CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000020755 ------------------------------------------------------------ ENST00000312993 ------------------------------------------------------------ SINFRUP00000129322 ------------------------------------------------------------ ENSMUST00000048305 ------------------------------------------------------------ ENST00000309574 ------------------------------------------------------------ SINFRUP00000152830 ------------------------------------------------------------ ci0100130512 MSSTPVTLGEKTGKKLVLKASLLQPYLVTIPTAERKTSSTVLKLLTRFFESHPEVKKVQS CG9351-RA ------------------------------------------------------------ ENSMUST00000020755 ------------------------------------------------------------ ENST00000312993 ---------------------------RGSGRRGLSGSCHPFSRLNLWSHGEFGPLRSRR SINFRUP00000129322 ------------------------------------------------------------ ENSMUST00000048305 ------------------------AARSLSGLLGGRARSAWTIAPGRRRREKAAARGSDP ENST00000309574 ------------------------------------------------------------ SINFRUP00000152830 ------------------------------------------------------------ ci0100130512 AGRKKRKISGEIKQPNEFRKNFVFGINEVTKALEKDKLSFFITCKSAKPAALTQHLALLS CG9351-RA ------------------------------------------------------------ ENSMUST00000020755 ----------------------------------MSDTRRRVKVYTLNEDRQWDDRGTGH ENST00000312993 RRHRHYCLYRLLRVRSADEVSEEAAARAVETAATMSDTRRRVKVYTLNEDRQWDDRGTGH SINFRUP00000129322 ----------------------------------MSDTRRRVKVYTLNEDRQWDDRGTGH ENSMUST00000048305 GAGHASGGAAPRRPAVALRSRSSPFAAARLFWTLMTDTRRRVKVYTLNEDRQWDDRGTGH ENST00000309574 ----------------------------------MTDTRRRVKVYTLNEDRQWDDRGTGH SINFRUP00000152830 ----------------------------------MTDTRRRVKVYTLNEDRQWDDRGTGH ci0100130512 ASRGTPTAGLANLSATLAPLLELKSVLALGFLKTMSDTRRRVKVYTLNEERQWDDQGTGH CG9351-RA ---------------------------------MTTDTRRRVKLYALNAERQWDDRGTGH :*******:*:** :*****:**** ENSMUST00000020755 VSSTYVEELKGMSLLVRAESDGSLLLESKINPNTAYQKQQARTLIVWSEAENYDLALSFQ ENST00000312993 VSSTYVEELKGMSLLVRAESDGSLLLESKINPNTAYQKQQD-TLIVWSEAENYDLALSFQ SINFRUP00000129322 VSSTFVERLKGTSLLVRAESDGSLLLESKISPNTAYQKQQD-TLIVWSEADNYDLALSFQ ENSMUST00000048305 VSSGYVERLKGMSLLVRAESDGSLLLESKINPNTAYQKQQD-TLIVWSEAENYDLALSFQ ENST00000309574 VSSGYVERLKGMSLLVRAESDGSLLLESKINPNTAYQKQQD-TLIVWSEAENYDLALSFQ SINFRUP00000152830 VSSGYVDRLKGTSLLVRAESDGSLLLESKINPNTAYQKQQD-TLIVWSEAENYDLALSFQ ci0100130512 VSSAYVERLTGMTLIVRAEQDGSLLLESRILPDTAYQKQQE-TLIVWSEGENTDLALSFQ CG9351-RA VSSTYVERLKGISLLVRAESDGSLLLESKIQPDTAYQKQQD-TLIVWSEGDNFDLALSFQ *** :*:.*.* :*:****.