CLUSTAL W (1.82) multiple sequence alignment SINFRUP00000139858 ------------------------------------------------------------ SINFRUP00000160029 ------------------------------------------------------------ ENST00000296477 ------------------------------------------------------------ ENSMUST00000046502 ------------------------------------------------------------ ci0100130300 ------------------------------------------------------------ CG4049-RA MEESNPNYDVNQRLQKPEGWPHVNEFHPSMMYPDDPRRYFHNASTDPQHQPQQHPQQQPE SINFRUP00000139858 ------------------------------------------------------------ SINFRUP00000160029 ------------------------------------------------------------ ENST00000296477 ------------------------------------------------------------ ENSMUST00000046502 ------------------------------------------------------------ ci0100130300 ------------------------------------------------------------ CG4049-RA QHPEQHPQHPLHSQQQPQQHPQQQPQQHPQQQTQQPPQLQPQQHPQAQIQPPIPVPISTP SINFRUP00000139858 ---------------------------RPPGSPENTSQSKPPSSKIKKQKPSKGNKSSKS SINFRUP00000160029 ------------------------------------------------------------ ENST00000296477 ---------------------------------------------EQLRRHQGKNLASED ENSMUST00000046502 ---------------------------------------------TSLEGMCGTEHA--- ci0100130300 ------------------------------------------MEEELEEEEDESDNSDPE CG4049-RA MEGTMEVPVKMPEYCPETSQPVEPDRVINPLAEVAKNTVPYGHKRKNSAGEDQAANKKLS SINFRUP00000139858 SKASKTSKPAHMRKNIRKLLKEDQLEAGTKTAQQEEMDRRKRLEQQRK------------ SINFRUP00000160029 ---------------FRKLLREHQLEAVTKAAQQDELERRRRLEQQRKQ----------- ENST00000296477 PKKKRAQKPSHMRRNIRKLLREDQLEPVTKAAQQEELERRKRLEQQRKDYAAPIPTVPLE ENSMUST00000046502 -----------------QLGEDGQRPPRCTSTTSSQSEPSEQLRHQGK------------ ci0100130300 SPSIQDPSVAGECSASNENGEKTQKNNEINGNTTTKKRRRKKIDPNKRK----------- CG4049-RA MAAAEEKKNSHLRKNIRDVMNENNLDTTTLAAQREESERLARVAGQQKS---MREIQKQV . .. : : :: : : SINFRUP00000139858 ----EFPAPAPVVPDS---QLVDTASLLGEVSHLVPDLLSKQDVICLDSSGDEDEKVDSK SINFRUP00000160029 ----DFPTPALTKYKTGENTVVLVVHILIHVSLFLTFSKRSTDVICLSSS--EDDPLASR ENST00000296477 FLPEEIALRASDGPQLPPRVLAQEVICLDSSSGSEDEKSSRDEVIELSSGEEDTLHIVDS ENSMUST00000046502 -------ILASEDP---------------KKKRAQKPSHMRRNIRCVLGKENWRVLLVVI ci0100130300 ----------------------------KIRKMFTEDKLNTDTLLAMKEEESRMKRIEEQ CG4049-RA VHKQIFRILQLDESEGIESCAVANPVEHHPPVDFPEEEIASDTFDDSNSSSLSGGSIEDV : . : SINFRUP00000139858 VP-----TLGLRDDIIELSSGDEDSLQISSESADEDAHGTAGTEESSGAHINDALNLPDA SINFRUP00000160029 GP-----TRGE---------GSE-------------------KSKRSGTHTDDAFNRPDA ENST00000296477 SE-----SVSE---------DDE-------------------EEEKGGTHVNDVLNQRDA ENSMUST00000046502 TE-----KLDQ---------SGY-------------------RETSIFTDTNSDIN---- ci0100130300 AHN----------------------------------------RVIQQMHVEDSMNQPDD CG4049-RA LHKGASVQPSEVVTIDDSSDDDCILLSEEEEEEDDEDLNESDDATNSGMHVKDIYNVPDE : : . .. * SINFRUP00000139858 HGRVLVNINHPAEEKDLYLAPQLARAVKPHQIGGIRFLYDNLVESLERYKTSSGFGCILA SINFRUP00000160029 QGRVLVNLNHPSEEKDIFLLPQLARAIKPHQIGGIRFLYDNLIESVENFGNSSGFGCILA ENST00000296477 LGRVLVNLNHPPEEENVFLAPQLARAVKPHQIGGIRFLYDNLVESLERFKTSSGFGCILA ENSMUST00000046502 ---TCLFTDHS----QVFLT---FVCFVSYQIGGIRFLYDNLVESLERFKTSSGFGCILA ci0100130300 QGRVLVNVNRPPTEPEIFLSPQLARSVLPHQIGGIRFMFDNIVESLTHFEKSPGFGCILA CG4049-RA NGQVVVNMAHPEGEETLYLAPQIAKVIKPHQIGGVRFLYDNIIESTRRYNKSSGFGCILA . : :. ::* : . .:****:**::**::** .: .*.******* SINFRUP00000139858 HSMGLGKTLQVISFIDVLMRNTETHTVLAIVPVNTIQNWLTEFNLWLPAQESLPPETDPT SINFRUP00000160029 HSMGLGKTLQVISFIDILFRHTRAHTVLAIVPVNTLQNWLSEFNTWVPAPETLPPDTDPG ENST00000296477 HSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQNWLAEFNMWLPPPEALPADNKPE ENSMUST00000046502 HSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQNWLAEFNMWLPAPEALPADSKPE ci0100130300 HSMGLGKTLQVISFIDIFLRYTTARTVLCVVPVNTLMNWVSEFEMWLPTEAKSENSSD-- CG4049-RA HSMGLGKTLQVVSFCDIFLRHTSAKTVLCVMPINTLQNWLSEFNMWIPR------YSTDS ***********:** *:::* * ::***.::*:**: **::**: *:* . SINFRUP00000139858 VITGRSFNVHVLNDEHKTTLARAKVVEDWSRDGGVLLMGYEMYRLLTMKKSFVMGKRRKS SINFRUP00000160029 LVAPRAFKVHILNDEHKNTATRAKVVEEWARDGGVLLMGYEMYRLLSLKKNYVAGRKKKN ENST00000296477 EVQPRFFKVHILNDEHKTMASRAKVMADWVSEGGVLLMGYEMYRLLTLKKSFATGRPKKT ENSMUST00000046502 EVQPRFFKVHILNDEHKTVASRAKVTADWVSEGGVLLMGYEMYRLLTLKKSLATSRPKKT ci0100130300 -FSPRPFRVHLLCDNYKNIDSLSKVVSEWYTHGGVLLLGYEMYRLLTSRKPRKK-KAKKP CG4049-RA NVRPRNFDIFVLNDQQKTLTARAKVILNWVHDGGVLLIGYELFRLLALKLVKTRKRKGS- . * * :.:* *: *. : :** :* .