CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000029194 MENLQSKFSLVQGSNKKLNGMEDDGSPPVKKMMTDIHANGKTLTKV---K ENST00000259119 MENLQTNFSLVQGSTKKLNGMGDDGSPPAKKMITDIHANGKTINKVPTVK SINFRUP00000144355 -------------------------------------------------- Q9PU32_Oreochromis_aureus -------------------------------------------------- SINFRUP00000147297 -------------------------------------------------- Q9YI02_Brachydanio_rerio -------------------------------------------------- ENST00000288796 -------------------------------------------------- Q9YI03_Brachydanio_rerio -------------------------------------------------- Q9PU31_Oreochromis_aureus -------------------------------------------------- CG7233-RA -------------------------------------------------- ci0100143682 -------------------------------------------------- ENSMUST00000029194 KEHLDDYGDASVEPDGEHAKRNRVSLPETLNLNPSLKHTLAQFHLSS--- ENST00000259119 KEHLDDYGEAPVETDGEHVKRTCTSVPETLHLNPSLKHTLAQFHLSS--- SINFRUP00000144355 -----------------------------LDLSPGLKHTLAQFTLSS--- Q9PU32_Oreochromis_aureus -----------------------MEG-TSFQPHPGLQQTLQQFNLSS--- SINFRUP00000147297 -----------------------MEG-ASFQPHPGLQQTLKQFHLSS--- Q9YI02_Brachydanio_rerio -----------------------MEAPSSFQPHPGLQQTLKQFHLSS--- ENST00000288796 -------------------MEAAAGGRGCFQPHPGLQKTLEQFHLSS--- Q9YI03_Brachydanio_rerio -------------------METVA--RQSFQPHPGLQQTLKQFHLSS--- Q9PU31_Oreochromis_aureus -------------------METVS--RPSFQPHPGLQQTLKQFHLSS--- CG7233-RA ------MTEYVTPMISTVLKKYQTSATKSLQGPGHALTTAGVLDIVTNGR ci0100143682 -----------MYGAANIQINAAMDNLRRKTYSESLKTTLNCYQLSS--- * : : ENSMUST00000029194 --QSSLGGPAAFS----ARYSQESMSPTVFLPL----------------- ENST00000259119 --QSSLGGPAAFS----ARHSQESMSPTVFLPL----------------- SINFRUP00000144355 --QSSLGGPAAFS----ARTGHE-HSQAGMPPL----------------- Q9PU32_Oreochromis_aureus --RRSLGGPAAFS----ARWHQDSLFGKDGKSV----------------E SINFRUP00000147297 --MRSLGGPAAFS----ARWHQDSLFGKDGKSA----------------E Q9YI02_Brachydanio_rerio --MSSLGGPAAFS----ARWQQDMLFKKDGKSA----------------E ENST00000288796 --MSSLGGPAAFS----ARWAQEAYKKESAKEAGAAAVPAPVPAATEPPP Q9YI03_Brachydanio_rerio --MISLGGPAAFS----ARWQHDLLFKKDGKDI--------------PEP Q9PU31_Oreochromis_aureus --MSSLGGPAAFS----ARWQHELLFKKDGKEP---------------EP CG7233-RA SESPGLNGKCQASPPVVALIKKEILSSPEPQDLHHHECSTRG-------T ci0100143682 --ADSLSGPSSYS-----ALAAQLWFKENKQSP----------------- .*.