CLUSTAL W (1.82) multiple sequence alignment ENST00000264042 ------------MGEIEGTYRVLQTAGMRLGAQTPVG-------VSTLEPGQTLLP---- ENSMUST00000041983 ------------MGEIEGTYRALPTSGTRLGGQTAIG-------VSTLEPEQSLSP---- SINFRUP00000137345 ------------MGEIEGSFRVLQTPGTRLGAQFSPG-------ISTLEPGQSPGSNLIG SINFRUP00000158637 --------------------ERSSTAGQRLGAPESLG-------VSTLEPGLRPPG---- SINFRUP00000139349 --------------------------GQRLGAPETLG-------ISTLDPAHRPPA---- ENST00000319562 ----------------MGEIEQRPTPGSRLGAPENSG-------ISTLERGQKPPP---- ENSMUST00000026635 ------------------------------------------------------------ ci0100132376 ------------------------------------------------------------ CG31536-RB MSLADMGTASRSAGGEGGRHYDLATGGAGSGGHPVGGGLPGGRMTHSLSTPSGVDGTPST : ENST00000264042 --RMQEKHLHLRVKLLDNTMEIFDIEPKCDGQVLLTQVWKRLNLVECDYFGMEFQNT-QS ENSMUST00000041983 --RMQEKHMRIRVKLLDSTVELFDIEPKCDGQVLLTQVWKHLNLIECDYFGLEFKNV-QS SINFRUP00000137345 GNRNFAKSLQIRVHGLDDCQEFFDVDPKALGQTLLSEVFSRGNLTESDYFGLEFQNM-QM SINFRUP00000158637 --QPPGRQVPMRVQLLDDTQEVFEIPPRSPGKVLFDLVCDHLNLTEGDYFGLEYTNH-HK SINFRUP00000139349 --MPPGRHVTVRVRMLDDTEELFDVSQKASGKVLLDLVCSHMNLIEGDYFGLEFQNH-QK ENST00000319562 --TPSGKLVSIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGDYFGLEFPDH-KK ENSMUST00000026635 ------------------------------------------------------------ ci0100132376 ------------------------------GNMLLQSVMKDINLLESDYFGIQYTDR-QG CG31536-RB PRHRGGKKLTVRIQMLDDSITMFQVQAKALGRVLFEQVCRQLNLLEADYFGLEYQEVSTH : : : : : : :: : : : : ENST00000264042 YWIWLEPMKPIIRQIRR-PKNVVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERL ENSMUST00000041983 YWIWLEPMKPIIRQVRK-PKNAVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERL SINFRUP00000137345 NWVWLEPAKPIVKQVRR-PANTMFRLAVKFFPPDPGQLQEEYTRYLFSMQMKRDLMEGRL SINFRUP00000158637 MPVWLDLLKPTLKQIRR-PKNTILRFVVKFFPPDHTQFTEELTRYLFALQIKHDLACGHL SINFRUP00000139349 IIVWLDHIKPIIKQLRR-PKHTILRFAVKFFPPDHAQLLEELTRYLFALQIKQDISSGRL ENST00000319562 ITVWLDLLKPIVKQIRR-PKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRL ENSMUST00000026635 ------------------------------------------------------------ ci0100132376 NRVFLDPLKKIKSQITN-ISNVVLHFVVKFFPPDPGQLQEEYTRYLFALQVKQDIVDGLL CG31536-RB TKYWLDLEKPMNRQVGLSLIDPVLRFCIKFYTPDPAQLEEEYT----------------- : : :. : : : : :: : : : : ENST00000264042 TCADTTAALLTSHLLQS-EIGDYDETLDREHL--KVNEYLPGQQHC-----LEKILEFHQ ENSMUST00000041983 TCTANTAALLISHLLQS-EIGDYDETLDREHL--KANEYLPNQEKS-----LEKILDFHQ SINFRUP00000137345 ICAENTGALLVSHLVQG-SCS--------------CNIFLFR------------------ SINFRUP00000158637 ICNDTSAALMVSHIIQS-EIGDFDETQSWHHLLHNK--YLPDQDAI-----RDKITECHR SINFRUP00000139349 TCNDTSAALMVSHIVQCKYLGGVFSFGSRDHRVDRRDYRFPHTQFI-----SKHCHVTQY ENST00000319562 TCNDTSAALLISHIVQS-EIGDFDEALDREHLAKNK--YIPQQDAL-----EDKIVEFHH ENSMUST00000026635 ------------------------------------------------------------ ci0100132376 PCNENTLVVMASYIAQS-EFGDWNSFDCSDLSYLRDLKLLPPLVDMNEHDLLVKVSENHK CG31536-RB ------------------------------------------------------------ :: : : ENST00000264042 KHVGQTPAESDFQVLEIARKLEMYGIRFHMASDREGTKIQLAVSHMGVLVFQGTTKINTF ENSMUST00000041983 RHTGQTPAESDFQVLEIARKLEMYGIRFHMASDREGTKINLAVSHMGVLVFQGTTKINTF SINFRUP00000137345 ---GQTPAESDFQILEIARKLEMYGIRFHPAADREDTKINLAVSHMGLHVFQGHTKINTF SINFRUP00000158637 KHVGQTPAVSDYHLLEIARRLEMYGIRLHPAKDREGTKLSLAAAHTGVLVFQGYTKINSF SINFRUP00000139349 RLTGQTPAESDYQLLEVARRLEMYGIRLHPAKDREGTRLSLTVAHTGVLVFQGHTKINSF ENST00000319562 NHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAF ENSMUST00000026635 ---------------EVARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAF ci0100132376 IRTGETKADSDYHLLDIVRRLEQYGLRLLPAKDQENTDIKLAVAHMGVVVFRGNSKINTF CG31536-RB --SGQSPAEADLNLLETARRCELYGMKMHPAKDVEGVPLNLAVAHMGITVFQNITRINTF ::: .*: * **::: * * *.. :.*:.:: *: **:. ::**:* ENST00000264042 NWSKVRKLSFKRKRFLIKLHPEVHGPYQ---DTLEFLLGSRDECKNFWKICVEYHTFFRL ENSMUST00000041983 NWSKVRKLSFKRKRFLIKLHPEVHGPYQ---DTLEFLLGSRDECKNFWKICVEYHTFFRL SINFRUP00000137345 NWSKMRKLSFKRKRFLIKLHPEVHGPHQ---DTLEFLMASRDQCKIFWKICVEYHSFFRL SINFRUP00000158637 NWSKIRKLSFKRKRFLIKLRAEPANAHH---DTLEFAMASRDCCKVFWKICVEYHAFFRL SINFRUP00000139349 NWAKVRKLSFKRKRFLIKLRPDLNSSYQ---DTLEFLMASRDCCKVFWKICVEYHAFFRL ENST00000319562 NWAKVRKLSFKRKRFLIKLRPDANSAYQ---DTLEFLMASRDFCKSFWKICVEHHAFFRL ENSMUST00000026635 NWAKVRKLSFKRKRFLIKLRPDVNSSYQ---DTLEFLMAGRDFCKSFWKICVEHHAFFRL ci0100132376 NWARIRKLSFKKKRFLIKLRTETSKNGQNVGDILVFVMASRDTCKNFWRHCIEYHAFFRL CG31536-RB SWAKIRKISFKRKRFLVKLHPEGYVSNG-------YYGINGNMSLDRRGEITTPPTRYDL .