CLUSTAL W (1.82) multiple sequence alignment ENST00000017003 ------------------------------------------------------------ ENSMUST00000021238 ------------------------------------------------------------ SINFRUP00000159489 ------------------------------------------------------------ ENSMUST00000032892 MVAAPCARRLARRSHSALLAALMVLLLQTLVVWNFSSLDSGAGEQRRAGAAAGAAEQQQP ENST00000261381 ------------------------------------------------------------ SINFRUP00000129411 ------------------------------------------------------------ ci0100148193 ------------------------------------------------------------ CG32300-RB ------------------------------------------------------------ ENST00000017003 ---------------------------------------MVASARVQKLVRRYKLAIATA ENSMUST00000021238 ------------------------------------------------------------ SINFRUP00000159489 ---------------------------------------MVASARVQKLLRRYKLAIAAA ENSMUST00000032892 AAPRRERRDLAAHLPAARGGPGGRAGGGGARGGGPGGARAQQPASRGALASRARDPQPSP ENST00000261381 ------------------------------------------------------------ SINFRUP00000129411 ------------------------------------------------------------ ci0100148193 ------------------------------------------------------------ CG32300-RB ----------------------------------------MEQSVSARWLKRYRAFFLIL ENST00000017003 LAILLLQGLVVWSFSGLEEDEAGEKGRQRKPRPLDPGEGSKDTDSSAGRRGSTGRRHGRW ENSMUST00000021238 ------------------------------------------------------------ SINFRUP00000159489 LTILLIQGLVVWSLRSLEEGEAERKIRRSKLPDHNIQDPKRDIALWEKHKSLPGKNRGKW ENSMUST00000032892 LITLETQDGYFSHRPKEKVRTDSNN-ENSVPKDFENVD-NSNFAPRTQKQKHQPELAKKP ENST00000261381 ------QDGYFSHRPKEKVRTDSNN-ENSVPKDFENVD-NSNFAPRTQKQKHQPELAKKP SINFRUP00000129411 ------QDIYRSHRPKEKPPQDSNNNENSVPKDFDTIDSNSNLGARSKHAKHKLDRAKAQ ci0100148193 ------------------------------------------------------------ CG32300-RB LLIVAIQLFLAYKSLDIVGGGSGSGFDAAEAPASPPPPHAQARVQPPARTKLTAQQLG-F : : ENST00000017003 RGRAESPGVPVAKVVRAVTSRQRASRRVPPAPPPEAPGRQNLSG-------------AAA ENSMUST00000021238 ------------------------------------------------------------ SINFRUP00000159489 SVRLERTGGTAASALRRGTSRKGEKSGIKPKPPQEQSVIRPGWGGGVLRDLSSSRNHSDA ENSMUST00000032892 PSRQKEHLQRKLDAQDKRQGQSVLGKGPKEVLPPREKATG-------------------N ENST00000261381 