CLUSTAL W (1.82) multiple sequence alignment ci0100138411 ------------------------------------------------------------ ci0100152342 ------------------------------------------------------------ ci0100146877 ------------------------------------------------------------ CG6293-RA ------------------------------------------------------MELNNV ci0100132537 ------------------------------------------------------------ ci0100132623 ------------------------------------------------------MELN-- ENST00000302269 ----------------------------------------------------------MR ENSMUST00000025212 ---------------------------------------------------------PYF SINFRUP00000150933 ------------------------------------------------------------ ENSMUST00000028815 -MGIGKNTASKSVEAGGSTEGKYEEEAKHSNFFTLPVVINGGATSSGEQDNEDTELMAIY ENST00000278812 MMGIGKNTTSKSMEAGSSTEGKYEDEAKHPAFFTLPVVINGGATSSGEQDNEDTELMAIY SINFRUP00000128512 ------------------------------------------------------------ ci0100138411 --------------------------SGLLY-GLNDVPP---------WYLCIAFGLQHY ci0100152342 -------EKSTNQEIETATDETPQSSSGLLY-GLNDVPS---------WYLCIAFGLQHY ci0100146877 -----------------------DPSTDMLY-TVDDTPS---------WYTCTVLGLQHY CG6293-RA TIEDATDASKSYSQAANTPPSNEKPKPQLLY-AINDNPP---------WYLSIFLAFQHY ci0100132537 ------------MSSKNTDPESDEATHKLAY-GIEDTPP---------WYLSLVLGFQHY ci0100132623 ----SVPVDETSVSTKCKDSPGKKSTNRLLY-GVTDVPP---------WYTCILLGFQHY ENST00000302269 AQEDLEGRTQHETTRDPSTPLPTEPKFDMLY-KIEDVPP---------WYLCILLGFQHY ENSMUST00000025212 PEQHEVVDSAGTSHRDRQAPLPT-PKFDMFMVQVQDTDPGAHGHESAMGSPLDRLSPQHY SINFRUP00000150933 ---------------------------DMIY-TIEDVPP---------WYLCILLGLQHY ENSMUST00000028815 TTENGIAEKSSLAETLDSTGSLDPQRSDMIY-TIEDVPP---------WYLCIFLGLQHY ENST00000278812 TTENGIAEKSSLAETLDSTGSLDPQRSDMIY-TIEDVPP---------WYLCIFLGLQHY SINFRUP00000128512 --------KSPMSETLDSRDSADARRVDMIY-TIEDTPP---------WYLCVFLGLQHY : : * . :. *** ci0100138411 LVAIGSLIGIPMMLASKLCIPDDGEGDLGRANLISATFVVSGACTLIQTTIGNRLPIMQG ci0100152342 LLAIGSLVGVPLILASMLCIPNDAMGDVGRASLISTTFVVSGACTLIQTTIGNRLPIMQG ci0100146877 LIAIGGIVGLPLLLAGPLCIANDDDGDVARALIISSLFFVAGICTMLQTTFGIRLPIMQG CG6293-RA LTMIGAIVSIPFILTPALCMSDE---DANRGIIISTMIFVTGIVTYFQATWGVRLPIVQG ci0100132537 LTMFGSTLAVPLILSGSLCISNN---DLAKSQLISTGFFVGGIVTIIQTLLGTRLPIVQG ci0100132623 LTMFGSTVAVPLILAGPLGVANN---NVAKGQIISTIFLASGISTLLQTIIGNRLPIVQG ENST00000302269 