*:::**:***:****:**:.: : : . : . : : * ENST00000264042 LDQPKPKAKAVFFSRGSSFRYSGRTQKQLVDYFKDSGMKRIPYERRHSKTHTSVRALTAD ENSMUST00000041983 SDQPKPKAKAVFFSRGSSFRYRQEMRRLSLTACS-------LFCRRHSKTRTSLHALTVD SINFRUP00000137345 FDQPQPKTKAILFTRGSSFRYSGRTQKQLVEFIR-----------ENGSKRT-------- SINFRUP00000158637 FEEPKPKPKAILFTRGSSFRFKDG------------------------------------ SINFRUP00000139349 YEEPKRKPKPVLFTRGSSFRFSGRTQKQVIDYVKESEFKKIPFERSASRFHMFHSLFCFP ENST00000319562 FEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSIRSLASQP ENSMUST00000026635 FEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSTRSLVSQP ci0100132376 EIHPDPAPKPKIIKRGSTFRYSGKTQKQLHELVRNSNFRRTTFVRASARKPTIQPNNRTP CG31536-RB TLGSDKSSSLSRSEAGTYDVIQAEIQHAKRQELATG------------------------ .. .. *: ENST00000264042 LPKQSISFPEGLRTPASPSSAN---------AFYSLSPSTLVPSGLPEFKDSSSSLTDPQ ENSMUST00000041983 LPKQSVSFTDGLRTSASLSSANV--------SFYPPPSSSLSPPGLPNLKDSSSSLVDPQ SINFRUP00000137345 -PYQRCVFPH-----------------------------TICRVELGNLTIHTVFLFEPS SINFRUP00000158637 ------------------------------------------------------------ SINFRUP00000139349 LV---------------------------------------------------------- ENST00000319562 TELNSEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAGEPGSHPSPAPRRSPAGNK ENSMUST00000026635 TAPNSEVPKQSPQSASLTFGEGTESPGGQSCQQAKETKACTLELGPHQSPALPKSPPGSK ci0100132376 HENARDTLKSNTSSADSPASRIS---------KSRSNSTRSGSSSSYKYNSHPLPPPPPP CG31536-RB ------------------------------------------------------------ ENST00000264042 VSYVKSPAAERRSG-AVAGGPDTPSAQPLGPPALQPGPGLSTKSPQPSPSSRKSPLSLSP ENSMUST00000041983 APVIKSTAAERSSGPSSSDGPSTQSAHLPGPPVLRPGPGFSMDSPQPSPSSLKSHLSLCP SINFRUP00000137345 DSVVDS-------------------------PQLSP---FSSKGP-LSPSLQMSNLSLS- SINFRUP00000158637 ----------------------------------------------FLVNGWSSVCAC-- SINFRUP00000139349 -----------------------------GAGSNSPCLSASACHPHGMVNGQKSLELCGH ENST00000319562 QADGAASAPTEEEEE--VVKDRTQQSKPQPPQPSTGSLTGSPHLSELSVNSQGGVAPANV ENSMUST00000026635 AADGTTVVPPEEEEEEEGGKDGIRPSNPQPPQPSTGSLTGSPHLSELSINSQGGAAPANV ci0100132376 PPPTGQDDGDDTSDTFPSPPPLPPKSARSTPAPVRQWPKMNGNTPAEYINTDDLNIKVKL CG31536-RB ----------------------------------------VATASHQNGNGNGNGHTLS- . ENST00000264042 AFQVPLGPAEQGSSPLLSPVLSDAG--GAGMDCEE-PRHKRVPADEAYFIVKEILATERT ENSMUST00000041983 ELQAALSTAEQGASPVLSPVLSGAG--TARMDNQEEQKHKHMPEDEAYFIAKEILATERT SINFRUP00000137345 ---------GQAPSPLQSPNLCEVGS-TVRLEEEEEGRRKRYPTDKAYFIAKEILTTERT SINFRUP00000158637 --------------------------------------VQKFPTDKAYFIAKELLTTERT SINFRUP00000139349 ------SPDGRQPSPLTSPLLNDAG--SIRTDDEDEVRRKRFPTDQAYFIAKELLTTERT ENST00000319562 TLSPNLSPDTKQASPLISPLLNDQA--CPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERT ENSMUST00000026635 TLSPNLSPDNKQASPLISPLLNDQA--CPRTDDEEEGRRKRFPTDKAYYIAKEVSTTERT ci0100132376 RKPPRRSESNASKNLSAGPQNPALKSIHDQNQTISLSASERYPSSQAYYIAKEILTTERT CG31536-RB ----------------------------TQHDIEAEVKKRKWPTEPSYFLAKELLMTERT .: * . :*::.