PSRQKELLKRKLEQQEKGKGHTFPGKGPGEVLPPGDRAAA-------------------N SINFRUP00000129411 SMLGKSAVHGRGHAHN----HTFGSK-PQRQVPTVSAALQ-------------------G ci0100148193 ------------------------------------------------------------ CG32300-RB QPECDILAREAISALQRAKTKDCREHIAQIACAIQAGRFYAPQLRSSCPAGNHTANVSLG ENST00000017003 GEALVGAAGFP---PHGDTGSVEGAPQPTDNGFTPKCEIVGKDALSALARASTKQCQQEI ENSMUST00000021238 ------------------------------------------------------------ SINFRUP00000159489 RSGTDGAARFPGAAVLGEPGSVDLAHQASSSDFAPKCDIIGKDALSALHRAESQHCRQEI ENSMUST00000032892 SSQGKDLSRHSHARKSGGGGSPETK-----SDQAPKCDISGKEAISALTRAKSKHCRQEI ENST00000261381 SSHGKDVSRPPHARKTGGS-SPETK-----YDQPPKCDISGKEAISALSRAKSKHCRQEI SINFRUP00000129411 SNQ-DPPSQQVEKMAVELPTGSELR-----KEQ-PQCEISGKEAISALSRAKSRGCRQQI ci0100148193 ----------------------------------PRCDITIKDSISALSRATTDRCKQQI CG32300-RB CFKDEKDRRLLAGYYSSSKTSNSPAKCVELCLQSGYPYAGVQYGRECFCGYDPPPKASKL : : ENST00000017003 ANVVCLHQAGSLMPKAVPRHCQLTGKMSPGIQWDESQAQQPMDGP----PVRIAYMLVVH ENSMUST00000021238 ------------MPKSVPRHCQLAGKMSPGVQWEEIRAQQPVGGP----PVRIAYMLVVH SINFRUP00000159489 ANIVCQHQAGQLMPGTLPQFCPQLGFSSQVQAVGELDNSLSNVEN----PVRVAFVLMVH ENSMUST00000032892 AETYCRHKLGLLMPEKVARFCPLEGKANKNVQWDE-DAVEYMPAN----PVRIAFVLVVH ENST00000261381 GETYCRHKLGLLMPEKVTRFCPLEGKANKNVQWDE-DSVEYMPAN----PVRIAFVLVVH SINFRUP00000129411 AQVYCKHKERALMPEKVPRYCPMEGKANVNVQWDE-NPGDASHPT----PVRIAFVLVVH ci0100148193 ADAACKMQDGTLFPKSMPRLVNVACSVTSLCSKFTFDAPMPTSFDPDIRPVRICYMLVVH CG32300-RB PDSSCNTKCLGNAKEICGGFYAMNIYETGIAKFTAQLAATTPSEE--TKRVRIAFLLTLN . **:.::* :: ENST00000017003 GRAIRQLKRLLKAVYHEQHFFYIHVDKRSDYLHREVVELAQGYDNVRVTPWRMVTIWGGA ENSMUST00000021238 GRAIRQLKRLLKAVYHEQHFFYIHVDKRSNYLYREVVELAQHYENVRVTPWRMVTIWGGA SINFRUP00000159489 GRAVRQLKRLIKAIYHRDHYYYIHVDKG---LFTSLTVMTRAAFNGPLFQSTCFHMCG-- ENSMUST00000032892 GRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQFSRQYDNVRVTSWRMATIWGGA ENST00000261381 GRASRQLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQVSRQYSNVRVTPWRMATIWGGA SINFRUP00000129411 GRASRQFQRLFKAIYHTSHYYYIHVDQRSSYLHREVLSLATQYPNVRVTPWRMSTIWGGA ci0100148193 GRAIRQLRRLLKVIYHRDHYYYIHVDKRSDYLLREVLKETEQYPNIKVAPWRMATIWGGS CG32300-RB GRALRQVHRLLKALYAPEHVYYIHVDERQDYLYRKLLELESKFPNIRLARKRFSTIWGGA *** **.:*::*.:* .