CLUSTAL W (1.82) multiple sequence alignment ENST00000264039 ------------------------------MELRARGWWLLCAAAALVAC ENSMUST00000045970 ------------------------------MELRTRGWWLLCAAAALVVC ENSMUST00000033450 --------------------------------MARLGLLALLCTLAALSA ENST00000262862 --------------------------------MARFGLPALLCTLAVLSA Q90Z52_Brachydanio_rerio --------------------------------MKMIVVFTVCMSVVVLAS SINFRUP00000135869 -------------------------------------------------- ENST00000276212 -------------------------------------------------- SINFRUP00000152480 -------------------------------------------------- SINFRUP00000138304 -------------------------------------------------- CG4974-RA MAARSVRLAQLLLFTLLCGFVGLSAAKHLDLDGIHHHQHHLHSATTHHRR ci0100146542 ---------------------------------MVSIHQLFVVFIGISVT ci0100150498 --------------------------------------MTIVVSAIIFLS ENST00000264039 ARGDPASKSRSCGEVRQIYGAKGFSLSDVPQAEISGEH--LRICPQGYTC ENSMUST00000045970 ARGDPASKSRSCSEVRQIYGAKGFSLSDVPQAEISGEH--LRICPQGYTC ENSMUST00000033450 SLLAAELKSKSCSEVRRLYVSKGFNKNDAPLYEINGDH--LKICPQDYTC ENST00000262862 ALLAAELKSKSCSEVRRLYVSKGFNKNDAPLHEINGDH--LKICPQGSTC Q90Z52_Brachydanio_rerio --AQADQKSKNCNEVRTAYSSKGFNVNDVPNKGVQGAH--LKVCPQGFSC SINFRUP00000135869 -------------------------------------------------- ENST00000276212 -------------------------------------------------- SINFRUP00000152480 -------------------------------------------------- SINFRUP00000138304 ---------------------------------PGESL--RVCVHPGPSC CG4974-RA RLQRDSRAKDAVGGSTHQCDAVKSYFESIDIKSSGTYS--EKGAICGGNC ci0100146542 VVTRGSSPPQRCHQVLEFYRQQNFN----ETLDVEVVN--GKVCRE-PSC ci0100150498 AFEVVRSGGETCGEVRRTFRTRALGPADMVPIMPAEVTGLSVCQSVGPTC ENST00000264039 CTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDS ENSMUST00000045970 CTSEMEENLANHSRMELESALHDSSRALQATLATQLHGIDDHFQRLLNDS ENSMUST00000033450 CSQEMEEKYSLQSKDDFKTVVSEQCNHLQAIFASRYKKFDEFFKELLENA ENST00000262862 CSQEMEEKYSLQSKDDFKSVVSEQCNHLQAVFASRYKKFDEFFKELLENA Q90Z52_Brachydanio_rerio CTLEMEEKLSQLSRVDLKVPVHQLSSNLQSTFTQRHRHFDQFFRELLDNA SINFRUP00000135869 ---------------------------VFALLIILSLLLTEAFDLVLRHG ENST00000276212 -----------------------------------------AFEIVVRHA SINFRUP00000152480 ---------------------------LHSLLSVSLPLFPDMFQYLLSFS SINFRUP00000138304 CTSKMEDSYMAAVRSETQQKMRSYSFELKYLIAGHTKAYQETFDSLVSFT CG4974-RA CNNATELELRDKAAGMFEQLLHHHTSSLRGVLETNAKQFQSHVLELAQIS ci0100146542 CTGKMERNLRLKVEEDLKAGVLRGGEQVGGELKAKHDNLDKFFIELIDQS ci0100150498 CTPSMEEKYMEASVRELRELVKRKTTPLEKHFRAIAKKFRGYWNQMVKRA : : : ENST00000264039 ERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGAN------------ ENSMUST00000045970 