**: **** ENST00000264042 YLKDLEVITVWFRSAVVKEDA---MPATLMTLLFSNIDPIYEFHRGFLREVEQRLALWEG ENSMUST00000041983 YLKDLEVITVWFRSVLIKEEA---MPAALMALLFSNIDPVYEFHRGFLHEVEQRLALWEG SINFRUP00000137345 YLKDLEVITVWFRSAVIKENA---MPEGLMTLLFSNIDPIYEFHRDFFKELDQRLALWEG SINFRUP00000158637 FIKDLQVITESFDSFVGKDEA---FPDAIKTLIFSSYDPVYKFHQGFLKEVEQRLAQWEG SINFRUP00000139349 YVKDLEVVTVSFQNAVGQEEA---TPDSLKKSIFSIFEPLHKFHTGFLREVEQRLALWEG ENST00000319562 YLKDLEVITSWFQSTVSKEDA---MPEALKSLIFPNFEPLHKFHTNFLKEIEQRLALWEG ENSMUST00000026635 YLKDLEVIASWFQSTVSKEDS---MPEALKSLIFPNFEPLHKFHTNFLKEIEQRLALWEG ci0100132376 YVKDLEVITTWFKSALQKEGSESLLPENTANQLFGGIGSLVALHQQFLCTLDDRLSSWEG CG31536-RB YKKDLDVLNTTFRQVLSLGDV------EQLQPLFELLDSLAQHHNLFLRDIEHRMVQWEG : ***:*: * . : :* .: * *: ::.*: *** ENST00000264042 PSKAHTKGSHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKRCKKLEAVYKEFEL ENSMUST00000041983 PSSAHLKGDHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKHCKKLEAVYKEFEL SINFRUP00000137345 RSNAHVKGDYQRIGDVMLRNMGALKEFTSYLQKHDEVLTELEKATKRLKNLETVYKEFEL SINFRUP00000158637 RSNAHIKGDYQRIGDILLKNIQGLRHLTIHLQKHSECLVELERASRSSRKVEALCRDFEQ SINFRUP00000139349 RSNAHIKGDSQRIGDVMLKNLQALRPLTVSLHKQSEALLELEKACRSCPRLEDLCRDFEL ENST00000319562 RSNAQIR-DYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRRLENFCRDFEL ENSMUST00000026635 RSNAHVRGDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALETSIKGSRRLEHFCRDFEL ci0100132376 RGSTGAT-NDQLVDDLMLSHMLVLKKYLASLENGESLITAIEEVGDAEPKFESLYREFEL CG31536-RB RG----GHEAHRIGDVMMKHMAALPIYDEYVQTHLDILHCMNDMYEGDERFRQVYKEFEQ . . : :.*::: :: : . . : :: ... . ::** ENST00000264042 QKVCYLPLNTFLLKPIQRLLHYRLLLRRLCGHYSPG--HHDYADCHDALKAITEVTTTLQ ENSMUST00000041983 QKVCYLPLNTFLLKPVQRLVHYRLLLSRLCAHYSPG--HRDYADCHEALKAITEVTTELQ SINFRUP00000137345 QKVCYLPLNTFLLKPIQRLMHYKLILERLCKHYPPM--HRDHDDCKEALKEVTDIATQLQ SINFRUP00000158637 QRVCYLPFNMFLLRPLHRLLHYKLILERLCKHYPPT--HDDFRDCRASLADISEMVLQLQ SINFRUP00000139349 QKVCYIPLNVFILRPLHRLIHYKQILERLCKHYPAT--HVDFRDCRAALADVSEVVEQLQ ENST00000319562 QKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPS--HADFRDCRAALAEITEMVAQLH