********:* *:******* *******.:* ******* ENSMUST00000020755 EKAGCDEIWEKI-QVQGKDPSVEVTQDLIDESE-EERF----------EEMPETSHLIDL ENST00000312993 EKAGCDEIWEKICQVQGKDPSVEVTQDLIDESE-EERF----------EEMPETSHLIDL SINFRUP00000129322 EKAGCDEIWEKI-CVQGKDPALDITQDPIDESE-EERFP---------EEIPETSHLVEL ENSMUST00000048305 EKAGCDEIWEKICQVQGKDPSVDITQDLVDESE-EERF----------DDMSSPG--LEL ENST00000309574 EKAGCDEIWEKICQVQGKDPSVDITQDLVDESE-EERF----------DDMSSPG--LEL SINFRUP00000152830 EKAGCDEIWEKICQVQGKDPSVDITQDVVDESE-DERL----------DEMSSPG--LEL ci0100130512 EKAGCDEIWEKICQVQGKDPSVDITQDIPEDGEDEEEFGGGRLDDSGESLQRQSTSPYVL CG9351-RA EKAGCDEIWEKICQVQGKDPSVEITQDIVEESE-DERF---------------------- ************ ******::::*** ::.* :*.: : ENSMUST00000020755 PACELSKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQACENLENTEGLHHL ENST00000312993 PTCELNKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQACENLENTEGLHHL SINFRUP00000129322 PPCELSRLEEIADLVTSVLSSPIRREKLALALVSEGYIKKLLGLFRVCEDLDNREGLHHL ENSMUST00000048305 PSCELSRLEEIAELVASSLPSPLRREKLALALENEGYIKKLLELFHVCEDLENIEGLHHL ENST00000309574 PSCELSRLEEIAELVASSLPSPLRREKLALALENEGYIKKLLELFHVCEDLENIEGLHHL SINFRUP00000152830 PPCELNRLEDLAELVASSLPSPLRREKLALAVENEGYIRKLLDLFHVCEDLENREGLHHI ci0100130512 PACELGELEEIAEVFTTSLPSLVRRDQLARSIEESDYIRKLLDLFRTCEDLDHTDGLHKL CG9351-RA --------------EDICLSTPLRKEKLSMALESESYIKKLLNLFHVCEDLDNTEGLHHL : : : : *.: :*:::*: :: ...**:*** **:.**:*:: :***:: ENSMUST00000020755 YEIIRGILFLNKATLFEVMFSDECIMDVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPI ENST00000312993 YEIIRGILFLNKATLFEVMFSDECIMDVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPI SINFRUP00000129322 YEIVRGVLFLNKAALFEVMFSDDCIMDVVGCLEYDPALVQPKRHREFLTKTAKFKEVIPI ENSMUST00000048305 YEIIKGIFLLNRTALFEVMFSEECIMDVIGCLEYDPTLSQPRKHREFLTKTAKFKEVIPI ENST00000309574 YEIIKGIFLLNRTALFEVMFSEECIMDVIGCLEYDPALSQPRKHREFLTKTAKFKEVIPI SINFRUP00000152830 YEIIKGIFLLNRTALFEVMFSEECIMDVIGCLEFDPALPQPRRHREFLTKTAHFKEVIPI ci0100130512 YEIMKTIFLLNRSSLFDVMLQDSNIVPVVGCLEYDPALSEPRRHRDYLLKEVNFKEVLPI CG9351-RA FEIFKNIFLLNKNALFEIMFADDTIFDVVGCLEYDPSVSQPKKHRQYLKQLAKFREAVPI :**.: :::**: :**::*: :. *. *:****:**:: :*::**::* : .:*:*.:** ENSMUST00000020755 TDSELRQKIHQTYRVQYIQDIILPTPSVFEEN-FLSTLTSFIFFNKVEIVSMLQEDEKFL ENST00000312993 TDSELRQKIHQTYRVQYIQDIILPTPSVFEEN-FLSTLTSFIFFNKVEIVSMLQEDEKFL SINFRUP00000129322 TDSELRQKIHQTYRVQYIQDIILPTPSVFEEN-FLSTLTSFIFFNKVEIVSMLQEDEKFL ENSMUST00000048305 SDPELKQKIHQTYRVQYIQDMVLPTPSVFEEN-MLSTLHSFIFFNKVEIVGMLQEDEKFL ENST00000309574 SDPELKQKIHQTYRVQYIQDMVLPTPSVFEEN-MLSTLHSFIFFNKVEIVGMLQEDEKFL SINFRUP00000152830 SDPELRQKIHQTYRVQYIQDMVLPTPSVFEEN-MLSTLHSFIFFNKVEIVGMLQDDEKFL ci0100130512 KNPELLKKIHQTFRLQYIQDVVLPTPSVFEEN-MLSTLSSVIFFNKVEIVSLVQEDETLL CG9351-RA KNLDLLAKIHQTFRVQYIQDIILPTPSVFVEDNMLNTLSSFIFFNKVEIVTMIQDDERYL .: :* *****:*:*****::******* *: :*.