LTCFSGTIAVPFLLAEALCVGHD---QHMVSQLIGTIFTCVGITTLIQTTVGIRLPLFQA ENSMUST00000025212 LTCFSGTIAVPFLLAEALCVGRD---QHMVSQLIGTIFTCVGITTLIQTTVGIRLPLFQA SINFRUP00000150933 LTCFSGTVAVPFLLAEAMCVGRD---QNTVSQLIGTIFTTVGITTLIQSTVGIRLPLFQA ENSMUST00000028815 LTCFSGTIAVPFLLADAMCVGDD---QWATSQLIGTIFFCVGITTLLQTTFGCRLPLFQA ENST00000278812 LTCFSGTIAVPFLLADAMCVGYD---QWATSQLIGTIFFCVGITTLLQTTFGCRLPLFQA SINFRUP00000128512 LTCFSGTIAVPFLLAEAMCVGFD---QWATSQLIGTIFFCVGITTLLQTTLGCRLPLFQA * :.. :.:*::*: : : : : . :*.: : * * :*: * ***:.*. ci0100138411 ISIAFLPPTLVILSLPHNQCPPALPDGYMNTNVTLYNDS-GLIIDGQEVWHRRIREVQGA ci0100152342 NSFSFLPPSIAILSLPHNQCPPALPIGYMNTTVTLYNDS-GLIVDGEEVWHRRMREVQGA ci0100146877 GTFSFLPPTFAILSLPHNKCPPALPSGFNNVTYTLYNDTDGSIIDGTEVWQRRIREVQGA CG6293-RA GTISFLVPTLAILALPQWKCP-------EQAVMDAMDEA-----EREELWQVRMRELSGA ci0100132537 AAFSFLTPAIAIMSSSKYSPCP------NLSTNTSVNNS------IEFDWKPRMLEVQGA ci0100132623 AAFSFLTPAIAIMTSIPDPVPT------NITNGNTTAVN------SEF-WKVRMVQVQGA ENST00000302269 SAFAFLVPAKAILALERWKCPP---------EEEIYGNWSLPLN-TSHIWHPRIREVQGA ENSMUST00000025212 SAFAFLVPAKSILALERWKCPS---------EEEIYGNWSMPLN-TSHIWHPRIREVQGA SINFRUP00000150933 SAFAFLIPAQAILSLDRWSCPS---------EEEIYGNWSAPLD-TAHVWHPRIREIQGA ENSMUST00000028815 SAFAFLAPARAILSLDKWKCNT---------TEITVANGTAELL--EHIWHPRIQEIQGA ENST00000278812 SAFAFLAPARAILSLDKWKCNT---------TDVSVANGTAELLHTEHIWYPRIREIQGA SINFRUP00000128512 SAFAFLAPARAILSLEKWNCNN---------TEVPVFN-STQLFHTEHIWQPRIREIQGA :::** *: *:: : * *: ::.** ci0100138411 IVIGAFFEFLLGATGAVGFLMRFIGPLTIVPTVTLIGLDLFTTAAR-CAEVQWGVAFFTI ci0100152342 IAVAAILEVILGATGAIGFLMRYIGPLTIVPTITLIGLDLFATAAN-NAKVQWGIAFFTI ci0100146877 IAVASCLPILLGLTGAVGFLLRFIGPLTIAPAVALIGLDLFAAAYG-NASSQWGIAMFTA CG6293-RA IAVSAMVQVILGYTGLVGKILKYVTPLTIVPTVSLVGLTLFEHAAE-TASKHWGIAVGTT ci0100132537 ILVASCLQVLIGLTGVIGFLMSYIGPLTVAPTITLVGLSLFGTAADNFAGTHWGISFMTM ci0100132623 IMVASCTQVLLGLTGLIGIVMSRIGPLTIAPTIALVGLGLFGPAGD-FAGKHWGISILTM ENST00000302269 IMVSSVVEVVIGLLGLPGALLNYIGPLTVTPTVSLIGLSVFQAAGD-RAGSHWGISACSI ENSMUST00000025212 IMVSSMVEVVIGLMGLPGALLSYIGPLTVTPTVSLIGLSVFQAAGD-RAGSHWGISACSI SINFRUP00000150933 IIVSSTIEVVIGFCGLPGLLLEYIGPLTITPTVTLIGLSVFTTAGE-RAGSHWGLTALCI ENSMUST00000028815 IIMSSLIEVVIGLLGLPGALLRYIGPLTITPTVALIGLSGFQAAGE-RAGKHWGIAMLTI ENST00000278812 IIMSSLIEVVIGLLGLPGALLKYIGPLTITPTVALIGLSGFQAAGE-RAGKHWGIAMLTI SINFRUP00000128512 IIVSSMVEVCIGALGLPGLLLKYIGPLTITPTVALIGLSGFQAAGE-RAGKHWGIAMLTI * :.: . :* * * :: : ***:.