : :         * :: ..    .::.:: *:: **: *.*:*  

ENST00000321068         IPQKFHRSVMGPKGSRIQQITRDFSVQIKFPDREENAVHS--TEPVVQENGDE----AGE
ENSMUST00000042498      IPQKFHRSVMGPKGSRIQQITRDYNVQIKFPDREENPVHS--VEPSIQENGDE----AGE
SINFRUP00000137357      IPQKFHRSIMGPKGSRIQQITRDHNVLIKFPEREDLQAPS--ADIAVKENGET----NGE
SINFRUP00000158862      IAQRYHRAIMGPKGCRIQHITREHEVQIKFPERDD-SAAG--QDAFLHENGEV----GPE
ci0100149712            VDEQYHRTVIGQKGRNIQGVTSQYNVQVKFPSRNNAPANG--DKGEVVENGTN----EEE
CG5170-RC               IPQRHHRTIMGARGFKVQQVTFEFDVQIKFPDRDATEPVEGLTNGGSGENGGENEGQEGE
                        : ::.**:::* :* .:* :* :..* :***.*:         .    ***        *

ENST00000321068         GREAKDCDPGSPRRCDIIIISGRKEKCEAAKEALEALVPVTIEVEVPFDLHRYVIGQKGS
ENSMUST00000042498      GREAKETDPGSPRRCDIIIISGRKEKCEAAKEALEALVPVTIEVEVPFDLHRYIIGQKGS
SINFRUP00000137357      LKEA--LDPNAPKKCDVIVISGRKERCDTALEALKALVPVTIEVEVPFELHRYIIGQKGS
SINFRUP00000158862      --------EFIPRKCDIITISGRAEKCELAKAALLALVPITEDVEVSYELHRFIIGQKGS
ci0100149712            -------------NKDLILITGHKDRCQKAKEAILALVPISEQVDVPYKFHRYIIGQKGL
CG5170-RC               QEVEKEAEQEPVRQCDVIRITGRIEKCEAAKQALLDLIPIEEELSVPFDLHRTIIGPRGA
                                     . *:* *:*: ::*: *  *:  *:*:  ::.*.:.:** :** :* 

ENST00000321068         GIRKMMDEFEVNIHVPAPELQSDIIAITGLAANLDRAKAGLLERVKELQAEQEDRALRSF
ENSMUST00000042498      GIRKMMDEFEVNIHVPAPELQSDTIAITGLAANLDRAKAGLLDRVKELQAEQEDRALRSF
SINFRUP00000137357      GIRKMMDEFEVNIQVPAPDQQSHNIYITGLASQLDRAKEGLLERVKELQAEQEDRALRSY
SINFRUP00000158862      GIRKMMEEYEVNIWVPQPEKQLDVIKVTGLAANVERAKQGLLERVKELQAEQEDRALRSF
ci0100149712            GVRKLMEDYDITISIPPADQNSNFITITGVSSKLEAAKEGLMERVKVIEGEEEDRVLRGF
CG5170-RC               NVRQFMSKHDVHVELPPSELKSDVIKVCGTPARVAEAREALVKMIEDYEADRADRELRSF
                        .:*::*...:: : :* .: : . * : * .:.:  *: .*:. ::  :.:. ** **.:

ENST00000321068         KLSVTVDPKYHPKIIGRKGAVITQIRLEHDVNIQFPDKDDGNQPQDQITITGYEKNTEAA
ENSMUST00000042498      KLSVTVDPKYHPKIIGRKGAVITQIRLEHEVNIQFPDKDDGNQPQDQITITGYEKNTEAA
SINFRUP00000137357      RLTMTVDPKYHPKIIGRKGAVITNIRTEHDVNIQFPEKND--ESQDQITITGYELKAIAA
SINFRUP00000158862      KVTMTVDPKFHPKIIGRKGAVISQIRRDHDVNIQFPDKGD--EDQDLIVISGYERNVEEA
ci0100149712            TLTVDVPNQYHPQIIGRRGVTVTDIRNKHSVNIQFPDRDD--EKKDQIRIIGYEKNTESA
CG5170-RC               VLQVDVDTEFHSKLIGRHGAVINKLRADHDVIISLPKRDE--PNDRIISITGYQANAEAA
                         : : *  ::*.::***:*..:..:* .*.* *.:*.:.:    .  * * **: :.  *

ENST00000321068         RDAILRIVGELEQMVSEDVPLDHRVHARIIGARGKAIRKIMDEFKVDIRFPQSGAPDPNC
ENSMUST00000042498      RDAILKIVGELEQMVSEDVPLDHRVHARIIGARGKAIRKIMDEFKVDIRFPQSGAPDPNC
SINFRUP00000137357      RDAIQAIVDELEEMISEDITLDSRVHARIIGARGKGIRKIMDEFKVDLRFPPTGAADPNL
SINFRUP00000158862      RRTIQQLVAELQEMVSQDVHLDPRTHARIIGARGKAIRKLMEEFKVDIRFPPPGSDEPDK
ci0100149712            RDAVMKIVNELESHISQDIHIDRKVHPRLIGTKGRAIKKIMEDFGVDIRFPK----DEDI
CG5170-RC               RDAILEIVGDPETLHREVIEIDKRIHPHLIGQRRRTIRKIIEDNKVNIKFSAD-DDNPNS
                        * ::  :* : :    : : :* : *.::** : : *:*::::  *:::*.     : : 

ENST00000321068         VTVTGLPENVEEAIDHILNLEEEYLADVVDSEALQVYMKP-----------PAHEEAKAP
ENSMUST00000042498      VTVTGLPENVEEAIDHILNLEEEYLADVVDSEALQVYMKP-----------PAHEESRAP
SINFRUP00000137357      VTVIGRPELVDEAIDHLLNLEEEYMADVVENEAKMAYRRPAA---------SAADEHRGP
SINFRUP00000158862      VTVMGLPDTVDNAIDHLLNLEEEYMLNLTETETLAAYMKPPSRYGGAGGAGGMDDSGGGP
ci0100149712            VTVTGALEKVDECVEHILNLEEEYMQDIAEQEETKRYSHSTYQ--------GNEKSSRST
CG5170-RC               IFISGKIEDVENVKELLFGMAEDYERDYLDNVAIAPPTIGAFLTGQ-----GSGSDAAGA
                        : : *  : *::  : ::.: *:*  :  :                        ..  ..

ENST00000321068         SRG-FVVRDAPWT---ASSSEKAPDMSSSEEF--PSFGAQ---VAPKTLPWGPKR
ENSMUST00000042498      SKG-FVVRDAPWT---SNSSEKAPDMSSSEEF--PSFGAQ---VAPKTLPWGPKR
SINFRUP00000137357      SKG-FVVREAPWA---TAN-EKAPDMSSSEDF--PSFGAP---VATKASPWGPKR
SINFRUP00000158862      AKG-FVVRDAPWN---TSGNK----------------------------------
ci0100149712            NKAPFVVRDAPWH---QPGSVDTNNLEEFPSLGGPSSGNK---SSSAAPAWGRRY
CG5170-RC               SENGFVIKDAPWEKQKQAKNLTAPNTQSQEDFPHFAAGGAPVASTPITSVWGPKN
                         .  **:::***