CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000048248 ----HPHPHPP---------------------------QHAQYVGPYRLEKTLGKGQTGL ENST00000291930 GLTLGKGPESPDGDVSVPERKDEVAGGGGEEEEAEERGRHAQYVGPYRLEKTLGKGQTGL ENST00000308219 ------------------------------------------------------------ ENSMUST00000018971 -----------------------------------------------------GLSPTGL SINFRUP00000148465 ------------------------------------------------------------ SINFRUP00000131984 ------------------------------------------------------------ SINFRUP00000137409 ------------------------------------------------------------ CG6114-RA ------------------------------------------------------------ ci0100133458 ---------------------------------MSSGNNTAQYVGPYRLDKTLGKGQTGL ENSMUST00000048248 VKLGVHCITGQKVAVKIVNREKLSES----VEREIAILKLIEHPHVLKLHDVYENKKYLY ENST00000291930 VKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLY ENST00000308219 ---------------------------------------LIEHPHVLKLHDVYENKKYLY ENSMUST00000018971 VKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLY SINFRUP00000148465 -----------------------------------------------------------Y SINFRUP00000131984 -----------------------------------------------------------Y SINFRUP00000137409 --------------------------VSNQVEREIAILKLIEHPHVLKLHDVYENNKYLY CG6114-RA -------------------------------------MKLIDHPHVLGLSDVYENKKYLY ci0100133458 VKMGIHCSTGKKVAIKVVNREKLSENVINKVEREIAIMKLIDHPHILGLYDVYENKKYLY * ENSMUST00000048248 LVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYS---ICHRDLKPENLLL ENST00000291930 LVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYS---ICHRDLKPENLLL ENST00000308219 LVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHS---ICHRDLKPENLLL ENSMUST00000018971 LVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHS---ICHRDLKPENLLL SINFRUP00000148465 LVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIMSALDFCHSHSIELVCKRAPFAQTQFT SINFRUP00000131984 LVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHS---ICHRDLKPENLLL SINFRUP00000137409 LVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHS---ICHRDLKPENLLL CG6114-RA LILEHVSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHS---ICHRDLKPENLLL ci0100133458 LILELISGGELFDYLVRKGRLTPREARHFFKQIVSAVDFCHHHN---VCHRDLKPENLLL *:** :**********:******:***:**:**:**:**** :. :*:* .:. : ENSMUST00000048248 DEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFAL ENST00000291930 DEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFAL ENST00000308219 DEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFAL ENSMUST00000018971 DERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFAL SINFRUP00000148465 SQISNIWEVFSGVNSLSRPSTVSNSTD--PERAAHKIAP----------------TFLPP SINFRUP00000131984 DEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADAWSCGVILFAL SINFRUP00000137409 DEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRRADVWSCGVILFAL CG6114-RA DEKNNIKIADFGMASLQPAGSMLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYAL ci0100133458 DEKNNIRVADFGMASLQPEGYLLETSCGSPHYACPEVIRGEKYDGRTADVWSCGVILFAL .: .