* :*****: * .: * : : * ENST00000017003 SLLRMYLRSMRDLLEVPGWAWDFFINLSATDYPTRTNEELVAFLSKNRDKNFLKSHGRDN ENSMUST00000021238 SLLRMYLRSMKDLLEIPGWTWDFFINLSATDYPTRTNEELVAFLSKNRDKNFLKSHGRDN SINFRUP00000159489 -------------------------------FP-RTNDELIAFLSQQRDKNFLKSHGREN ENSMUST00000032892 SLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDN ENST00000261381 SLLSTYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDN SINFRUP00000129411 SLLNMYLQSMEDLLKMADWSWDFFINLSAADYPIRTNDQLVAFLSKYRNMNFIKSHGRDN ci0100148193 SLLQTLLRAISDVLRIWK-DWDFFINLSALDFPIEKDEKLVQYLSKYRDKNFMKSHGRED CG32300-RB SLLTMLLQCMEDLLQS-NWHWDFVINLSESDFPVKTLDKLVDFLSANPGRNFVKGHGRET :* .. ::*: :** . **:*.***: ENST00000017003 SRFIKKQGLDRLFHECDSHMWRLGERQIPAGIVVDGGSDWFVLTRSFVEYVVYT--DDPL ENSMUST00000021238 SRFIKKQGLDRLFHECDSHMWRLGERQIPAGIVVDGGSDWFVLTRSFVEYVVYT--DDPL SINFRUP00000159489 VRFIKKQGLDRLFHECDNHMWRLGERSIPEGLEVSGGSDWFALNRRFVEYVINS--QDDL ENSMUST00000032892 ARFIRKQGLDRLFLECDTHMWRLGDRRIPEGIAVDGGSDWFLLNRKFVEYVAFS--TDDL ENST00000261381 ARFIRKQGLDRLFLECDAHMWRLGDRRIPEGIAVDGGSDWFLLNRRFVEYVTFS--TDDL SINFRUP00000129411 ARFIRKQGLDRLFFECDTHMWRLGDRKIPEGIAVDGGSDWFLVSRPFVDYVVNS--QDEL ci0100148193 EKFIRKQGLNRVFVECDQHMWRLGERQLPEGITVNGGSDWVALNRRLCDFAVNG--NDQL CG32300-RB QKFIQKQGLDKTFVECDTHMWRIGDRKLPAGIQVDGGSDWVALSRPFVGYVTHPREDDEL :**:****:: * *** ****:*:* :* *: *.*****. :.* : :. * * ENST00000017003 VAQLRQFYTYTLLPAESFFHTVLENSLACETLVDNNLRVTNWNRKLGCKCQYKHIVDWCG ENSMUST00000021238 VAQLRQFYTYTLLPAESFFHTVLENSPACASLVDNNLRVTNWNRKLGCKCQYKHIVDWCG SINFRUP00000159489 VLGLKQFYSYALLPAESFFHTVLGNSHMCDSLIDNNLRVTNWNRKLGCKCQYKHIVDWCG ENSMUST00000032892 VTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCG ENST00000261381 VTKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWCG SINFRUP00000129411 VSSMKRFYAYTLLPAESFFHTVLENSAHCQTMVDNNLRLTNWNRKLGCKCQYKHIVDWCG ci0100148193 LTQLKHWYEYTLLPAESFFHTLVQNSDLCETFVDNNIRVTNWNRARGCKCQYKHIVDWCG CG32300-RB LQALLKLFRHTLLPAESFFHTVLRNTKHCTSYVDNNLHVTNWKRKQGCKCQYKHVVDWCG : : : : ::**********:: *: * : :***:::***:* ********:***** ENST00000017003 CSPNDFKPQDFLRLQQ-VSRPTFFARKFESTVNQEVLEILDFHLYGSYPPGTPALKAYWE ENSMUST00000021238 CSPNDFKPQDFLRLQQ-VSRPTFFARKFESTVNQEVLEILDFHLYGSYPPSTPALKAYWE SINFRUP00000159489 CSPNDFKPQDLIRIQQ-LTRPTFFARKFESTVNQEVIEILDTHLYGQYAPGTIAIKAYWE ENSMUST00000032892 CSPNDFKPQDFHRFQQ-TARP-FFARKFEAIVNQEIIGQLDSYLYGNYPAGTPGLRSYWE ENST00000261381 CSPNDFKPQDFHRFQQ-TARPTFFARKFEAVVNQEIIGQLDYYLYGNYPAGTPGLRSYWE SINFRUP00000129411 CSPNDFKPSDLPRFQQ-ASRPTFFARKFEASVSQEIINQLDSYLFGAYPSGTPSLQAYWE ci0100148193 CSPNDFYPSDLVRLR--TSRPVFFARKFEESINQEVVNHLDFKLYGDYPPGTPALHSLWE CG32300-RB CSPNDFKPEDWPRLQATEQKSLFFARKFEPVINQAVLLQLEEWLYGPYTSEYANLHGYWQ ****** *.