*:::*:** * * * :**:: ci0100138411 TVLTLCSQYLKKVEVPFPKFSFRRRKWYMEKSGIFRMFPVLIALLSAWLLCFILTVTDVF ci0100152342 VVLTLCSQYLKNVTIPFTKFSFHRRKCYIGKSGFFRMFPVLIALLSAWLLCYIFTITNVF ci0100146877 FIVIVCSQFLKNIKVPTPAYS-KSKKCHMTRTPIFKLFPVLFALILAWLLCLILTVTNAL CG6293-RA GMLTLFSQIMSNVPVPILAYR-KGHGLEIRQFQLFRLFPVLLTIMIMWGLCGILTATDVF ci0100132537 ALIIIFSQHLRNVGVPLPVYTRGK-GWTFPRVYIFSLFPVIIGIMFSWAICGIITVAGGF ci0100132623 FLIILFSQHLRNVAVPVPRFKPGQDGKRFMSVNVFRLFPVILAVLLAWMFCGILTVAGAL ENST00000302269 LLIILFSQYLRNLTFLLPVYR-WGKGLTLLRIQIFKMFPIMLAIMTVWLLCYVLTLTDVL ENSMUST00000025212 LLIVLFSQYLRNLTFLLPVYR-WGKGLTLFRVQIFKMF--VLAIMTVWLLCYVLTLTDVL SINFRUP00000150933 FLIVLFAQYLRETSIPVPFYS-REKGLTSTRVQIFKMFPIILAIMVVWLVCYIFTLTNLL ENSMUST00000028815 FLVLLFSQYARNVKFPLPIYK-SKKGWTAYKFQLFKMFPIILAILVSWLLCFIFTVTDVF ENST00000278812 FLVLLFSQYARNVKFPLPIYK-SKKGWTAYKLQLFKMFPIILAILVSWLLCFIFTVTDVF SINFRUP00000128512 FLVLLFSQYARNVHFPLPIYK-AKKGWTSYRLQVFKMFPIIMAILVSWLLCFIFTVTDVF :: : :* : . : .* :* ::: :: * .* ::* :. : ci0100138411 PNDPSKPYYKARTDLRANVIYNSPWFRFPYPGQWGLPIVTIGGVIGMLAAIISSTIESIG ci0100152342 PNDATKPYYRARTDIRSNVIHNSPWFRFPYPGQWGLPVVTVGGFIGMLAAIIAGTVESIG ci0100146877 PTSSSHPGWRARTDIRTNVIRNAPWFRFPYPGQWGLPRVTIAGVIGMMAGVVAGFVESIG CG6293-RA P-----PSHPSRTDVRLNVLTSAKWFYVPYPGQFGWPSVTLSGVLGMLAGVLACTVESLS ci0100132537 PSSSEVYGYAARTDIRLGVLDDAPWFRVPYPGQWGVPVVTLSGVLGMISGVLASIIESVG ci0100132623 PSSQDQYGYFARTDVRIGVLAQASWFRVPYPGQWGLPVVTLSGVLGMISGVLASIIESVG ENST00000302269 PTDPKAYGFQARTDARGDIMAIAPWIRIPYPCQWGLPTVTAAAVLGMFSATLAGIIESIG ENSMUST00000025212 PADPTVYGFQARTDARGDIMAISPWIRIPYPCQWGLPTVTVAAVLGMFSATLAGIIESIG SINFRUP00000150933 PSDPSRYGYKARTDARGDIMTSAPWFRMPYPCQWGLPVVTVAGVLGMLSATMAGIVESIG ENSMUST00000028815 PSNSTDYGYYARTDARKGVLLVAPWFKVPYPFQWGMPTVSAAGVIGMLSAVVASIIESIG ENST00000278812 PPDSTKYGFYARTDARQGVLLVAPWFKVPYPFQWGLPTVSAAGVIGMLSAVVASIIESIG SINFRUP00000128512 PPEPDKYGFYARTDARQGILAAAPWFKIPYPFQWGVPTVTAAGVIGMMSAVVASIIESIG * :*** * .:: : *: .*** *:* * *: ...:**::. :: :**:. ci0100138411 DYHACARLADVPPPPSHALNRGIMMEGIGVMLAGLLGTGSGTTSFSQNVAAIGITRVGSR ci0100152342 DYHACARLAGVPPPPSHALNRGIMMEGIGVMLAGLIGTGSGTTSFSQNVAAIGITRVGSR ci0100146877 DYYACARLSGAPNPPTHAINRGILTEGFGCLLAGVIGTSTATTSFSENIGAIGITRVGSR CG6293-RA YYPTVSQMSGAHSPPLHAINRGIGTEGFGTVLAGLWGAGNGTNTFGENVGAIGVTKIGSR ci0100132537 DYYACARLCRIPSPPHHAVNRGIFMEGIGCILAGAWGTGSGTTSYSENIGAIGITKVGSR