*****:***::***: : : . SINFRUP00000139858 KKPTGPVIIDLDEEDRQQELMKGIERAIARPGPDVVICDEGHRIKNYHASTSQALKNIRS SINFRUP00000160029 KKATGPVVINVDEEDRQQELLKGIEKALARPGPDVVICDEGHRIKNCHASTSHALKKIQT ENST00000296477 KKRSHPVIIDLDEEDRQQEFRREFEKALCRPGPDVVICDEGHRIKNCQASTSQALKNIRS ENSMUST00000046502 KKRSHPVIIDLDEEDRQQEFRREFEKALCRPGPDVVICDEGHRIKNCQASTSQALKNIRS ci0100130300 SKSKSSMVIDVEEEDRLSSLSAGMQDSLLQPGPDLIICDEGHRIKNSHASISQMLKNVKT CG4049-RA -------VIRPDGMDSSSDLMNLVYEALVKPGPDLVICDEGHRIKNSHAGISLALKEIRT ::* : * ..: . :: :****::********** :*. * **:::: SINFRUP00000139858 RRRVVLTGYPLQNNLLEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLM SINFRUP00000160029 RRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCVDSTPEDVQLM ENST00000296477 RRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLM ENSMUST00000046502 RRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLM ci0100130300 RRRVVLTGYPLQNNLIEYWCMVDFVRPNFLGTRQEFSNMFERPISNGQCKDSTVADVRLM CG4049-RA RRRIVLTGYPLQNNLLEYWCMVDFVRPNYLGTRTEFCNMFERPIQNGQCVDSTPDDIKLM ***:***********:***********::**** **.******* **** *** *::** SINFRUP00000139858 RYRSHVLHSLLEGFVQRRGHDVLRDQLPSKQEHVILVRLSPIQRALYTEFMKRFREAGNT SINFRUP00000160029 RYRSHVLHSLLEGFVQRRGHDVLRDQLPSKQEHVILVRLSPLQRALYTEFMNRFKEAGNT ENST00000296477 RYRSHVLHSLLEGFVQRRGHTVLKIHLPAKEENVILVRLSKIQRDLYTQFMDRFRDCGSS ENSMUST00000046502 RYRSHVLHSLLEGFVQRRGHTVLKIHLPAKEENVILVRLSQIQRDLYTQFMDRFRDCGTS ci0100130300 RFRSHVLHSLLKGFVQRRSHSVLQKTLPHKEEHVLMIRLSQWQKKLYNTFIKQKMEGGSG CG4049-RA RYRAHVLHSLLLGFVQRRSHTVLQLTLPQKYEYVILVKMTAFQRKLYDTFMTDVVRT--- *:*:******* ******.* **: ** * * *:::::: *: ** *: SINFRUP00000139858 GWLG-LNPLKAFCVCCKIWNHPDVLY-EALQKENQAN------EQDLDLDDITSAGN-PR SINFRUP00000160029 GWLS-LNPLKAFSVCCKIWNHPDVLF-EALQKENLAG------DQDLDLDDITTTAP-TR ENST00000296477 GWLG-LNPLKAFCVCCKIWNHPDVLY-EALQKESLAN------EQDLDVEELGSAGTSAR ENSMUST00000046502 GWLG-LNPLKAFCVCCKIWNHPDVLY-EALQKENLAN------EQDLDVEELGSAGTSAR ci0100130300 NWCSSANPIKAFSVCCKIWNHPDVLHRTVLQKTDLQSNGSELLDADFDLPDLNVDSPSRK CG4049-RA --KAFPNPLKAFAVCCKIWNHPDVLY--NFLKKCETD-------LDLEIDEEVTKGAATP . **:***.************. : * . *::: : . SINFRUP00000139858 CPAPGSG-------LKAKVADPCNSKNNTTLPINHTQDRANQVITYEWAKDIMSSYHMG- SINFRUP00000160029 CLSTPN----------QKPKPPENPHPIGGLSLNQLQEKANQVITYEWAKDIMSDYKPG- ENST00000296477 CPPQGTKGKGEDSTLASSMGEATNSKFLQGVGFNPFQERGNNIVTYEWAKDLLTNYQTG- ENSMUST00000046502 CPPHGTKVKGEDSALPSSMGEATNSKFLQGVGFNPFQERGNNIVTYEWAKELLTNYQTG- ci0100130300 LKQLPK----------TSENPTSLANTVQTNAVGPFSAD-KPESSLDWAKELLTGYTPG- CG4049-RA IVEPSADSSLSLASPLEKKINGSGDPINSIETPSFYDEKPEPLNYGSFGSEGKNNYWMDS . . . : .:..: ..