CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000058967 ------------------------------------------------------------ ENST00000265593 ------------------------------------------------------------ SINFRUP00000137171 ------------------------------------------------------------ SINFRUP00000140125 ------------------------------------------------------------ ENSMUST00000031894 -------------------------------------MERSQSQRHGGEQSWWGSAPQYQ ENST00000275908 -------DSKSRGLRSYTGGRTGASRPRPGRGSGGGNMEQSRSQQRGGEQSWWGSDPQYQ ci0100142005 --------------------------------------------------------MAAS CG31116-RA MFNNSHSHQDEYIREYAFEPELLINREDYQRKEERSQKSTAASSASTPVRQRWDEVIAKQ ENSMUST00000058967 ----GDGTGAGAGSAGRELSQGREAEGGKRTVHRDGGCNGCGGRGGGGGGRDGASSAAVR ENST00000265593 ----MAAAAAEEGMEPRALQYEQTLMYGRYTQDLGAFAKEEAARIRLGGPEPWKGPPSSR SINFRUP00000137171 ------------------------------------------------------------ SINFRUP00000140125 -------------------------MYGRYTQELGVYAKEEAARLRDGGGLRRNASVRGR ENSMUST00000031894 YMPFEHCTSYGLPSENGGLQHRPRKDMGPRHNAHPTQIYGHQKEQYSYKAQDGGMPKKMG ENST00000275908 YMPFEHCTSYGLPSENGGLQHRLRKDAGPRHNVHPTQIYGHHKEQFSDREQDIGMPKKTG ci0100142005 AAAKAMTRSQSTGEGETHLDYEPTLMYGKYSKELSEFARNEAARIKREK------SLKKL CG31116-RA KEQQRKQSIEIDPPGDDKNQIEIEIEAFYYMYGRYTKDLGEFAKDEARKLKILEKRRKQE ENSMUST00000058967 ADP--------------VCSVRCHKFLVSRVGEDWIFLVLLGLLMALVSWAMDYAIAVCL ENST00000265593 AAPELLEYGRSRCARCRVCSVRCHKFLVSRVGEDWIFLVLLGLLMALVSWVMDYAIAACL SINFRUP00000137171 -----------------VCTVRCQKFLISRVGEDWIFLILLGLVMALVSWVVDFCIAICL SINFRUP00000140125 TAD-VLEYQKDPCAKCQLCASRCQKFLILRVGEDWIFLILLGLLMALVSWVMDYAIAFCQ ENSMUST00000031894 SSSTMDSLDEDHYSKCQDCVHRLGRVLRRKLGEDWIFLVLLGLLMALVSWCMDYVSAKSL ENST00000275908 SSSTVDSKDEDHYSKCQDCIHRLGQVVRRKLGEDGIFLVLLGLLMALVSWSMDYVSAKSL ci0100142005 ETTPLTPYSNTRCGKMKQHFVVCKKWCLKKIRAEWIFLLLLGIIMALLSFLMDYTIQKCQ CG31116-RA DKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGISICT : :: : :** ***::***:*: :* . ENSMUST00000058967 QAQQWMSRGLNTNILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVL ENST00000265593 QAQQWMSRGLNTSILLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVL SINFRUP00000137171 QAQKWMYGGLDSNIFLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVL SINFRUP00000140125 EAQKWMYAGLDSNLLLQYLAWVTYPVVLITFSAGFTQILAPQAVGSGIPEMKTILRGVVL ENSMUST00000031894 QAYKWTYAQMKPSLPLQYLAWVTFPLILILFSALFCQLISPQAVGSGIPEMKTILRGVVL ENST00000275908 QAYKWSYAQMQPSLPLQFLVWVTFPLVLILFSALFCHLISPQAVGSGIPEMKTILRGVVL ci0100142005 RAHYWLYTELKDYIVLQYFAWVLFPIVFITFSVGFVHIVSPQAVGSGIPEMKTIMRGVVL CG31116-RA NARIWLYRDLTSQPFVQYIAWVSLPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQL .* * : :*::.