CLUSTAL W (1.82) multiple sequence alignment ENST00000318846 -----------------------------------ACAQGAGAEPAGGRRIARARHLRAR ENSMUST00000062341 ------------------------------------------------------------ SINFRUP00000151274 ------------------------------------------------------------ ENSMUST00000049378 ------------------------------------------------------------ ENST00000326685 ------------------------------------------------------------ ENST00000214870 MPAFLGLKCLGKLCSSEKSKVTSSERTSARGSNRKRLIVEDRRVSGTSFTAHRR-ATITH ENSMUST00000036850 MPSLLGLKCLGKLCSSEIGKVPSPERASLRNSHR-RLLIEDLSVPETPDPAHRRRGTVIH SINFRUP00000147941 ------------------------------------------------------------ SINFRUP00000163174 ------------------------------------------------------------ CG31352-RA ------------------------------------------------------------ ENST00000318846 GSGCRSAGPPRLRAAAEMSAVSQPQAAPSPLEKSPSTAILCNTCGNVCKGEVLRVQDKYF ENSMUST00000062341 -----------------LPTVSQPQAAHAPLEKPASTAILCNTCGNVCKGEVLRVQNKYF SINFRUP00000151274 ------------------------------------------------------------ ENSMUST00000049378 --------------------STVPYQQSPYSPRGGSNVIQCYRCGDTCKGEVVRVHNNHF ENST00000326685 ------------------MNTSIPYQQNPYNPRGSSNVIQCYRCGDTCKGEVVRVHNNHF ENST00000214870 LLYLCPKDYCPRGRVCNSVDPFVAHPQDPHHPS-EKPVIHCHKCGEPCKGEVLRVQTKHF ENSMUST00000036850 LVYLYSAGCGPPELRFSSYDPSVAHPQDPHHSS-EKPVIHCHKCGEPCKGEVLRVQTKHF SINFRUP00000147941 ----------------------VAHAPGTHNPSTEKPLLQCYKCGEPCKGEVLRVQNKHF SINFRUP00000163174 ---------------------------------SGRRMVHCFRCGEPCRGQVLRVQANHF CG31352-RA ---------------------------------MGKQKIYCAKCTKKCSGEVLRVADNHF : :: : : ENST00000318846 HIKCFVCKACGCDLAEGGFFVRQGEYICTLDYQRLYGTRCFSCDQFIEGEVVSALGKTYH ENSMUST00000062341 HIRCFVCKACGCDLAEGGFFVRQGEHICTRDYQRLYGTRCFSCDRFIEGEVVSALGKTYH SINFRUP00000151274 ---------CGCELAQGGFFVRQGEYICTLDYQGLYGTRCFSCQDFIEGEVVSALGKTYH ENSMUST00000049378 HIRCFTCQVCGCGLAQSGFFFKNQEYICTQDYQQLYGTRCDSCRDFITGEVISALGRTYH ENST00000326685 HIRCFTCQVCGCGLAQSGFFFKNQEYICTQDYQQLYGTRCDSCRDFITGEVISALGRTYH ENST00000214870 HIKCFTCKVCGCDLAQGGFFIKNGEYLCTLDYQRMYGTRCHGCGEFVEGEVVTALGKTYH ENSMUST00000036850 HIKCFTCKVCGCDLAQGGFFIKNGDYLCTLDYQRMYGTRCHGCGEFVEGEVVTALGKTYH SINFRUP00000147941 HLKCFTCKVCGCDLAQGGFFMKNGEYLCMLDYQRMHGTRCNGCGDFVEGEVVTALGKTYH SINFRUP00000163174 HVKCFTCKVCGCDMAQSGFFMRNGEYLCPLDFQRLHGTLCNNCREFVEGEVVTVLGKTYH CG31352-RA HKACFQCCQCKKSLATGGFFTKDNAYYCIPDYQRLYGTKCANCQQYVEGEVVSTMGKTYH : * :* .*** :: : * *:* ::** * .* :: ***::.:*:*** ENST00000318846 PDCFVCAVCRLPFPPGDRVTFNGKECMCQKCSLPVSVGSSAHLS---------------- ENSMUST00000062341 PDCFVCAVCRLPFPPGDRVTFNGKECMCQKCSPPTLLGNSAHVA---------------- SINFRUP00000151274 PRCFVCSSCKQPFPAGDRVTFNGKECVCQNCTQPLPANSPAPI----------------- ENSMUST00000049378 PKCFVCSLCRKPFPIGDKVTFSGKECVCQTCSQSMTSSKPIKI----------------- ENST00000326685 PKCFVCSLCRKPFPIGDKVTFSGKECVCQTCSQSMASSKPIKI----------------- ENST00000214870 PNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPKETT----------------- ENSMUST00000036850 PNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPKEAS----------------- SINFRUP00000147941 PACFVCTICKRPFPAGDRVTFNGKDCLCQYCVEPLSPGPKDIL----------------- SINFRUP00000163174 PACFVCTVCKQSFTAGEFVTFSGKDFFCQHCFQPLSPTQLSYP----------------- CG31352-RA QKCFTCSKCKQPFKSGSKVTNTGKEVLCEQCVTGAPVSPSRQATGGGVSSPAPPAESPTR **.