ENSMUST00000026635 QKVCYLPLNTFLLRPLHRLMHYKHVLERLCKHHPPN--HADFRDCRAALAEITEMVAQLH ci0100132376 QKVCYLPFNSFLLKPMQRIAHYKLITERLMNYYEAESTLQQHPDLQSAYKEACVLCTATQ CG31536-RB QKVCYLPIGELLLKPLNRLLHYQLILERLCDYYGEE--HIDYADAMAVHHLLVRSTKGIR *:***:*:. ::*:*::*: **: : ** :: :. * : ENST00000264042 HILIRLENLQKLTELQRDLVGIENLIAPGREFIREGCLHKLTKKGLQQRMFFLFSDMLLY ENSMUST00000041983 QSLTRLENLQKLTELQRDLVGVENLIAPGREFIREGCLHKLTKKGLQQRMFFLFSDMLLY SINFRUP00000137345 SSLIRLENFQKLTELQRDLIGIENLTAPGRKFIREGCLYKLTKKGLQQRMFFLFSDMLLY SINFRUP00000158637 GTMMKMENFQKLLELKKDLTGIDNLTIPGREFIRLGCLSKLSAKGLQQRMFFLFSDSLVY SINFRUP00000139349 GSLIKMENFQKLLELKKDLTGIDNLVVPGREFIRLGCLSKLSGKGLQQRMFFLFNDVILY ENST00000319562 GTMIKMENFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFFLFNDVLLY ENSMUST00000026635 GTMIKMENFQKLHELKKDLIGIDNLVTPGREFIRLGSLSKLSGKGLQQRMFFLFNDVLLY ci0100132376 ERLKRAHNLQKMAQLRRDLIGVEHLLKPNRTFIREGSLYKLSRKGFQQRLFFLFSDCLVY CG31536-RB SQLPDSANFVELCELQRDIN-FEQLVQPHRRLIRQGCLLKHSKRGLQQRMFFLFSDLLLY : *: :: :*::*: .::* * * :** *.* * : :*:***:****.* ::* ENST00000264042 TSKGVAGTSHFRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQKTIVVAASTRLEKEKWM ENSMUST00000041983 TSKSVTGASHFRIRGFLPLRGMLVEESENEWSVPHCFTIYAAQKTIVVAASTRLEKEKWM SINFRUP00000137345 TSKGVTATNQFKVHGQLPLHGMIVEESENEWSVPHCFTIYAAQRTIVVAA---------- SINFRUP00000158637 TSRGMTPSNQFKVHGQLPLYGLTIRESEEEWGVPHSFTLYGQRQSVVVAA---------- SINFRUP00000139349 TSRGMMPTNQFKVHGQLPLHGMTIRESEDEWGVPHAFTLVGQQQSVVVAASSLAEMQKWM ENST00000319562 TSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWV ENSMUST00000026635 TSRGLTASNQFKVHGQLPLYGMTIEESEEEWGVPHCLTLRGQRQSIIVAASSRSEMEKWM ci0100132376 TSKGVTSTNQFKVHAELPLQGMIIEVNEGESAVPNCFSILSASKTVIVAAATQEEMDKWL CG31536-RB GSKSPLDQS-FRILGHVPVRSLLTENAEHN-----TFSIFGGQCAITVSAGTTAEKTLWL *:. . *:: . :*: .: . : : : ::: . :: *:* ENST00000264042 LDLNSAIQAAKSGGDTAPALPG---------------RTVCTRPPRSPNEVSLEQESEDD ENSMUST00000041983 QDLNAAIQAAKTIGDSPPVLLG---------------GPVYTRTPRSSDEVSLE-ESED- SINFRUP00000137345 ------------------------------------------------------------ SINFRUP00000158637 ---RYAPCTYRGR--TAG-----------------------------PSSPVKETEDSNE SINFRUP00000139349 EDIRVAIETQKPP--TASSDL----------------LTSSLSGSKCPEDSAVEAESEDE ENST00000319562 EDIQMAIDLAEKSSSPAPEFL----------------ASSPPDNKSPDEATAADQESEDD ENSMUST00000026635 EDIQMAIDLAEKSNGPTPELL----------------ASSPPDNKSPDEATAADQESEDD