CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000027740 -------------------------------------------------- ENST00000263726 -----------------------MMQSATVPAEGAVKGLPEMLGVP---- ENST00000224036 -----------------------MLLETGLERDRAR---PGAAAVCTLGG ENSMUST00000053167 -----------------------MLLEAELDCHRERPGAPGASALCTFSR O42286_Brachydanio_rerio -------------------------------------------------- ENSMUST00000031591 -------------------------------------------------- ENST00000261731 -------------------------------------------------- SINFRUP00000136545 -------------------------------------------------- ENST00000254457 -------------------------------------------------- ENSMUST00000018842 -------------------------------------------------- O13106_Brachydanio_rerio -------------------------------------------------- SINFRUP00000151087 -----------------------------------------------GVS ci0100140604 MTSKQVAGVIMMHNIPLYDITTNLNLTRLLNVVKSMWTRWKEGDHCDVTE ENSMUST00000041730 ------------------------MLDGIKMEEHALRPGPATLGVLLGSD ENST00000259471 ------------------------MLDGIKMEEHALRPGPATLGVLLGSD CG10619-RB ---MVMAEIGGHLAHQLPLHNHNHNQTGLQPSLVMNHHLDLDCHGHDVIK ENSMUST00000027740 --EIPQCAGCNQHILDKFILKVL-DRHWHSSCLKCADCQMQLAD--RCFS ENST00000263726 MQQIPQCAGCNQHILDKFILKVL-DRHWHSSCLKCADCQMQLAD--RCFS ENST00000224036 TREIPLCAGCDQHILDRFILKAL-DRHWHSKCLKCSDCHTPLAE--RCFS ENSMUST00000053167 TPEIPMCAGCDQHILDRFILKAL-DRHWHSKCLKCSDCHVPLAE--RCFS O42286_Brachydanio_rerio ---IPVCAGCNQHIVDRFILKVL-DRHWHSKCLKCSDCQSQLAD--KCFS ENSMUST00000031591 --MMVHCAGCERPILDRFLLNVL-DRAWHIKCVQCCECKTNLSE--KCFS ENST00000261731 --MMVHCAGCERPILDRFLLNVL-DRAWHIKCVQCCECKTNLSE--KCFS SINFRUP00000136545 -------------------------------------------------- ENST00000254457 ---MVHCAGCKRPILDRFLLNVL-DRAWHVKCVQCCECKCNLTE--KCFS ENSMUST00000018842 ---MVHCAGCKRPILDRFLLNVL-DRAWHVKCVQCCECKCNLTE--KCFS O13106_Brachydanio_rerio ---MVHCAGCERPILDRFLLSVL-DRAWHAKCVQCCDCKCSLTD--RCFS SINFRUP00000151087 PGSMLQCTSCEKPILDRFLLKVL-DRPWHVKCVQCCDCKCTLSE--KCFS ci0100140604 DXEGPLCSRCNHVISNKFVFQVD-GKFWHGDCVVCSDCECPLSN--RCYV ENSMUST00000041730 CPHPAVCEGCQRPISDRFLMRVN-ESSWHEECLQCAACQQALTT--SCYF ENST00000259471 CPHPAVCEGCQRPISDRFLMRVN-ESSWHEECLQCAACQQALTT--SCYF CG10619-RB KQRLSHCVGCGGQIHDQYILRVAPDLEWHAACLKCQECRQFLDESCTCFV ENSMUST00000027740 RAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDF--VYHLHCFACI ENST00000263726 RAGSVYCKEDFFKRFGTKCTACQQGIPPTQVVRKAQDF--VYHLHCFACI ENST00000224036 