CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000028787 -------------------------------------------------- ENST00000290417 -------------------------------------------------- SINFRUP00000131908 -------------------------------------------------- SINFRUP00000159405 -----------------------------------------LDCLVAEQG ENSMUST00000026076 ---------------MFLATLYFVLPLLDLLMSAEVSGGDRLDCVKASDQ ENST00000281639 ---------------MFLATLYFALPLLDLLLSAEVSGGDRLDCVKASDQ Q98TT8_Brachydanio_rerio -------------------------------------------------- Q98TT9_Brachydanio_rerio -------------------------------------------------- ENSMUST00000022699 ----MILANAFCLFFFLDETLRSLASPSSPQGSELHGWRPQVDCVRANEL ENST00000306793 ----MILANVFCLFFFLDETLRSLASPSS-QGPELHGWRPPVDCVRANEL SINFRUP00000138265 ----------------------SPGAPHS-SGPGAH--SEWVDCIQASEM SINFRUP00000161418 -----------------------------LTALLEVILASRDDCLVAGDS ENSMUST00000025224 MGLSWSPR---PPLLMILLLVLSLWLPLGAGNSLATENRFVNSCTQARKK ENST00000274721 MVRPLNPRPLPPVVLMLLLLLPPSPLPLAAGDPLPTESRLMNSCLQARRK CG17204-RA --------------------------------MLRICNYSHNIRILGMDE ENSMUST00000028787 -------------------------------------------------- ENST00000290417 -------------------------------------------------- SINFRUP00000131908 -------------------------------------------------- SINFRUP00000159405 CVQEHSCMGLYRVLEYCAAEEAVSPLGSDARTECLEAQNALQNYR--PLQ ENSMUST00000026076 CLKEQSCSTKYRTLRQCVAGKETNFSLTSGLEAKDECRSAMEALKQKSLY ENST00000281639 CLKEQSCSTKYRTLRQCVAGKETNFSLASGLEAKDECRSAMEALKQKSLY Q98TT8_Brachydanio_rerio ----------------------------------------------SPLY Q98TT9_Brachydanio_rerio ----------------------------------------------PFLY ENSMUST00000022699 CAAESNCSSRYRTLRQCLAGRDRNTMLAN-----KECQAALEVLQESPLY ENST00000306793 CAAESNCSSRYRTLRQCLAGRDRNT-LAN-----KECQAALEVLQESPLY SINFRUP00000138265 CNQNPNCSSRYRVMRQCLVGKEKDAMLDNN----RECQAALEVLLGSPLY SINFRUP00000161418 CSSDETCSPRLRTLRQCVAG---NGSMKLGPGARSQCANAMSALLSSPLH ENSMUST00000025224 CEANPACKAAYQHLGSCTSSLSRPLPLEES-AMSADCLEAAEQLRNSSLI ENST00000274721 CQADPTCSAAYHHLDSCTSSISTPLPSEEP-SVPADCLEAAQQLRNSSLI CG17204-RA KLHQRIFNDNLALIDTPLIAMGSGSGSGTVTTSVSGYGLGMGMGLSGSFN ENSMUST00000028787 ----------MAHCMESALLLLLLLGSAS--------------------- ENST00000290417 ----------MVRCLGPALLLLLLLGSAS--------------------- SINFRUP00000131908 -------------------------------------------------- SINFRUP00000159405 VCKCQRGSRREEHCLRVYWTVRFAAYDEY---EVSPYEELKLNLVRNIEM ENSMUST00000026076 NCRCKRGMKKEKNCLRIYWSMYQSLQGND-LLEDSPYEPVNSRLSDIFRA ENST00000281639 NCRCKRGMKKEKNCLRIYWSMYQSLQGND-LLEDSPYEPVNSRLSDIFRV Q98TT8_Brachydanio_rerio DCKCRRGMKKEKNCLRIFWSIYQSLQAND-LLEDSPYEPVNSRLSDIFRL Q98TT9_Brachydanio_rerio DCRCKRGMKKEKNCLRTPWGIYQHLQGND-LLEDSPYEPVNSRLSDIFRL ENSMUST00000022699 DCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRL ENST00000306793 DCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRL SINFRUP00000138265 