CLUSTAL W (1.82) multiple sequence alignment SINFRUP00000140434 ------------------------------------------------------------ ENST00000265138 --------------------------------------RSHFICDLDFFVLHYIFIDFVI SINFRUP00000144363 ------------------------------------------------------------ ENST00000222250 ------------------------------------------------------------ ENSMUST00000002989 ------------------------------------------------------------ SINFRUP00000133851 ------------------------------------------------------------ ENSMUST00000048068 ---------------------APVTAASRSRLPRPGATADLGGRAASPGGMGGEAG---A ENST00000268042 LGEPVPHRVPHGCRGGLTLPRAPVTAAPLCSRPRLRASADLRGRKESPGGMGGEAGCAAA ENST00000235941 ------------------------------------------------------------ ENSMUST00000049093 ------------------------------------------------------------ SINFRUP00000141728 ------------------------------------------------------------ ci0100150811 ------------------------------------------------------------ ci0100132861 ------------------------------------------------------------ CG1105-RA ------------------------------------------------------------ SINFRUP00000140434 -MVLGKVKSFTVSFDCLNDSNVPVFSSGDCVSGRVTIEVTGEIRVKSLKIHAKGLAKVRW ENST00000265138 NMVLGKVKSLTISFDCLNDSNVPVYSSGDTVSGRVNLEVTGEIRVKSLKIHARGHAKVRW SINFRUP00000144363 -MVLGKVRALAIYFDSLNENNLPVFSGGDLVSGRVVVEVTGDVRVKSLDIHARGVAKVRW ENST00000222250 -MLFDKVKAFSVQLDGATAGVEPVFSGGQAVAGRVLLELSSAARVGALRLRARGRAHVHW ENSMUST00000002989 -MLFDKVKAFVVEIDGARTGTEPVFHGGQAVAGRVLLELAGAARVGALRLRARGRARAHW SINFRUP00000133851 -MIFDKLKKLDIVFDSPEVDCPPVFSSGDVVSGRVILDLFGEIRLNSLKLHAEGFAKVHW ENSMUST00000048068 DGPRGRVKSLGLVFEDESKG---CYSSGETVAGHVLLEAAEPVALRGLRLEAQGRATSAW ENST00000268042 VGAEGRVKSLGLVFEDERKG---CYSSGETTHAHTP-----PFKLNSLHLFNELLEYAAF ENST00000235941 MVMFKKIKSFEVVFNDPEK----VYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLW ENSMUST00000049093 MVMFKKIKSFEVVFNDPEK----VYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLW SINFRUP00000141728 ------------------------------------------------------------ ci0100150811 -----------------------------------------------VKIKFVGKANVHW ci0100132861 -----------------------------------------------------GEANVHW CG1105-RA ----MGLKGCELQLDNPWNT----YYAGQTVNGQVKFTFDSPKKVRGIIIRFLGEANTEW : : : . : : : SINFRUP00000140434 TESRNAG-SNTAYTQNYTEEVEYLNHKDILIGHERDDDN--------------------- ENST00000265138 TESRNAG-SNTAYTQNYTEEVEYFNHKDILIGHERDDDN--------------------- SINFRUP00000144363 TESRNAG-ANTTYTQNYTEEVEYLHHYDTLIGEERGESR--------------------- ENST00000222250 