CLUSTAL W (1.82) multiple sequence alignment SINFRUP00000132938 -------------------------------------------------- ENST00000246010 -------------------------------------------------- ENSMUST00000047382 ----------------TLGLGSRAWRVSWERA------------------ SINFRUP00000141011 -------------------------------------------------- Q98865_Brachydanio_rerio -------------------------------------------------- Q98866_Brachydanio_rerio -------------------------------------------------- ENST00000298168 ------------GGAESFCLGVRNWGRVGVLLG----------------- ENSMUST00000001538 MGLPSPIRSDATHRASSKKVGSLTCRRGGSLLGMRGSSIWRKAEQPVSNA Q8JIK8_Tropheus_duboisi -------------------------------------------------- Q8JIK7_Astatoreochromis_alluau -------------------------------------------------- Q8JIL0_Astatotilapia_brownae -------------------------------------------------- Q8JIK9_Labidochromis_caeruleus -------------------------------------------------- ci0100143489 ------------------MLSCLPQSFESKLS------------------ ENSMUST00000004994 ----------------MTTLAGAVPRMMRPGPG----------------- ENST00000258386 ----------------MTTLAGAVPRMMRPGPG----------------- CG6716-RB -----------------MTVTAFAAAMHRP-------------------- SINFRUP00000132938 -------------------------------------------------- ENST00000246010 -------------------------------------------------- ENSMUST00000047382 --------AAAAAGPGAGGALGSGSLRVSSRRGPRLARALPLCLSGGGGA SINFRUP00000141011 -------------------------------------------------- Q98865_Brachydanio_rerio -------------------------------------------------- Q98866_Brachydanio_rerio -------------------------------------------------- ENST00000298168 -------------------------------------------------- ENSMUST00000001538 SVVSGLQLKSPEASGCAGSSTASSSPASQGQQSPRCGASQKQTAEGVSRT Q8JIK8_Tropheus_duboisi -------------------------------------------------- Q8JIK7_Astatoreochromis_alluau -------------------------------------------------- Q8JIL0_Astatotilapia_brownae -------------------------------------------------- Q8JIK9_Labidochromis_caeruleus -------------------------------------------------- ci0100143489 -------------------------------------------------- ENSMUST00000004994 -------------------------------------------------- ENST00000258386 -------------------------------------------------- CG6716-RB -------------------------------------------------- SINFRUP00000132938 -------------------------EQTYGEVNQLGGVFVNGRPLPNAIR ENST00000246010 -------------------------EQTYGEVNQLGGVFVNGRPLPNAIR ENSMUST00000047382 RALPDCAGPSPRRSGARQLAGPRAMEQTYGEVNQLGGVFVNGRPLPNAIR SINFRUP00000141011 -------------------------EPAFGEVNQLGGVFVNGRPLPNAIR Q98865_Brachydanio_rerio ------------------------MEPAFGEVNQLGGVFVNGRPLPNAIR Q98866_Brachydanio_rerio ------------------------MEPAFGEVNQLGGVFVNGRPLPNAIR ENST00000298168 -----------------------AMEPAFGEVNQLGGVFVNGRPLPNAIR ENSMUST00000001538 ELSLTGLHQLQRRLLAGPPLLGCVTKPAFGEVNQLGGVFVNGRPLPNAIR Q8JIK8_Tropheus_duboisi ------------------------------------GVFVNGRPLPNAIR Q8JIK7_Astatoreochromis_alluau ------------------------------------GVFVNGRPLPNAIR Q8JIL0_Astatotilapia_brownae ------------------------------------GVFVNGRPLPNAIR Q8JIK9_Labidochromis_caeruleus ------------------------------------GVFVNGRPLPNAIR ci0100143489 ----------PDELKKLHEKQKEFLDQTFGEVNQLGGVFVNGRPLPNALR ENSMUST00000004994 -----------QNYPRSGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIR ENST00000258386 -----------QNYPRSGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIR CG6716-RB --------------FFNGYSTMQDMNSGQGRVNQLGGVFINGRPLPNNIR : : ***:******* :* SINFRUP00000132938 LRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKP ENST00000246010 LRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKP ENSMUST00000047382 LRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKP SINFRUP00000141011 LRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKP Q98865_Brachydanio_rerio LRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKP Q98866_Brachydanio_rerio LRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKP ENST00000298168 LRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKP ENSMUST00000001538 LRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKP Q8JIK8_Tropheus_duboisi LRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKP Q8JIK7_Astatoreochromis_alluau LRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKP Q8JIL0_Astatotilapia_brownae LRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKP Q8JIK9_Labidochromis_caeruleus LRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKP ci0100143489 LRIIELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKP ENSMUST00000004994 HKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKP ENST00000258386 HKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKP CG6716-RB LKIVEMAADGIRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKP :*:*:* ***** **************** **:***** **.****** SINFRUP00000132938 R-VTTPNVVKNIREYKQNDPGIFAWEIRDRLLADGVCDKYNVPSVSSISR ENST00000246010 R-VTTPNVVKHIRDYKQGDPGIFAWEIRDRLLADGVCDKYNVPSVSSISR ENSMUST00000047382 R-VTTPNVVKHIRDYKQGDPGIFAWEIRDRLLADGVCDKYNVPSVSSISR SINFRUP00000141011 R-VTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKFNLPSVSSISR Q98865_Brachydanio_rerio R-VTTPNVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKFNLPSVSSISR Q98866_Brachydanio_rerio R-VTTPNVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKFNLPSVSSISR ENST00000298168 R-VTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKYNVPSVSSISR ENSMUST00000001538 R-VTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKYNVPSVSSISR Q8JIK8_Tropheus_duboisi R-VTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKFNLPSVSSISR Q8JIK7_Astatoreochromis_alluau R-VTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKFNLPSVSSISR Q8JIL0_Astatotilapia_brownae R-VTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKFNLPSVSSISR Q8JIK9_Labidochromis_caeruleus R-VTTPTVVKHIRTYKQRDPGIFAWEIRDRLLADGVCDKFNLPSVSSISR ci0100143489 R-VTTPGVVNAIKDYKVRDPGIFAWEIRDRLLSDAVCDKYNVPSVSSISR ENSMUST00000004994 KQVTTPDVEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISR ENST00000258386 KQVTTPDVEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISR CG6716-RB R-IATPEIENRIEEYKRSSPGMFSWEIREKLIREGVCDRSTAPSVSAISR : ::** : : *. ** .**:*:****::*: :.***: . ****:*** SINFRUP00000132938 ILRNKIGNLSQPNQ-----YESNKQG---STQAGLSYNHIYPY--SYPNA ENST00000246010 ILRNKIGSLAQPGP-----YEASKQP---PSQPTLPYNHIYQY--PYPSP ENSMUST00000047382 ILRNKIGSLAQPGP-----YEASKQP---PPQPALPYNHIYQY--PYPSP SINFRUP00000141011 ILRNKIGNLSQQGQ-----YESGKQAPHPPPQPTLPYNHLYS----YPT- Q98865_Brachydanio_rerio ILRNKIGNLSQQNQ-----YESSKQASHPQPQPTIPYNHLYS----YPTP Q98866_Brachydanio_rerio ILRNKIGNLSQQNQ-----YESSKQASHPQPQPTIPYNHLYS----YPTP ENST00000298168 ILRNKIGNLAQQGH-----YDSYKQH-QPTPQPALPYNHIYS----YPSP ENSMUST00000001538 ILRNKIGNLAQQGH-----YDSYKQH-QPAPQPALPYNHIYS----YPSP Q8JIK8_Tropheus_duboisi ILRNKIGNLSQQSQ-----YESGKQAPHPPPQPTLPYNHLYS----YPT- Q8JIK7_Astatoreochromis_alluau ILRNKIGNLSQQSQ-----YESGKQAPHPPPQPTLPYNHLYS----YPT- Q8JIL0_Astatotilapia_brownae