RGESVYCKDDFFKRFGTKCAACQLGIPPTQVVRRAQDF--VYHLHCFACV ENSMUST00000053167 RGESVYCKDDFFKRFGTKCAACQLGIPPTQVVRRAQDF--VYHLHCFACV O42286_Brachydanio_rerio RGDSVYCKDDFFKRFGTKCAACQQGIPPTQVVRRAQDF--VYHLHCNACI ENSMUST00000031591 REGKLYCKNDFFRRFGTKCAGCAQGISPSDLVRKARSK--VFHLNCFTCM ENST00000261731 REGKLYCKNDFFRRFGTKCAGCAQGISPSDLVRKARSK--VFHLNCFTCM SINFRUP00000136545 ------------RRFGTKCAGCLQGISPSDLVRKARSK--VFHLNCFTCM ENST00000254457 REGKLYCKNDFFRCFGTKCAGCAQGISPSDLVRRARSK--VFHLNCFTCM ENSMUST00000018842 REGKLYCKNDFFRCFGTKCAGCAQGISPSDLVRRARSK--VFHLNCFTCM O13106_Brachydanio_rerio REGRLYCKNDFFRRYGTKCGGCAQGISPSDLVRKARSK--VFHLNCFTCI SINFRUP00000151087 REGKLYCKNDFFRRFGTKCDGCAQGILPSDLVRRAKSK--VFHLNCFTCM ci0100140604 RNEELFCSDDFCRRFGKKCGGCGGALYPNDLVHKVGQINSVFHVRCFVCY ENSMUST00000041730 RDRKLYCKQDYQQLFAAKCSGCMEKIAPTEFVMRALEC--VYHLGCFCCC ENST00000259471 RDRKLYCKQDYQQLFAAKCSGCMEKIAPTEFVMRALEC--VYHLGCFCCC CG10619-RB RDGKTYCKRDYVRLFGTKCDKCGNSFSKNDFVMRAKTK--IFHIECFRCS : :. ** * : .:.* :. ::*: * * ENSMUST00000027740 ICNRQLATGDEFYLMEDGRLVCKEDYETA--------------------- ENST00000263726 ICNRQLATGDEFYLMEDGRLVCKEDYETA--------------------- ENST00000224036 VCKRQLATGDEFYLMEDSRLVCKADYETA--------------------- ENSMUST00000053167 VCKRQLATGDEFYLMEDSRLVCKADYETA--------------------- O42286_Brachydanio_rerio VCKRQLATGDEYYLMEDSRLVCKADYETA--------------------- ENSMUST00000031591 VCNKQLSTGEELYVIDENKFVCKDDYLSS-SSLKE--------------- ENST00000261731 VCNKQLSTGEELYVIDENKFVCKDDYLSS-SSLKE--------------- SINFRUP00000136545 VCNKQLSTGEELYVIDENKFVCKEDFLSS-GATKE--------------- ENST00000254457 MCNKQLSTGEELYIIDENKFVCKEDYLSNSSVAKE--------------- ENSMUST00000018842 MCNKQLSTGEELYIIDENKFVCKEDYLSNSSVAKE--------------- O13106_Brachydanio_rerio MCNKQLSTGEELYILDEYKFVCKEDYLNN-SNGKD--------------- SINFRUP00000151087 MCNKQLSTGEELYVLDEFKFVCKEDYHN--SSGKD--------------- ci0100140604 VCNNNLEPGKPFQAN-ERGLLCKDDYVAMTSSGDSEEEVWGESNAHVISD ENSMUST00000041730 VCERQLRKGDE-FVLKEGQLLCKGDYEKE--------------------- ENST00000259471 VCERQLRKGDE-FVLKEGQLLCKGDYEKE--------------------- CG10619-RB ACARQLLPGDEFALRDAGALYCKEDHDVLEKSSQSSLTSSSVE------- * .:* *. : ** *. ENSMUST00000027740 -------------------------------------------------- ENST00000263726 -------------------------------------------------- ENST00000224036 -------------------------------------------------- ENSMUST00000053167 -------------------------------------------------- O42286_Brachydanio_rerio -------------------------------------------------- ENSMUST00000031591 -----------------------------GSLNSVSSCTDRSLSPDLQDP ENST00000261731 -----------------------------GSLNSVSSCTDRSLSPDLQDA SINFRUP00000136545 -----------------------------ANLNSVSSCTDRSLSPDLQDP ENST00000254457 -----------------------------NSLHSATTGSDPSLSPDSQDP ENSMUST00000018842 -----------------------------NSLHSATTGSDPSLSPDSQDP O13106_Brachydanio_rerio -----------------------------TNLLSITTCSDPSLSPESQDP SINFRUP00000151087 -----------------------------TILLSVTSCSDPSMSPDSQDP ci0100140604 VTGVASEVKMTKQLIDEGEAKPGVWENEGGEVSKLAGFENRHPGQDDEDS ENSMUST00000041730 -----------------------------------KDLLSSVSPDESDSV ENST00000259471 -----------------------------------KDLLSSVSPDESDSV CG10619-RB -----------------------------SNNNISSSNNNNTNLSNNNHS ENSMUST00000027740 --------------------KQNDDSEAGAKR--PRTTITAKQLETLKNA ENST00000263726 --------------------KQNDDSEAGAKR--PRTTITAKQLETLKNA ENST00000224036 --------------------KQRE-AEATAKR--PRTTITAKQLETLKSA ENSMUST00000053167 --------------------KQRE-AEATAKR--PRTTITAKQLETLKSA O42286_Brachydanio_rerio --------------------KQRE-ADSTAKR--PRTTITAKQLETLKNA ENSMUST00000031591 LQDDPKETDNSTSSDKETANNENEEQNSGTKRRGPRTTIKAKQLETLKAA ENST00000261731 LQDDPKETDNSTSSDKETANNENEEQNSGTKRRGPRTTIKAKQLETLKAA SINFRUP00000136545 TQDDIKETDNSTSSDKETNNIENEEQNSGTKRRGPRTTIKAKQLETLKAA ENST00000254457 SQDDAKDSESANVSDKEAGSNENDDQNLGAKRRGPRTTIKAKQLETLKAA ENSMUST00000018842 SQDDAKDSESANVSDKEGGSNENDDQNLGAKRRGPRTTIKAKQLETLKAA O13106_Brachydanio_rerio -QDDYKDSESGPMSDKETCNNENDEQNLGGKRRGPRTTIKAKQLETLKAA SINFRUP00000151087 -QDDGKDSETGHLSDKDACGNENDEQGAVGKRRGPRTTIKAKQLETLKAA ci0100140604 LMSQQTKDSSASTAIDTSPPQQGCIAIAATKRRGPRTTIKAKQLETLKNA ENSMUST00000041730 KSEDEDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKAS ENST00000259471 KSEDEDGDMKPAKGQGSQSKGSGDDGKDPRRPKRPRTILTTQQRRAFKAS CG10619-RB SELGSMSDSGSESGSHKSIRDKRPSGPSDGKPTRVRTVLNEKQLHTLRTC . : ** :. :* .::: . ENSMUST00000027740 YKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGR-HRW ENST00000263726 YKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGR-HRW ENST00000224036 YNTSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGR-QRW ENSMUST00000053167 YNTSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGR-QRW O42286_Brachydanio_rerio YNNSPKPARHVREQLSTETGLDMRVVQVWFQNRRAKEKRLKKDAGR-QRW ENSMUST00000031591 FAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARR ENST00000261731 FAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARR SINFRUP00000136545 FVATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARR ENST00000254457 FAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARR ENSMUST00000018842 FAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARR O13106_Brachydanio_rerio FAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARR SINFRUP00000151087 FAATPKPTRHIREQLSQETGLNMRVIQVWFQNRRSKERRMKQLSTLGSRR ci0100140604 FLSTPKPTRHIREKLAQDTGLSMRVIQVWFQNRRSKERRIKQLNTMVARR ENSMUST00000041730 FEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRHQQ---- ENST00000259471 FEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRHQQ---- CG10619-RB YNANPRPDALMKEQLVEMTSLSPRVIRVWFQNKRCKDKKKTIQMKLQMQQ : ..:* ::* * *.*. **::*****:*.* :: ENSMUST00000027740 GQFYKSVKRSRGGSKQEKESSAEDCGVSDSELSFREDQILS--ELGHTNR ENST00000263726 GQFYKSVKRSRGSSKQEKESSAEDCGVSDSELSFREDQILS--ELGHTNR ENST00000224036 GQYFRNMKRSRGGSKSDKDSVQE-GQDSDAEVSFPDEPSLA--EMGPANG ENSMUST00000053167 GQYFRNMKRSRGSSKSDKDSIQE-GQDSDAEVSFTDEPSMA--DMGPANG O42286_Brachydanio_rerio GQYFRNMKRSRGTSKSDKDSTQEDGMDSDAEVSFTDEAAMS--DLGHSNG ENSMUST00000031591 HAFFRSPRRMRPLGGRLDESEMLGSTPYTYYGDYQSDYYAP--GGNYDFF ENST00000261731 HAFFRSPRRMRPLGGRLDESEMLGSTPYTYYGDYQGDYYAP--GSNYDFF SINFRUP00000136545 HAFFRGPRRMRALGGRLEDPDILGPGAYGYYGEYQGDYYGP--GSNYDFF ENST00000254457 HAFFRSPRRMRPLVDRLEPGELIPNGPFSFYGDYQSEYYGP--GGNYDFF ENSMUST00000018842 HAFFRSPRRMRPLVDRLEPGELIPNGPFSFYGDYQSEYYGP--GGNYDFF O13106_Brachydanio_rerio HMFFRSPRRMRALGDRMEPGELMANGHFSFYGDYQSEYYGP--GSNYDYF SINFRUP00000151087 HVFFRGQRRMRALGERLEPDELA---HFSYYGDYPGDYYGP--GGNYEYF ci0100140604 QYFDHVPN-------------IDVTNEQRFYAGWQNICVFI--SSNSIYY ENSMUST00000041730 ---------------------QQEQQNSQRLGQDVLSSRME--GMMASYT ENST00000259471 ---------------------QQEQQNSQRLGQEVLSSRME--GMMASYT CG10619-RB EKEGRKLGYGAMQGIPMIASSPVRHDSPLNLQGLDVQTYQPPWKALSDFA ENSMUST00000027740 IYGNVGDVTGGQLMN----GSFSMDGTG-----QSYQDLRDGSPYGIPQS ENST00000263726 IYGNVGDVTGGQLMN----GSFSMDGTG-----QSYQDLRDGSPYGIPQS ENST00000224036 LYGSLGEPTQALGRPSGALGNFSLEHGGLAGP-EQYRELRPGSPYGVPPS ENSMUST00000053167 LYSSLGEPAPALGRPVGGLGSFTLDHGGLTGP-EQYRELRPGSPYGIPPS O42286_Brachydanio_rerio IYSSLSESSPALSRQGGNHPAFPLEHGAIIPSQEPYHDIQASSPYSLLQS ENSMUST00000031591 AHGPPS-QAQSPADSS-----------------FLAASGPGSTPLGALEP ENST00000261731 AHGPPS-QAQSPADSS-----------------FLAASGPGSTPLGALEP SINFRUP00000136545 PHGPPSSQAQSPAESP-----------------YMLGSGPG-----GMEG ENST00000254457 