CLUSTAL W (1.82) multiple sequence alignment SINFRUP00000135770 ---------------------------------------------VMPSLPPTPA---GV ENST00000291281 ------------MATAPSYPAGLPGSPGPGSPPPPGGLELQSPPPLLPQIPAPGS---GV ENST00000234179 MSANNSPPSAQKSVLPTAIPAVLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTV ENSMUST00000003191 MSANNSPPSAQKSVFPATVSAVLPAPSPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTV SINFRUP00000156531 MSAS-SPPSLPRAFLHSLNPHRPSSPSSWPSPSGPIYMRLSNGSHSVPSPTNSRGSFHGV ENSMUST00000002765 MSVP--------PLLRPPSPLLPAAAAVAAAA-----AALVPGSGPAPFPAPGAAPAGGI CG7125-RA ----------------------------------------------MEGPE--------V : SINFRUP00000135770 SFIIQIGLTRESVLMPLT----ADLAYVKQIACSIVDTKFPECGFYGIYDKILLFKHDTS ENST00000291281 SFHIQIGLTREFVLLPAA----SELAHVKQLACSIVDQKFPECGFYGLYDKILLFKHDPT ENST00000234179 SFLLQIGLTRESVTIEAQ---ELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMN ENSMUST00000003191 SFLLQIGLTRESVTIEAQ---ELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMN SINFRUP00000156531 SFLLQIGLTRETVNLEAS---DLSLSAVKDLVCSIVDQKFPECGFFGMYDKILLFRHNLN ENSMUST00000002765 SFHLQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGLYDKILLFRHDPA CG7125-RA TFLFQFGSVRDAVCVPAN---SLTLKTLKDLACDFINTKIPDSGLTYLSERILLFVHDYS :* :*:* *: * : * ::::.*.:: *:*:.*: : ::**** *: SINFRUP00000135770 TNNILQLVKNAGDIQEGDLVEVVLSAA----ATFEDFQIRPHALNVHSYRAPAFCDHCGE ENST00000291281 SANLLQLVRSSGDIQEGDLVEVVLSAS----ATFEDFQIRPHALTVHSYRAPAFCDHCGE ENST00000234179 SENILQLITSADEIHEGDLVEVVLSAL----ATVEDFQIRPHTLYVHSYKAPTFCDYCGE ENSMUST00000003191 SENILQLITSADEIHEGDLVEVVLSAL----ATVEDFQIRPHALYVHSYKAPTFCDYCGE SINFRUP00000156531 DENILQRLTSAEDIHEGDLIEVVLSAQ----ATVEDFQIRPHALYVHSYKAPTFCDYCGE ENSMUST00000002765 SDNILQLVKIASDIQEGDLIEVVLSAS----ATFEDFQIRPHALFVHSYRAPAFCDHCGE CG7125-RA TPNVLHIINSAAEVVDETLVEIVLTASPILYPTSEMPTLKPHSLNVHSYKGPTFCDFCGE *:*: : : :: : *:*:**:* .* * ::**:* ****:.*:***.*** SINFRUP00000135770 MLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSTTSLGSSQSLRLSITDSGYS ENST00000291281 MLFGLVRQGLKCDGCGLNYHKRCAFSIPNNCSGARKRRLSSTSLASGHSVRLGTSESLPC ENST00000234179 MLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGP----------GLS ENSMUST00000003191 MLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGP----------GLS SINFRUP00000156531 MLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGP----------SLS ENSMUST00000002765 MLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGLGTVRTASAEFSTS CG7125-RA MLFGLVRQGLKCDGCGQNYHKRCVVKIPNNCN-----RSNDATSRRS---------FTLQ **:*********:*** ******...*****. * . .: : SINFRUP00000135770 VG----TTSTCTEESSLIRSHTQMPRTPSEARRFYTGRPVHLDKILMSKVKVPHTFAVHS ENST00000291281 TA----EELSRSTTELLPRRPPSSSSSSSASS--YTGRPIELDKMLLSKVKVPHTFLIHS ENST00000234179 VP-----RPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHS ENSMUST00000003191 VP-----RPLQPECVPLLSEESHTHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHS SINFRUP00000156531 VP-----RPASSENAVLLLDEQRSHQEAGKRILSWSGRPIWMEKMVLGRVKVPHTFAIHT ENSMUST00000002765 VPDEPLLSPVSPGFEQKSPSESFIGREKRSNSQSYIGRPIQLDKLLMSKVKVPHTFVIHS CG7125-RA AP----RSPSGSSQQSLVSTEDSTGRNDSSSSLVKRMTHSSGSRNGLMVLRIPHTFMVHT . . .: : :::**** :*: SINFRUP00000135770 YTRPTVCQYCKRLLRGLFRQGLQCKDCKFNCHKRCAYKVPNDCLGETIGDPE-------- ENST00000291281 YTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDCLGEALINGD-------- ENST00000234179 YTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDT ENSMUST00000003191 YGRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPCSVGTDA SINFRUP00000156531 YTRPTICQYCKRLLKGLFRQGMQCKDCRFNCHKRCASKVPRDCLGEVDFNGEPASPGPDS ENSMUST00000002765 YTRPTVCQFCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGELLSPGAES CG7125-RA YGIPTVCQLCKKLLKGLFKQGLQCRDCQYNTHKKCMDKVPHDCTGEAQLSQLQIQAGAKE * **:** **:**:***:**:**:**::* **:* :**.:* **. . SINFRUP00000135770 -VPMDY-STEYDASDKSS-IDDSDEACSIPGSFSP------------------------- ENST00000291281 -VPMEE-ATDFSEADKSALMDESEDSGVIPGSHSENA----------------------- ENST00000234179 DIPMDIDNND-INSDSSRGLDDTEEPSPPEDKMFFLD----------------------- ENSMUST00000003191 DMPMDIDSSD-VNSDGSRGLDDSEEPSPPEDKMFFLD----------------------- SINFRUP00000156531 DTTMDTMEVDSSDLDGSRGLDDPEEPSTPDERMFEMD----------------------- ENSMUST00000002765 DVVMEEGSDDNDSERNSGLMDDMDEAMVQDTEMALAEGQ--------------------- CG7125-RA RDNFFREEFDDSDGDDGSEYGKYKSAMSSGVNLVAGRPREAPKALTNAHNSPPELVNGGL : : . .. ... SINFRUP00000135770 --------------------DNSQNGVSGDQNVYIPLMRVVQSVRQTTRRSSTAIKEGWM ENST00000291281 --------------LHASEEEEGEGGKAQSSLGYIPLMRVVQSVRHTTRKSSTTLREGWV ENST00000234179 ----------PSDLDVERD-EEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWM ENSMUST00000003191 ----------PTDLDVERD-EETVKTISPSTSNNIPLMRVVQSIKHTKRRSSTVVKEGWM SINFRUP00000156531 ----------SPFLDREKD-EEPIKTISPSTSSNIPLMRVVQSIKHTKRRSSTVVKEGWM ENSMUST00000002765 -------SGGAEMQDPDADQEDSNRTISPSTSNNIPLMRVVQSVKHTKRRSSTVMKEGWM CG7125-RA VDDSSVSGGETSKSSSDGQSEQSQSSTSSSPSANIPLMRIVQSVKHTKKRGGQALKEGWL :: : . *****:***:::*.::.. ::***: SINFRUP00000135770 VHYSDKDTLRKRHYWRLDCKCIILFQNNNSNKYYKEIPLSEILEVRPARNFALVPAGTNP ENST00000291281 VHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILTVESAQNFSLVPPGTNP ENST00000234179 VHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNP ENSMUST00000003191 VHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRVSSPQDFTSISQGSNP SINFRUP00000156531 VHYTSRDNLVR--------------GNMSFSPFPQEIPLSEILQVEQSRDYSNLAQGSNP ENSMUST00000002765 VHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILCLEPAKPSALTPVGATP CG7125-RA VHYTSLDKAVKRYYWRLDSKTITLFVSEQGSKYHKELPLAELLSIES---HLGDPRPECN ***:. *. : : : :: . . : :*:**:*:* : . SINFRUP00000135770 HCFELITGTMCYFVGEDPNTLPPLPPSNSQTLPPTPPSPSQVAPNSGVGREVAKAWASAI ENST00000291281 HCFEIVTANATYFVGEMPG--------------GTPGGPS------GQGAEAARGWETAI ENST00000234179 HCFEIITDTMVYFVGENNGD-------------SSHNP---VLAATGVGLDVAQSWEKAI ENSMUST00000003191 HCFEIITDTVVYFVGENNGS-------------SSHNP---VLAATGVGLDVAQSWEKAI SINFRUP00000156531 HCFEIITSTMVYYVGENNCS-------------PYHNP---ALAASGVGMEVAQGWEKAI ENSMUST00000002765 HCFEITTANVVYYVGENVVN-------------PSSSPPNNSVLPSGIGPDVARMWEVAI CG7125-RA YCFELRLPNLSYFVGQDPQVG-----------AKEEQAVRLPPPDSGIGSDIAKSWETSI :***: . *:**: : : * * : *: * :* SINFRUP00000135770 HQALMPVSFQDAPPAAGNT--THRQASISISVSNSQIQENVDIGTVYQIFADEVLGSGQF ENST00000291281 RQALMPVILQDAPSAPGHA--PHRQASLSISVSNSQIQENVDIATVYQIFPDEVLGSGQF ENST00000234179 RQALMPVTPQASVCTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQF ENSMUST00000003191 RQALMPVTPQASVCTSPGQGKDHKDLATSISVSNCQVQENVDISSVYQIFADEVLGSGQF SINFRUP00000156531 RQALMPVTPQPSVASAAGQGRDHKELSISISVSNSQIQENVDIASVYQIFSDEVLGSGQF ENSMUST00000002765 QHALMPVIPKGSSVGSGSN--SHKDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQF CG7125-RA RQAFMHVT------------------NTQCCESEEQVQD---MGQLYQIFPDEVLGSGQF ::*:* * . . *: *:*: : :. :****.