* . SINFRUP00000139858 ILENSAKMVLLFHLIEESVKKRDKLLVFSQSLSTLTVIEDFLSKRPMPSGIASSEPRSQN SINFRUP00000160029 VLENSAKMVLLFHLIEESVRKGDKLLVFSQSLSTLTVIEDFLAKRPVPPSPKKDKP-NQT ENST00000296477 VLENSPKMVLLFHLIEESVKLGDKILVFSQSLSTLALIEEFLGKREVPCPPGTEGQGAQK ENSMUST00000046502 VLENSPKMVLLFHLIEESVKLGDKILVFSQSLSTLALIEEFLGKRDMPCLPGAEGQGTQK ci0100130300 KVEFSGKMVVLMKIINSSIESGDKILVFSQSLSTLSLIEEFLSNQYIP--FQDPHQISSK CG4049-RA SILPKPGCVEVIKQTDTNMSSNFESITGSSEIVDLDTNEIKTVETTIQAPCSNNQLDNGC : . * ::: : .: : :. *..: * * : : SINFRUP00000139858 WVRNLNYYRLDGSTSASERERLINQFNDPENKAAWVFLLSTRAGCLGVNLIG--ANRVVV SINFRUP00000160029 WVRNINYYRLDGSTTVSERERLINQFNDPSNTSAWLFLLSTRAGCLGVNLIG--ANRVVV ENST00000296477 WVRNISYFRLDGSTPAFERERLINQFNDPSNLTTWLFLLSTRAGCLGVNLIG--ANRVVV ENSMUST00000046502 WVRNVSYFRLDGSTPAFERERLINQFNDPSNLTTWLFLLSTRAGCLGVNLIG--ANRVVV ci0100130300 WCKNESYFRLDGNTHSADREKMINQFNNPENKKLWLFLLSTRAGCLGINLIG--ANRVVV CG4049-RA NAGKPSEWNAAGSKNSSGVAAAEPFKKLLKSKQRNEEFSCSWAVDLMKNYVSGLISNSPK : . :. *.. : .. : .: * * * :. .. SINFRUP00000139858 FDASWNPCHDAQAVCRVYRYGQRKPCFIYRLVCDFTLEKKIYDRQVSKQGMSDRVVDDLN SINFRUP00000160029 FDASWNPCHDAQAVCRVYRYGQRKPCHIYRLVCDFTLEKKIYDRQISKQGMSDRVVDDLN ENST00000296477 FDASWNPCHDAQAVCRVYRYGQKKPCYIYRLVADYTLEKKIYDRQISKQGMSDRVVDDLN ENSMUST00000046502 FDASWNPCHDAQAVCRVYRYGQKKPCHIYRLVADYTLEKKIYDRQISKQGMSDRVVDDLN ci0100130300 FDASWNPCHDAQAVCRVYRYGQQKTCHIYRLVSDQSMEKKIYDRQISKQGMSDRVVDKLN CG4049-RA MEIFFCILKESLNLGDRILYGQTKPCFVYRIVMDRCLEKKIYDRQIKKQGMSDRIVDECN :: : ::: : *** *.*.:**:* * :********:.*******:**. * SINFRUP00000139858 PGLNFTRKEVESLLHFVEE--------EAG--QFNLAIQEDFEEVIYQACKLYPHLVTKE SINFRUP00000160029 PVLTFTRREVESLLHFVEE--------VPDPSQVQLQPQDGLESVLRKALHFYPQLITKQ ENST00000296477 PMLNFTRKEVENLLHFVEK--------EPAP-QVSLNVKGIKESVLQLACLKYPHLITKE ENSMUST00000046502 PMLNFTRKEVENLLHFVEK--------EPAP-QTSLDIKGIKESVLQLACLKYPHLITKE ci0100130300 PTQVFSKQDAVKLMEYSDI--------ELPPVDLSDLQEFMDDPVLLATCQHCGHWLTKK CG4049-RA PEAHLSMKDITNLCQDYDSDEDTVEEVNKSTGDLSKPGSPSEEGSKPGSANMSPNASNKS * :: :: .* . : : . . : : : .