** . *: **. . : ::: *. *. :: : : . ENSMUST00000048248 LVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPW ENST00000291930 LVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPW ENST00000308219 LVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTVQHIQKHIW ENSMUST00000018971 LVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVDAARRLTVQHIQKHIW SINFRUP00000148465 LQGALPFDDDNLRNLLEKVKLGVFHMPHFIPPDCQNLLRGMIEVDASKRLTVSSVES--- SINFRUP00000131984 LVGALPFDDDNLRNLLEKVKLGVFHMPHFIPPDCQNLLRGMIEVDPTKRLTLEQIQKHTW SINFRUP00000137409 LVGALPFDHDNLRQLLEKVKSGVFHMPHFIPPDCQSLLKGMIEVNPEKRLTLEAIQKHAW CG6114-RA LVGALPFDDDNLRQLLEKVKRGVFHIPHFVPPDCQSLLRGMIEVNPDRRLTLAEINRHPW ci0100133458 LVGALPFDDDNLRHLLEKVKRGVYHIPHFISPDAQNLLRGMIEVRPEKRLTLQAVLNHKW * ******.****:****** **:*:***:.**.*.**:***** . :**:: : ENSMUST00000048248 YLGGKHE--PDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHRELRSE ENST00000291930 YLGGKHE--PDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHRELRSE ENST00000308219 YIGGKNE--PEP-EQPIP-RKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSE ENSMUST00000018971 YIGGKNE--PEP-EQPIP-RKVQIRSLPSLEDIDPDVLDSMHSLGCFRDRNKLLQDLLSE SINFRUP00000148465 -LGGKNE--PEP-EQPVP-RKVTIRSLPSADDIDPDVLDSMHSLGCFRDKNKLLKDLLSD SINFRUP00000131984 YLAGKNE--PEP-EQPVP-RKVAVRTLASAEEIDPDVLESMNSLGCFRDKDKLTSDLLAA SINFRUP00000137409 YQGGRNE--PCP-EQPPP-RRVCVRRILSLTELDPDVLDSMYSLGCFRDRVKLTRDLQCE CG6114-RA VTAGGKG--ELELELPMM-EVVQTHVIPTATAVDPDVLNAICSLGCFKEKEKLIQELLSS ci0100133458 MLVGDMNGVLDPGKSLGPSTPVECLPINEEDDADPDVLVSMSSLGCFRDRSKLIQDLMSD * * : ***** :: *****::: :* :* . ENSMUST00000048248 EENQEKMIYYLLLDRKERYPSCEDQDLPPR------NDVDPPRKRVDSPMLS-------- ENST00000291930 EENQEKMIYYLLLDRKERYPSCEDQDLPPR------NDVDPPRKRVDSPMLS-------- ENST00000308219 EENQEKMIYFLLLDRKERYPSQEDEDLPPR------NEIDPPRKRVDSPMLN-------- ENSMUST00000018971 EENQEKMIYFLLLDRKERYPSHEDEDLPPR------NEIDPPRKRVDSPMLN-------- SINFRUP00000148465 DDNQEKMIYFLLLDRKERYPSQEDQNLPPR------NEIDPPRKRVDSPMLN-------- SINFRUP00000131984 DDNQEKMIYFLLLDRKERYPSHEDQNLPPR------NETDPPRKRVDSPLLS-------- SINFRUP00000137409 DQSDVTSTTATTLTKEPKQGSTTTPRSTRA------HEKPKAAPNPKTQTLP-------- CG6114-RA SHNTEKVIYFLLLERKRRRPALEDDDEIAQKSRSELDAVDPPRKRLDTCRINGTNAPSYG ci0100133458 EQNTEKVVYYMLLRRKKRHPSFDDDADLLP-----CKHPDAPRKRVDSTSSRSSLSSS-- ... . * :: : : . . . .: ENSMUST00000048248 --RHG-KRRPERKSMEVLSITDAG--SGGSPV-------------PTRRALEMAQHSQRS ENST00000291930 --RHG-KRRPERKSMEVLSITDAG--GGGSPV-------------PTRRALEMAQHSQRS ENST00000308219 --RHG-KRRPERKSMEVLSVTD-----GGSPV-------------PARRAIEMAQHGQRS ENSMUST00000018971 --RHG-KRRPERKSMEVLSVTD-----GGSPV-------------PARRAIEMAQHGQRS SINFRUP00000148465 --RHG-KRRPERKSMEVLSVTD-----GGSPV-------------PARRAIDMTQHGQRR