DCRCKRGMKKELQCLQNYWTIHMGLGDG--MLTVAPKG------------ SINFRUP00000161418 GCQCKRGMKKEKNCLSIYWSLHQSIIHGLKLVESYPYETVQ-RDYDYVRL ENSMUST00000025224 DCRCHRRMKHQATCLDIYWTVHPARSLGDYELDVSPYEDTVTSKPWKMNL ENST00000274721 GCMCHRRMKNQVACLDIYWTVHRARSLGNYELDVSPYEDTVTSKPWKMNL CG17204-RA YLGSMHGVPSYPFNISGFHQRHMAAAAAD--------------------- ENSMUST00000028787 -------------FTDGNRCVDAAEACTADERCQQLRSEYVARCLGRAAP ENST00000290417 -------------SVGGNRCVDAAEACTADARCQRLRSEYVAQCLGRAAQ SINFRUP00000131908 -----------------NQCLKAAQDCGLYEKCGSLRSEYVLACTKKVPG SINFRUP00000159405 SRMASIMAASSLSLDGQNQCLKAAQDCGLYEKCGSLRSDYVVACTKRPAA ENSMUST00000026076 VPFIS-----VEHISKGNNCLDAAKACNLDDTCKKYRSAYITPCTT-SMS ENST00000281639 VPFIS-----VEHIPKGNNCLDAAKACNLDDICKKYRSAYITPCTT-SVS Q98TT8_Brachydanio_rerio APIISG----EAAFTKDNNCLNAAKACNLNDTCKKYRSLYISPCTS-RVS Q98TT9_Brachydanio_rerio APIYSG----EPALAKENNCLNAAKACNLNDTCKKYRSAYISPCTS-RVS ENSMUST00000022699 ASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNREISP ENST00000306793 ASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNREISP SINFRUP00000138265 ---FN--CLDPEK--NCNPCLDAAKACNLNGSCKRQRSTFIGICIKEDPN SINFRUP00000161418 ASITAG--KSDIGMTTVNRCLAAAKACNVDDLCQKLRTEYVSACIK-PTA ENSMUST00000025224 SKLNMLK-------PDSDLCLKFAMLCTLHDKCDRLRKAYGEACSG---- ENST00000274721 SKLNMLK-------PDSDLCLKFAMLCTLNDKCDRLRKAYGEACSG---- CG17204-RA --------------NEPFDIIDTGLGYGGNGNAGVYYQSGQDVEVDLSTE : . . ENSMUST00000028787 GGRPGPGGCVRSRCRRALRRFFARGPPALTHALLFCGCEG---SACAERR ENST00000290417 GG------CPRARCRRALRRFFARGPPALTHALLFCPCAG---PACAERR SINFRUP00000131908 TN-----RCNQQKCHRTLRRFLERVPEEYSLPVLFCPCT---STLCGERR SINFRUP00000159405 SD----SSCNRQKCHRALRRFLERVPEEYSFALLFCPCS---DPLCGERR ENSMUST00000026076 N-----EVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCR---DVACTERR ENST00000281639 N-----DVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCR---DIACTERR Q98TT8_Brachydanio_rerio TT----EVCNKRKCHKALRQFFDKVPPKHSYGMLFCSCPSGDHSACSERR Q98TT9_Brachydanio_rerio TA----EVCNKRKCHKALRQFFDKVPPKHSYGMLYCSCPLGDQSACSERR ENSMUST00000022699 -T----ERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQ---DQACAERR ENST00000306793 -T----ERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQ---DQACAERR SINFRUP00000138265 RG----ETCSRKRCHKALRSFLDRVPPEFSHRLLFCPCQ---TEGCAERR SINFRUP00000161418 KS----GLCNRGKCNKALRRFFDRVPADYTHELLFCPCT---DTACAERR ENSMUST00000025224 ------IRCQRHLCLAQLRSFFEKAAESHAQGLLLCPCAP-EDAGCGERR ENST00000274721 ------PHCQRHVCLRQLLTFFEKAAEPHAQGLLLCPCAP-NDRGCGERR CG17204-RA II-----KQHFQLSDYDLFFLTSLLSPQSTCHTALDTCRE--DPSCSSS- . * : . : * * . ENSMUST00000028787 RQTFAPACAFSGPGLVP-----PSCLEPLERCERSRLCR----------- ENST00000290417 RQTFVPSCAFSGPGPAP-----PSCLEPLNFCERSRVCRCARAAAGPWRG SINFRUP00000131908 RKNIVPSCSYQQMEGS-----RHNCLQQQSICRQDDLCR----------- SINFRUP00000159405 RKTIVPSCSYEENGRGEERVGKPNCLSLQSYCSRDELCR----------- ENSMUST00000026076 RQTIVPVCSYEERERP-------NCLNLQDSCKTNYICR----------- ENST00000281639 