TESRSAG-SSTAYTQSYSERVEVVSHRATLLAP--------------------------- ENSMUST00000002989 TESRSAG-SSTAYTQSYSERVEVVNHRATLLAP--------------------------- SINFRUP00000133851 TESRSAG-SSTAYTQNYSDEVEYLNRREVLLQAGQDTEAVVLRTTVFKSLNLQLTKRRCY ENSMUST00000048068 GPSAGARVCIGGGSPAASSEVEYLNLRLSLLEAP--AGEG-------------------- ENST00000268042 CSEK-------NFLQKIIYIVKTLDLILTIIKIKYNIGEG-------------------- ENST00000235941 MQGS----------QQCKQTSEYLRYEDTLLLEDQPTGENE------------------- ENSMUST00000049093 MQGS----------QQCKQTLDYLRYEDTLLLEEQPTGENE------------------- SINFRUP00000141728 -----------------------------FPLISDSDGS--------------------- ci0100150811 SE-------SRGSGKN-RRTVHYRSSETYFEQTSYVYGQGSM------------------ ci0100132861 SV-------TRSSGDNSTTTTHYRNSETYFNQQLCVYGQG-------------------- CG1105-RA SEEKSV---TTSEGKTENEVTQLKGHEEYFKIQYYLLGGK-------------------- : SINFRUP00000140434 ----------------SEEGLTTIHSGRHEYAFSLELPQ-TPLATSFEGKHGSVRYWVKA ENST00000265138 ----------------SEEGFHTIHSGRHEYAFSFELPQ-TPLATSFEGRHGSVRYWVKA SINFRUP00000144363 ----------------VVSHLPLTHR-----SPSSRLSV-RALATSFEGKHGSVRYWVKA ENST00000222250 ----------------DTGETTTLPPGRHEFLFSFQLP--PTLVTSFEGKHGSVRYCIKA ENSMUST00000002989 ----------------DSGDIATLPAGRHEFPFSFQLP--ISLVTSFEGKHGSVRYSIKA SINFRUP00000133851 IEPQHRQFNIFVFSVADNGEVTVLPEGRHEFPFSFQLPE-ETLVTSFEGKHGSIRYWVKV ENSMUST00000048068 -------------------VTLLQPG-KHEFPFRFQLPS-EPLATSFTGKYGSIQYCVRA ENST00000268042 -------------------IILLQPG-KHEFPFRFQLPS-EPLVTSFTGKYGSIQYCVRA ENST00000235941 -------------------MVIMRPGNKYEYKFGFELPQ-GPLGTSFKGKYGCVDYWVKA ENSMUST00000049093 -------------------MVIMRPGNKYEYKFGFELPQ-GPLGTSFKGKYGCVDYWVKA SINFRUP00000141728 --------------------VVLRPGNKYEYTFGFELPQNGQLVSTYKGKFGYVHYYVKA ci0100150811 ---------------GPYQNEKKLPGGQSNFPFQFILPP--QLPSSFEGAHGYVRYVVHA ci0100132861 ----------------PHQNSTELPAGQSSFPFQFLLPS--QLPSSFEGVYGYVRYIVHA CG1105-RA -----------------NSSETELPPGTHTYPFTCALPP--NLPSSFEGEFGHVRYTIKV *. * ::: * .* : * ::. SINFRUP00000140434 ELHRPWLLPMKTKKEFTVFEHIDINTPLLLS-------PQAGTKDKTLCCWFCTSGPISL ENST00000265138 ELHRPWLLPVKLKKEFTVFEHIDINTPSLLS-------PQAGTKEKTLCCWFCTSGPISL SINFRUP00000144363 ELHRPWLVPVKVKKEFIVFEHIDINMPLLLA-------PQTGTKEKTLCCWFCASGPISL ENST00000222250 TLHRPWVPARRARKVFTVIEPVDINTPALLA-------PQAGAREKVARSWYCNRGLVSL ENSMUST00000002989 TLHRPWVPARCARKVFTVIEPVDINTPALLASGCPMGEPQAGAREKVARSWYCTRGLVSL SINFRUP00000133851 KLHRPRATVKKIKKEFTVIEPIDINTPALLA-------PQAGTKDKMARAWYRNFGQVSV ENSMUST00000048068 VLERPQVPDQSVRRELQVVSHVDVNTPPLLT-------PMLKTQEKMVGCWLFTSGPVSL