** *: :* **. * ::::**::**********:*** * ENSMUST00000058967 KEYLTLKTFVAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLS-LFGGIYEHESR ENST00000265593 KEYLTLKTFIAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSKFLS-LFGGIYENESR SINFRUP00000137171 KEYLTFKTFVAKVIGLTCALGSGMPLGKEGPFVHIASLCAALLSKFMS-LFGGIYENESR SINFRUP00000140125 KEYLTFKTFVAKVIGLTCALGSGMPLGKEGPFVHVASLCAALLSKFMAALFGGIFMNELR ENSMUST00000031894 KEYLTLKAFVAKVVALTAGLGSGIPVGKEGPFVHIASICAAVLSKFMS-MFSGVYEQPYY ENST00000275908 KEYLTMKAFVAKVVALTAGLGSGIPVGKEGPFVHIASICAAVLSKFMS-VFCGVYEQPYY ci0100142005 HEYLTFRVLVAKMIGLTTSLGSRLPIGKEGPFVHIASIVATLLNKFGI-NFSTPFENESR CG31116-RA KEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIASIVAQLLSKLVT-SFQGIYENESR :****::.::**::.** *** :*:********:**: * :*.*: * : : ENSMUST00000058967 NTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVW ENST00000265593 NTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVW SINFRUP00000137171 NIEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFS--------LE SINFRUP00000140125 NTEMLSAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVW ENSMUST00000031894 YTDILTVGCAVGVGCCFGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVW ENST00000275908 YSDILTVGCAVGVGCCFGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVW ci0100142005 TSEMLAAACAVGVACNFAAPIGGVLFSIEVTTTYFAVRNYWRGFFSAVCGALAFRLLAVW CG31116-RA NSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYWRGFFAAVCGATVFRLLAVW ::*:..*****.. *.:*:**********:*:***********:*. . : ENSMUST00000058967 NRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTI ENST00000265593 NRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTI SINFRUP00000137171 GADS-----------------------AASLCSIASGFGGALFVYLNRLIVQFMRKQKTI SINFRUP00000140125 NKDEETITALFKTRFRLDFPFDLQELPAFAVLGIACGFGGALFVYLNRLIVECMRKQKTI ENSMUST00000031894 NKDAVTITALFRTNFRMDFPFDLKELPAFAVIGICCGFLGAVFVYLHRQVMLGVRKHKCL ENST00000275908 NKDAVTITALFRTNFRMDFPFDLKELPAFAAIGICCGLLGAVFVYLHRQVMLGVRKHKAL ci0100142005 NSEEETITALFKTNFRVEFPYDLQELLAFCGIGIVCGLAGALFVYIHRQIVNLNRNHQKV CG31116-RA FQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGGASYVWVHRRYVLFMRSNKRM : . . .: .*: ** :*:::* : *.:: : ENSMUST00000058967 NRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAG------------QLSQKETLVTLFDN ENST00000265593 NRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAG------------QLSQKETLVTLFDN SINFRUP00000137171 NRFLMKKRLLYPALVTLLVSTLTFPPGFVQFMAGKLVLATFVPVILQLTQKESLVTLLDN SINFRUP00000140125 NKFLLRKRLVYPALVTLLVSTLTFPPGFGQFMAG------------QLTQHESLVALFDN ENSMUST00000031894 SQFLAKHRLLYPGIVTFVIASLTFPPGMGQFMAG------------ELMPREAISTLFDN ENST00000275908 SQFLAKHRLLYPGIVTFVIASFTFPPGMGQFMAG------------ELMPREAISTLFDN ci0100142005 KEFLQRNRFIYPLIVSFVISSLTYPRGFGQFMAG------------ELTLKEALDTLFDN CG31116-RA NKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAG------------ELSTHEQVTQLFSN ..** ::*:::* :::::::::::* * **:** ::: :: ::::* :* : *:.* ENSMUST00000058967 RTWVRQGLVEDLELPSTSQA-WSPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPV ENST00000265593 RTWVRQGLVEELEPPSTSQA-WNPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPV SINFRUP00000137171 RTWAKHGIAEEFDYIGHSQA-WQHPQVNVFVTLVLFIVMKFWMSALATTIPVPCGAFMPV SINFRUP00000140125 RTWCRQGVAEEFDYISHHQA-WRHPQVNVFVTLFLFIVMKFWMSAVATTMPVPCGAFMPV ENSMUST00000031894 NTWVKH--IGDPQSLGQSAV-WLHPQVNVIIIILLFFVMKFWMSIVATTMPIPCGGFMPV ENST00000275908 NTWVKH--AGDPESLGQSAV-WIHPRVNVVIIIFLFFVMKFWMSIVATTMPIPCGGFMPV ci0100142005 KTWAKLGYIDESGVLNDTQAGWKHPTVNIYVTLVLFVVVHFFTTAIAITIAVPSGVFMPV CG31116-RA FTWSRDDLTVEQ---AAVVTHWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPSGMFIPV ** : : . * . ..: :.:: :. * : :* *:.:*.