RQTIVPVCSYEEREKP-------NCLNLQDSCKTNYICR----------- Q98TT8_Brachydanio_rerio RQTIVPACSYEDKEKP-------NCLSLQASCKTNYICR----------- Q98TT9_Brachydanio_rerio RQTIVPACSYEDKERP-------NCLTLQASCKTNYICR----------- ENSMUST00000022699 RQTILPSCSYEDKEKP-------NCLDLRSLCRTDHLCR----------- ENST00000306793 RQTILPSCSYEDKEKP-------NCLDLRGVCRTDHLCR----------- SINFRUP00000138265 RQTIVPDCSYNDKDKP-------NCLELRTLCRQDSLCR----------- SINFRUP00000161418 RQTIVPSCSYESAEKP-------SCITQMRICNADYVCR----------- ENSMUST00000025224 RNTIAPSCALPSVTPN--------CLDLRSFCRADPLCR----------- ENST00000274721 RNTIAPNCALPPVAPN--------CLELRRLCFSDPLCR----------- CG17204-RA LQPMLTHCELHRCNRN-------ACMSSLQAFYKGPHED----------- : : . * *: . ENSMUST00000028787 --------PRLLAFQAS-------CAPAPGSRDRCPEEG-G---PRCLRV ENST00000290417 WGRGLSPAHRPPAAQASPPGLSGLVHPSAQRPRRLPAGP-GRPLPARLRG SINFRUP00000131908 --------SRLADFLNN-------CHPSPLKASGCL----KDSVALCLRA SINFRUP00000159405 --------SRLADFHQN-------CQPSPKSASGCV----RESRAMCLKA ENSMUST00000026076 --------SRLADFFTN-------CQPESRSVSNCL----KENYADCLLA ENST00000281639 --------SRLADFFTN-------CQPESRSVSSCL----KENYADCLLA Q98TT8_Brachydanio_rerio --------SRLADFLTN-------CQPEARSISGCL----KENYADCLLA Q98TT9_Brachydanio_rerio --------SRLADFFTN-------CQPEPLSLSGCL----KENYADCLLS ENSMUST00000022699 --------SRLADFHAN-------CRASYRTITSCP----ADNYQACLGS ENST00000306793 --------SRLADFHAN-------CRASYQTVTSCP----ADNYQACLGS SINFRUP00000138265 --------SRLADYTEN-------CRVSAHTTSTCP---NQDNHQACLSS SINFRUP00000161418 --------SRLAQFQYA-------CEPSDGSASGCK----QGPHRDCLLA ENSMUST00000025224 --------SRLMDFQTH-------CHPMDILGTCAT------EQSRCLRA ENST00000274721 --------SRLVDFQTH-------CHPMDILGTCAT------EQSRCLRA CG17204-RA --------LNLDIAFCL-------CKKTSSQQNGNG-----NRHDMCMIA . : ENSMUST00000028787 YAGL-IGTVVTPNYLDNVS--ARVAPWCGCAASGNRREECEAFRKLFTRN ENST00000290417 PRGVPAGTAVTPNYVDNVS--ARVAPWCDCGASGNRREDCEAFRGLFTRN SINFRUP00000131908 YAGL-IGTVMTPNYISNS--SSEVSLSCNCEGSGNQWQDCLRLQKMFTLN SINFRUP00000159405 YSGL-IGTIMTPNYVRNS--STEVSLWCTCDGSGNEWQACQRVLHMFSSN ENSMUST00000026076 YSGL-IGTVMTPNYIDSS--SLSVAPWCDCSNSGNDLEDCLKFLNFFKDN ENST00000281639 YSGL-IGTVMTPNYIDSS--SLSVAPWCDCSNSGNDLEECLKFLNFFKDN Q98TT8_Brachydanio_rerio YSGL-IGTVMTP-------------------------------------- Q98TT9_Brachydanio_rerio YSGL-IGTVMTP-------------------------------------- ENSMUST00000022699 YAGM-IGFDMTPNYVDSNPTGIVVSPWCNCRGSGNMEEECEKFLKDFTEN ENST00000306793 YAGM-IGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTEN SINFRUP00000138265 YARL-IGTDMTPNYVDNSFSNWTISPWCTCEGSGNQEEECYNFLRFFTEN SINFRUP00000161418 YTGL-IGSTVTPNYVDNS--TSSVAPWCSCSVSGSQREECDHFLGYFTNN ENSMUST00000025224 YLGL-IGTAMTPNFISKVN--TTVALSCTCRGSGNLQDECEQLERSFSQN ENST00000274721 YLGL-IGTAMTPNFVSNVN--TSVALSCTCRGSGNLQEECEMLEGFFSHN CG17204-RA QEKLHPVCAQRP--------PDNSNPASSNGIYYHPPPACHVVADSCKED : * : . ENSMUST00000028787 