********* SINFRUP00000135770 GVVYGGKHRMTGRDVAVKVIDKLRFPTKQESQLRNEVAILQGLRHLGIVNLERMFETPEK ENST00000291281 GVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEK ENST00000234179 GIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPER ENSMUST00000003191 GIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPER SINFRUP00000156531 GIVYGGKHRKSGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPER ENSMUST00000002765 GIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPER CG7125-RA GVVYGGVHKKTQREVAIKVIDKLRFPTKQEAQLKNEVAILQNISHCGVVNLERMFETPER *:**** *: : *:**:*:***:*******:**:*******.: * *:**** ******: SINFRUP00000135770 VFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLL ENST00000291281 VFVVMEKLHGDMLEMILSSEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLL ENST00000234179 VFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLL ENSMUST00000003191 VFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLL SINFRUP00000156531 VFVVMEKLHGDMLEMILSSEKSKLPERITKFLVTQILVALRHLHFKNIVHCDLKPENVLL ENSMUST00000002765 VFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLL CG7125-RA IFVVMEKLKGDMLEMILSHARGRLSERVTKFLITQILIALKYLHSQNIVHCDLKPENVLL :*******:********* :.:*.*::***::****:**: ** :************** SINFRUP00000135770 ASADPFP-------QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMW ENST00000291281 ASADPFP-------QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMW ENST00000234179 ASAEPFP-------QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMW ENSMUST00000003191 ASAEPFP-------QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMW SINFRUP00000156531 ASAEPFP-------QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMW ENSMUST00000002765 ASADPFPQAKSYCQQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMW CG7125-RA SSDAEFP-------QVKLCDFGYARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMW :* ** ********:************************* .:********* SINFRUP00000135770 SVGVIMYVSLSGTFPFNEDEDINDQIHNAAFMYPPNPWKQISSDAIDLINNLLQVKMRKR ENST00000291281 SVGVIMYVSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISAGAIDLINNLLQVKMRKR ENST00000234179 SVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKR ENSMUST00000003191 SVGVIVYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISSEAIDLINNLLQVKMRKR SINFRUP00000156531 SVGVIVYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWKDISAE---------------- ENSMUST00000002765 SVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKR CG7125-RA SVGVIIYVSLSGTFPFNEEEDINDQIQNAAFMYPPNPWKEISSNAIDLINNLLQVKQRKR *****:************:***:***:*******..** .** : :: :: : SINFRUP00000135770 YSVDKSLSHVYLQDYQAWLDLRELETKLGE-RYITHESDDSRWQAFAQEHTLPYPAHLVP ENST00000291281 YSVDKSLSHPWLQEYQTWLDLRELEGKMGE-RYITHESDDVRWEQFAAEHPLPGSGLPTD ENST00000234179 YSVDKSLSHPWLQDYQTWLDLREFETRIGE-RYITHESDDARWEIHAYTHNLVYPKHFIM ENSMUST00000003191 YSVDKSLSHPWLQDYQTWLDLREFETRIGE-RYITHESDDARWEIHAYTHNLEYPKHFIM SINFRUP00000156531 ------------------------------------------------------------ ENSMUST00000002765 YSVDKTLSHPWLQDYQTWLDLRELECRIGE-RYITHESDDSRWEQYAGEQGLQYPAHLIS CG7125-RA YTVDKSLLHYWLQDKQTYRDLRNLEAQVGAGRYLTHEADDLRWDCAGDM----------- : : : : : : : : SINFRUP00000135770 PPPAPASDDEGGEDADVQCLTERVSIL ENST00000291281 RDLGGACPPQ---DHDMQGLAERISVL ENST00000234179 APNPDDMEEDP---------------- ENSMUST00000003191 APNPDDMEEDP---------------- SINFRUP00000156531 --------------------------- ENSMUST00000002765 LSASHSDSPEA-EEREMKALSERVSIL CG7125-RA --------------------------- : : : ::