CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000059811 -----------------------------MASPPDTDG---------------------- ENST00000305123 -----------------------------MASPPESDG---------------------- SINFRUP00000134170 ----------------------------------EPQN---------------------- SINFRUP00000158846 ------------------------------------DS---------------------- ENSMUST00000040514 ------------------------MASAPLPGPPASAGGDGPNLNN-------------- ENST00000247066 MASCSFTRDQATRRLRGAAAAAAAALAAVVTTPLLSSGTPTALIGTGSSCPGAMWLSTAT ENSMUST00000057314 -------------------------MKPAGTGPTVSSGGECTDVSLGSPFP--------- CG5686-RA ------------------------------MASISDDG---------------------- . ENSMUST00000059811 ---------------FSDVRKVGYLRKPKSMHKRFFVLR-------AASEAGG----PAR ENST00000305123 ---------------FSDVRKVGYLRKPKSMHKRFFVLR-------AASEAGG----PAR SINFRUP00000134170 ---------------YEDVQKSGYLRKHKSMHRRFFVLR-------AASEHG-----PAR SINFRUP00000158846 ---------------CEDVRRSGYLRKQKSMHRRYFVLR-------AASERG-----PAR ENSMUST00000040514 ----------NNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGTGGDEASAAGGSPPQPPR ENST00000247066 GSRSDSESEEEDLPVGEEVCKRGYLRKQKHGHRRYFVLK--------LETADA----PAR ENSMUST00000057314 ------------WPCLPDVRLCGHLRKQKSQRRRFFVLR--------AD--------PPR CG5686-RA ------------------MALSGYLKKLKTMKKKFFVLY--------EETSTS----AAR : *:*:* * ::::*** . ..* ENSMUST00000059811 LEYYENEKKWR--------------HKSSAP-----KRSIPLESCFNINKRADSKNKHLV ENST00000305123 LEYYENEKKWR--------------HKSSAP-----KRSIPLESCFNINKRADSKNKHLV SINFRUP00000134170 LEYYENEKKFR--------------SKSPVP-----KKVLNLETCFNINKRADSKNKHMI SINFRUP00000158846 LEYYESEKKFR--------------GKAPVP-----KKAVALETCFNINKRADSKNKHMI ENSMUST00000040514 LEYYESEKKWR--------------SKAGAP-----KRVIALDCCLNINKRADAKHKYLI ENST00000247066 LEYYENARKFRHSVRAAAAAAAAAASGAAIPPLIPPRRVITLYQCFSVSQRADARYRHLI ENSMUST00000057314 LECYESEKKF-------------LASGCRPP---RPRRTVSLEGACTISKRADARQRHLI CG5686-RA LEYYDTEKKFL---------------QRAEP-----KRVIYLKNCFNINRRLDTKHRFVI ** *:. :*: * :: : * . .:.:* *:: :.:: ENSMUST00000059811 ALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKAHHDGAG----GGCGGSCSGSSG--V ENST00000305123 ALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGHHDGAAALGAGGGGGSCSGSSG--L SINFRUP00000134170 VLYTRSESFAIAADSEEIQNEWYQAMLDL------------------------------- SINFRUP00000158846 VLYTRAESFALAAENEADQDEWYQAMVDLQCKSK-------------------------- ENSMUST00000040514 ALYTKDEYFAVAAENEQEQEGWYRALTDLVSEGRSGEGGSGTTG-GSCSASLPGVLGGSA ENST00000247066 ALFTQDEYFAMVAENESEQESWYLLLSRLILESKRRRCGTLGAQPDGEPAALAAAAA--- ENSMUST00000057314 VIYTSDSSLGVAAASEAEQQAWYSALLEVRATAAAAAATAMGFSPQEAPESWIFAP---- CG5686-RA VLSSRDGGFGIVLENENDLRKWLDKLLVLQRNIANSNGTAHSP----------------- .: : :.:. .* * : : ENSMUST00000059811 GEAGEDLSY-DTGPG-PAFKEVWQVILKPKGLGQTKNLI-GIYRLCLTSKTISFVKLN-- ENST00000305123 GEAGEDLSYGDVPPG-PAFKEVWQVILKPKGLGQTKNLI-GIYRLCLTSKTISFVKLN-- SINFRUP00000134170 ------------------------------------------------------------ SINFRUP00000158846 ------------------------------------------------------------ ENSMUST00000040514 GAAGCDDNYGLVTPATAVYREVWQVNLKPKGLGQSKNLT-GVYRLCLSARTIGFVKLN-- ENST00000247066 -------------AEPPFYKDVWQVIVKPRGLGHRKELS-GVFRLCLTDEEVVFVRLN-- ENSMUST00000057314 ------------------FQDVWPVTLRSKGLGRAQGLSSGSYRLCLGSGALSLLRKPGS CG5686-RA ------------------YDHVWQVVIQKKGISEKVGIT-GTYHCCLTSKSLTFVCIGPE ENSMUST00000059811 --------SEAAAVVLQLMNIRRCGHS--ENFFFIEVGRSAVTGPGEFWMQVDDSVVAQN ENST00000305123 --------SEAAAVVLQLMNIRRCGHS--ENFFFIEVGRSAVTGPGEFWMQVDDSVVAQN SINFRUP00000134170 ------------------------------------------------------------ SINFRUP00000158846 ------------------------------------------------------------ ENSMUST00000040514 --------CEQPSVTLQLMNIRRCGHS--DSFFFIEVGRSAVTGPGELWMQADDSVVAQN ENST00000247066 --------TEVASVVVQLLSIRRCGHS--EQYFFLEVGRSTVIGPGELWMQVDDCVVAQN ENSMUST00000057314 KGSRDSRATPPPVLRLSLLSVRRCGHA--DSFFFLELGRSAPIGPGELWLQAPDAVVAQS CG5686-RA KTP--NGEDRVASIEILLTTIRRCGHASPQCIFYVELGRQSVLGSGDLWMETDNAAIATN ENSMUST00000059811 MHETILEAMRAMSD--EFRPRSKSQSS-SSCSNPISVP--LRRHHLNNPPPSQVGLTRRS ENST00000305123 MHETILEAMRAMSD--EFRPRSKSQSS-SNCSNPISVP--LRRHHLNNPPPSQVGLTRRS SINFRUP00000134170 ------------------------------------------------------------ SINFRUP00000158846 ------------------------------------------------------------ ENSMUST00000040514 IHETILEAMKALKELFEFRPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRS ENST00000247066 MHELFLEKMRALCAD-EYRARCRSYSISIGAHL---LTLLSARRHLGLVPLEPGGWLRRS ENSMUST00000057314 IHETVLAAMKRLGS---------------------------------------------- CG5686-RA MHNTILSAMSAKTES--------------------------------------------- ENSMUST00000059811 RTESITATSPASMVGGKPGSFRVRASSDGEGTMS--------RPASVDGSPVSPSTNRTH ENST00000305123 RTESITATSPASMVGGKPGSFRVRASSDGEGTMS--------RPASVDGSPVSPSTNRTH SINFRUP00000134170 ------------------------------------------------------------ SINFRUP00000158846 ------------------------------------------------------------ ENSMUST00000040514 RTDSLAATPPA----AKCTSCRVRTASEGDGGAAGGAGTAGGRPMSVAGSPLSPGPVRAP ENST00000247066 RFEQF---------------CHLRAIGDGEDEMLFTRRFVTPSEPVAHSRRGRLHLPRGR ENSMUST00000057314 -----------------------NAAGKAEP------------------------PPQGN CG5686-RA -------------------NTNLINVYQNRPDLSHEPMRKRSSSANEASKPINVNVIQNS ENSMUST00000059811 AHR----------HRGSSRLHPP--LINHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGS ENST00000305123 AHR----------HRGSARLHPP--LN-HSRSIPMPASRCSPSATSPVSLSSSSTSGHGS SINFRUP00000134170 ------------------------------------------------------------ SINFRUP00000158846 ------------------------------------------------------------ ENSMUST00000040514 LSRSHTLSAGCGGRPSKVTLAPAGGALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGS ENST00000247066 RSR---------------RAVSVPASFFRRLAPSPARPRHPAEAPNNGARLSSEVSGSGS ENSMUST00000057314 PPK---------------SVPAAPTPTPYEIPASAAQARSPSERAKQDYFKPLERMGSTH CG5686-RA QNS----------LELRSCSSPHNYGFGRERCDSLPTRNGTLSESSNQTYFGSNHGLRSN ENSMUST00000059811 T----------------SDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFR--SSFRS ENST00000305123 T----------------SDCLFPRRSSASVSGSPSDGGFISSDEYGSSPCDFR--SSFRS SINFRUP00000134170 ------------------------------------------------------------ SINFRUP00000158846 ------------------------------------------------------------ ENSMUST00000040514 YPLPPGSHPHLPHPLHHPQGQRPSSGSASASGSPSDPGFMSLDEYGSSPGDLRAFSSHRS ENST00000247066 GNFGEEGNPQGKEDQEGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHSSGGNQCSGE ENSMUST00000057314 SYKG-----------LDLGGNYITMG---------------------------------- CG5686-RA TISG-----------IRPHSTNKHSNSPTFTMPLRCSESEESSISVDESDDNGSFSHYRL ENSMUST00000059811 VTPDSLGHTPPARGEEELSNYICMGGKGASTLAAPNGHYILSRGGNGHRYIPGANLGTSP ENST00000305123 VTPDSLGHTPPARGEEELSNYICMGGKGPSTLTAPNGHYILSRGGNGHRCTPGTGLGTSP SINFRUP00000134170 ------------------------------------------------------------ SINFRUP00000158846 ------------------------------------------------------------ ENSMUST00000040514 NTPESIAETPPARDGSGGELYGYMSMDRP-----------LSHCGRPYRRVSGD------ ENST00000247066 GQ-GSRGGQGSNGQGSGGNQCSRDGQGTAGGHGSGGGQRPGGGHGSGGGQGPGDGHGSGG ENSMUST00000057314 ----------------VRNDYVHMGGGEAG------------------------------ CG5686-RA NTRSSETAIPEENIDDFASAELFSKVTEQN------------------------------ ENSMUST00000059811 ALPGDEAAGAADLDN-------RFRKRTHSAGTSPTISHQKTPSQSSVASIEEYTEMMPA ENST00000305123 ALAGDEAASAADLDN-------RFRKRTHSAGTSPTITHQKTPSQSSVASIEEYTEMMP- SINFRUP00000134170 ------------------------------------------------------------ SINFRUP00000158846 ------------------------------------------------------------ ENSMUST00000040514 --------GAQDLDR-------GLRKRTYSLTTP---ARQRQVPQPSSASLDEYTLMRAT ENST00000247066 GKNSGGGKGSGSGKGSDGDGERGKSLKKRSYFGKLTQSKQQQMPPPPPPPPPPPPAGGTG ENSMUST00000057314 ------------------------------------------------------------ CG5686-RA ------------------------------------VSDENYIPMNPVNPTDAIHEKEKA ENSMUST00000059811 AYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEMHHLERRGGHHRPDTSNLHTDDGYMPMS ENST00000305123 AYPPGGGSGGRLPGHRHSAFVPTRSYPEEGLEMHPLERRGGHHRPDSSTLHTDDGYMPMS SINFRUP00000134170 ------------------------------------------------------------ SINFRUP00000158846 ------------------------------------------------------------ ENSMUST00000040514 FSGSSGRLCPSFPAS--SPKVAYNPYPEDYG-----DIEIGSHKSSSSNLGADDGYMPMT ENST00000247066 GKGKSGGRFRLYFCVDRGATKECKEAKEVKDAEIPEGAARGPHRARAFDEDEDDPYVPMR ENSMUST00000057314 ------------------------------------------------------------ CG5686-RA DMQRLEDASLHFNFPEHASEKLAKDFDLDSD----------------------------- ENSMUST00000059811 PGVAPVPSNRK--GNGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMMSPSGSC--S ENST00000305123 PGVAPVPSGRK--GSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMMSPSGGC--S SINFRUP00000134170 ------------------------------------------------------------ SINFRUP00000158846 ------------------------------------------------------------ ENSMUST00000040514 PGAALRSGGPNSCKSDDYMPMSPTSVSAPKQILQP--RLAAALPPSGAAVPAPPSGVGRT ENST00000247066 PGVA-----TPLVSSSDYMPMAPQNVSA----SKKRHSRSPFEDSRGYMMMFP------- ENSMUST00000057314 ------------------------------------------------------------ CG5686-RA --------------NQCCRPIRAYSIGNKVEHLKFNKRLGHLNDTGQNPNRVR------- ENSMUST00000059811 PDIGGG-SSSSSSISAAPSGSSYGKPWTNGVGGHHTHALPHAKPPVESGGGKLLPCTGDY ENST00000305123 PDIGGGPSSSSSSSNAVPSGTSYGKLWTNGVGGHHSHVLPHPKPPVESSGGKLLPCTGDY SINFRUP00000134170 ------------------------------------------------------------ SINFRUP00000158846 ------------------------------------------------------------ ENSMUST00000040514 FPVNGGGYKASSPAESSPEDSGYMRMWCG------------SKLSMENPDPKLLP-NGDY ENST00000247066 -------RVSPPPAPSPPKAPD----------------------TNKEDDSKDNDSESDY ENSMUST00000057314 ----------------------------------------------------------DY CG5686-RA ---------------------------------------------AYSVGSKSKIPRCDL ENSMUST00000059811 MNMSPVGDSNTSSPSEC----YYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGARHQH ENST00000305123 MNMSPVGDSNTSSPSDC----YYGPEDPQHKPVLSYYSLPRSFKHTQRPGEPEEGARHQH SINFRUP00000134170 ------------------------------------------------------------ SINFRUP00000158846 ------------------------------------------------------------ ENSMUST00000040514 LNMSPSEAGTAGTPPDFSAALRGGSEGLKGIPGHCYSSLPRSYKAPCSCS----GDNDQY ENST00000247066 MFMAPGAGAIPKNPRNP-------QGGSSSKSWSSYFSLPNPFRSS------PLGQNDNS ENSMUST00000057314 MWMAP-----PGLPPTP-------ARADPNK---------------------QLEDCEST CG5686-RA QRVVLVEDNKHEFTANR-------SQSSITKEGTSYGSSANRQKKSTSAPLLSLKNQINS ENSMUST00000059811 LRLSSSSGRLRYTATAEDSSSSTSSDSLGGGYCGARPESSLTHPHHHVLQPHLPRKVDTA ENST00000305123 LRLSTSSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPSLPHPHHQVLQPHLPRKVDTA SINFRUP00000134170 ------------------------------------------------------------ SINFRUP00000158846 ------------------------------------------------------------ ENSMUST00000040514 VLMSSPVGRILEEERLEPQATPGAGTFGAAG--GSHTQPHHSAVPSSMRPSAIGGRPEGF ENST00000247066 EYVPMLPGKFLGRGLDKEVSYNWDPK-------DAASKPSGEGSFSKPGDGGSPSKPSDH ENSMUST00000057314 EYVPMN--RFLPG------PFYYELK-------ARESELGHPGAHCSLRDRWRPTVAQ-- CG5686-RA DRMSDLMEIDFSQATNLEKQKFIKNNE-----IPKYIENVFPKAPRTDSSSLTLHATSQK ENSMUST00000059811 AQTNSRLARPTRLSLGDPKASTLPRVREQQQQQQSSLHPPEPKSPGEYVNIEFGSG---- ENST00000305123 AQTNSRLARPTRLSLGDPKASTLPRAREQQQQQQPLLHPPEPKSPGEYVNIEFGSD---- SINFRUP00000134170 ------------------------------------------------------------ SINFRUP00000158846 ------------------------------------------------------------ ENSMUST00000040514 LGQRCRAVRPTRLSLEG--LQTLP-------IMQEYPLPTEPKSPGEYINIDFGEAGTRL ENST00000247066 EPPKNKAKRPNRLSFITKGYKIKPKP------QKPTHEQREADSSSDYVNMDF------- ENSMUST00000057314 -----------------------PRS------SQGSELSGDYMSIPDYVGTDS------- CG5686-RA DIFNGTKLNNTAITSEDGYLEMKPVGNGYTPSSNCLPMKVEKLKLSDYQTAPP------- ENSMUST00000059811 ---QPGYLAGPATSRSSPSVRCPPQLH-------PAPREE-TGSEEYMNMDLGPGRRATW ENST00000305123 ---QSGYLSGPVAFHSSPSVRCPSQLQ-------PAPREEETGTEEYMKMDLGPGRRAAW SINFRUP00000134170 ------------------------------------------------------------ SINFRUP00000158846 ------------------------------------------------------------ ENSMUST00000040514 SPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSSDSRQRSPLSDYMNLDFSSPKSPKP ENST00000247066 --------TKRESNTPAPSTQGLPDSWG------IIAEPRQSAFSNYVNVEFGVP-FPNP ENSMUST00000057314 --------ARLGS---------------------------LDSCLNYVDLDLVPP-LEVP CG5686-RA ------------------------------------LTATAAPVHDLNKISTYNISAEKW ENSMUST00000059811 QESGGVELGRIG-PAPPGSATVCRPTRSVPNSRGDYMTMQIG-CPRQSY-----VDTSPV ENST00000305123 QESTGVEMGRLG-PAPPGAASICRPTRAVPSSRGDYMTMQMS-CPRQSY-----VDTSPA SINFRUP00000134170 ------------------------------------------------------------ SINFRUP00000158846 ------------------------------------------------------------ ENSMUST00000040514 STRSGDTVGSMDGLLSPEASSPYPPLPPRPSTSPSSLQQPLPPAPGDLYRLPPASAATSQ ENST00000247066 ANDLSDLLRAIPRANPLSLDSARWPLPPLPLSATGSNAIEEEGDYIEVIFNSAMTPAMAL ENSMUST00000057314 G--------AAPGKSPHSYASIKF------------------------------------ CG5686-RA REQPSRSEEKKSNSPLNDNTFSSKPTNVESTSKSHDVHSANQIDCEKVCAQSSDKLNNHL ENSMUST00000059811 APVSYADMRTGIAAEKASLPRPTGAAPPPSSTASSSVTPQGA-TAEQATHSSLLGGPQGP ENST00000305123 APVSYADMRTGIAAEEVSLPRATMAAASSSSAASASPTGPQG-AAELAAHSSLLGGPQGP SINFRUP00000134170 ------------------------------------------------------------ SINFRUP00000158846 ------------------------------------------------------------ ENSMUST00000040514 GPTAGSSMSSEPGDNGDYTEMAFGVAATPPQPIVAPPKPEGARVASPTSGLKRLSLMDQV ENST00000247066 ADSAIR-YDAETGRIYVVDPFSECCMDISLSPSRCSEPPPVARLLQEEEQERRRPQSRSQ ENSMUST00000057314 ------------------------------------------------------------ CG5686-RA ADKIVENNNLDIGGHEE----KKLVHSISSEDYTQIKDKSNDFTKFNEAGYKILQIKSDS ENSMUST00000059811 GGMSAFTRVNLSPNHNQSAKVIRADTQGCRRRHSSETFSAP---TRAGNTVPFGAG---- ENST00000305123 GGMSAFTRVNLSPNRNQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAG---- SINFRUP00000134170 ------------------------------------------------------------ SINFRUP00000158846 ------------------------------------------------------------ ENSMUST00000040514 SGVEAFLQVSQPPDPHRGAKVIRADPQGGRRRHSSETFSSTTTVTPVSPSFAHNSKRHNS ENST00000247066 SFFAAARAAVSAFPTDSLERDLSPSSAPAVASAAEPTLALSQVVAAAS------------ ENSMUST00000057314 ------------------------------------------------------------ CG5686-RA SLISSKLYQKGIHKDNLERSQRLTESVNTIPDNATATAVSSSSLTKFN------------ ENSMUST00000059811 ---------AAVGGSGGGGGGGSEDVKRHSSASFENVWLRPGDLGGVSKESAPVCGAAGG ENST00000305123 ---------AAVGG-GGGSSSSSEDVKRHSSASFENVWLRPGELGGAPKEPAKLCGAAGG SINFRUP00000134170 ------------------------------------------------------------ SINFRUP00000158846 ------------------------------------------------------------ ENSMUST00000040514 ASVENVSLRKSSEGSSTLGGGDEPPTSPGQAQPLVAVPPVPQARPWNPGQPGALIGCPGG ENST00000247066 ---------ALAAAPGIGAAAAAAGFDSASARWFQPVANAADAEAVRGAQDVAGGSNPGA ENSMUST00000057314 ------------------------------------------------------------ CG5686-RA ---------INSAKPAAAADSRSTGTDPSTPQNILQIKDLNFPSRSSSRISQPE------ ENSMUST00000059811 ------------LEKSLNYIDLDLAK---ERSQDCPSQQQSLPPPPPHQP---LGSNEGN ENST00000305123 ------------LENGLNYIDLDLVKDFKQCPQECTPEPQPPPPPPPHQP---LGSGESS SINFRUP00000134170 ------------------------------------------------------------ SINFRUP00000158846 ------------------------------------------------------------ ENSMUST00000040514 SSSPMRRETSVGFQNGLNYIAIDVRGEQGSLAQSQPQPGDKNSWSRTRSLGGLLGTVGGS ENST00000247066 -----------------HNPSANLARGDNQAGGAAAAAAAPEPPPRSRRVPRPPEREDSD ENSMUST00000057314 ------------------------------------------------------------ CG5686-RA ----------------LHYASLDLPHCSGQNPAKYLKRGSRESPPVSACPED-------- ENSMUST00000059811 SPR--------RSSEDLSNYASISFQKQPEDRQ---- ENST00000305123 STR--------RSSEDLSAYASISFQKQPEDRQ---- SINFRUP00000134170 ------------------------------------- SINFRUP00000158846 ------------------------------------- ENSMUST00000040514 GASGVCGGPGTGALPSASTYASIDFLSHHLKEATVVK ENST00000247066 NDD---------DTHVRMDFARRDNQFDSPKRGR--- ENSMUST00000057314 ------------------------------------- CG5686-RA -----------GNTYAKIDFDQSDSSSSSSNIFNT--