*. SINFRUP00000139858 PFHHESLLVDRKESKLTKAEKRAAKKSYEDEKRASVPY-------------SRPSYAPYY SINFRUP00000160029 PFPHESLLIDCKELKLSKDEKKAAKKGYEEEKRASVPY-------------TRPSYAHYY ENST00000296477 PFEHESLLLNRKDHKLTKAEKKAAKKSYEEDKRTSVPY-------------TRPSYAQYY ENSMUST00000046502 PFEHESLLLNRKDHKLTKAEKKAAKKSYEEDKRTSVPY-------------TRPSYAQYY ci0100130300 PFFHESLLLDCKNQRLTKAEKRAAQKSYERDKLASAAYNY-----------SRPSYANFY CG4049-RA NNGPTKPLDDQNTPKSPNGASHSPIKTEKNDGQEHAVHVDGIINTILDMHRHCVTKEPFM . * : : : .: .::. * : : . : : : SINFRUP00000139858 P---TSDQALSNMPMFNQRGWRHVS-------RPDDKPVASVRP-----IQSTPIPMMPR SINFRUP00000160029 P---ASDQSLTNIPAFSQRNWRPSP-------RAEEKSIGSVRP-----VPSTPVPMMPS ENST00000296477 P---ASDQSLTSIPAFSQRNWQPTL-------KGDEKPVASVRP-----VQSTPIPMMPR ENSMUST00000046502 P---ASDQSLTSIPAFSQRNWQPTL-------KGDEKPVASVRP-----VQSTPIPMMPR ci0100130300 SGKNGSSQPPTTQSSFLPRNKSSTFPSNPKFGQGTPKPIANVRP-----MQSTPMPMKLQ CG4049-RA HESLLVDQKDRKLSQAEKRQAHRSYELEKKAAVNQRFTYAPAKMNYKIVNNDGTVITKPM .* . . * . . .: . .: SINFRUP00000139858 QVGVG-----MAGSSSSGSLPVNFLQKAGVQVQR--IVTTTDIVIPGSNSTTDVQAR--I SINFRUP00000160029 QASSGSAPRDTSDASSLGGFPVHCLQKAGVFVQK--IVTTTDLVIPGSNSSTDVQAR--I ENST00000296477 HVPLGGSVSSASSTNPSMNFPINYLQRAGVLVQK--VVTTTDIVIPGLNSSTDVQAR--I ENSMUST00000046502 HVPLSGGVSSASSTNTSMNFPINYLQRAGSVSSKCMVCFSLDIVIPGLNSSTDVQAR--I ci0100130300 PNQPN---------GQTPGGNMWLYQKAGIRVQK--VVATESIPLPPNPASDTPGGRNCI CG4049-RA NQQIKTNTSSSTGGRSTRWIPADVWQRQGMTAQE--MTLPLDVVIP---TNSADKANIIL *: * .. : . .: :* :. .. : SINFRUP00000139858 NAGESIHIIRGSKGTYIRTNDGRIFAIRSGKLGR----GTVGDHVVPRDNPSFLSHPVSN SINFRUP00000160029 TAGESIHIIRGTKGTYIRTSDGRIFAVRAANKPKPAEENAASFPAKTFQAPAEESAKVDN ENST00000296477 NAGESIHIIRGTKGTYIRTSDGRIFAVRATGKPK----VPEDGRMAASGSQGPSCESTSN ENSMUST00000046502 NAGESIHIIRGTKGTYIRTSDGRIFAVRATGKPK----APEDGRMAASGSQGPSLASTSN ci0100130300 SAGETIWVIQGKKGTYIRTYAGRIFAVRPNDAAR-------------------------- CG4049-RA KAGQRVMVLKSAKGIYMQLDSGKIIAIRTTAKTE-------------PEKTNKDDVIDIT .**: : :::. ** *:: *:*:*:*. . SINFRUP00000139858 GCSSP-VNQQQHPSNGEQQPSSPLSSEILTEFSRYAASSGAGGTRNEMPSPSDTSSTPAG SINFRUP00000160029 GLLSPERKQQQQPSDILPRPLSPDSPEIISELQRYTGVVGGPGDQTQNGTPFENQVQPNG ENST00000296477 GRHSASSPKAPDP-EGLARPVSPDSPEIISELQQYADVAAARESRQSSPSTNAALPGPPA ENSMUST00000046502 GRHSASSPKAPDP-EGLARPVSPDSPEIISELQQYADVAAARESRQSSPSVSAALPGPPG