* *:** ENSMUST00000058967 FVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTHTVSTAVIVF ENST00000265593 FVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTHTVSTAVIVF SINFRUP00000137171 FVIGAAFGRLVGESMAAWFPDGIHSDGTVYSIVPGGYAVVGAAALSGAVTHTVSTAVIVF SINFRUP00000140125 FLIGAAFGRLVGEVMAAMFPDGIHADGSVYPIVPGGYAVVGAAALSGAVTHTVSTAVIVF ENSMUST00000031894 FVLGAAFGRLVGEIMAMLFPEGILFDDIIYKILPGGYAVIGAAALTGAVSHTVSTAVICF ENST00000275908 FVLGAAFGRLVGEIMAMLFPDGILFDDIIYKILPGGYAVIGAAALTGAVSHTVSTAVICF ci0100142005 FLTGAAFGRLVGESMAALYPDGFYSGAQIFRIVPGGYAVVGAASLSGAVTHTISTSVIVF CG31116-RA FKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVIIF * **.******* ** :*.*. . *:******:***:::*:*:**:*.:** * ENSMUST00000058967 ELTGQIAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVED ENST00000265593 ELTGQIAHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVED SINFRUP00000137171 ELTGQISHILPVMIAVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWG-HHEY-VLLTR SINFRUP00000140125 ELTGQISHILPVMIAVILANAVAQALQPSLYDSIIRIKKLPYLPELGMGHH--------- ENSMUST00000031894 ELTGQIAHILPMMVAVILANMVAQSLQPSLYDSIIQVKKLPYLPDLGWNQLSKFTIFVED ENST00000275908 ELTGQIAHILPMMVAVILANMVAQSLQPSLYDSIIQVKKLPYLPDLGWNQLSKYTIFVED ci0100142005 ELTGQISHILPVMISVLISNAIAQWLQPSIYESIIQIKGLPYLPDLRTGQRRLYSIFVQD CG31116-RA EMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVED *:****:*::*:*::*:::* :* ****:*:*** :* *****:* . : : ENSMUST00000058967 IMVRDVPHVALSCTFRDLRLALHR-TKGRMLALVESPESMILLGSIERSQVVALLGAQLS ENST00000265593 IMVRDVPHVALSCTFRDLRLALHR-TKGRMLALVESPESMILLGSIERSQVVALLGAQLS SINFRUP00000137171 SHVDNV-----------QRLYVHR-TVKWEWSCNLSFKSMLFMFSS-------------- SINFRUP00000140125 ------------------------------------------------------------ ENSMUST00000031894 IMVRDVKFVSASCTYGELRNLLQA-TTVKTLPLVDSKDSMILLGSVERSELQSLLQRHLC ENST00000275908 IMVRDVKFVSASYTYGELRTLLQT-TTVKTLPLVDSKDSMILLGSVERSELQALLQRHLC ci0100142005 FMVKNMKYISYTSTYKELDQLLKR-CKHKSLPLVDSPASMVLLGSVSRSSLEKILETKQT CG31116-RA FMVRDVKYIWHGISYQKLKEVLKLNKTLRSLPLVDSPDNMILLGSVQRYELIKMIEKHIG : : : :::: ENSMUST00000058967 PARRRQHMQKLRKAQLSPPSDQESPPS----------SETSIRFQVNTEDSGFSGAHGQT ENST00000265593 PARRRQHMQERRATQTSPLSDQEGPPT----------PEASVCFQVNTEDSAFPAARGET SINFRUP00000137171 ------------------------------------------------------------ SINFRUP00000140125 ------------------------------------------------------------ ENSMUST00000031894 AERRLKAAQDMARKLSELPYNGKAQLAGDWHPG---GRPESFAFVDEDEDEDLSRKMELP ENST00000275908 PERRLRAAQEMARKLSELPYDGKARLAGEGLPGAPPGRPESFAFVDEDEDEDLSGKSELP ci0100142005 SHR------------------------------------FSVAEAAATEDAAKSNVRNHE CG31116-RA REKRMEVAQKWQKEAQER----------------------ALEEEKKKQEVELKMRRPSR