* . * : ENSMUST00000029194 --------PSPQVLPG-PLLIPSDSSTELTQTLLEGESISCFQVGGEKRL ENST00000259119 --------PSPQVLPG-PLLIPSDSSTELTQTVLEGESISCFQVGGEKRL SINFRUP00000144355 --------PSPPVLGGGPLLVPSDSSTELTHSLLEGESISCFVVGGEKRL Q9PU32_Oreochromis_aureus MMLTLPPQTPP-VMSG-PLFIPSDRSTERCETVLEREPISCFVVGGDKRL SINFRUP00000147297 IMLAMPAQTPP-VMSG-PLFIPSDRSTERCETVLERETISCFVVGGEKRL Q9YI02_Brachydanio_rerio VLVNLPAQTPP-VMPG-PLFIPSDRSTERCETVLERETISCFVVGGEKRL ENST00000288796 VLHLPAIQPPPPVLPG-PFFMPSDRSTERCETVLEGETISCFVVGGEKRL Q9YI03_Brachydanio_rerio VLHLPPMQPPP-VMPG-PLFIPSDRSTERCETVLEGETISCFVVGGEKRL Q9PU31_Oreochromis_aureus VLQH---LPPP-VMPG-PLFVPSDRSTERCETVLEGETISCFVVGGEKRL CG7233-RA PPQIYSPATPPRELSQPILSVADAGCGELYETKLEGKTIGCFSVGGEMRL ci0100143682 -------PIPPPPLIQIPLLMPNDTSTQRSETILAGERISCFIVGGEKRL .* : : :.. . : .: * : *.** ***: ** ENSMUST00000029194 CLPQVLNSVLREFSLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNA ENST00000259119 CLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNA SINFRUP00000144355 CLPQVLNSVLRDFSLQQINTVCDELYVYCSRCNAEQLHILKVLGILPFNA Q9PU32_Oreochromis_aureus CLPQILNSVLRDFSLQQINSVCDDLHIYCSRCTADQLEILKVVGILPFSA SINFRUP00000147297 CLPQILNSVLRDFSLQQINSVCDDLHIYCSRCTADQLEILKVVGILPFSA Q9YI02_Brachydanio_rerio CLPQILNSVLRDFSLQQINSVCDDLHIYCSRCTADQLEILKVMGILPFSA ENST00000288796 CLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSA Q9YI03_Brachydanio_rerio CLPQILNTVLRDFSLQQINSVCDDLHIYCSRCTADQLEILKVMGILPFAA Q9PU31_Oreochromis_aureus CLPQILNTVLRDFTLQQINSVCDELHIYCSRCTADQLEILKVMGILPFSA CG7233-RA CLPQFLNNVLNDFSLEQINRIFDELGIYCSQCTHDQLVEFKAAKILPSDV ci0100143682 CLPQILTSVLREFSISEINRTCAELHIYCSRCSPDQLEILKVLGILPFNT ****.*..**.:*::.:** :* :***:*. :** :*. *** . ENSMUST00000029194 PSCGLITLTDAQRLCNALLRP-RTFPQNGSILPAKSSLAQLKETGSAFEV ENST00000259119 PSCGLITLTDAQRLCNALLRP-RTFPQNGSVLPAKSSLAQLKETGSAFEV SINFRUP00000144355 PSCGLITLTDAQRLCNALLRPGAALPADPSCKLSKQ--GLLKESEASFQV Q9PU32_Oreochromis_aureus PSCGLITQTDAERLCNALIYGGTYPPHCNKE-SG-SLEL--ERTEKSFKV SINFRUP00000147297 PSCGLITQTDAERLCNALIYGGTYPPHCNKE-LG-SLEL--ERTEKSFKV Q9YI02_Brachydanio_rerio PSCGLITQTDAERLCNALIYGGTFPPHADKELSC-SIEL--ERTEKSFKV ENST00000288796 PSCGLITKTDAERLCNALLYGGAYPPPCKKELAA-SLALGLELSERSVRV Q9YI03_Brachydanio_rerio PSCGLITKTDAERLCNALIYGGTYPPHSKKELYG-SIEL--ELTEKSFKI Q9PU31_Oreochromis_aureus PSCGLITKTDAERLCNALIYGGAYPPRCKKEMNGGSLEL--QFTDRSFKV CG7233-RA KASGLITRTDAERLCAALLHRSDRNSYVPIESLA--------KGALSFHV ci0100143682 TQCGLITKTDAERLVSALGVECGLNSKPDLTKVS--------CDIKGIRV .**** ***:** ** . : ...: ENSMUST00000029194 EHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKR ENST00000259119 EHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKR SINFRUP00000144355 EHQCLGKCQGLFVPQFYTQPEAPCIQCVECQLLFSPQKFVMHSHKSPDKR Q9PU32_Oreochromis_aureus YHECFGRCKGLFVPELYTSPGAACIQCMDCRLMYPPHKFVVHSHKRLENR SINFRUP00000147297 YHECFGRCKGLFVPELYVGPGAACIQCMDCRLMFPPHKFVVHSHKRLENR Q9YI02_Brachydanio_rerio YHECFGKCKGLFVPELYTSPNAACIQCLDCRLMFPTHKFVVHSHKRLENR ENST00000288796 YHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALENR Q9YI03_Brachydanio_rerio YHECFGKCKGLLVPELYTSPNAPCIQCMDCRLMYPTHKFVVHSHKSLENR Q9PU31_Oreochromis_aureus YHECFGKCKGLFVPELYTSPNAACIQCMDCRLMYPTHKFVVHGHKAQENR CG7233-RA YHKCFGKCEGICTPDMYSYQKPTCIKCLECDGWFSPQKFVGHVHRKFENH ci0100143682 YHECFGRGDGIFYPEFYLSPDSPCVSCLDCRISFSPARFVSHSHRGLEKH *:*:*: .