ci0100130300 -------------FTRLASPTQPDNNTLVCRVKFFVCLIYSHHQRCGEVNSTLN------ CG4049-RA DDGDTDTTKPQSPEEDVKDLTADDEPRVVKNKESNPATTSRPEMPAKDRKSTENVQHFKS . :: . . . SINFRUP00000139858 ---NEALQNNETLDLSRQLSDHLLSSGLEVRG-------------GKRRSSENQGNPQAG SINFRUP00000160029 ---TGNVNHHDASVTSVVQPNMDAAVAQDLRI-------------GSKRKASSP-PPEER ENST00000296477 QLMDSSAVPGTALGTEPRLGGHCLNSSLLVTGQPCGDRHPVLDLRGHKRKLATPPAAQES ENSMUST00000046502 QLMDNSTIPGTALGTEPCLGGHCLNSSLLVTGQPSGGRHPVLDLRGHKRKLATPSVTQES ci0100130300 ------------------------------------------------------------ CG4049-RA QTQPNTTLATTTNQHQLPSDLTYSQPQQSHQQ-------------PQQQASQQQPAQQPP SINFRUP00000139858 VKRSSAAAHFPGMSMG-------SSGLSFPPMGLNSSSILGNLSHMSHPLLMSGGGNGHI SINFRUP00000160029 PSKQHAAGKHSSASMA-------SQGFPFS------------------------GGYG-- ENST00000296477 SRRRSRKGHLPAPVQPYEHGYPVSGGFAMPPVSLNHNLTTPFTSQAGENSLFMGSTPSYY ENSMUST00000046502 VRRRSRKGHLPAPVQPYEHGYPVSGGFAMPPVSLNHNLTTPFTSQAGENSLFMGSNPSYY ci0100130300 ------------------------------------------------------------ CG4049-RA PPAYKHQNHLPAAGEGYSNANSIQPNVPLPP----------------------------- . : : : :: SINFRUP00000139858 PTP-SSSSLPTVFSSASTTSPMSSSSTAAPSSSLASGSLPPYLMNPNMTSLLSSGFPLNY SINFRUP00000160029 --------------------------------------LPPLGINPSMLGG-SLGLFMGA ENST00000296477 QLSNLLADARLVFPVTTDPLVPAGPVSSSSTATSVTASNPSFMLNPSVPGILPS-YSLPF ENSMUST00000046502 QLSNLLADARLVFPVTTDPLVPAGPVSSSSTATSVTASNPSFMLNPSVPGMLPS-YSLPF ci0100130300 ------------------------------------------------------------ CG4049-RA -HPGAPNSSEAPPPADSSYFQPKPFQHTYPPQYYDYYDNKHKSAPPGSGYHINNYTSYGN : SINFRUP00000139858 CQSLLSEPRMFPNPLLSGSGGFPVPNSNSQG--LLSHFNNPTSSLLGAALSQPDRREDTE SINFRUP00000160029 GAPYLQSPHTHP-----GESGYIYPDLFGFG--GASAVPASSSSTTTATLSTASSTSTVS ENST00000296477 SQPLLSEPRMFAPFPSPVLPSNLSRGMSIYPGYMSPHAGYPAGGLLRSQVPPFDSHEVAE ENSMUST00000046502 SQPLLSEPRMFAPFPSPGLPSNLSRGVSVYPGYMSPHAGYPAGGLLRSQVPPFDSHEVAE ci0100130300 ------------------------------------------------------------ CG4049-RA LNFAPYHSNLHPPASYIGAPSSYVNSNVFPRQHWSSVVNSSPASSESMRQPSYIGSTYPV SINFRUP00000139858 NGGSSSDD-----DVIEVTGQ SINFRUP00000160029 APGAMPPY-----ML------ ENST00000296477 VGFSSNDDEDKDDDVIEVTGK ENSMUST00000046502 VGFSSNDDEDKDDDVIEVTGK ci0100130300 --------------------- CG4049-RA NEWSSQ--------------- :: :