*: *: .* *. ** .*:: .*: * ENST00000318846 --------------------QGLRSCGGCGTEIKNGQALVALDKHWHLGCFKCKSCGKLL ENSMUST00000062341 --------------------QGLRSCGGCGLEIKNGQALVALDKHWHLGCFKCKTCGKLL SINFRUP00000151274 --------------------QAVHNCCGCGKEFKNEQSLVALDKHWHLGCFKCRVCNKVL ENSMUST00000049378 --------------------RGPSHCAGCKEEIKHGQSLLALDKQWHVSCFKCQTCSVIL ENST00000326685 --------------------RGPSHCAGCKEEIKHGQSLLALDKQWHVSCFKCQTCSVIL ENST00000214870 ---------------------FSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVL ENSMUST00000036850 ---------------------CSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVL SINFRUP00000147941 ---------------------GSSNCAGCGRDIKNGQALLALDRQWHLGCFKCKACSKVL SINFRUP00000163174 -----------------------NNCSGCGRDIKNGQALLALGGQWHLGCFKCKICHKVL CG31352-RA ATAHQQHGSVISHKAHLKEDYDPNDCAGCGELLKEGQALVALDRQWHVSCFRCKACQAVL * ** :*. *:*:**. :**:.**:*: * :* ENST00000318846 NAEYISKDGLPYCEADYHAKFGIRCDSCEKYITGRVLEAGE-KHYHPSCALCVRCGQMFA ENSMUST00000062341 NAEYISKDGLPYCEADYHSKFGIRCDGCEKYITGRVLEAGE-KHYHPSCALCVRCGQMFS SINFRUP00000151274 NAEYISKDGVPYCESDYHAMFGIQCESCQKYITGKVLEAGE-KHYHPTCARCARCEQMFA ENSMUST00000049378 TGEYISKDGVPYCESDYHSQFGIKCETCDRYISGRVLEAGG-KHYHPTCARCVRCHQMFT ENST00000326685 TGEYISKDGVPYCESDYHAQFGIKCETCDRYISGRVLEAGG-KHYHPTCARCVRCHQMFT ENST00000214870 TGEYISKDGAPYCEKDYQGLFGVKCEACHQFITGKVLEAGD-KHYHPSCARCSRCNQMFT ENSMUST00000036850 TGEYISKDGSPYCEKDYQGLFGVKCEACHQFITGKVLEAGD-KHYHPSCARCSRCNQMFT SINFRUP00000147941 TGEYISKDGAPYCEKDYQIHFGVQCEACHQFITGKVLEAGD-KHYHPSCARCSRCNQMFT SINFRUP00000163174 CGEYITRDGIPYCERDYQNKFGIQCAACQKFITGKVLEAGA-KHYHPTCAKCSQCGKLFT CG31352-RA NGEYMGKDAVPYCEKCYQKGFGVKCAYCSRFISGKVLQAGDNHHFHPTCARCTKCGDPFG .**: :*. **** *: **::* * ::*:*:**:** :*:**:** * :* . * ENST00000318846 EGEEMYLQGSSIWHPACRQAARTEDRN--------------------------------- ENSMUST00000062341 EGEEMYLQGSSIWHPACRQAARTEDKS--------------------------------- SINFRUP00000151274 EGEEMYLQGKGFHFPSRSCASPVKASTGSF------------------------------ ENSMUST00000049378 EGEEMYLTGSEVWHPICKQAARAEKKL--------------------------------- ENST00000326685 EGEEMYLTGSEVWHPICKQAARAEKKL--------------------------------- ENST00000214870 EGEEMYLQGSTVWHPDCKQSTKTEEKLR-------------------------------- ENSMUST00000036850 EGEEMYLQGSTVWHPDCKQSTKTEEKLRPPNIPRSSSDFFYPKSLIRRTGRSPALQLLSP SINFRUP00000147941 EGEEMYLQDAFVFS---------------------------------------------- SINFRUP00000163174 EGDEMYLQAT-------------------------------------------------- CG31352-RA