** *.********* ::*:** * ENSMUST00000020755 SEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLAKLGILPALEIVMG ENST00000312993 SEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLAKLGILPALEIVMG SINFRUP00000129322 TEVFAQLTDEGTDDSKRRELVNFVKEFCAFSQTLQPQNRDAFFKTLANLGILPALEIVMG ENSMUST00000048305 TDLFAQLTDEATDEEKRQELVNFLKEFCAFSQTLQPQNRDAFFKTLSNMGILPALEVILG ENST00000309574 TDLFAQLTDEATDEEKRQELVNFLKEFCAFSQTLQPQNRDAFFKTLSNMGILPALEVILG SINFRUP00000152830 TVLFAQLTDETTDDDKRHELG--------------------------------------- ci0100130512 TSLFKQLGDETVEDERRRELAGFVKELCSLSQTLQPTSRDDFFKQLGELGVLTAIESLLA CG9351-RA LDVFAVLTDPTTGDAKRRDTVLFLKEFCNYAQNLQPQGKDSFYKTLTCLGILQALELTLV :* * * . : :*:: :. : : : : : :: : : ENSMUST00000020755 MDDLQVRSAATDIFSYLVEFSPSMVREFVMQEAQQS-----DDDVLLINVVIEQMICDTD ENST00000312993 MDDLQVRSAATDIFSYLVEFSPSMVREFVMQEAQQS-----DDDILLINVVIEQMICDTD SINFRUP00000129322 MDDLQVRAAATDIFSYLVEFSPSMVREFVMQEPQQT-----DDDVLLINVVIKQMICDSD ENSMUST00000048305 MDDTQVRSAATDIFSYLVEYNPSMVREFVMQEAQQN-----DDDILLINLIIEHMICDTD ENST00000309574 MDDTQVRSAATDIFSYLVEYNPSMVREFVMQEAQQN-----DDDILLINLIIEHMICDTD SINFRUP00000152830 MDDVQVRAAATDIFSYLVEYNPSMVREFVMQEPQQN-----DDDILLINLIIEHMICDTD ci0100130512 SDDEPSHRLAIDIFAHVVEHSPSMVRDFAHKEMTEARSEGNDDDLFLLNLVIDQMICDPD CG9351-RA MNDKKTKSASIDILTAIVEFSPLVVRNYTLNQANRP-----EVERMLLNIAIEQMLNDSE :* : : **:: :**..* :**::. :: . : : :*:*: *.:*: *.: ENSMUST00000020755 PELGGAVQLMGLLRTLIDPENMLATTNKTEKSEFLNFFYNHCMHVLTAPLLTNTSED-KC ENST00000312993 PELGGAVQLMGLLRTLIDPENMLATTNKTEKSEFLNFFYNHCMHVLTAPLLTNTSED-KC SINFRUP00000129322 PELGGAVQLMGLLRTLIDPENMLASTNKTEKTEFLSFFYKYCMHVLTAPLLANTAHD-KI ENSMUST00000048305 PELGGAVQLMGLLRTLVDPENMLATANKTEKTEFLGFFYKHCMHVLTAPLLANTTED-KP ENST00000309574 PELGGAVQLMGLLRTLVDPENMLATANKTEKTEFLGFFYKHCMHVLTAPLLANTTED-KP SINFRUP00000152830 PELGGAVQLMGLLRTLVDPENMLATANKTEKTEFLSFFYKHCMHVLSAPLLANTTEE-KP ci0100130512 PELSCAMQLTGLLRVLLDPENMMA--NKNEKTEFLGFFYRNCMHVLMAPLLANTADETKL CG9351-RA PELGIAVQLMGIVKILLEPENMLT-----EKGDFLNFFYKYSVQTLVAPVILNTIGD-RP ***. *:** *::: *::****:: ** :**.***. .::.* **:: ** : : ENSMUST00000020755 EK---------------------------------DNMLGSNTTNTICPDNYQTAQLLAL ENST00000312993 EKADFFLKHYRYSWSFICTPSHSHSHSTPSSSISQDNIVGSNKNNTICPDNYQTAQLLAL SINFRUP00000129322 SK---------------------------------DLQEGSAKINPVCPDNFQTAQLLAL ENSMUST00000048305 SK-----------------------------------------------DDFQTAQLLAL ENST00000309574 SK-----------------------------------------------DDFQTAQLLAL SINFRUP00000152830 SK-----------------------------------------------DDFQTSQLLAL ci0100130512 GK-----------------------------------------------DDYQTAHLLSL