* *:: :. ******* :.* :: *: *:* *.. ::. *: ENST00000017003 NTYDAA-DGPSGLSDVMLTAYTAFARLSLHHAATAAPPM-GTPLCRFEPRGLPSSVHLYF ENSMUST00000021238 NIYDVA-DGPGGLSDVLLTAYTAFARLSLRHAATAVSPL-ATAVCRFEPRGLPSSVHLYF SINFRUP00000159489 SVFEQL-DGVGSLSDIALTTYMSFFRLGLKNLATRQN---QADACRFQPVGFPLSVHLYF ENSMUST00000032892 NVYDEP-DGIHTLSDVALTLYHSFIRLGLRRAESSLHTD-GENSCRYYPMGHPASVHLYF ENST00000261381 NVYDEP-DGIHSLSDVTLTLYHSFARLGLRRAETSLHTD-GENSCRYYPMGHPASVHLYF SINFRUP00000129411 NIYEQQTDGLASLSDSAASHYSAFARMGLTRAAGSLQGNPSDSSCRYTALGHPGSVHLYF ci0100148193 NVYDYL-DGPQSIPDSSLTYFTSFARVGLSHLNEQLT----NQALRVNS-KMPSDCNLSV CG32300-RB SLYHHE-DVHGSGDDLARSIGDSVMRLSAR-------------QAKLYPLELIELTH-YL . :. * * : :. *:. : . :: . ENST00000017003 YDDHFQGYLVTQAV------------QPSAQGPAETLEMWLMPQGSLKLLGRSDQAS-RL ENSMUST00000021238 YDDHFQGYLVTQAV------------QPSAQGPAETLEMWLMPQRSLKLLGHSDQAS-RL SINFRUP00000159489 YDDRFQGYLVRQEV------------QAVGSDVKETLEMWAVPQTTFILEPNLKEFE-RL ENSMUST00000032892 LADRFQGFLIKHHV------------TNLAVSKLETLETWMMPKKVFKVASPPSDFG-RL ENST00000261381 LADRFQGFLIKHHA------------TNLAVSKLETLETWVMPKKVFKIASPPSDFG-RL SINFRUP00000129411 LSDQFQGYLVRHAA------------TNHASTQPESLETWVTPRDHFTLAKPPHPNN-RL ci0100148193 KDEEFVGYVVTFDAGWVGRRGAGDDPATSEDGSRVQLQAFLSPQPSLRILDRSSNLAKRL CG32300-RB HRDQYKGFLVRYRA-------------RGSTGKPLHLETRVRPTQQGKLARN-ARFSKRL :.: *::: . *: * : ** ENST00000017003 QSLEVGTDWDPKERLFRNFGGLLGPLDEPVAVQRWARG-------PNLTATVVWIDPTYV ENSMUST00000021238 QSLEVGTEWDPKERLFRNFGGLLGPLDEPVAMQRWARG-------PNLTATVVWIDPTYV SINFRUP00000159489 KNLEIGTDWDPKERIFRNFGGVIGPMSEPLAVQKWARG-------PNLTATIVWIDPALV ENSMUST00000032892 QFSEVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKG-------PNVTVTVIWVDPVNV ENST00000261381 QFSEVGTDWDAKERLFRNFGGLLGPMDEPVGMQKWGKG-------PNVTVTVIWVDPVNV SINFRUP00000129411 QHIQVGTDWDPKERIFRNWGGLVGPEDEPVAVQRWSRSQ------SNLTATIVWIDPTNV ci0100148193 ETASVGTNWDVKELVIRDWGGLVGPNSDVHLVARWSRSE------DDFVVTVVVIDPLNV CG32300-RB RNFEVSTDFDQKEQIARNFGKLLGPQSDLLLSYTLQANADSGAASHSYNLTLLWIDPLGR . .:.