DGEEMYLQGSAIWHPRCGPGPSESGIILNGGGGTSSVVG--------------------- :*:**** ENST00000318846 -----------KETRTSSESIISVPASSTSGSPSRVIYAKLG------------------ ENSMUST00000062341 -----------KETRTSSESIVSVPASSTSGSPSRVIYAKLG------------------ SINFRUP00000151274 -----------QATRTSSESITSVPASSASGSPSRVIYAKLG------------------ ENSMUST00000049378 -----------KHRRTSETSIS--PPGSSIGSPNRVICAKVDNEILNYKDLAALPKVKSI ENST00000326685 -----------KHRRTSETSIS--PPGSSIGSPNRVIC---------------------- ENST00000214870 ------------PTRTSSESIYSRPGSSIPGSPGHTIYAKVD------------------ ENSMUST00000036850 PCLMNSNKNPRQPTRTSSESIYSRPGSSIPGSPGHTIYAKVD------------------ SINFRUP00000147941 -----------QPTRSSSESICSRPGSSVPGSPGHTIYAKVD------------------ SINFRUP00000163174 ----------FDLTHSVLPPLFPHSHSPPISSLS-WSQAKVD------------------ CG31352-RA -GASNGNFTDTECDRMSSSALSEMYIRSRTPSFNGSLYSSSRKHYRTVSPG--------- : .: . * . ENST00000318846 ------------------------------------------GEILDYR----------- ENSMUST00000062341 ------------------------------------------DEILDYR----------- SINFRUP00000151274 ------------------------------------------EEMLDYK----------- ENSMUST00000049378 YEVQRPDLISYEPHSRYTSDEMLERCGYGESLGTLSPYSQDIYENLDLRQRRASSPGYID ENST00000326685 ----------------------------------------DIYENLDLRQRRASSPGYID ENST00000214870 ------------------------------------------NEILDYK----------- ENSMUST00000036850 ------------------------------------------NEILDYK----------- SINFRUP00000147941 ------------------------------------------NEILDYR----------- SINFRUP00000163174 ------------------------------------------NEIIDYR----------- CG31352-RA ----------------------------LILREYGRPNAEDISRIYTYS----------- . ENST00000318846 ------------------------------------------------------------ ENSMUST00000062341 ------------------------------------------------------------ SINFRUP00000151274 ------------------------------------------------------------ ENSMUST00000049378 SPTYSRQGMSPTFSRSPHYYRSGPESGRSSPYHSQLDVRSSTPTSYQAPKHFHIPAGESN ENST00000326685 SPTYSRQGMSPTFSRSPHHYY--------------------------------------- ENST00000214870 ------------------------------------------------------------ ENSMUST00000036850 ------------------------------------------------------------ SINFRUP00000147941 ------------------------------------------------------------ SINFRUP00000163174 ------------------------------------------------------------ CG31352-RA ------------------------------------------------------------ ENST00000318846 ------------DLAALPKSKAIYDIDRPDMIS--YSPYISHS-AGDRQSY---GESPQ- ENSMUST00000062341 ------------DLAALPKNKAIYNIDRPDMIS--YSPYISHSAVGDRQSY---GESPQ- SINFRUP00000151274 ------------DLAALPKTKAIYNIDRPDMLS--YSPYISYA--SEERHY---AEVAK- ENSMUST00000049378 IYRKPPIYKRHGDLSTATKSKTSEDISQASKYSPAYSPDPYYASESEYWTY---HGSPKG ENST00000326685 ---------RSGDLSTATKSKTSEDISQTSKYSPIYSPDPYYASESEYWTY---HGSPK- ENST00000214870 ------------DLAAIPKVKAIYDIERPDLIT--YEPFYTSGYDDKQERQ-SLGESPRT ENSMUST00000036850 ------------DLAAIPKVKAIYDIERPDLIT--YEPFYTSGYEDKQERQ-SLGESPRT SINFRUP00000147941 ------------DLAAIPKVKAIYDIERPDLIT--YEPLYTTSLDDKEERQESVGE---- SINFRUP00000163174 ------------DLAAIPRVKAIFDIEHPDMIS--YENVNASSSTMEKRRN--------- CG31352-RA ----------YLTDAPHYLRKPIDPYDKTPLSPHFHRPSSYATTASNAGSVAGSRPPSRP :. *. .:. . : . ENST00000318846 --------------LLSPTPTEGDQDDRSYKQCRTS------------------------ ENSMUST00000062341 --------------LLSPTPTEGDQDDRSYKQCRTS------------------------ SINFRUP00000151274 --------------LSR-------------LACRRT------------------------ ENSMUST00000049378 MHMLAGVNLLCPLTVPRARRFSSGGEEEDFDRSMHKACD--------------------- ENST00000326685 --------------VPRARRFSSGGEEDDFDRSMHK------------------------ ENST00000214870 LSPTPSAEGYQDVRDRMIHRSTSQGSINSPVYSRHSYTPTTSRSPQHFHRP--------- ENSMUST00000036850 LSPTPSAEGYQDVRDRMIHRSTSQGSINSPVYSRHSYTPTTSRSPQHFHRPELLSPGVHR SINFRUP00000147941 ------------------------------------------------------------ SINFRUP00000163174 ------------------------------------------------------------ CG31352-RA HSRTRSAMKVLVDAIRSETPRPKSPGMNNEEPIELSHYP--------------------- ENST00000318846 ---------------------------------SPSSTGSVSLGRYTPTSRSPQHYSRPA ENSMUST00000062341 ---------------------------------SPSSAGSVSLGHYTPTSRSPQHYSRPA SINFRUP00000151274 ---------------------------------QKCSA---------------------- ENSMUST00000049378 ---------------------------------QNSGICPKRIDVFKSMPGCVSRCFGGS ENST00000326685 ---------------------------------LQSGIG--RLILKEEMKARSSSYADPW ENST00000214870 -------------------------------GNEPSSGRNSPLPYRPDSRPLTPTYAQAP ENSMUST00000036850 WSPLRTSSFSSTHSDSRPNPPFRHHFLPHVKGNEPSSGRNSPLPYRPDSRPLTPTYAQAP SINFRUP00000147941 ------------------------------------------------------------ SINFRUP00000163174 ------------------------------------------------------------ CG31352-RA -------------------------------AAKKPPPGEQPKIERDDFPAPPYPYTDPE ENST00000318846 ------------------------------------------------------------ ENSMUST00000062341 GTVSVGTSSC----LSLSQHPSPTSVFRHHYIPYFRGSESGRSTPSLSVHSDSRPPSSTY SINFRUP00000151274 ------------------------------------------------------------ ENSMUST00000049378 CWSRVPQNS--------------------------------------------------- ENST00000326685 TPPRSSTSS--------------------------------------------------- ENST00000214870 KHFHVPDQGINIYRKPPIYKQHAALAAQSKSSEDIIKFSKFPAAQAPDPSETPKIETDHW ENSMUST00000036850 KHFHVPDQGINIYRKPPIYKQHAALAAQSKASEDIIKFSKFPAAQAPDPNEIPKIETDHW SINFRUP00000147941 ------------------------------------------------------------ SINFRUP00000163174 ------------------------------------------------------------ CG31352-RA RRRRYSDTYKG-------------------------------------------VPASDD ENST00000318846 -----------------------------ARRSDGE--------------DGSLDQDNRK ENSMUST00000062341 QQAPRHFHVPDTGVKDNIYRKPPIYKQHAARRLDVE--------------DSSFDQDSRK