*: *::* ..*:.*::* :.. ** * *: ::: ENSMUST00000029194 TCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRN----- ENST00000259119 TCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRS----- SINFRUP00000144355 TCHWGFDSAKWPCYLQLARKYQGTPEEKKLKQLLDEVKEKFHYK------ Q9PU32_Oreochromis_aureus TVHWGFDSANWRAYVLLDPDYTGKEEKSHLEKLLKELKGKFDLTGKLSSK SINFRUP00000147297 TVHWGFDSANWRAYVLLDPDYNGKEQKSHLEQLLKELKGKYDLTCKRSSI Q9YI02_Brachydanio_rerio TCHWGFDSSNWRAYILLDQDYSEKEENSTLQQLLTELKGKFEMGNKHKT- ENST00000288796 TCHWGFDSANWRAYILLSQDYTGKEEQARLGRCLDDVKEKFDYGNKYKRR Q9YI03_Brachydanio_rerio TCHWGFDSANWRAYVLLSPDYTGKEEKARLEQLLDDIKEKFDFSNKYKRK Q9PU31_Oreochromis_aureus TCHWGFDSANWRAYILLGQDYTEKEEKARLELFLDEIKEKFDFANKYKRK CG7233-RA TCHWGFDSRNWHDYLHVALDVENRE---KYQIILDQLK------------ ci0100143682 TCHWGFDPENWRNYLLVPKDK-ESGKQNDLENLLKSLKAKFNFSNSPFGF * ****:. :* *: : . * .:* ENSMUST00000029194 --------------------------------GKRIQSKANTPSG----- ENST00000259119 --------------------------------GKRNQSKANAPSG----- SINFRUP00000144355 -------------------------------------------------- Q9PU32_Oreochromis_aureus SCRSP-SPIRAKRSKFD--KLQS---ADKDRKPDWLQSLSKSAHKDLKQV SINFRUP00000147297 SCR----------------------------------------------- Q9YI02_Brachydanio_rerio SYKAY-SPIPSKKLKHD--RSRSPS-ADREKPADWLQSLAASANKDLKQL ENST00000288796 VPRVSSEPPASIRPKTDDTSSQSPAPSEKDKPSSWLRTLAGSSNKSLGCV Q9YI03_Brachydanio_rerio ASQAS-DPIPAKKPKHDDFPAQSPS-GDKDKQPDWLRSLSASANKGLNCI Q9PU31_Oreochromis_aureus ASSKVSDPIPVKKSKHEDLSSQTPL-ADREKQHDWLQSLS-TPNKGLNCI CG7233-RA -------------------------------------------------- ci0100143682 NTPSLHSSLKRKQPEFAASPVKKR-----MKEEKVEESLFLSPPPPMCYG ENSMUST00000029194 ------MELPSWYP-VIKQEGDHVPQTHSFLHPSYYLYMC-DKVVAPNVS ENST00000259119 ------MELQSWYP-VIKQEGDHVSQTHSFLHPSYYLYMC-DKVVAPNVS SINFRUP00000144355 -------------------------------------------------- Q9PU32_Oreochromis_aureus QLKQRPSAFRPWSPKPAEKVKPAAKN--EVERS---CSRNQETHNLAFAH SINFRUP00000147297 -------------------------------------------------- Q9YI02_Brachydanio_rerio QFKQRPSAFRPWSPRVPSAERETPNH--KYERS---LAKTQDNLAVPNVS ENST00000288796 HPRQRLSAFRPWSPAVSASEKELSPHLPALIRDSFYSYKSFETAVAPNVA Q9YI03_Brachydanio_rerio QPRQRPSAFRPWSPNISVSDKDGAGRPASMLRESFYNYKSLESAVAPNVA Q9PU31_Oreochromis_aureus QSRQKPSAFRPWSPHISAGDKEPSSDPLALLRDGFYNYKSLEKWPPTSPS CG7233-RA -------------------------------------------------- ci0100143682 LPFNMRSAFKPWHSALGHTTTHVSEFSRHQEALTNALLPVIRNRRSLPDP ENSMUST00000029194 LT------------SAASQSKEATKAETSKSTSKQSEKPH---------- ENST00000259119 LT------------SAVSQSKELTKTEASKSISRQSEKAH---------- SINFRUP00000144355 -------------------------------------------------- Q9PU32_Oreochromis_aureus