PCLDGAIQAFDS---------LQP------SVLQDQTAGCCFPRVSWLYA ENST00000290417 RCLDGAIQAFASGWPPVLLDQLNPQGDPEHSLLQVSSTGRALERRSLLSI SINFRUP00000131908 NCLR---------------------------------------------- SINFRUP00000159405 TCLRKSARA----------------------------------------- ENSMUST00000026076 TCLKNAIQAFGNGSDVTMWQPAPPVQTTTATTTTAFRIKNKPLGPAGSEN ENST00000281639 TCLKNAIQAFGNGSDVTVWQPAFPVQTTTATTTTALRVKNKPLGPAGSEN Q98TT8_Brachydanio_rerio -------------------------------------------------- Q98TT9_Brachydanio_rerio -------------------------------------------------- ENSMUST00000022699 PCLRNAIQAFGNGTDVNMSPKGPTFSATQAPRVEKTPSLPDDLS---DST ENST00000306793 PCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDLS---DST SINFRUP00000138265 TCLSESPLSIG--------------------------------------- SINFRUP00000161418 SCLR---------------------------------------------- ENSMUST00000025224 PCLVEAIAAKMRFHRQLFSQDWADSTFSVVQQQNSNPALRLQPRLPILSF ENST00000274721 PCLTEAIAAKMRFHSQLFSQDWPHPTFAVMAHQNENPAVRPQPWVPSLFS CG17204-RA RECRWVLGRGWRS------------------------------------- ENSMUST00000028787 LTALALQALL---------------------------------------- ENST00000290417 LPVLALPALL---------------------------------------- SINFRUP00000131908 -------------------------------------------------- SINFRUP00000159405 -------------------------------------------------- ENSMUST00000026076 EIPTHVLPPCANLQAQKLKSNVSGSTHLCLSDNDYGKDGLAGASSHITTK ENST00000281639 EIPTHVLPPCANLQAQKLKSNVSGNTHLCISNGNYEKEGLG-ASSHITTK Q98TT8_Brachydanio_rerio -------------------------------------------------- Q98TT9_Brachydanio_rerio -------------------------------------------------- ENSMUST00000022699 SLGTSVITTCTSIQEQGLKANNSKELSMCFTELTTNISPGSKKVIKLYSG ENST00000306793 SLGTSVITTCTSVQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNSG SINFRUP00000138265 -------------------------------------------------- SINFRUP00000161418 -------------------------------------------------- ENSMUST00000025224 SILPLILLQTLW-------------------------------------- ENST00000274721 CTLPLILLLSLW-------------------------------------- CG17204-RA -------------------------------------------------- ENSMUST00000028787 --------------------------------- ENST00000290417 --------------------------------- SINFRUP00000131908 --------------------------------- SINFRUP00000159405 --------------------------------- ENSMUST00000026076 SMAAPPSCGLSSLPVMVFTALAALLSVSLAETS ENST00000281639 SMAAPPSCGLSPLLVLVVTALSTLL--SLTETS Q98TT8_Brachydanio_rerio --------------------------------- Q98TT9_Brachydanio_rerio --------------------------------- ENSMUST00000022699 SCRARLSTALTALPLLMVTLA------------ ENST00000306793 PSRARPSAALTVLSVLMLKLAL----------- SINFRUP00000138265 --------------------------------- SINFRUP00000161418 --------------------------------- ENSMUST00000025224 --------------------------------- ENST00000274721 --------------------------------- CG17204-RA ---------------------------------