ci0100132623 DYYACARLAQVPPPPTHAINRGVFTEGIGCVIAGSLGTGNGTTSYSENIGAIGITKVGSR ENST00000302269 DYYACARLAGAPPPPVHAINRGIFTEGICCIIAGLLGTGNGSTSSSPNIGVLGITKVGSR ENSMUST00000025212 DYYACARLAGAPPPPVHAINRGIFTEGICCIIAGLLGTGNGSTSSSPNIGVLGITKVGSR SINFRUP00000150933 DYYACARLSGAAAPPVHAINRGIFTEGVCCIIAGLLGTGNGSTSSSPNIGVLGITKVGSR ENSMUST00000028815 DYYACARLSCAPPPPIHAINRGIFVEGLSCVLDGIFGTGNGSTSSSPNIGVLGITKVGSR ENST00000278812 DYYACARLSCAPPPPIHAINRGIFVEGLSCVLDGIFGTGNGSTSSSPNIGVLGITKVGSR SINFRUP00000128512 DYYACARLSCAPPPPIHAINRGIFVEGLSCVLDGLFGTGNGSTSSSPNIGVLGITKVGSR * : :::. ** **:***: **. :: * *:...:.: . *:..:*:*::*** ci0100138411 RVLQTAGIMFMFLGYFSKFGSIFVTLPDPVIGGMFFAMF-------GMISAVGLSNLKYV ci0100152342 RVLQTAGVLFMILGYFSKFGSIFVTVPDPVIGGMFYIMF-------GMISAVGLSNLKYV ci0100146877 RVLQVAGFIFFILGMLSKFGSIFVTIPDPVIGGLFCVMF-------GMIAAVGISNLQYV CG6293-RA RVIQWAALIMVLQGVIGKFGAIFILIPDSVVGGIFCVMF-------GMIIAFGLSTLQYV ci0100132537 RVVQAGAIIMIILAVIGKFGALFTTIPDPIVGGMFCVMF-------GMIAAVGMSSLQFV ci0100132623 RVVQAGALIMIVLAVIGKFGALFTTIPDPVVGGMFCVMF-------GMIAAVGMSSLQFV ENST00000302269 RVVQYGAAIMLVLGTIGKFTALFASLPDPILGGMFCTLF-------GMITAVGLSNLQFV ENSMUST00000025212 RVVQYGAGIMLILGAIGKFTALFASLPDPILGGMFCTLF-------GMITAVGLSNLQFV SINFRUP00000150933 RVVQYGAGIMFLLGAVGKFTALFASLPDPILGGMFCTLFGECVAVSGMITAVGLSNLQLV ENSMUST00000028815 RVIQYGAALMLGLGMVGKFSALFASLPDPVLGALFCTLF-------GMITAVGLSNLQFI ENST00000278812 RVIQCGAALMLALGMIGKFSALFASLPDPVLGALFCTLF-------GMITAVGLSNLQFI SINFRUP00000128512 RVIQYGAAMMLFLGLVGKFSALFASLPDPVLGALFCTLF-------GMITAVGLSNLQFV **:* .. ::. . ..** ::* :**.::*.:* :* : : *** *.*:*.*: : ci0100138411 DLDSNRNIFVIGVSLFMGLAIANWTKANSSAIKTGVTEIDQIFTIILSSAMLVGGVVGFF ci0100152342 DLDSNRNIFVIGVSLFMGLSVANWAKANSSAINTGVTELDQIFTIILSSAMLVGGVVGFF ci0100146877 DLNSPRNLFIVGFALFMGLTVPEWMKANKGVIQTGVIEIDQILTVFLETAMLVGGLLALL CG6293-RA DLRSARNLYILGLSIFFPMVLCRWMQKNPGAIDTGNKTVDSTLSVLLGTTILVGGVLGCL ci0100132537 DLDSSRNLLIMGFSTFMGIALPEWVKKNNQLIRTGVPELDQIFIVLLQTGMFVAGVLGFV ci0100132623 DLDSSRNLLIMGFSTFMGIALPEWVRKNRNLIQTGSVEGDQIVLVLLQTGMFISGLLGFI ENST00000302269 DMNSSRNLFVLGFSMFFGLTLPNYLESNPGAINTGILEVDQILIVLLTTEMFVGGCLAFI ENSMUST00000025212 DMNSSRNLFVLGFSMFFGLTLPNYLDSNPGAINTGIPEVDQILTVLLTTEMFVGGCLAFI SINFRUP00000150933 DLNSSRNLFVLGFSIFFGLTLPAYLDAHPKSINTGVAELDQILTVLLSTEMFVGGFLAFC ENSMUST00000028815 DLNSSRNLFVLGFSIFFGLVLPSYLRQNP--LVTGITGIDQILNVLLTTAMFVGGCVAFI ENST00000278812 DLNSSRNLFVLGFSIFFGLVLPSYLRQNP--LVTGITGIDQVLNVLLTTAMFVGGCVAFI SINFRUP00000128512 DLNSSRNLFVLGFSIFFGLVLPSYLKQNP--LVTGIVEIDQVLNVLLTTAMFVGGSVAFI *: * **: ::*.: *: : : : : : ** *. . ::* : :::.