CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000032277 -------------MYGSARSVGKVEP-----------SSQSPGRSPRLPRSPRLGHRRTN ENST00000239822 --FSAHTFPDLATMYGSARSVGKVEP-----------SSQSPGRSPRLPRSPRLGHRRTN SINFRUP00000162450 -------------MYGSARSVGRGDANHSGGRDGGSTGSQGSGRSPRLPRSPRMGHRRTN ENST00000288221 HFFSSVTPHNTRKMYGSARTITNLEG--------------SPSRSPRLPRSPRLGHRRTS ENSMUST00000048093 -------------MYGSARTISNLEG--------------SPSRSPRLPRSPRLGHRRTS SINFRUP00000139809 ------------------------------------------------------------ SINFRUP00000144016 ------------------------------------------------------------ ci0100135724 ------------------------------------------------------------ CG30336-RA ------------------------------------------------------------ ENSMUST00000032277 STGGSSGNSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHEN--VGAETPKSTMTLGRS ENST00000239822 STGGSSGSSVGGGSGKTLSMENIQSLNAAYATSGPMYLSDHEN--VGSETPKSTMTLGRS SINFRUP00000162450 STGGSGG-GPGGAGGKTLSMENIQSLNAAYATSGPMYLSDNEVAMTGDNLPKSSGTMTTI ENST00000288221 SGG-------GGGTGKTLSMENIQSLNAAYATSGPMYLSDHEG-VASTTYPKGTMTLGRA ENSMUST00000048093 SGG-------GGGTGKTLSMENIQSLNAAYATSGPMYLSDHEG-VASTTYPKGTMTLGRA SINFRUP00000139809 ------------------------------------------------------------ SINFRUP00000144016 ------------------------------------------------------------ ci0100135724 --------------MMSSSDGNKLQVNGEDDRGS-------------------------- CG30336-RA ------------------------------------------------------------ ENSMUST00000032277 GG-RLPYGVRMTAMG----SSPNIASSG----------VASDTIAFGEHHLPPVSMASTV ENST00000239822 GG-RLPYGVRMTAMG----SSPNIASSG----------VASDTIAFGEHHLPPVSMASTV SINFRUP00000162450 GRQRVTYGSRSSSSGVVAASTPNISTTVPGNAILPVGMIAGDALAFGDHH-----MASTV ENST00000288221 TN-RAVYGGRVTAMG----SSPNIASAG-----LSHTDVLSYTDQHGGLTGSSHHHHHQV ENSMUST00000048093 TN-RAVYGGRVTAMG----SSPNIASAG-----LSHTDVLSYTDQHGGLSGSSHHHHHQV SINFRUP00000139809 ------------------------------------------------------------ SINFRUP00000144016 ------------------------------------------------------------ ci0100135724 ------------------------------------------------------------ CG30336-RA ------------------------------------------------------------ ENSMUST00000032277 PHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERA ENST00000239822 PHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERA SINFRUP00000162450 PHSLRQARDNTILDLQAQLKEVLRENEMLRREAEVKESKLSSSMNSIKTFWSPELKKERA ENST00000288221 PSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERV ENSMUST00000048093 PSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERV SINFRUP00000139809 ------------------------------------------------------------ SINFRUP00000144016 ------------------------------------------------------------ ci0100135724 ---LRSSGGDFILQLQQDLES-------LRREIDIKESKLQSNMNSIKTFWSPELKKERA CG30336-RA ------------------------------------------------------------ ENSMUST00000032277 LRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSR-TGEPC ENST00000239822 LRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSR-TGEPC SINFRUP00000162450 LRKDEASKITVWKEQYRVIQDEAQHLQMTVQALQDELRIQRDLNQLFQQDPASH-VRELA ENST00000288221 LRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNR-GAEHF ENSMUST00000048093 LRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNR-GAEHF SINFRUP00000139809 -----------------------QHLQMTIQALQDELRTQRDLNHLLQQESSNRSASEHF SINFRUP00000144016 ------------------------------------------------------------ ci0100135724 LRKEERNQIVTLKEQLKVTQEENQHLHLTTQALQDELRAQRDLNQLLHEDFVTS------ CG30336-RA ------------------------------------------------------------ : : : : : :: ENSMUST00000032277 VA-ELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQ ENST00000239822 VA-ELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQ SINFRUP00000162450 LTSEPTEENYRRLQAEHERQAKELFLLRKTLEEMEIRIDTQKQTLGARDESIKKLLEILQ ENST00000288221 T-IELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQ ENSMUST00000048093 T-IELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQ SINFRUP00000139809 TTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLGARDESIKKLLEMLQ SINFRUP00000144016 --LDPSEENFLRLQSDHERQAKELLLLRKTMEEMETRIDSQKQTLDARDESIQRLLELLQ ci0100135724 PSDGGDKESTRIMQDNYDRLLRENELLQSTMEELESRIEAQRQTLGTRDESVRKLLEMLQ CG30336-RA ------------------------------------------------------------ : :: : : : : : :: :: ENSMUST00000032277 SKGLSA----KATEEDHERTRRLAEAEMHVHHLESLLEQKEKENNMLREEMHRRFENAPD ENST00000239822 SKGLSA----KATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPD SINFRUP00000162450 SKGPSA----KASEEDQEQTRRLADAEMHRHHLESLLDQRDREITALREELHRRYEGTPE ENST00000288221 SKGLPS----KSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPE ENSMUST00000048093 SKGLPS----KSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPE SINFRUP00000139809 SKGLPPGPGRASEEEEQERARRIAEAEAQLGHLEVILDQKEKENIHLREELHRRNQLHQD SINFRUP00000144016 GQGQGT-----WSRGHRAGIITMAAQEAEA----------HQENMHVREVANHLHLLS-- ci0100135724 CKGLPKSDDEGLNVEVDSMKAQIIGYQSRLGHMESLLHDKNIEVQQFPDAFICIRLHPYI CG30336-RA ------------------------------------------------------------ : : :: . ENSMUST00000032277 SAKTKALQTVIEMKDS---KISSMERGLRDLEEEIQMLKSNGALSSEEREEEMKQMEVYR ENST00000239822 SAKTKALQTVIEMKDS---KISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYR SINFRUP00000162450 STKTKALQTVIDMKDA---KINSMDRNMRDMEEELLMLKSNGLLSCEERQEEMKQMEVYR ENST00000288221 PAKTKALQTVIEMKDT---KIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYK ENSMUST00000048093 PAKTKALQTVIEMKDT---KIASLERNIRDLEDEVQMLKANGVLNTEDREEEIKQIEVYK SINFRUP00000139809 PSKTKALQTIIEMKDT---KIASLERNIRDLEDEIQMLKANSLLNTEDREEEIKQMEVYK SINFRUP00000144016 LADTCPLS---LVQDT---KISSLERNIRDLEDEVQMLKTSGLLQPDDRQDELKQVEVYK ci0100135724 YPYPRPLIHPLTPPDPQEAKISSLERMNREVELELESTKHEADIIMTQHREDVKQLEAVK CG30336-RA -----------------------------------MLSVLVPFQPTHNHHPNPIRIEIQ- : : : : : : ::. : ::* ENSMUST00000032277 SHSKFMKNKVEQLKEELSSKDAQGEELKKRAAGLQSEIGQVKQELSRKDTELLALQTKLE ENST00000239822 SHSKFMKN----------------------------KIGQVKQELSRKDTELLALQTKLE SINFRUP00000162450 SHTKFMKNKVD---ESERTDSPRFTFISPFCSPCLFQMEQVKQDLSRKDTELLGLQTKLE ENST00000288221 SHSKFMKTK----------------------------IDQLKQELSKKESELLALQTKLE ENSMUST00000048093 SHSKFMKTK----------------------------IDQLKQELSKKESELLALQTKLE SINFRUP00000139809 NHSKFMKTK----------------------------IDQLKQELSKKESELLALQTKLE SINFRUP00000144016 SHSKFMKMK----------------------------IEQLKQELNKKESEMQALQTKLE ci0100135724 SHSDFMKNK----------------------------VDQLKSDVQKKETEIVTLQTRLD CG30336-RA -------------------------------------LDEFRLEIQRRDQEILAMAAKMK :: : :.: ::.::: *: : :::. ENSMUST00000032277 TLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAR ENST00000239822 TLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAE SINFRUP00000162450 TLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKEATLNKKSKQIQEISE ENST00000288221 TLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTE ENSMUST00000048093 TLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTE SINFRUP00000139809 TLNNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTE SINFRUP00000144016 TLTNQNSDCKQHIDVLKESFSAKEQRANTLQTEVDALRVRLEEKEQFLTKKTKQLQDLTD ci0100135724 TLNNQQSDNRQHIDVLKESLNAKDQRASVLQSEVDSLRNRLDEKQRILDEKQDYLLRLQE CG30336-RA TLEEQHQDYQRHIAVLKESLCAKEEHYNMLQTDVEEMRARLEEKNRLIEKKTQGTLQTVQ ** :* .