ENSMUST00000058967 HKPLKPALKRGPSNSTSLQEGTTGNMESAGIALRSLFCGSPPLEATSE---LEKSESCDK ENST00000265593 HKPLKPALKRGPSVTRNLGESPTGSAESAGIALRSLFCGSPPPEAAS-----EKLESCEK SINFRUP00000137171 ------------------------------LLLRILFL---------------------- SINFRUP00000140125 ------------------------------------------------------------ ENSMUST00000031894 LTPAPPPPSPPPPPSQFPIAPSNPEEPNGPLPSHKQPPEASDSADQRSSTFQRLLHCLLG ENST00000275908 PSLALHPSTT---------APLSPEEPNGPLPGHKQQPEAPEPAGQRPSIFQSLLHCLLG ci0100142005 RN------------------------HSAGADLKHVIAEDSDP----------------- CG31116-RA FEVLP---------------------APDILSLRQIANDEMLPPKKR------------- ENSMUST00000058967 RKLKRVRISLASDSDPEAEMSPEEILEWEEQQLDEPVNFSDCKIDP--APFQLVERTSLH ENST00000265593 RKLKRVRISLASDADLEGEMSPEEILEWEEQQLDEPVNFSDCKIDP--APFQLVERTSLH SINFRUP00000137171 -----------------------QIAEWEEMQLDEQVNFDDCKIDP--APFQLVERTSLH SINFRUP00000140125 ------------------------------------------------------------ ENSMUST00000031894 KAHSKKKKITQDSTDLVDNMSPEEIEAWEREQLSQPVCFDCCCIDQ--SPFQLVEQTTLH ENST00000275908 RARPTKKKTTQDSTDLVDNMSPEEIEAWEQEQLSQPVCFDSCCIDQ--SPFQLVEQTTLH ci0100142005 -------------------LNTPTTSEQVTNFYSEQVNFDDCQIDP--SPFQLVERASLH CG31116-RA ------------AETMHGSLAPRKSILKKTNSFNLKTYAQPMGHSPSITPYTTITGNSEF : ENSMUST00000058967 KTHTIFSLLGVDHAYVTSIG--RLIGIVTLKELRKAIEGSVTAQGVKVRPPLASFRDSAT ENST00000265593 KTHTIFSLLGVDHAYVTSIG--RLIGIVTLKELRKAIEGSVTAQGVKVRPPLASFRDSAT SINFRUP00000137171 KTHTIFSLLGLDHAYVTSIG--RLIGMVSLIELRKAIEGSVKAKGVKLRPPLASFRDSGT SINFRUP00000140125 ------------------------------------------------------------ ENSMUST00000031894 KTHTLFSLLGLHLAYVTSMG--KLRGVLALEELQKAIEG-HTKSGVQLRPPLASFRNTTS ENST00000275908 KTHTLFSLLGLHLAYVTSMG--KLRGVLALEELQKAIEG-HTKSGVQLRPPLASFRNTTS ci0100142005 KVHSLFSLLGLSHAYVTSIG--KLVGVVSLKELRMAVQG-VTEDKGNTRPQRNAHLQIRY CG31116-RA RIRSAFEAIFKKSTTLQDVQPDPETGSLSPAASNHEVEVPRTPSTPGVSKKVQLPAQSNW : : : : : : ENSMUST00000058967 SSSDT------------------------------------------------------- ENST00000265593 SSSDT------------------------------------------------------- SINFRUP00000137171 SSSEN------------------------------------------------------- SINFRUP00000140125 ------------------------------------------------------------ ENSMUST00000031894 IRKTPGGPPPPAEGWNVPEDGDGAPGREVMVPTMPETPVPPPSPEAPSCLAPARAEGELE ENST00000275908 TRKSTGAPPSSAENWNLPEDRPGATGTGDVIAASPETPVPSPSPEPPLSLAPGKVEGELE ci0100142005 N----------------------------------------------------------H CG31116-RA DFVTD------------------------------------------------------- ENSMUST00000058967 ETTEVHALWGPRSRHGLPREGTPSDSDDKCQ----- ENST00000265593 ETTEVHALWGPHSRHGLPREGSPSDSDDKCQ----- SINFRUP00000137171 EATELRKLWDHHN-TSLPRDLNQLESDEKSQ----- SINFRUP00000140125 ------------------------------------ ENSMUST00000031894 ELEMVGSLEPEEELADILHGPSLRSTDEEDEDELIL ENST00000275908 ELELVESPGLEEELADILQGPSLRSTDEEDEDELIL ci0100142005 DTQELSSLNLEENNEEESEEDEVYSNKNHN------ CG31116-RA QIMLVSYSLTTFISYHFIHFLGICVFNLL------- :