CLUSTAL W (1.82) multiple sequence alignment ENST00000325782 -------MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAA-------------------- ENST00000300093 -------MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAA-------------------- ENSMUST00000033154 -------MNAAAKAGKLARAPADLGKGGVPGDAVPGAPVA-------------------- ci0100148424 -----------------------MSRKDIP------------------------------ CG12306-RA ----------------MAAKPEDKS----------------------------------- ENST00000274289 MELLRTITYQPAASTKMCEQALGKGCGADSKKKRPPQPPEESQPPQSQAQVPPAAPHHHH ENSMUST00000022212 MELLRTITYQPAAGTKMCEQALGKACGGDSKKKRPQQPSEDGQP---QAQVTPAAPHHHH SINFRUP00000154880 ------------------------------------------------------------ ENST00000308348 ---------MEPAAGFLSPRPFQRAAAAPAPPAGPGPPPSALRGPELEMLAG-------- ENSMUST00000030442 ---------MEPAAGFLSPRPFPRAAAPSAPPAGPGPPANASPRSEPEVLAG-------- SINFRUP00000152714 ------------------------------------------------------------ ENST00000325782 --APPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLK ENST00000300093 --APPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLK ENSMUST00000033154 --APLAKEIPEVLVDPRSRRQYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLK ci0100148424 -----MKEIPEILKDVSTGKKYQRGRFLGKGGFAKCYEIVDLETKKIFAGKIVPKALLVK CG12306-RA ------TDIPDRLVDINQRKTYKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIK ENST00000274289 HHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAK ENSMUST00000022212 HHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAK SINFRUP00000154880 -----------------------------QGGFAKCYEMTDLSTNKVYAAKIIPHARVSK ENST00000308348 --LPTSDP-GRLITDPRSGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAK ENSMUST00000030442 --PRAPDPPGRLITDPLSGRTYTKGRLLGKGGFARCYEATDTESGIAYAVKVIPQSRVAK SINFRUP00000152714 ------------------------------------------------------------ : :: : ENST00000325782 PHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRR-----RSLLELHKRRK ENST00000300093 PHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRR-----RSLLELHKRRK ENSMUST00000033154 PHQKEKMSMEISIHRSLAHQHVVGFHDFFEDSDFVFVVLELCRR-----RSLLELHKRRK ci0100148424 PHQKDKMAQEITLHRSVSHENVVGFHGFFEDSDFVYVVLELCRR-----RSLMELHKRRK CG12306-RA HNQKEKTAQEITIHRSLNHPNIVKFHNYFEDSQNIYIVLELCKK-----RSMMELHKRRK ENST00000274289 PHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSR-----RSMAHILKARK ENSMUST00000022212 PHQREKIDKEIELHRLLHHKHVVQFYHYFEDKENIYILLEYCSR-----RSMAHILKARK SINFRUP00000154880 PHQREKIDREIELHRILHHKNIVHFYHHFEDKENIYILLEYCSR-----KSLAHILKARK ENST00000308348 PHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSR-----KSLAHIWKARH ENSMUST00000030442 PHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSR-----KSLAHIWKARH SINFRUP00000152714 -----QILNEIELHRNLSHKHVVKFSHHFEDQDNIYIFLELCTDSFPSLQSLAHIWKARH : ** :** : * ::* * .*** : :::.** * :*: .: * *: ENST00000325782 ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGE ENST00000300093 ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGE ENSMUST00000033154 ALTEPEARYYLRQIVLGCQYLHRNQVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYEGE ci0100148424 AVTEPEARYYMRQIILGMQYLHSKKIIHRDLKLGNLFLTDDMEIKIGDLGLATQVDFDGE CG12306-RA SITEFECRYYIYQIIQGVKYLHDNRIIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGE ENST00000274289 VLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEH ENSMUST00000022212 VLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEH SINFRUP00000154880 VLTEPEVRYYLRQIVSGLRYLHEQEILHRDLKLGNFFVNESMELKVGDFGLAAKLEPAGN ENST00000308348 TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQ ENSMUST00000030442 TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITDNMELKVGDFGLAARLEPPEQ SINFRUP00000152714 TLTDPEVRYYLRQIISGLKYLHSRGILHRDLKLGNFFVNENMELRLGDFGLAAKLETVEQ : : * ***: **: * :*** . ::********:*:.: :.:::**:***:::: . ENST00000325782 RKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKN ENST00000300093 RKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKN ENSMUST00000033154 RKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKN ci0100148424 RKKTLCGTPNYIAPEVLGKKGHSYEVDIWSLGCIMYTLLIGKPPFETTSLKETYSRIKKN CG12306-RA RKKTLCGTPNYIAPEILTKKGHSFEVDIWSIGCVMYTLLVGQPPFETKTLKDTYSKIKKC ENST00000274289 RRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREA ENSMUST00000022212 RRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREA SINFRUP00000154880 RRKTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREA ENST00000308348 RKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQV ENSMUST00000030442 RKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQV SINFRUP00000152714 RKKTICGTPNYLAPEVLNRQGHGPESDVWSLGCVMYTLMCGNPPFETLDLKETYRCIKEV *::*:******::**:* ::**. * *:*::**:***:: * ***** **:** *:: ENST00000325782 EYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFS ENST00000300093 EYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFS ENSMUST00000033154 EYSIPKHINPVAASLIQKMLQTDPTARPTIHELLNDEFFTSGYIPARLPITCLTIPPRFS ci0100148424 EYRIPPSISPIARNLITKMLRNDPPSRPSVHNLLQDDFFTCGYLPPRLPTTCLSIAPRF- CG12306-RA EYRVPSYLRKPAADMVIAMLQPNPESRPAIGQLLNFEFLKGSKVPMFLPSSCLTMAPRIG ENST00000274289 RYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFH ENSMUST00000022212 RYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFH SINFRUP00000154880 RYSLPSSLSAQAKQLITNLLAKTPEDRPNLDLLLRHDFFTQGFSPERLPASCCHSAPDFH ENST00000308348 HYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTPDRLPISSCVTVPDLT ENSMUST00000030442 HYTLPASLSLPARQLLAAILRASPRDRPSIEQILRHDFFTKGYTPDRLPVSSCVTVPDLT SINFRUP00000152714 QYHLPSTISHPAQKLISGILQKNPSDRLSLDQILSHEFF-KGFTPDKLPPSSCAMVPELH .* :* : * :: :* * * : :: :*: . * *. :. * : ENST00000325782 IAPSSLDPSNRKPLTVLNKG---------------------------------------- ENST00000300093 IAPSSLDPSNRKPLTVLNKG---------------------------------------- ENSMUST00000033154 IAPSSLDPSSRKPLKVLNKG---------------------------------------- ci0100148424 -TPALLNSAQRKPLHDINN----------------------------------------- CG12306-RA SNDTIEDSMHRKPLMEMNGIRPDDTR---------------------------------- ENST00000274289 LSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKEDEDIYKLRHDLKKTSITQQPSKHR ENSMUST00000022212 LSSPAKNFFKKAAAALFGGKKDKARYNDTHNKVSKEDEDIYKLRHDLKKVSITQQPSKHR SINFRUP00000154880 VSSPAKSFFKKAAAALFGGRREKVKYYETLNKLTKEEEEIYQLQHDLERTAITQQ-RNQK ENST00000308348 PPNPARSLFAKVTKSLFGRKK-KSKNHAQE----RDE--VSGLVSGLMRTSVGHQDARPE ENSMUST00000030442 PPNPARSLFAKVTKSLFGRKKNKNKNHSED----QDN--VSCLA---------------- SINFRUP00000152714 PPSPAKKFFAKMAKSLFGKKKSKGEQAAPC----TSGPCTSG------------------ . . : . :. : : : : ENST00000325782 ---LENPLPER-----------------------PREKEEPVVRETGEVVDCHLSDMLQQ ENST00000300093 ---LENPLPER-----------------------PREKEEPVVRETGEVVDCHLSDMLQQ ENSMUST00000033154 ---VENPLPDR-----------------------PREKEEPVVRETNEAIECHLSDLLQQ ci0100148424 ---AGSTNSAA-----------------------ATLKCEPASQNDVESPDFHMDDLMKQ CG12306-RA ---LESTFLKANLH--------------------DAITASAQVCRHSEDYRSDIESLYQQ ENST00000274289 TDEELQPPTTTVARSGTPAVENKQQIG-DAIRMIVRGTLGSCSSSSECLEDSTMGSVADT ENSMUST00000022212 ADEEPQPPPTTVARSGTSAVENKQQIG-DAIRMIVRGTLGSCSSSSECLEDSTMGSVADT SINFRUP00000154880 VSENGSPLPPSVENPVAPATENQPPSSRDTIRLIVRGSLGSCSSSSECLEDNTTGSVAET ENST00000308348 APAASGPAPVSLVETAPEDS-------------SPRGTLASSGDG--FEEGLTVATVVES ENSMUST00000030442 -PVVSGQAPASLVETAAEDS-------------SPRGTLASSGDG--FEEGLTVATVVES SINFRUP00000152714 -PCTSGPCTKSISR-------------------SFKGTVASSAEP--CEDVATPAAVADS : : . . : . ENST00000325782 LHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDST ENST00000300093 LHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDST ENSMUST00000033154 LTSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDST ci0100148424 LITLIDSNPSQRRLIEMDEAEDPAANPVLWISKWVDYTDKYGLGYQLCDNSNGVLFNDCT CG12306-RA LTNLINGKPRILQGNLGDENTDPAAQPLFWISKWVDYSDKYGFGYQLCDEGIGVMFNDTT ENST00000274289 VARVLRGCLENMPEADCIPKEQLSTS-FQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGA ENSMUST00000022212 VARVLRGCLENMPEADCIPKEQLSTS-FQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGA SINFRUP00000154880 VASVLRGCLESMPKADNIPKGSNSCN-LQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGT ENST00000308348 ALCALRNCIAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQLSSRRVAVLFNDGT ENSMUST00000030442 ALCALRNCVAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQLSSRRVAVLFNDGT SINFRUP00000152714 AVKVLSGCLATMPAANRNPPCLSRPQFFLWVTKWVDYSNKYGFGYQLSNQSVGVLFNEGT . . *::*****::*:*:****... .*:**: : ENST00000325782 RLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPR ENST00000300093 RLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPR ENSMUST00000033154 RLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLNYFRNYMSEHLLKAGANITPR ci0100148424 RLLLYNNDEQIEYIDKEMSESYHTLKSYPDTLTKKVTLLKYFRNYMSEHLLKAGANMAPK CG12306-RA KLILLPNQINVHFIDKDGKETYMTTTDYCKSLDKKMKLLSYFKRYMIEHLVKAGANNVNI ENST00000274289 HMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGD-LPSV ENSMUST00000022212 HMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGD-LPSV SINFRUP00000154880 HMSLLPDRKTIHYYAELGQRSVFPTCEVPEHFVGQVTVLKYFSHYMEENLMDGGD-LGSM ENST00000308348 HMALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRYFASYMEQHLMKGGD-LPSV ENSMUST00000030442 HMALSANRKTVHYNPTSTKHFSFSMGSVPRALQPQLGILRYFASYMEQHLMKGGD-LPSV SINFRUP00000152714 HLSLCDQRSTVHYCLTNNKHFTFPADALPEQLHSQKEIVELMANYMEQNLMEGGD-LLCG :: * : :.: . : : :: : ** ::*:..* ENST00000325782 EGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCP--LMAAVTYIDEKRD ENST00000300093 EGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCP--LMAAVTYIDEKRD ENSMUST00000033154 EGDELARLPYLRTWFRTRSAIILHLSNGTVQINFFQDHTKLILCP--LMAAVTYINEKRD ci0100148424 EGDQFSRLPFLRTWFRTRSAIILHLSNGTLQINFFNDHTKIILCP--LMGAVTYIDVTKK CG12306-RA ESDQISRMPHLHSWFRTTCAVVMHLTNGSVQLN-FSDHMKLILCP--RMSAITYMDQEKN ENST00000274289 TDIRR-PRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICSQNEEYLLTYINEDRI ENSMUST00000022212 TDIRR-PRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICNQSEEYLLTYINEDRI SINFRUP00000154880 TDANM-PRLYLLQWLKSDRALMMLFNDGTFQVNFYHDHTKIVLCCQRDEYMLTYINEDRV ENST00000308348 EEVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSG-WEPLLVTFVARNRS ENSMUST00000030442 EEAEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSG-WEPLLVTFVARNRS SINFRUP00000152714 EQASG-APPLLLQWVKTEHALVMLFNNGTLQV---------------------------- * *.:: *::: :.:*:.*: : ::: : : ENST00000325782 FRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS- ENST00000300093 FRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS- ENSMUST00000033154 FQTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS- ci0100148424 FCTYRLTQLQKHGCCRELAHRLRYARTMLEKLISSRSTTVRQKDIA CG12306-RA FRTYRFSTIVENGVSKDLYQKIRYAQEKLRKMLEKMFT-------- ENST00000274289 STTFRLTTLLMSGCSSELKNRMEYALNMLLQRCN------------ ENSMUST00000022212 STTFRLTTLLMSGCSLELKNRMEYALNMLLQRCN------------ SINFRUP00000154880 SKTFKLSSLLTSGCTADLQERMAYSLNMLLQRCS------------ ENST00000308348 ACTYLASHLRQLGCSPDLRQRLRYALRLLRDRSPA----------- ENSMUST00000030442 ACTYLASHLRQLGCSPDLRQRLRYALRLLRDQSPA----------- SINFRUP00000152714 ---------------------------------------------- : : : :