LA------------PAVHAKDSNTPDRGTAAISVQELHNGD--------- SINFRUP00000147297 -------------------------------------------------- Q9YI02_Brachydanio_rerio LP------------IAAFKNNEQPAHRFSQPTESHNTGKTESSRPRKRWP ENST00000288796 L-------------APPAQQKVVSSPPCAAAVSRAPEPLATCTQPRKRKL Q9YI03_Brachydanio_rerio L-------------TPPQKGGQASPSAPSSSHPHGAESEG-ASRGRKRRL Q9PU31_Oreochromis_aureus LRCHYARYGLCPHRYPPLPTQVEANLQVRAHTPTPDLARGELPRSSSPQH CG7233-RA -------------------------------------------------- ci0100143682 EIMSPKTLQKKEPDRKRRSESEEGKIKEKLRQPVSPVTTKCEDLTPTKQP ENSMUST00000029194 -----ESSQHQKTVSYPD------VSLEEQEKMDLKTSRELYSCLDSSIS ENST00000259119 -----SSGKLQKTVSYPD------VSLEEQEKMDLKTSRELCSRLDASIS SINFRUP00000144355 -------------------------------------------------- Q9PU32_Oreochromis_aureus -----AQPTT-KPAHSSNTNR--AEDMDTDGEIDVDDCDDG-PVQSSSLA SINFRUP00000147297 -------------------------------------------------- Q9YI02_Brachydanio_rerio SAERQSQPAT-KTSLCTPIKQRLQENHDSDEEIQVDNCAEV-AVSR-SLM ENST00000288796 TVDTPGAPETLAPVAAPE------EDKDSEAEVEVESREECTFTSSLSSL Q9YI03_Brachydanio_rerio TGDTQPSPQPCAAATASKPLPASPEEHESDVEVEVESREE--LTSSLSSL Q9PU31_Oreochromis_aureus MKSLGLLPQQPANLRCLR--MTRTPRWRSRWRAATKPLRPCPPSGRHLLP CG7233-RA -------------------------------------------------- ci0100143682 HEDSKQFVSSIAGINDQHTSPVHTLDSVPPLVAMSNAVAAASAMLELSSS ENSMUST00000029194 NNSTSRKKSESAVCSLVRGTSKR----DSEDSSP---------------- ENST00000259119 NNSTSKRKSESATCNLVRDINKVGIGLVAAASSP---------------- SINFRUP00000144355 -------------------------------------------------- Q9PU32_Oreochromis_aureus SPPSACTSVSQTLTPQSMARAQERPSWLPGTVCP---------------- SINFRUP00000147297 -------------------------------------------------- Q9YI02_Brachydanio_rerio SPPFTNGVGVMTLSPHSSAEVHDGRARLAAGHCS---------------- ENST00000288796 SSPSFTSSSSAKDLGSPG--ARALPSAVPDAAAP-ADAP--SG------- Q9YI03_Brachydanio_rerio SSPSFPSSSSAKDLSSPSGPVATLPAVVTPAAGP-PEGPLLSGGEGHAMN Q9PU31_Oreochromis_aureus HPAAQPKTSASPGVQGPICTIMSAESTAPAATSVSAPAPVTSSESG---- CG7233-RA -------------------------------------------------- ci0100143682 GQHRNTSVDLEKENKSSQHNVIPPTPTQPCVVPLDATRQHYKWSFDSSSH ENSMUST00000029194 -----------LLVRD--GEDDKGKIMEDVMRTYVRQQEKLNSILQRKQQ ENST00000259119 -----------LLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQ SINFRUP00000144355 -------------------------------------------------- Q9PU32_Oreochromis_aureus ----EMGTMRQMLYAGLDTKEAREKLLQEIVRMRVKQEEKLAAALQAKRS SINFRUP00000147297 -------------------------------------------------- Q9YI02_Brachydanio_rerio ----ELELLKQTLSSDLSSKEAREKFLQEIIRMRVKQEEKLAAALQAKRS ENST00000288796 -LEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRS Q9YI03_Brachydanio_rerio NLESELETLRQALDNGLDSKESKEKFLHEIVKMRVKQEEKLGSALQAKRS Q9PU31_Oreochromis_aureus -LESELESLRQALDSGLDSKESKEKFLHEIVKMRVKQEEKLGSALQAKRS