ERTLQEAFPGAFGDLYTQNTRAFRDLYAELRLYYRGAN------------ ENSMUST00000033450 EKSLNDMFVKTYGHLYMQNSELFKDLFVELKRYYVAGN------------ ENST00000262862 EKSLNDMFVKTYGHLYMQNSELFKDLFVELKRYYVVGN------------ Q90Z52_Brachydanio_rerio EKSLNHMFVRTYGLMYVKNKELFEGFFSDLRRYYSHGSS----------- SINFRUP00000135869 RNATLTLLKSEFPGLGTGAQSSVGQLFMDMSLYILGSD------------ ENST00000276212 KNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSD------------ SINFRUP00000152480 QGHLSSLLEGTYTPMSRHALPHVNQLFSSLSLYLRGAN------------ SINFRUP00000138304 SNLTSSLFDTAYSALASDCRPLVFQLFSSIKRHLSGDP------------ CG4974-RA ENMTHSLFSKVYTRMVPSSRMMIHQLYTEIMNHLIYTSNYTNSNGQLGRR ci0100146542 KSQLDILFYETYGSLYIDNSEIFSFFFKELEEYYRGGP------------ ci0100150498 RS-----QGINEGTNTSHLERFYDGLLIPSKARLSSFN------------ : ENST00000264039 ------LHLEETLAEFWARLLERLFKQLHPQLLLPDDY----------LD ENSMUST00000045970 ------LHLEETLAEFWARLLERLFKQLHPQ-LLPDDY----------LD ENSMUST00000033450 ------VNLEEMLNDFWARLLERMFRLVNSQYHFTDEY----------LE ENST00000262862 ------VNLEEMLNDFWARLLERMFRLVNSQYHFTDEY----------LE Q90Z52_Brachydanio_rerio -----EVNLDDMLAEFWSELLERMFRLVNVQYEFSDSY----------ME SINFRUP00000135869 -----SS-VDHMVSVLYGRLFLLTYRRLLGASVPSAS-----------EE ENST00000276212 -----IN-VDDMVNELFDSLFPVIYTQLMNPGLPDSAL--------DINE SINFRUP00000152480 -----VS-VEASVHQFFNNLFPLTYTRLINPGIQGGT-------MSDMGD SINFRUP00000138304 -----VSSLDNAVHRFYDDLFPLVYQRLLNPGMGHPSPQPSSFHSGTHKH CG4974-RA GIGSVQSNLEEAVRHFFVQLFPVAYHQMVHLSKNNLGD-----LHEDYVN ci0100146542 ------LMVEEISENFFTSLMLKVFQLLNKSYLLDDEY----------MA ci0100150498 --------ATKNLNGILSSLFILSLEDEIGLKIPKEK------------- : *: ENST00000264039 CLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQV ENSMUST00000045970 CLGKQAEALRPFGDAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQV ENSMUST00000033450 CVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVARDVVSKVSVV ENST00000262862 CVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVAGDVVSKVSVV Q90Z52_Brachydanio_rerio CVSRHTDQLKPFGDVPRKLRLQLTRSFIAVRAFTRGLTLMPDVVRKVSTV SINFRUP00000135869 CVRGAWKDSAAFGPYPKLVTTRLSRSLLATRVFLQALNLGIEVVNTTNHL ENST00000276212 CLRGARRDLKVFGNFPKLIMTQVSKSLQVTRIFLQALNLGIEVINTTDHL SINFRUP00000152480 CLRMIRQDVNPFGPHPAVMAQELSGALGVGRQLGLALEEGLEVMNATEHV SINFRUP00000138304 CLRTMRQEVGPFGPHPRLLLSSLSRVLGVGRALSQLLKLAGEVVNATERL CG4974-RA CLQHNFDEMHPFGDIPQQVQSNLGKSVHMSNVFMNALLQAAEVLSEADAL ci0100146542 CIGENVGRIRPFTDIPDRLSMQLQQAFVASRAFVRGLETGSDVIKKLSKI ci0100150498 -IECALTKATSYLTPYAVLKSKFENLLNPVGVFLKALTVGLRAAEVSRRI : : : . : * . : ENST00000264039 P---LGPECSRAVMKLVYCAHCLG-----VPGARPCPDYCRNVLKGCLAN ENSMUST00000045970 P---LAPECSRAIMKLVYCAHCRG-----VPGARPCPDYCRNVLKGCLAN ENSMUST00000033450 N---PTAQCTHALLKMIYCSHCRG-----LVTVKPCYNYCSNIMRGCLAN