SINFRUP00000131984 --RHG-KRRPERKSMEVLTVTE-----GGSPV-------------PVRRAIDMATHGQSR SINFRUP00000137409 --TKGPVERPHLQPIKSLPLHNP---SSRSPS-------------PSPLLSPIPQGGGGV CG6114-RA QISEGSPLTPRRQAFNFRSYSSTRNHQRRSPTTVTSSVRSSSYHSPTRCNSPMSSAQQQA ci0100133458 --SGDVSTASGGRTSSAGSLGSGGGREGRRKLS-----------AETLCNTDRSSSATRK . . :. . . . . ENSMUST00000048248 R-SVSGASTGLSSSPLSSPRS------PVFSFSPEPGAGDEARGGGSPTSKTQTLPSRGP ENST00000291930 R-SVSGASTGLSSSPLSSPRS------PVFSFSPEPGAGDEARGGGSPTSKTQTLPSRGP ENST00000308219 R-SISGASSGLSTSPLSSPR---------------------------------------- ENSMUST00000018971 R-SISGASSGLSTSPLSSPRGTKSNPLPACTQTQPPGASLGTPLALSPGPPTLPAPARLL SINFRUP00000148465 M-EVKTRET--------------------------------------------------- SINFRUP00000131984 R-HHLHPDHNGKSVPMTQVT---------------------------------------- SINFRUP00000137409 G-SLS------------------------------------------------------- CG6114-RA N-AISRPSSPAAGTRHSTYGDRDRSGHHSSVSRTPSHSSQKSIEGDVVVVREPRIERRDS ci0100133458 NNTVHQRSRSLTGERDSHMTS--------------------------------------- ENSMUST00000048248 RGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASP--------------- ENST00000291930 RGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASP--------------- ENST00000308219 ---------------VTPHPSPRGSPLP---TPKGTPVHTPKESP--------------- ENSMUST00000018971 PTGTEPNTKSVPTIQVTPHPSPRGSPLP---TPKGTPVHTPKESP--------------- SINFRUP00000148465 --------------------------------------FEVTEAS--------------- SINFRUP00000131984 -----------------PLPSPRGSPLP---TPKGTPVHTPKDSP--------------- SINFRUP00000137409 --------------------------------------LTPPSSP--------------- CG6114-RA LRQERGGGSPRDRGDCGIPPGSPGGNSSGSTSASPSVHHRANSGPTIAISMFHDPDSNSV ci0100133458 ---------------SGSSTNSRMGQVSSHHPQNQSTTTGSNQPP--------------- . ENSMUST00000048248 --------TGTPGTTPPPSPGGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMS ENST00000291930 --------TGTPGTTPPPSPGGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMS ENST00000308219 --------AGTPNPTPPSSPSV--GGVPWRARLNSIKNSFLGSPRFHRRKLQVPTPEEMS ENSMUST00000018971 --------AGTPNPTPPSSPSV--GGVPWRTRLNSIKNSFLGSPRFHRRKLQVPTPEEMS SINFRUP00000148465 --------RVSAEGCCEKADAG--EGMPWRTRLNSIKNSFLGSPR-HRRKLQVPTQEEMS SINFRUP00000131984 --------TGTPSPTPPPSP-----SVPWRARLNSFKNSFLGSPRFHRRKMQVPTQEDMS SINFRUP00000137409 --------GGGSGMAASSSAH-------WRTRLNSFKNNLLGSPRFHRRKLQVPTSEDMS CG6114-RA VNPNGSPMMNNSSPGMPGSPCNTPGGQLWKTRLTNIKNSFLGSPRFHRRKMQVSADEVH- ci0100133458 ----VQAISGSQTPTPPSSPSN-----PWRQRLNSIKNSFIGSPRFHRRKMHAPSSEDVN : *: **..::*.::****:****::..: * ENSMUST00000048248 SLTPES-SPELAKRSWFGNFIS--------LDKEEQ-IFLVLKDKPLSSIKADIVHAFLS ENST00000291930 SLTPES-SPELAKRSWFGNFIS--------LDKEEQ-IFLVLKDKPLSSIKADIVHAFLS ENST00000308219 NLTPES-SPELAKKSWFGNFIS--------LEKEEQ-IFVVIKDKPLSSIKADIVHAFLS ENSMUST00000018971 NLTPES-SPELAKKSWFGNFIN--------LEKEEQ-IFVVIKDKPLSSIKADIVHAFLS SINFRUP00000148465 