CG7233-RA -------------------------------------------------- ci0100143682 ILSASGTQDIRMLQSLLEKESDKQLIVHELVKMKSRFEEKLDIQARVKRD ENSMUST00000029194 LQMEVEMLSSSKA--MKELTEEQQNLQKELESLQSEHAQRMEEFYIEQRD ENST00000259119 LQMEVKMLSSSKS--MKELTEEQQNLQKELESLQNEHAQRMEEFYVEQKD SINFRUP00000144355 -------------------------------------------------- Q9PU32_Oreochromis_aureus LQQELEFVRVAKKGRLREAIEAKRNLRKEIERLRVDWERKMREAEESCGR SINFRUP00000147297 -------------------------------------------------- Q9YI02_Brachydanio_rerio LQQELEFVRVTKKGRLREAIEAKRNLRKEIERLRVECEKKVRDASESCDR ENST00000288796 LHQELEFLRVAKKEKLREATEAKRNLRKEIERLRAENEKKMKEANESRLR Q9YI03_Brachydanio_rerio LQQELEFLRVAKKEKLREATEAKRNLRKEIERLRAESERKMREANESRMR Q9PU31_Oreochromis_aureus LQQELEFLRVAKKEKLREATEAKRNLRKEIERLRAESEKKMKEANESRIR CG7233-RA -------------------------------------EVELKEMHKAQRE ci0100143682 LEAELEQVKALKKRRLEEATDARNEMQQEMDAMRHEHDMRIQDVNKMLAD ENSMUST00000029194 LEKKLEQVMQQKCTCDSTLEKDRE-AEYAAQLAELRQRLDHAEADRQELQ ENST00000259119 LEKKLEQIMKQKCTCDSNLEKDKE-AEYAGQLAELRQRLDHAEADRQELQ SINFRUP00000144355 -------------------------------------------------- Q9PU32_Oreochromis_aureus LKRELERERQLR-VCDKGCEAERLRVKYSTQIEELHVQLQQAEADREQLR SINFRUP00000147297 -------------------------------------------------- Q9YI02_Brachydanio_rerio LKRDLDRERRTR-VCDKNCEAGRLRAKYSSQIEDLQMKLQQAEVDREQLR ENST00000288796 LKRELEQARQAR-VCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLR Q9YI03_Brachydanio_rerio LKRELEQARQLR-VCDKGCEAGRLRAKYSAQIEDLQVKLQHAEADREQLR Q9PU31_Oreochromis_aureus LKRELEQARQLR-VCDKGCEAGRLRAKYSAQIEDLQMKLQHAEADREQLR CG7233-RA LEHKKRKVRWV--------------------------------------- ci0100143682 IWKQVDELKMKSTNSEDDVNVIKTSDGHLSNMILDSGKTSHENSFRKPSL ENSMUST00000029194 DELRQEREARQKLEMMIKELKLQIGKSSKPSKD----------------- ENST00000259119 DELRQEREARQKLEMMIKELKLQILKSSKTAKE----------------- SINFRUP00000144355 -------------------------------------------------- Q9PU32_Oreochromis_aureus RELQQEREARQTLESVVKDLQTQLALQAGSILPGECKDTSTEAHRQTAQP SINFRUP00000147297 -------------------------------------------------- Q9YI02_Brachydanio_rerio EDLLKERDARQNLERVVKELQEQLGHKAET----EANTQPTKGDQDIS-- ENST00000288796 ADLLREREAREHLEKVVKELQEQLWPRARP-EAAGSEGAAELEP------ Q9YI03_Brachydanio_rerio ADLIHEREAREHLERVVKELQEQLWPKSPSKNGTDVEHPPAKDSNN---- Q9PU31_Oreochromis_aureus ADLLHEREAREHLERMVKELQQQIKH------------------------ CG7233-RA -------------------------------------------------- ci0100143682 NLCNRKSLQSLTSSSVCKRSPSSEEVVDVT-------------------- ENSMUST00000029194 ---- ENST00000259119 ---- SINFRUP00000144355 ---- Q9PU32_Oreochromis_aureus TNGS SINFRUP00000147297 ---- Q9YI02_Brachydanio_rerio ---- ENST00000288796 ---- Q9YI03_Brachydanio_rerio ---- Q9PU31_Oreochromis_aureus ---- CG7233-RA ---- ci0100143682 ----