ci0100132376 EDFSVAIARAGREMEMYESPL--------------------NNAAGSLSRLSMEQSSEDG CG31536-RB AELSKAAADIKNRPPNMQLQLTTLKNCSSSEEGLDLFGLSNGNNSSLNSSVNGGGPLTTQ ENST00000264042 ARGVRSSLEGHG---QHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSHGW ENSMUST00000041983 GRGNRGSLEGNS---QHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSNGW SINFRUP00000137345 ------------------------------------------------------------ SINFRUP00000158637 LCAAS-LMERHL---SER---------CRQDVGRYVGRSLTTERSLP------------- SINFRUP00000139349 TAASQTSLERPA---PHRGNTMVHVCWHRNTSVSMVDFSVAVENQLSGNLLRKFKNSNGW ENST00000319562 LSASRTSLERQA---PHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGW ENSMUST00000026635 LSASRTSLERQA---PHRGNTMVHVCWHRSTSVSMVDFSIAVENQLSGNLLRKFKNSNGW ci0100132376 EGSVRNSMERLKPPMQHRSNATMHVCWHRNTSVSSSDHLVSLKNQLSGYLLRKFKNSNGW CG31536-RB QQKLQLQQQQQNRTQPSRSNTALHVCWHRGATVGLGDHLIAAEHQLSGYLLRKFKNSSGW : ENST00000264042 QKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFKSHVYFF ENSMUST00000041983 QKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSLPREADSIHKDYVFKLQFKSHVYFF SINFRUP00000137345 ------------------------------------------------------------ SINFRUP00000158637 -----------------AHDDYPLASLPLLGYSVTVPSESENIHKDYVFKLHFKSHVYYF SINFRUP00000139349 QKLWVVFTNFSLFFYKSHQDDYPLASLPLLGYSVSVPSDSENIHKDYVFKLHFKSHIYYF ENST00000319562 QKLWVVFTNFCLFFYKSHQVS--------------------------------------- ENSMUST00000026635 QKLWVVFTNFCLFFYKSHQDSHPLASLPLLGYSLTIPSESENIHKDYVFKLHFKSHVYYF ci0100132376 QKLWVVFTNFCLFFYKSNQDESPLASLPLLGYTINSPTEADGIRKDFVFKLKFKTHVYFF CG31536-RB QKLWVVFTSFCLYFYKSYQDEFALASLPLLGYTVGPPGHQDAVQKEFVFKLSFKNHVYFF : : :: : : :: : : : : ENST00000264042 RAESKYTFERWMEVIQGASSSAGRAPSIVQDGPQPSSGLEGMVRGKEE---------- ENSMUST00000041983 RAESKYTFERWMDVIKRASSSPGRPPSFTQDCSHHSPGLEAEIREKEACPSPCLDKNL SINFRUP00000137345 ---------------------------------------------------------- SINFRUP00000158637 RSESEYTFERW----------------------------------------------- SINFRUP00000139349 RSESEYTFERWMEVIRSATLSSSGARGPSNKES------------------------- ENST00000319562 -----------------VSHRAGGPGTLGVAA-------------------------- ENSMUST00000026635 RAESEYTFERWMEVIRSATSSASRAHILSHKESHLY---------------------- ci0100132376 RAESQYTYNRWIEVISSATVTSQRTRLFSRMDS------------------------- CG31536-RB RAESAHTYNRWLEVLRSTTQTQDFKNVHSHAVLGN-----------------------