PQGPPSSQAQTPVDLP-----------------FVPSSGPSGTPLGGLEH ENSMUST00000018842 PQGPPSSQAQTPVDLP-----------------FVPSSGPSGTPLGGLDH O13106_Brachydanio_rerio PQGPPSSQAHTPGDLG-----------------FMPSSGPAGTPLGNMDP SINFRUP00000151087 -QGPPSSQAQTPADLG-----------------YMPTSIPAGTPLGVLDH ci0100140604 VNDSEDQIIKTIKRRK-----------------LAAKRQSFKHAMGKNKY ENSMUST00000041730 PLAPPQQQIVAMEQSP------------------YGSSDPFQQGLTPPQM ENST00000259471 PLAPPQQQIVAMEQSP------------------YGSSDPFQQGLTPPQM CG10619-RB LHADLDSNGAINTHTP-----------------AFQQLVNQMHGYDLNGM ENSMUST00000027740 PSSISSLPSHAPLLNGLDYTVDSNLGIIA-HAGQGVSQTLRAMAG--GPT ENST00000263726 PSSISSLPSHAPLLNGLDYTVDSNLGIIA-HAGQGVSQTLRAMAG--GPT ENST00000224036 PAAPQSLPGPQPLLSSLVYP-DTSLGLVP-SGAPGGPPPMRVLAG-NGPS ENSMUST00000053167 PAAPQSLPGPQPLLSSLVYP-DTNLSLVP-SGPPGGPPPMRVLAG-NGPS O42286_Brachydanio_rerio PGPLQPLPRHQPLISSLVYP-ESGLPMVGQSGGQNMTPGVRMMAAGNGPS ENSMUST00000031591 PLAGPHGA-DNPRFTDMIS--HPDTPSPEPGLPGALHPMPGEVFSGG-PS ENST00000261731 PLAGPHAA-DNPRFTDMIS--HPDTPSPEPGLPGTLHPMPGEVFSGG-PS SINFRUP00000136545 --SGHHPS-EDQRFTDMIS--HAETPSPDPGLPGSLQPVPGEAYGGG-PS ENST00000254457 PLPGHHPSSEAQRFTDILAHPPGDSPSPEPSLPGPLHSMSAEVFGPSPPF ENSMUST00000018842 PLPGHHPSSEAQRFTDILAHPPGDSPSPEPSLPGPLHSMSAEVFGPSPPF O13106_Brachydanio_rerio HHGAHHPSNDTQCFSEMISHHPGDSPSPEPSAPASIHSISTDMCDSTPPF SINFRUP00000151087 HHQGHHHAGELQCFPDTR--HPADSPSPEPHAPGSGRSISGEMCGPGTPY ci0100140604 RVPHFTPQQYRIFLINNKTLDISQVTYIWILRNRGIYDVTVDLKWRHRPL ENSMUST00000041730 P-------GNDSIFHDIDSDTSLTSLSDCFLGSSDVGSLQARVGN---PI ENST00000259471 PGDHMNPYGNDSIFHDIDSDTSLTSLSDCFLGSSDVGSLQARVGN---PI CG10619-RB PILPPHPHSHPAQGPPHQHPPPPGGPHNHQNQQPNQQPGGSSLDS--GIT ENSMUST00000027740 SDLSTGSSVGYPDFPTSPASWLDEMDHPPF ENST00000263726 SDISTGSSVGYPDFPTSPGSWLDEMDHPPF ENST00000224036 SDLSTGSSGGYPDFPASPASWLDEVDHAQF ENSMUST00000053167 SDLSTESSSGYPDFPASPASWLDEVDHAQF O42286_Brachydanio_rerio SDLSTGSSGGYPDFPASPASWLDEVDHAQF ENSMUST00000031591 PPFPMSGTSGYSGPLSHPNPELNEAAVW-- ENST00000261731 PPFPMSGTSGYSGPLSHPNPELNEAAVW-- SINFRUP00000136545 PPFSLASNSSYSAPMSHQGQEMGESAAW-- ENST00000254457 SSLSVNGGASYGNHLSHP-PEMNEAAVW-- ENSMUST00000018842 SSLSVNGGASYGNHLSHP-PEMNEAAVW-- O13106_Brachydanio_rerio TSLNSLSANGYSNQLS---SEMNEGTVW-- SINFRUP00000151087 TNV-SLSDNGYTNQLSQPSSEMSEGTVW-- ci0100140604 HTRGRSSMKFKFLLFNRFV----------- ENSMUST00000041730 DRLYSMQSSYFAS----------------- ENST00000259471 DRLYSMQSSYFAS----------------- CG10619-RB SHHHPDSTDSYVTYLESDDSMQGSP-----