ENST00000268042 VLERPKVPDQSVKRELQVVSHVDVNTPALLT-------PVLKTQEKMVGCWFFTSGPVSL ENST00000235941 FLDRPSQPTQETKKNFEVVDLVDVNTPDLMA-------PVSAKKEKKVSCMFIPDGRVSV ENSMUST00000049093 FLDRPSQPTQEAKKNFEVMDLVDVNTPDLMA-------PVSAKKEKKVSCMFIPDGRVSV SINFRUP00000141728 LLERPQQPTLECKKSFDVEEPLDVNTPDLLS-------PTGGMKEKKVTCMFIPDGQVSL ci0100150811 SIDKPWKFDPNTKTAFTVLDMLDLNQEQHAR------SPATMNDSKTLCCLCCASGPIAA ci0100132861 AIDRPGKFVTNIQTVFTVLDILDLNFEPTAR------YPATMNDSKTLCCLCCVSAPITA CG1105-RA TLDRPWKFDQDMKMAFTVIAPVDLNLNPRVK------EPFKLELEKSFCCFCCRSGPLAV :.:* : : * :*:* * .* . . :: SINFRUP00000140434 SAKIERKGYTPGESIQIFAEIENCS-SRMVVPKAAIYQTQTFYAKG---KMKEVKQLVAN ENST00000265138 SAKIERKGYTPGESIQIFAEIENCS-SRMVVPKAAIYQTQAFYAKG---KMKEVKQLVAN SINFRUP00000144363 SAKIERKGYTPGESIQIFAEVENCS-SRVVVPKAALYQTQTFFAKG---KGKQIQQLVSN ENST00000222250 SAKIDRKGYTPGEVIPVFAEIDNGS-TRPVLPRAAVVQTQTFMARG---ARKQKRAVVAS ENSMUST00000002989 SAKIDRKGYTPGEVIPIFAEIDNGS-TRAVQPRAALVQTQTFMARG---ARKQKRAVVAS SINFRUP00000133851 TAKIDRKGYTPGEVIPVFAEFDNST-SRTVVPKAYIIQTQTFIARG---TMKQKRAVVST ENSMUST00000048068 SVKIERKGYCNGEAIPIYAEIENCS-SRLVVPKAAIFQTQTYLASG---KTKTVRHMVAN ENST00000268042 SAKIERKGYCNGEAIPIYAEIENCS-SRLIVPKAAIFQTQTYLASG---KTKTIRHMVAN ENST00000235941 SARIDRKGFCEGDEISIHADFENTC-SRIVVPKAAIVARHTYLANG---QTKVLTQKLSS ENSMUST00000049093 SARIDRKGFCEGDDISIHADFENTC-SRIVVPKAAIVARHTYLANG---QTKVFTQKLSS SINFRUP00000141728 NAKIDRSGFCEGEDICINAKFENTC-SRIVVPKAAIIAKQIYQANG---RTKVFRQKLSS ci0100150811 EVHIDRTGYVPGEFIAVNANVENGSSSKLPGTSASIIQSVTFKTTR-KSRTRSNTVVEIN ci0100132861 EVHIDRRGYVPGEFISVNANVENGSSSKLPSTSASIIQNVTFKATT-HSKTFTNKVIMVQ CG1105-RA ITNIPQTGFVSGQVLPITCEVDNTSNVNLTAVKFELRKLVTFHTNQPRSEKRESKVIIAN ..* : *: *: : : ...:* . : : : SINFRUP00000140434 LRGESLSSGKTETWSGKMLKIPPVSP-SILDCNIIRVEYSLMVYVDIPG-AINLSLNLPL ENST00000265138 LRGESLSSGKTETWNGKLLKIPPVSP-SILDCSIIRVEYSLMVYVDIPG-AMDLFLNLPL SINFRUP00000144363 LRGDPLPQGKSQSWEGKQLKIPPVSP-SILDCPIIRVEYALMVYVDVPG-GLNLSVSLPL ENST00000222250 LAGEPVGPGQRALWQGRALRIPPVGP-SILHCRVLHVDYALKVCVDIPG-TSKLLLELPL ENSMUST00000002989 VDGEPVGPNRRALWPGRALRIPPVGP-SILQCRVLSVDYSLKVFVDIPG-SSKLLLELPL SINFRUP00000133851 LSGDVVGAECRETWHGRAIKIPPVGP-SVLHCRIIKVEYMLKV----------------- ENSMUST00000048068 VRGNHIGSGSTDTWNGKMLKIPPVTP-SILDCCIIRVDYSLAVYIHIPG-AKRLMLELPL ENST00000268042 VRGNHIASGSTDTWNGKTLKIPPVTP-SILDCCIIRVDYSLAVYIHIPG-AKKLMLELPL ENST00000235941 VRGNHIISGTCASWRGKSLRVQKIRP-SILGCNILRVEYSLLIYVSVPG-SKKVILDLPL ENSMUST00000049093 VRGNHIISGTCASWRGKSLRVQKIRP-SILGCNILKVEYSLLIYVSVPG-SKKVILDLPL SINFRUP00000141728 