SINFRUP00000151274 -------------------------------RARVR--------------MERIRTENVR ENSMUST00000049378 -----------------------------LENLRRT--------------WYSLDPTPNP ENST00000326685 -----------------------------REALHTA--------------GYEMSLNGSP ENST00000214870 PGPPSFAVVGPDMKRRSSGREEDDEELLRRRQLQEEQLMKLNSGLGQLILKEEMEKESRE ENSMUST00000036850 PGPPSLAAVGTDPRRRSSGREEDEEELLRRRQLQEEQLMKLNSGLGQLILKEEMEKESRE SINFRUP00000147941 ------------------------------------------------------------ SINFRUP00000163174 -------------------------------RQDSQ---------------SVVKESFDE CG31352-RA EDENVENGKPNGKVKNGEEQQRLQREAEQLEKLNSGIGSAIAKDLKEHAKYRKWKQNNLD ENST00000318846 KSSWLMLKGDA---------DTRTNS-PDLDTQSLSHSSGTDRDPLQRMAGDSF-HSRT- ENSMUST00000062341 KTTWLLLKGDA---------DTRTNS-PDLDSQSLSLSSGTDQEPLQRMAGDSL-YSQY- SINFRUP00000151274 GAARVRCSGGS---------ESGRST-PSLSTFSDGKSPSSTYVPVPR------------ ENSMUST00000049378 TSSSASFPDPL---------ISKSASLPAYRRNGLHRTPSADLFHYDSMNAVNWGMREY- ENST00000326685 RSHYLADSDPL---------ISKSASLPAYRRNGLHRTPSADLFHYDSMNAVNWGMREY- ENST00000214870 RSSLLASRYDSPINSASHIPSSKTASLPGYGRNGLHRPVSTDFAQYNSYGDVSGGVRDYF ENSMUST00000036850 RAS-LASRYDSPLHSASHAPSSKTSSLPGYGKNGLHRPVSTDFVQYNSYGDISGGVR--- SINFRUP00000147941 ------------------------------------------------------------ SINFRUP00000163174 RKSIPKSTSHG-----------SLGLNAIYSRHSYTPSLSRSPQHFHRPGEE-------- CG31352-RA PRNASRTPSASKEPLYKLRYESPIGASPSRNLDHQKPFYEDEMFDRSTSYRGSLGKSLGN ENST00000318846 -------------------------------------------QIYPYDSLIVTNRIRVK ENSMUST00000062341 -------------------------------------------KIYPYDSLIVTNRIRVK SINFRUP00000151274 ---------------------------------------------------------HFH ENSMUST00000049378 -------------------------------------------KIYPYELLLVTTRGRNR ENST00000326685 -------------------------------------------KIYPYELLLVTTRGRNR ENST00000214870 MPHLELAFLLQTLPDGHMPAMRMDRGVSMPNMLEPKAS----AAIFPYEMLMVTNRGRNK ENSMUST00000036850 ------AFLSQTLPDGHMPAVRMDRGVSMPNMLEPKANTVCLSQIFPYEMLMVTNRGRNK SINFRUP00000147941 ------------------------------------------------------------ SINFRUP00000163174 ------------------------------------------------------------ CG31352-RA APSYNAIHSYRSPPKPGYGFKTTTLPYIRNGFSSDFSYGGLGDKTHSTDLSCGKSEASVD ENST00000318846 LPKDVDRTRLERHLSPEEFQEVFGMSIEEFDRLALWKRNDLKKKALLF ENSMUST00000062341 LPKDVDRTRLERHLSPEEFQEVFGMSIEEFDRLALWKRNDLKKKALLF SINFRUP00000151274 IP---------------------------------------------- ENSMUST00000049378 LPKDVDRTRLERHLSQEEFYQVFGMTISEFERLALWKRNELKKQARLF ENST00000326685 LPKDVDRTRLEGN---------------------FWKSGCL------- ENST00000214870 ILREVDRTRLERHLAPEVFREIFGMSIQEFDRLPLWRRNDMKKKAKLF ENSMUST00000036850 ILRDVDRTRLERHLAPEVFWEIFGMSIQEFDKLPLWRRNDMKKKAKLF SINFRUP00000147941 ------------------------------------------------ SINFRUP00000163174 ------------------------------------------------ CG31352-RA SITEGDRRALMGGDLPASSTYSGALSYHYPQAGLIRRSLPNMSHSMLN