CG9351-RA QN-----------------------------------------------EDYQTAQLLGI : : :::**::**.: ENSMUST00000020755 ILELLTFCVEHHTYHIKNYIMNKDLLRRVLVLMNSKHTFLALCALRFMRRIIGLKDEFYN ENST00000312993 ILELLTFCVEHHTYHIKNYIMNKDLLRRVLVLMNSKHTFLALCALRFMRRIIGLKDEFYN SINFRUP00000129322 ILELLTFCVEHHTYHIKTYIMNKDLLRRVLVLMNSKHTFLALCALRFMRRIIGLKDEYYN ENSMUST00000048305 VLELLTFCVEHHTYHIKNYIINKDILRRVLVLMASKHAFLALCALRFKRKIIGLKDEFYN ENST00000309574 VLELLTFCVEHHTYHIKNYIINKDILRRVLVLMASKHAFLAL------------------ SINFRUP00000152830 ILELLTFCVEHHTYHIKNYIINKDILRRVLVLTASQHAFLALCALRFMRRIIGLKDEFYN ci0100130512 ILELVTFSVEHHTYHVKNYILSKDLLRRVLVLLNSRHKFLSLAALRFTRKIVSTLDEFYN CG9351-RA VLDILSFCVEHHSYHIKNFLLQKDLLKRILVLMKSTHTFLVLGALRLLRKIIALKDEFYN :*::::*.****:**:*.:::.**:*:*:*** * * ** * : : :: ENSMUST00000020755 RYITKGNLFEPVINALLDNGTRYNLLNSAVIELFEFIRVEDIKSLTAHIVENFYKALESI ENST00000312993 RYITKGNLFEPVINALLDNGTRYNLLNSAVIELFEFIRVEDIKSLTAHIVENFYKALESI SINFRUP00000129322 RYIIKGNLFEPVINALLDNGTRYNLLNSAIIELFEFIKVEDIKSLIAHIVDNFYKALESI ENSMUST00000048305 RYIMKSFLFEPVVKAFLNNGSRYNLMNSAIIEMFEFIRVEDIKSLTAHVIENYWKALEDV ENST00000309574 ------------------------------------------------------------ SINFRUP00000152830 RYIMRNFLFEPVIKAFLNNGSRYNLMNSAIIEMFEYVRVEDVKSLTAHIVENYWKALEDV ci0100130512 RYIVKGDLFKPVVDSLFRSGSRYNLINSTILEMFEYIRVEDIKSLISYVVENHHERLKEI CG9351-RA RHIVKCNLFAPVVDAFIRNNGRYNLLESAILELFEFIKLEDIRTLCVYFVENFSKIFDEI : :: :: :: :: :: :: : : : : .: : : ENSMUST00000020755 EYVQTFKGLKTKYEQ----EKDRQ-NQKLN--SVPSILRSNRFRRDAKALEEDEEMWFNE ENST00000312993 EYVQTFKGLKTKYEQ----EKDRQ-NQKLN--SVPSILRSNRFRRDAKALEEDEEMWFNE SINFRUP00000129322 EYVQTFKGLKGRYEQ----EKDRQ-SQRIS--RSHPSFPSSRYRRDARSLDEDEELWFND ENSMUST00000048305 DYVQTFKGLKLRFEQ----QRERQDNPKLD--SMRSILRNHRYRRDARTLEDEEEMWFNT ENST00000309574 ------------------------------------------------------------ SINFRUP00000152830 DYVQTFKGLKLRYEQ----QRERQDNPKLD--SMRSILRNHRFRRDARTLEDEEEMWFNT ci0100130512 EYVKTFVGLKLRFDQ----QKGRELKQNPDPISDAVAIPNHRYRRDARAMEEEEELWFEK CG9351-RA EYVQTFKYLKNRYDQYQDRLKDRDKMENRTDGGLPIIRSGGRFRRDQRQMEEEEEMWFNE : : : : : : ENSMUST00000020755 DDD--EEGKAV------------------------------------------------- ENST00000312993 DEE--EEGKAV------------------------------------------------- SINFRUP00000129322 DDD--DDE---------------------------------------------------- ENSMUST00000048305 DEDDMEDGEAV------------------------------------------------- ENST00000309574 ------------------------------------------------------------ SINFRUP00000152830 DEDDLEDGDAV------------------------------------------------- ci0100130512 DDEDGEDHNSS------------------------------------------------- CG9351-RA EDDFTEEIDTYNNVMKSVSEKNGPQTQNQQKSSPPHSTSPHSGLLGSLSTTASSTATSAT