* ::** *****: **::: **::*: :* **:**: : :* . ENSMUST00000032277 -RAPSAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTN ENST00000239822 EKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTN SINFRUP00000162450 EKGTLNGEIHDLKDMLEVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTSN ENST00000288221 EKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSN ENSMUST00000048093 EKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLTNLKDRVKSLQTDSSN SINFRUP00000139809 EKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQLGNLKDRVKSLQTDSSN SINFRUP00000144016 EKSTLTGEIRDLKDMLDVKERKVNVLQKKIENLLEQLKDKDKQLAGLRERVQGFQTDSSN ci0100135724 DKSCDASELSHLRDTLDVKDRKILVLHKKIESLSEVVRERDGMLEEKKRALVALEEDSCT CG30336-RA ERNRLTSELTELKDHMDIKDRKISVLQRKIENLEDLLKEKDNQVDMARARLSAMQAHHSS : .*: .::* :::*:**: **::***.* : ::::: : : : .:: . . ENSMUST00000032277 TDTALTTLEEALADKERTIERLKEQRDRDEREKQEEIDTYKKDLKDLREKVSLLQGDLSE ENST00000239822 TDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSE SINFRUP00000162450 TDTALTTLEESLAEKERIIERLKEQRDRDDREKTEELDCNKKELKELKERLSLLQGDLSD ENST00000288221 TDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTE ENSMUST00000048093 TDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTE SINFRUP00000139809 TDTALATLEEALSEKERIIERLKDQREREDRERLEEVESYKKENKDLKEKVNSLQIELTE SINFRUP00000144016 TDTALATLEEALSEKERVIENLREQKEREDRTRLEELDQMRKENQELKDKLTALQ----- ci0100135724 SDSALTTMEEALADKDKIVEALQHEISLLRQQLRDESADLNQQLKNAEQQLDCSRRDVTE CG30336-RA SEGALTSLEEAIGDKEKQMAQLRDQRDRAEHEKQEERDLHEREVADYKIKLRAAESEVEK :: **:::**::.:*:: : *:.: . : :* .:: : . :: . : ENSMUST00000032277 KEASLLDIKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEATLEAR-- ENST00000239822 KEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEAR-- SINFRUP00000162450 RETSLLDLKEHASSLASSGLKKDSKLKSLEITLEQKREECLKLENQLKRVENAALEAQ-- ENST00000288221 KESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKK-AHNIEDDS-- ENSMUST00000048093 KESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECNKLEAQLKK-AHNIEDDS-- SINFRUP00000139809 KESNLIDLKEHASSLASSGLKKDSKLKSLEIAIEQKKEECSKLETQLQKKVHEVEQHSGP SINFRUP00000144016 ------------------------------------------------------------ ci0100135724 RETSISELQEQATSLASSIVKKDSFIKQLEINIQKHTEDFNRLQNQHKKAQQQAMTET-- CG30336-RA LQTRLERAVTER--------------ERLEIKLEASQSELGKSKAELEKATCEMGRSS-- : : : : : : : ENSMUST00000032277 -ASPEMSDRIQQLEREISRYKDESSKAQTEVDRLLEILKEVENEKNDKDKKIAELERQVK ENST00000239822 -ASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVK SINFRUP00000162450 -ANTEVSERIQNLEQEVARHKEDSGKAQAEVDRLLEILREMENEKNDKDKKINELERQMK ENST00000288221 RMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELERHMK ENSMUST00000048093 RMNPEFADRLKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELERHMK SINFRUP00000139809 RGNPEYVDRVKLLEKEVNYYKDEANKAQTEVERLLDILREVETEKNDKDKKIAELERGII SINFRUP00000144016 ------------------------------------------------------------ ci0100135724 -TKEEFNLKIRNLEIEVQSKVDEASRCQGDLDRLLGILKETENEKHSKDEKISAMEKKHK CG30336-RA -------ADWESTKQRIARLELENERLKHDLERSQVLVHYDQFPRHYPNNLSSVYS---- : :: ENSMUST00000032277 DQNKKVANLKHKEQVEKKKSAQMLEEARRREDSLSDSSQQLQ------------------ ENST00000239822 DQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALR SINFRUP00000162450 DQSKKVASLKHKEQVEKSKNARLMEEARKREDNLSENSQQAKDTLRQKVERIEELEEALR ENST00000288221 DQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQ------------------ ENSMUST00000048093 DQNKKVANLKYNQQLEKKKNAQLLEEVRRREDSMVDNSQHLQRQRANELYLYVVQMSRCP SINFRUP00000139809 