*::* ** : *::* ::** .: . . *:: :** ENST00000017003 VATSYDITVD-TETE-VTQYKPPLSRPLRPGPWTVRLLQFWEP---LGETRFLVLPLTFN ENSMUST00000021238 VATSYDITVD-ADTE-VTQYKPPLSLPLRPGAWTVRLLQFWEP---LGETRFLVLPLTFN SINFRUP00000159489 VAASYDITVD-LDAE-YTQYKPPLQRPLRPGTWTVKVLKHWKR---VAEVRFLVTPLTFK ENSMUST00000032892 IAATYDILIE-STAE-FTHYKPPLNLPLRPGVWTVKILHHWVP---VAETKFLVAPLTFS ENST00000261381 IAATYDILIE-STAE-FTHYKPPLNLPLRPGVWTVKILHHWVP---VAETKFLVAPLTFS SINFRUP00000129411 IAATYDILVD-TSTE-VTHYRPPLTLPLRPGVWTLRVLHHWNP---LGQTSFVVAPVELH ci0100148193 VADYNDFRTP-SKAAGVTETPLSLKKPLRPGRWLVRFYVQRQFTNICAELDFYVTPQEFK CG32300-RB LQDFNELHVEDSTSDVINHSKTLLKHPITPGIWTAKLIGRNSI---YAQLKFLIAPLAYY : :: : .. * *: ** * :. .: * : * ENST00000017003 R--KLPLRKDDASWLHAGPPHNEYMEQSFQGLSSILNLPQP---ELAEEAAQRHTQLTGP ENSMUST00000021238 R--KLPLRKDDASWLHAGPPHNEYMEQSFQGLSGILNLPQA---EALEEAARRHTELTGS SINFRUP00000159489 D--KEPLRKVEDSWLHAGPPRDLYLEQSMQQLSSVLQLPPQ---EPAMQEARRKAQLVDQ ENSMUST00000032892 N--KQPIKPEEALKLHNGPPRSAYMEQSFQSLNPVLSLHIN---PAQVEQARKNAAFTGT ENST00000261381 N--RQPIKPEEALKLHNGPLRNAYMEQSFQSLNPVLSLPIN---PAQVEQARRNAASTGT SINFRUP00000129411 R--QQPLQQEDALRLHGGPARNSYMEQSFHGLNPVLRLPVS---LGAVEEAEANAGLTGA ci0100148193 GGIEGDSVLREINRGVVDDAQVNAANRNLYSIRTTLNLARNN--QAETELASESNHVAGL CG32300-RB K--GYPLAKSSDAEALNAGLTVALPEDFEMPVEWQQHLQTDDEQFTMREESLAKGKMLGQ . : : * : : . ENST00000017003 ALEAWTDRELSSFWSVAGLCAIGPS------PCP---------SLEPCRLTSWSSLSPDP ENSMUST00000021238 ALEAWTDGELSNFWSVAGLCAIGPS------ACP---------SLELCRLTSWSSLSPDP SINFRUP00000159489 PLQEWVDSSVGTFWVTGNICASRTS------SCP---------ALVLCSKTTWSSLSPDP ENSMUST00000032892 ALEAWLDSLVGGTWTAMDICTTGPT------ACP---------VMQTCSQTAWSSFSPDP ENST00000261381 ALEGWLDSLVGGMWTAMDICATGPT------ACP---------VMQTCSQTAWSSFSPDP SINFRUP00000129411 PLRRWLHGLLEGHWSAADVCSMGPS------ACP---------VMQRCRLTAWSSASPDP ci0100148193 KLRNWVDFVVSSGWKAKDACLVAQSPETWREAQPRRCFMPRQGTPNLCENTNWSSLSPDP CG32300-RB ELHSWIDGLVGQFFQLRESCVVEADS---EVS------------LPLCSDAPWSSLAPDP *. * . : : * . * : *** :*** ENST00000017003 KSELGPVKADGRLR ENSMUST00000021238 KSELGPVKADGRLR SINFRUP00000159489 KSELGPVKSDGRIR ENSMUST00000032892 KSELGAVKPDGRLR ENST00000261381 KSELGAVKPDGRLR SINFRUP00000129411 KSELKPPREDGRIR ci0100148193 KTELISVKPDGRIR CG32300-RB KSDVDALLK----- *::: . :