* :. ci0100138411 LDNTLPGTESERGLK-----------------AYNVKENEHGSSYQSKIDESYNLPFP-- ci0100152342 LDNTLPG----------------------------------------------------- ci0100146877 FDNTIPGTESERGIVRWR-------------NAQNGKEVFDKKTLLQQEADCYKLPFP-- CG6293-RA LDNIIPGTPEERGLIDWA-------------NEMPLGD----DNVNDGTATDYDFPLG-- ci0100132537 LDNTIPGTEKERGLLAWRKLQEVTTSPTTENNQEANTNTHESISSNQQTQKAKTPPQPSS ci0100132623 LDNTIPGTDEERGILKW------------------LSHEHEGADANVEIKQVYDFPGP-- ENST00000302269 LDNTVPGSPEERGLIQWKAG-------------------AHANSDMSSSLKSYDFPIG-- ENSMUST00000025212 LDNTVPGSPEERGLIQWKAG-------------------AHANSETSASLKSYDFPFG-- SINFRUP00000150933 LDNTIPGTREERGLVHWRT-------------------------SSSSSSSSYDFPLG-- ENSMUST00000028815 LDNTIPGTPEERGIKKWKKG-------------------VSKGSKSLDGMESYNLPFG-- ENST00000278812 LDNTIPGTPEERGIRKWKKG-------------------VGKGNKSLDGMESYNLPFG-- SINFRUP00000128512 LDNTIPGSPEERGLRKLKRG-------------------SGLSAAELEGMRTYDLPFG-- :** :** : ci0100138411 -----------------TTCCR---FVK-------------------------------- ci0100152342 ------------------------------------------------------------ ci0100146877 -----------------TNCCR---FARYVPFLPEFRQRYKEIDDDNADVTTSV------ CG6293-RA -----------------MDAIRRWKWTYYIPFMPTYKLQKQS------------------ ci0100132537 VYNLPFGWIDNTRCASSCNNPSLTKVASYVPICPSFRKRYSQNDNNCETIENQNTVCNTV ci0100132623 ----------------LQKGVDRVKGFRYVFLCPTFDVSFTKCS-----LSRDDTIA--- ENST00000302269 -----------------MGIVKRITFLKYIPICPVFKGFSSSSKDQIAIPEDTPENTETA ENSMUST00000025212 -----------------MGMVKRTTFFRYIPICPVFRGFSKKTQNQPPVLEDTPDNIETG SINFRUP00000150933 -----------------MSVVRRARWLRWFPISPTFTGFQASN-NPPAVKEEEVEGADIT ENSMUST00000028815 -----------------MNIIKKYRCFSYLPISPTFAGYTWKGFGKSENSRSSDKDSQAT ENST00000278812 -----------------MNIIKKYRCFSYLPISPTFVGYTWKGLRKSDNSRSSDEDSQAT SINFRUP00000128512 -----------------MDFLRRHRIFKYIPISPTFNGYQWGWLPKSCRNRGGPEN---- . : ci0100138411 ------ ci0100152342 ------ ci0100146877 ------ CG6293-RA ------ ci0100132537 L----- ci0100132623 ------ ENST00000302269 SVCTKV ENSMUST00000025212 SVCTKV SINFRUP00000150933 LASTKV ENSMUST00000028815 V----- ENST00000278812 G----- SINFRUP00000128512 ------ :