VRGNHIISGMCDAWQGKTIRVPKIKP-SMLGSNIIRVEYALMIYIHIPG-SEKLILELPL ci0100150811 GQG--MDAGKSLQWNNERLQVPALPPSMLRFCNIIDIQYHLQFTVVTPGTSINLRLNLPI ci0100132861 GQG--LDAGQSMQWNNQRLKVPALPPSMLRFCNIIDIQYLLQFRVVTPCGSRNLKLNVPI CG1105-RA LSVGPVNGGESRTFT-QQMEIPALPPTNLLNCGIIALDYDLHVECEVSGPHRNLTGKVPI : : . :.: : * : . :: ::* * . : : : SINFRUP00000140434 VIGTIPLHPFGSRTSSVSSQ---------CSM--SWLGMGLPERPEAPPSYAEIVTEEQR ENST00000265138 VIGTIPLHPFGSRTSSVSSQ---------CSMNMNWLSLSLPERPEAPPSYAEVVTEEQR SINFRUP00000144363 VIGTIPLNACASRTSSISSN---------CST-LSWLG--LQERPEAPPSYCDLAISEAE ENST00000222250 VIGTIPLHPFGSRSSSVGSH---------ASFLLDWRLGALPERPEAPPEYSEVVADTEE ENSMUST00000002989 VIGTVPLHPLGSRSASVGSR---------ASFLQDWGLCTMMDRPEAPPEYSEVVRESQL SINFRUP00000133851 ------------------------------------------------------------ ENSMUST00000048068 VIGTIPYSGFGRRNSSVASQ---------FSMDMCWLALALPEQPEAPPNYADVVSEEEF ENST00000268042 VIGTIPYNGFGSRNSSIASQ---------FSMDMSWLTLTLPEQPEAPPNYADVVSEEEF ENST00000235941 VIGSR--SGLSSRTSSMASR---------TSSEMSWVDLNIPDTPEAPPCYMDVIP-EDH ENSMUST00000049093 VIGSR--SGLSSRTSSMASR---------TSSEMSWIDLNIPDTPEAPPCYMDIIP-EDH SINFRUP00000141728 VIGT---AGLGSRSNSVSSQE-----GSVSNASQSWVSLRMPSE---PPSYCDIT--RDC ci0100150811 QLGTIPLQGLTP------------------------------------------------ ci0100132861 QLGNIPVQGF-------------------------------------------------- CG1105-RA TLGTIPLAGVRPPTQFTDAPSAVQSEDPSLAPTQPVSPASPPGGDGVGGALGWNVADSTG : SINFRUP00000140434 QGSLDVPAAR-EELD----GPLFAYIHEFRFQPPPLYSEV------------------- ENST00000265138 RNNLAPVSAC-DDFERALQGPLFAYIQEFRFLPPPLYSEIDPNPDQSADDRPSCPSR-- SINFRUP00000144363 RRDCLQGCDR-SNVDGDEQRSLLPYITEFRYLPPPLYSEV------------------- ENST00000222250 AALGQSPFPLPQDPDMSLEGPFFAYIQEFRYRPPPLYSEEDPNPLLGDMRPRCMTC--- ENSMUST00000002989 VCASPGPSSLLHDLGVTTEGPYFACLQEFRYCPPPLYSEEDPNPPSEAVRPRCMTC--- SINFRUP00000133851 ----------------------------------------------------------- ENSMUST00000048068 SRHVP-PYPQPSDCDGEACYSMFACIQEFRFQPPPLYSEVDPHPGDAQETQPVSFIL-- ENST00000268042 SRHIP-PYPQPPNCEGEVCCPVFACIQEFRFQPPPLYSEVDPHPSDVEESQPVSFIL-- ENST00000235941 RLESP-TTPLLDDMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNN-----VQ---- ENSMUST00000049093 RLESP-TTPLLDDVDDSQDSPIFMYAPEFQFMPPPTYTEVDPCVLNNNNNNNNVQ---- SINFRUP00000141728 RLDQP-LTPLLDDFDG-EDSPIFMNVPAFQYPPLPAYAEVDICTDV------------- ci0100150811 ----------------------------------------------------------- ci0100132861 ----------------------------------------------------------- CG1105-RA GGSLYPNIPPPQFVETQYRAPTIAGRDDSEHTQMIGDGAFAPRYPTFQFNNATAPPASQ :