ENST00000262862 N---PTAQCTHALLKMIYCSHCRG-----LVTVKPCYNYCSNIMRGCLAN Q90Z52_Brachydanio_rerio S---ASPSCVRASMKMLYCPYCSG-----QVALKPCKNYCLNVMRGCLAN SINFRUP00000135869 R---PSRDCSRALLRLWYCPHCQG-----ILGQPACRGFCHTVMHGCLGG ENST00000276212 K---FSKDCGRMLTRMWYCSYCQG-----LMMVKPCGGYCNVVMQGCMAG SINFRUP00000152480 S---LSKECVRGLVKMVYCSHCRG-----LTLIKPCVGYCLNVMRGCLAS SINFRUP00000138304 T---LSRECGRGLVRMQYCSHCRG-----LTLIRPCTGLCVNIMRGCL-- CG4974-RA YGEQLTDTCKLHLLKMHYCPNCNGHHSSSRSETKLCYGYCKNVMRGCSAE ci0100146542 S---LSDECSSSLMRMKYCGRCGG------TMAPECDGFCLNVVRGCLCS ci0100150498 A---TGGPCIDAITKMRYCSHCYG-----YTLIKTCPGLCHNVVRGCLVG * :: ** * * * . * :::** ENST00000264039 QA-DLDAEWRNLLDSMVLITDK-FWGTSGVESVIGSVHTWLAEAINALQD ENSMUST00000045970 QA-DLDAEWRNLLDSMVLITDK-FWGPSGAESVIGGVHVWLAEAINALQD ENSMUST00000033450 QG-DLDFEWNNFIDAMLMVAER-LEGPFNIESVMDPIDVKISDAIMNMQD ENST00000262862 QG-DLDFEWNNFIDAMLMVAER-LEGPFNIESVMDPIDVKISDAIMNMQD Q90Z52_Brachydanio_rerio QA-DLDTEWNNFLDSMLGLAER-LEGPFNFESVVDPIDVKISDAIMNMQE SINFRUP00000135869 VA-EVQPHWKSYIDGLGKLAGS-MRGEQDMEAVVLLLPSMIKLALKHAVN ENST00000276212 VV-EIDKYWREYILSLEELVNG-MYRIYDMENVLLGLFSTIHDSIQYVQK SINFRUP00000152480 VS-ELDQPWRRYTSLLEQLTHA-TAGHHSLELALLGVRGHVNEALLYAQL SINFRUP00000138304 -------------------------------------------------- CG4974-RA YAGLLDSPWSGVVDSLNNLVTTHILSDTGIINVIKHLQTYFSEAIMAAMH ci0100146542 LQ-QVGGVWKKYIDTMDSLLEK-LSGSFNIEIVLGSIDVQISEAIMTFQE ci0100150498 MA-ELDMFWKYYIVSINNMANKLVNTEGGFDVYFPQILRNISLIVQSVTY : : : . : . : ENST00000264039 NRDTLTAKVIQGCGNPKVNPQGPGPEEKR------RRGKLAPRERP---- ENSMUST00000045970 NKDTLTAKVIQACGNPKVNPHGSGPEEKR------RRGKLALQEKP---- ENSMUST00000033450 NSVQVSQKVFQGCGPPKPLPAGRISRSISESAFSARFRPYHPEQRP---- ENST00000262862 NSVQVSQKVFQGCGPPKPLPAGRISRSISESAFSARFRPHHPEERP---- Q90Z52_Brachydanio_rerio NSMQVSQKVFQGCGQPKLSMGFRSRRSAKDSGFPGRFRPYSPEARP---- SINFRUP00000135869 ARTRLTALVS------------------------LTLK------------ ENST00000276212 NAGKLTTTIGKLCAHSQQRQYRSAYYPEDLFIDKKVLKVAHVEHEE---- SINFRUP00000152480 HGPLITATV----------------------------------------- SINFRUP00000138304 -------------------------------------------------- CG4974-RA NGPELEKKVKKTCGTPSLTPYSSGEPDARPPPHKNNVKWATDPDPG---- ci0100146542 HKVAITKTVFGICGKPKSNPNATLPTLTMSYPQPHGAEESYPVHYP---- ci0100150498 NQESVTLILQQCKIHPERVARSLDRLPIADADELNELRTALASRKRRRRH : : ENST00000264039 -------------------------------------------------- ENSMUST00000045970 -------------------------------------------------- ENSMUST00000033450 -------------------------------------------------- ENST00000262862 -------------------------------------------------- Q90Z52_Brachydanio_rerio -------------------------------------------------- SINFRUP00000135869 -------------------------------------------------- ENST00000276212 -------------------------------------------------- SINFRUP00000152480 -------------------------------------------------- SINFRUP00000138304 -------------------------------------------------- CG4974-RA -------------------------------------------------- ci0100146542 -------------------------------------------------- ci0100150498 RNRPDRKPRAEPRRGRQSRDRKNRNIDLHLKSRSLLELSRDRVRPPFEML ENST00000264039 -------------------------------PSGT---LEKLVSEAKAQL ENSMUST00000045970 -------------------------------STGT---LEKLVSEAKAQL ENSMUST00000033450 -------------------------------TTAAGTSLDRLVTDVKEKL ENST00000262862 -------------------------------TTAAGTSLDRLVTDVKEKL Q90Z52_Brachydanio_rerio -------------------------------TTAAGTTLDRLLTDVKKKL SINFRUP00000135869 -------------------------------------------------- ENST00000276212 -------------------------------TLSSRRRELIQKLKSFISF SINFRUP00000152480 -------------------------------------------------- SINFRUP00000138304 -------------------------------------------------- CG4974-RA -------------------------------MVLFLSTIDKSKEFYTTIV ci0100146542 -------------------------------SLYPGYQGPSSFEDLAG-- ci0100150498 LEDSSLPNIPLPTREKMVRKKKNPMVDEMKIPTSLKFGLSNHITRFADEL ENST00000264039 RDVQDFWISLPGTLCS-EKMALSTASDDRCWNGMARGRYLPEVMGDGLAN ENSMUST00000045970 RDIQDFWISLPGTLCS-EKMAMSPASDDRCWNGISKGRYLPEVMGDGLAN ENSMUST00000033450 KQAKKFWSSLPSTVCNDERMAAGNENEDDCWNGKGKSRYLFAVTGNGLAN ENST00000262862 KQAKKFWSSLPSNVCNDERMAAGNGNEDDCWNGKGKSRYLFAVTGNGLAN Q90Z52_Brachydanio_rerio KHAKKFWSTLPDTVCVGERIAPS----DDCWNGTAKSRYESVVMSSGLAN SINFRUP00000135869 -------------------------------------------------- ENST00000276212 YSALPGYICSHSPVAENDTLCWNGQELVERYSQKAARNGMKNQFNLHELK SINFRUP00000152480 -------------------------------------------------- SINFRUP00000138304 -------------------------------------------------- CG4974-RA DNFCDEQQHSRDDHSCWSGDRFGDYTQLLINPGTDSQRYNPEVPFNAKAQ ci0100146542 ------YGADPDNWIGDSPLSRKSRSTKKNRKRRGRKRSRDISMDQRGML ci0100150498 NTTRDFFASFSDDLCSSSDPVSFQVSNYGHCWDGVKMANSYKKPTPDKGI ENST00000264039 QINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRS---------------A ENSMUST00000045970 QINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRG---------------A ENSMUST00000033450 QGNNPEVQVDTSKPDILILRQIMALRVMTSKMKN---------------A ENST00000262862 QGNNPEVQVDTSKPDILILRQIMALRVMTSKMKN---------------A Q90Z52_Brachydanio_rerio QVSNPDVEVDITKPDMVIRRQIAVLKEMTSWLKA---------------A SINFRUP00000135869 -------------------------------------------------- ENST00000276212 MKGPEPVVSQIIDKLKHINQLLRTMSMPKGRVLD---------------K