ENSMUST00000020755 --------ITPVEKSKTEDDFPDSYEKFME--------TKKAKE-----------SEDKE ENST00000312993 --------VAPVEKPKPEDDFPDNYEKFME--------TKKAKE-----------SEDKE SINFRUP00000129322 --------GETVEKSRIEDDFSDSYGKYME--------AKKGWH-----------HQS-M ENSMUST00000048305 --------VSPSDKTKNDDDIMDPISKFME--------RKKLKE-----------SEEKE ENST00000309574 ------------------------------------------------------------ SINFRUP00000152830 --------VRPSDKMKTEEDLMEPISKFME--------RKKLKE-----------PEDKE ci0100130512 --------FSSGDAFDTDAPKIN-IDSILEGDKPQDKTVKKSNE-----------LNKLN CG9351-RA SGAPVASGSSSPEAISADEQTQAAVHLAAAALQHHQQQQQQQQQNPFQQQTQPEIAELQQ ENSMUST00000020755 NLPKRASSGGFKFTFSHSPS-ATNGTNS---TNSKSVVSQTTPASSNVASSKTTSLATSV ENST00000312993 NLPKRTSPGGFKFTFSHSAS-AANGTN------SKSVVAQIPPATSNGSSSKTTNLPTSV SINFRUP00000129322 NIPSVLSERSGTFTISTVRSGAANGAGNNVKAAALPTATAVTPNSSSASSVKTVSLP-AT ENSMUST00000048305 VLLKTNLSGRQSPSFKLSLS-SGTKTNLTSQSSATSL-PGSPGSPGSPGSPGSPGSVPKS ENST00000309574 ------------------------------------------------------------ SINFRUP00000152830 ILAKSSFSGRQNPSFKLAFS-GSTKTSLSSPPPSAPLSPGSPGSPGSPGS-GARGSSNTA ci0100130512 TMLQLETKGEENFSNGSIAPKAEVKSTDEAPVTVKNGLVGLVDYSDDDSDDEEESQEKAT CG9351-RA QLSSVEAPQSQELELSQSAAASASPTSSSSSLEASTSSSSASSSSSSSSSSSPPGSSAAA : ENSMUST00000020755 TATKGNLVGLVDY----------------------------PDDEEE--DEEEESS---- ENST00000312993 TATKGSLVGLVDY----------------------------PDDEEE--DEEEESS---- SINFRUP00000129322 PVMKTTLVGLVDY----------------------------PDDEDEEDDDEEEQS---- ENSMUST00000048305 TSQTAAIT---------------------------------------------------- ENST00000309574 ------------------------------------------------------------ SINFRUP00000152830 VTTKGGLVGLVDY----------------------------PDDDEEEDDEDDGESKEDS ci0100130512 AVKCEPDLNASLT----------------------------KTNSVEGKQKEILESE--- CG9351-RA SLCDSATVAAVAASQFLSTIATAMAASVTAAAATNSSPSISPAPAVSSPDIENADAQLPP ENSMUST00000020755 --PRKRPRLGS------------------------------------------------- ENST00000312993 --PRKRPRLGS------------------------------------------------- SINFRUP00000129322 --PRKRPRLTS------------------------------------------------- ENSMUST00000048305 ---TK------------------------------------------------------- ENST00000309574 ------------------------------------------------------------ SINFRUP00000152830 LPPTKKPRL--------------------------------------------------- ci0100130512 -PVRKKPRLIEQVANN-------------------------------------------- CG9351-RA SDDASSPASGEQDANSTEGTSSEADKTTAKKGLVDYESDSGEDDYEEDEYSEGPQAQKRA ENSMUST00000020755 --- ENST00000312993 --- SINFRUP00000129322 --- ENSMUST00000048305 --- ENST00000309574 --- SINFRUP00000152830 --- ci0100130512 --- CG9351-RA RQA