SLTPES-SQELAKKSWFGNFIN--------LEKEEQ-IFIVIKDKPLSSIKADIVHAFLS SINFRUP00000131984 SLTPDS-SPELAKRSWFGNFIN--------LEKEEQ-IFIVIRDKPLSSIKADIVHAFLS SINFRUP00000137409 SLTPES-SPELAKKSWFGNFIS--------LEKEEQ-IFMVIRDKPLSSVKADIVHAFLS CG6114-RA -LTPES-SPELTKRSWFGNLIT--------TEKDET-FTILVKGKPIATVKAHLIHAFLS ci0100133458 NPSHMSPSMELTKRSWFGQFISGSSSNVVAREREDAPLTLVMNNRTLNNVKADLIHTFLT : * * **:*:****::*. :::: : :::..:.: .:**.::*:**: ENSMUST00000048248 IPSLSHSVLSQTSFRAEYKASG--GPSVFQ-KPVRFQVDISSSEG-----PEPSPRRDGS ENST00000291930 IPSLSHSVLSQTSFRAEYKASG--GPSVFQ-KPVRFQVDISSSEG-----PEPSPRRDGS ENST00000308219 IPSLSHSVISQTSFRAEYKATG--GPAVFQ-KPVKFQVDITYTEG-----GEA------Q ENSMUST00000018971 IPSLSHSVISQTSFRAEYKATG--GPAVFQ-KPVKFQVDITYTEG-----GEA------Q SINFRUP00000148465 VGTL-------------------------------------------------------- SINFRUP00000131984 VSFLFRAAIA-------------------------------------------------- SINFRUP00000137409 IPSLSHSVLSQTSFRAEYKSSG--GPSVFQ-KPVKFQVDIAFSEGE---RDRERTEREGR CG6114-RA MAELSHSVVSPTSFRVEYKRNGN-GPVMFQ-RHVKFQVDISAICK------------QGD ci0100133458 IANLTHSVVGPMKFRCEYRPQGSGGHSMFPGKLVKFQADIIRMPSTGLTPDGDHPPKSSR : * : ENSMUST00000048248 SGGGIYSVTFTLISGPSRRFKRVVETIQAQLLST-----HDQPSVQALADEKNGAQTRPA ENST00000291930 GGGGIYSVTFTLISGPSRRFKRVVETIQAQLLST-----HDQPSVQALADEKNGAQTRPA ENST00000308219 KENGIYSVTFTLLSGPSRRFKRVVETIQAQLLST-----HDPPAAQHLSEPPP------- ENSMUST00000018971 KENGIYSVTFTLLSGPSRRFKRVVETIQAQLLST-----HDQPSAQHLSEPQPPLQPPQE SINFRUP00000148465 ------------------------------------------------------------ SINFRUP00000131984 ------------------------------------------------------------ SINFRUP00000137409 METGIYSVTFTLISG-NRRFRRVVETIQAQLLSS-----HDQPMVQTLCGE--------- CG6114-RA IADMLFALTFTLLSGNIRRFRRICEHIQSQVCSKRFPGPSSPPTVTSVTQAVSESSSCGS ci0100133458 STYGNYHVSFVLLSGPNRRFKRVLELIQIQLAAHP----FVPQSKPAGDISAYSRELQQL ENSMUST00000048248 GTPPRSLQPPPGRSDPDLSSSPRRGPPKDKKLLATNGTPLP------------------- ENST00000291930 GAPPRSLQPPPGRPDPELSSSPRRGPPKDKKLLATNGTPLP------------------- ENST00000308219 PAPGLSWGAGLKGQK-----------VATSYESSL------------------------- ENSMUST00000018971 PQPPQELQPPLQPPQEPQPPQELQPPLQPPQEPQLPLH---------------------- SINFRUP00000148465 ------------------------------------------------------------ SINFRUP00000131984 ------------------------------------------------------------ SINFRUP00000137409 ------------------------------------------------------------ CG6114-RA VSSERLSYKRQVIENDMENDSIFSYKSGNGRRASTTNNNNANPVDIPGSPIAVRSNSETA ci0100133458 CTSAVNLHNNDVIQHK-------------------------------------------- ENSMUST00000048248 ----------------------- ENST00000291930 ----------------------- ENST00000308219 ----------------------- ENSMUST00000018971 ----------------------- SINFRUP00000148465 ----------------------- SINFRUP00000131984 ----------------------- SINFRUP00000137409 ----------------------- CG6114-RA EHERNRELQSERQATTMSGSAIA ci0100133458 -----------------------