ILRNKIGNLSQQSQ-----YESGKQAPHPPPQPTLPYNHLYS----YPT- Q8JIK9_Labidochromis_caeruleus ILRNKIGNLSQQSQ-----YESGKQAPHPPPQPTLPYNHLYS----YPT- ci0100143489 ILRNKIGNVLHPNNPLNPNYVPISNIENSTPPQSTNMRPTYNS--PIYNH ENSMUST00000004994 ILRSKFGKGEEEEA-----DLERKEAEESEKKAKHSIDGILS--ERASAP ENST00000258386 ILRSKFGKGEEEEA-----DLERKEAEESEKKAKHSIDGILS--ERASAP CG6716-RB LVRGRDAPLDNDMS-----SASGSPAGDGTKASSSCGSDVSGGHHNNGKP ::*.: . . . SINFRUP00000132938 MSPTGTKMGSPPGVPVTAGHMSLSRPWPSAHTVTNILG------------ ENST00000246010 VSPTGAKMGSHPGVPGTAGHVSIPRSWPSAHSVSNILG------------ ENSMUST00000047382 VSPTGTKMGTHPGVPGSAGHVSIPRSWPSAHSVSNILG------------ SINFRUP00000141011 -----SKVPNP-GMPTLPGHMAMHRIWPSSHSVTDILG------------ Q98865_Brachydanio_rerio IAAAGTKVPTPPGMPTLPGHMAMHRIWPSSHSVTDILG------------ Q98866_Brachydanio_rerio IAAAGTKVPTPPGMPTLPGHMAMHRIWPSSHSVTDILG------------ ENST00000298168 ITAAAAKVPTPPGVPAIPGSVAMPRTWPSSHSVTDILG------------ ENSMUST00000001538 ITAAAAKVPTPPGVPAIPGSVALPRTWPSSHSVTDILG------------ Q8JIK8_Tropheus_duboisi -----SKVPTPPGMPTLPGHMAMHRIWPSSHSVTDILG------------ Q8JIK7_Astatoreochromis_alluau -----SKVPTPPGMPTLPGHMAMHRIWPSSHSVTDILG------------ Q8JIL0_Astatotilapia_brownae -----SKVPTPPGMPTLPGHMAMHRIWPSSHSVTDILG------------ Q8JIK9_Labidochromis_caeruleus -----SKVPTPPGMPTLPGHMAMHRIWPSSHSVTDILG------------ ci0100143489 YMVPPTGKPNMPNAPPTIRGSPMPCHPFYSHSVTEILRGSRFDQPQLQGT ENSMUST00000004994 QSDEGSDIDSEPDLPLKRKQ-RRSRTTFTAEQLEELER------------ ENST00000258386 QSDEGSDIDSEPDLPLKRKQ-RRSRTTFTAEQLEELER------------ CG6716-RB SDEDISDCESEPGIALKRKQ-RRCRTTFSASQLDELER------------ : . . . : : :: SINFRUP00000132938 --IRAFMDPT---------------------------------------- ENST00000246010 --IRTFMEQTGALAGSEGTAYS-----------PKMEDWAGVNRTAFP-- ENSMUST00000047382 --IRTFMEQTGALAGSEGAAYS-----------PKMEDWAGVNRAAFP-- SINFRUP00000141011 --IRSITEQQ---S------------------------------------ Q98865_Brachydanio_rerio --IRSITEQQ---ISDNPSFPS-----------AKLEEWRAINRSNFSP- Q98866_Brachydanio_rerio --IRSITEQQ------N-------------------AEWIA--------- ENST00000298168 --IRSITDQ----VSDSSPYHS-----------PKVEEWSSLGRNNFPA- ENSMUST00000001538 --IRSITDQG---VSDSSPYHS-----------PKVEEWSSLGRNNFPA- Q8JIK8_Tropheus_duboisi --IRSITEQ----------------------------------------- Q8JIK7_Astatoreochromis_alluau --IRSITEQ----------------------------------------- Q8JIL0_Astatotilapia_brownae --IRSITEQ----------------------------------------- Q8JIK9_Labidochromis_caeruleus --IRSITEQ----------------------------------------- ci0100143489 APSNSMTSESISVAPPNGSYHHQLLPVSVPSVIPKLEEWNNMTPYGVPPP ENSMUST00000004994 AFERTHYPDIYTREELAQRAKLT---------EARVQVWFSNRRARWRKQ ENST00000258386 AFERTHYPDIYTREELAQRAKLT---------EARVQVWFSNRRARWRKQ CG6716-RB AFERTQYPDIYTREELAQRTNLT---------EARIQVWFSNRRARLRKQ .: SINFRUP00000132938 -------------------------------------------------- ENST00000246010 ------------------------ATPAVNGLEKP--------ALEADIK ENSMUST00000047382 ------------------------TSPAVNGLEKP--------ALEADIK SINFRUP00000141011 -------------------------------------------------- Q98865_Brachydanio_rerio -----------------------ANSPLVNGVDKP--------HLEPEAK Q98866_Brachydanio_rerio -------------------------------------------HSEQLCH ENST00000298168 -----------------------AAPHAVNGLEKG--------ALEQEAK ENSMUST00000001538 -----------------------AAPHAVNGLEKG--------ALEQEAK Q8JIK8_Tropheus_duboisi --------------------------QSKHGCMEG--------G------ Q8JIK7_Astatoreochromis_alluau --------------------------QSKHGCMEG--------G------ Q8JIL0_Astatotilapia_brownae --------------------------QSKHGCMEG--------G------ Q8JIK9_Labidochromis_caeruleus --------------------------QSKHGCMEG--------G------ ci0100143489 ---------------------TQVTTVHLNGGEKSSPVSRDITSLQQSPT ENSMUST00000004994 -------------------AGANQLMAFNHLIPGGFPPTAMP----TLPT ENST00000258386 -------------------AGANQLMAFNHLIPGGFPPTAMP----TLPT CG6716-RB HTSVSGGAPGGAAASVSHVAASSSLPSVVSSVPSMAPLAMMPGSLDPATV SINFRUP00000132938 -------------------------------------------------- ENST00000246010 YTQSASTLSAVG-----GFLPACAY-----PASNQHGVYSAPGGGYLAPG ENSMUST00000047382 YTQSASSLSAVG-----GFLPACAY-----PASNQHGVYSAPAAGYLSPG SINFRUP00000141011 -------------------------------------------------- Q98865_Brachydanio_rerio YNQTPNGLPTVN-----SYVTAPSIHHYHPPTQVSPYMGYSGTTSAYVTG Q98866_Brachydanio_rerio SSQHPS-LPPSH-----PSVTLHGVQRHH--------VGLCDRP--HMAA ENST00000298168 YGQAPNGLPAVG-----SFVSASSMAPYPTPAQVSPYMTYSAAPSGYVAG ENSMUST00000001538 YGQ----------------------------------------------- Q8JIK8_Tropheus_duboisi -------------------------------------------------- Q8JIK7_Astatoreochromis_alluau -------------------------------------------------- Q8JIL0_Astatotilapia_brownae -------------------------------------------------- Q8JIK9_Labidochromis_caeruleus -------------------------------------------------- ci0100143489 SEENRSSHPLST-----LYVTPPANTPYVTSAPQMANNSHHYVTPAYIPS ENSMUST00000004994 YQLSETSYQPTS-IPQAVSDPSSTVHRPQPLPPSTVHQSTIPSNADSSSA ENST00000258386 YQLSETSYQPTS-IPQAVSDPSSTVHRPQPLPPSTVHQSTIPSNPDSSSA CG6716-RB YQQQYDFYGSHANISVSAAAPMASSNLSPGITTTPPHHHQFYNPSANTAS SINFRUP00000132938 -------------------------------------------------- ENST00000246010 PPWPPAQGPPLAPPGAGVAVHGGELAAAMTFKHPSREGSL---------- ENSMUST00000047382 PPWPPAQAPPLTPHGAGVAVHGGELAAAMTFKH--REGTD---------- SINFRUP00000141011 -------------------------------------------------- Q98865_Brachydanio_rerio PTWQPPSGSALSPHSCDISSP-----LAFKSMSATRDSVH---------- Q98866_Brachydanio_rerio AQWQ-----------CSLSPQ-----L----------------------- ENST00000298168 HGWQHAGGTSLSPHNCDIPAS-----LAFKGMQAAREGSH---------- ENSMUST00000001538 -------------------------------------------------- Q8JIK8_Tropheus_duboisi -------------------------------------------------- Q8JIK7_Astatoreochromis_alluau -------------------------------------------------- Q8JIL0_Astatotilapia_brownae -------------------------------------------------- Q8JIK9_Labidochromis_caeruleus -------------------------------------------------- ci0100143489 YGHPGWQQQSLPMNGVDPVLTGNPAPQRSVHSLQNGGVQH---------- ENSMUST00000004994 YCLP-----STRHG---FSSYTDSFVPPSGPSNPMNPTIG---------- ENST00000258386 YCLP-----STRHG---FSSYTDSFVPPSGPSNPMNPTIG---------- CG6716-RB YIMPGENGNTTPTGNIIVSSYETQLGSVYGTETETHQTMPRNESPNESVS SINFRUP00000132938 -------------------------------------------------- ENST00000246010 -----------PAPAARPRTPSVAYTDCPSRPRPPRGSSPRTRARRERQA ENSMUST00000047382 -----------RKPPS---------------------------------- SINFRUP00000141011 -------------------------------------------------- Q98865_Brachydanio_rerio -----------SLVASAL-------------------------------- Q98866_Brachydanio_rerio -------------------------------------------------- ENST00000298168 -----------SVTASAL-------------------------------- ENSMUST00000001538 -------------------------------------------------- Q8JIK8_Tropheus_duboisi -------------------------------------------------- Q8JIK7_Astatoreochromis_alluau -------------------------------------------------- Q8JIL0_Astatotilapia_brownae -------------------------------------------------- Q8JIK9_Labidochromis_caeruleus -------------------------------------------------- ci0100143489 -----------GYPKLAVSAP----------------------------- ENSMUST00000004994 ----------NGLSPQVMGL-LTNHGGVPHQPQTDYALSPLTGG------ ENST00000258386 ----------NGLSPQVMGL-LTNHGGVPHQPQTDYALSPLTGG------ CG6716-RB SAFGQLPPTPNSLSAVVSGAGVTSSSGANSGADPSQSLANASAGSEELSA SINFRUP00000132938 -------------------------------------------------- ENST00000246010 DPGAQVCAAAPAIGTGRIGGLAEEEASA---------------------- ENSMUST00000047382 -PGGK---ATDALGS--LHGLPIPASTS---------------------- SINFRUP00000141011 -------------------------------------------------- Q98865_Brachydanio_rerio -------------------------------------------------- Q98866_Brachydanio_rerio -------------------------------------------------- ENST00000298168 -------------------------------------------------- ENSMUST00000001538 -------------------------------------------------- Q8JIK8_Tropheus_duboisi -------------------------------------------------- Q8JIK7_Astatoreochromis_alluau -------------------------------------------------- Q8JIL0_Astatotilapia_brownae -------------------------------------------------- Q8JIK9_Labidochromis_caeruleus -------------------------------------------------- ci0100143489 QTGDGKNSGNQKLDRPPIHSNGQTSST----------------------- ENSMUST00000004994 ---LEPTTTVSASCSQRLEHMKNVDSLP---------------------- ENST00000258386 ---LEPTTTVSASCSQRLDHMKSLDSLP---------------------- CG6716-RB ALKVESVDLIAASQSQLYGGWSSMQALRPNAPLSPEDSLNSTSSTSQALD SINFRUP00000132938 -------------------------------------------------- ENST00000246010 --GPRGARPASPQAQPCLWPDPPHFLYWSGFLGFSELGF----------- ENSMUST00000047382 -------------------------------------------------- SINFRUP00000141011 -------------------------------------------------- Q98865_Brachydanio_rerio -------------------------------------------------- Q98866_Brachydanio_rerio -------------------------------------------------- ENST00000298168 -------------------------------------------------- ENSMUST00000001538 -------------------------------------------------- Q8JIK8_Tropheus_duboisi -------------------------------------------------- Q8JIK7_Astatoreochromis_alluau -------------------------------------------------- Q8JIL0_Astatotilapia_brownae -------------------------------------------------- Q8JIK9_Labidochromis_caeruleus -------------------------------------------------- ci0100143489 -------------------------------------------------- ENSMUST00000004994 -TSQPYCPP--------MDPVTGYQYGQYGQ---SKPWTF---------- ENST00000258386 -TSQSYCPPTYSTTGYSMDPVTGYQYGQYGQ---SKPWTF---------- CG6716-RB VTAHQMFHPYQHTPQYASYPAPGHAHSHHGHPHAPHPHAHPHPQYAGAHP SINFRUP00000132938 ------------------------------------------ ENST00000246010 ------------------------------------------ ENSMUST00000047382 ------------------------------------------ SINFRUP00000141011 ------------------------------------------ Q98865_Brachydanio_rerio ------------------------------------------ Q98866_Brachydanio_rerio ------------------------------------------ ENST00000298168 ------------------------------------------ ENSMUST00000001538 ------------------------------------------ Q8JIK8_Tropheus_duboisi ------------------------------------------ Q8JIK7_Astatoreochromis_alluau ------------------------------------------ Q8JIL0_Astatotilapia_brownae ------------------------------------------ Q8JIK9_Labidochromis_caeruleus ------------------------------------------ ci0100143489 ------------------------------------------ ENSMUST00000004994 ------------------------------------------ ENST00000258386 ------------------------------------------ CG6716-RB HYPPPSSSAHFMPQNFNAAAFPSPSKVNYTTMPPQPFYPSWY