SISTWSSTLHQ------------------------------------------------- SINFRUP00000144016 ------------------------------------------------------------ ci0100135724 EQTMKIKSLQT----------EMIEEARRKGAAQDRDVAKYL------------------ CG30336-RA ------------------------------------------------------------ : ENSMUST00000032277 --------------------------VEELLMAMEKVKQELESMKAKLSSTQQSLAEKET ENST00000239822 ESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKET SINFRUP00000162450 ESVQINAEREMVLAQEESARSLQEKQMEELLGAMEKVKQELESMRAKLASTQQSLCEKEA ENST00000288221 --------------------------IEELMNALEKTRQELDATKARLASTQQSLAEKEA ENSMUST00000048093 SVSLRTRCSLGLSKGEMTCDLPCAFQIEELMNALEKTRQELDATKARLASTQQSLAEKEA SINFRUP00000139809 --------------------------LEELMNTLERTRQELDSTKQRLSSTQQSLQERDS SINFRUP00000144016 ------------------------------------------------------------ ci0100135724 --------------------------LAELVAEFTKTKQVLEETGMRVASMEVMVESKDR CG30336-RA ------------------------------YVCLRCVHIIERLAYILLSIIYEPICIKHI : : : : : ENSMUST00000032277 HLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKK-TQEEVAALKREKD ENST00000239822 HLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKK-TQEEVAALKREKD SINFRUP00000162450 HLSTLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKKTQDEVALLKREKD ENST00000288221 HLANLRIERRKQLEEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKD ENSMUST00000048093 HLANLRIERRKQLEEILEMK---------------------------------------- SINFRUP00000139809 HLTNMRQERRKQLEEILEMKQQALLAAISEKDANIALLELSASNKKKTQEEVMALKRERD SINFRUP00000144016 ------------------------------------------------------------ ci0100135724 MLEKLRGERRKQMEEALEMKQEALLAAISEKDSNIALLELSQPRKKSNADEVCLLRREKD CG30336-RA HIYVLSVSTSISIYLYLNMYLHVHITHPNYQLPTTTQLQQLQL----------------- : : : : : : : : : ENSMUST00000032277 RLVQQLKQQTQNRMKLMADNYEDDHFRSSRSNQTNHKPSPD------------------- ENST00000239822 RLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPD------------------- SINFRUP00000162450 RLVQQLKQQTQNRMKLMADNYEDDHLKTAP-DHANHKPSPDQMVPPLLALSQNRSKLKLY ENST00000288221 RLVHQLKQQTQNRMKLMADNYDDDHHHYHHHHHHHHHRSPGRSQHSNHRPSPDQ------ ENSMUST00000048093 ------------------------------------------------------------ SINFRUP00000139809 KLMHQLKQ---------------------------------------------------- SINFRUP00000144016 ------------------------------------------------------------ ci0100135724 ALVQQLKQQTQNRLKLMQE--DSDIASDAKRSDAKRKTRNK------------------- CG30336-RA ------------------------------------------------------------ :: : ENSMUST00000032277 --------QDEEEGIWA------------------------------------------- ENST00000239822 --------QDEEEGIWA------------------------------------------- SINFRUP00000162450 IAHLTDLCHDRDPSILSQLTPPSHYHHSNPEDWEEELQKMSVEQLEWELEVCEKESGELQ ENST00000288221 ------------------------------------------------------------ ENSMUST00000048093 ------------------------------------------------------------ SINFRUP00000139809 ------------------------------------------------------------ SINFRUP00000144016 ------------------------------------------------------------ ci0100135724 ----------EEDGIWA------------------------------------------- CG30336-RA ------------------------------------------------------------ ENSMUST00000032277 ---------------------------- ENST00000239822 ---------------------------- SINFRUP00000162450 EYANSVLQQIADYCPDILEQVVNALEES ENST00000288221 ---------------------------- ENSMUST00000048093 ---------------------------- SINFRUP00000139809 ---------------------------- SINFRUP00000144016 ---------------------------- ci0100135724 ---------------------------- CG30336-RA ----------------------------