SINFRUP00000152480 -------------------------------------------------- SINFRUP00000138304 -------------------------------------------------- CG4974-RA TGKLNELVDKLFKIRKSIGAAAPSNSIQATHDIQ---------------N ci0100146542 RPSSRYVEDK---------------------------------------- ci0100150498 EGQLQNPEVKVVTLKRDVQTIIEDVRTITKELMKSSGSEQIPSDLLQRPS ENST00000264039 YNGNDVDFQDASDDGSGSGSGDGCLDDLCSRKVSRKSSSSRTPLTHALPG ENSMUST00000045970 YGGNDVDFQDASDDGSGSGSGGGCPDDTCGRRVSKKSSSSRTPLTHALPG ENSMUST00000033450 YNGNDVDFFDISDESSGEGSGSGCEYQQCPSEFE-YNATDHSGKS----- ENST00000262862 YNGNDVDFFDISDESSGEGSGSGCEYQQCPSEFD-YNATDHAGKS----- Q90Z52_Brachydanio_rerio YTGNDIS-FTSDDAGSGEESGSGCDSPSCEGDGDIYFSTPAPGKPRILK- SINFRUP00000135869 -------------------------------------------------- ENST00000276212 NLDEEGFESGDCGDDEDECIGGSGDGMIKVKNQLRFLAELAYDLDVDDAP SINFRUP00000152480 -------------------------------------------------- SINFRUP00000138304 -------------------------------------------------- CG4974-RA DMGEGSGGGEGQIGDDEEEYGGAHGSGDGSGDGPHTPIEESEGTTTNEVE ci0100146542 -------------------------------------------------- ci0100150498 YITSHLQTDEIPCDDEDECFDNGSGEQSGEDPDVIRPDKPSLSLEKIPFP ENST00000264039 LSEQEGQKTSAASCPQPPTFLLPLLLFLALTVARPRWR------------ ENSMUST00000045970 LSEQEGQKTSAATCPEPHSFFLLFLVTLVLAAARPRWR------------ ENSMUST00000033450 --ANEKADSAGGAHAEAKPYLLAALCILFLAVQG-EWR------------ ENST00000262862 --ANEKADSAG-VRPGAQAYLLTVFCILFLVMQR-EWR------------ Q90Z52_Brachydanio_rerio TQEVEQASSGTRLAPCSLALALASLLLTLLTLQT-R-------------- SINFRUP00000135869 -------------------------------------------------- ENST00000276212 GNSQQATPKDNEISTFHNLGNVHSPLKLLTSMAISVVCFFFLVH------ SINFRUP00000152480 -------------------------------------------------- SINFRUP00000138304 -------------------------------------------------- CG4974-RA SRDSGKTSGSNPLEGTATWMLLTLVTMLFSSCS----------------- ci0100146542 -------------------------------------------------- ci0100150498 IAKTNTSIKRADQVTSTTSFTLVFNNEATMPAIVVGIAKEQNKSNISLST ENST00000264039 ------------------------------------ ENSMUST00000045970 ------------------------------------ ENSMUST00000033450 ------------------------------------ ENST00000262862 ------------------------------------ Q90Z52_Brachydanio_rerio ------------------------------------ SINFRUP00000135869 ------------------------------------ ENST00000276212 ------------------------------------ SINFRUP00000152480 ------------------------------------ SINFRUP00000138304 ------------------------------------ CG4974-RA ------------------------------------ ci0100146542 ------------------------------------ ci0100150498 SRQSGGGHGYASQLKSRKLYDILLCVVFSILIAQGA