CLUSTAL W (1.82) multiple sequence alignment ENST00000286824 -------------MASRRMET-------KPVITCLKTLLIIYSFVFWITG-----VILLA ENSMUST00000033514 -------------MASRRMET-------KPVITCLKTLLIIYSFVFWITG-----VILLA SINFRUP00000140037 -----------------------------------------------ITG-----AILLA SINFRUP00000133548 -------------MAPRRMES-------KPVILCLKTVLLLYSFVFWVTG-----VVLLS ENSMUST00000048113 -------------VAPRKMET-------KFVVSCLKIFLLIYCFGFWSTG-----VILLV SINFRUP00000133051 -----------------------------------------------FTG-----VILLA ENST00000003603 -----------------------------------------------ITG-----VILLA ENSMUST00000033604 -----------MASPSRRLQT-------KPVITCLKSVLLIYTFIFWITG-----VILLA ci0100140307 -------------MVSRSMKT-------TPAVTCMKTLLAIFTLIFLVIG-----IALLV ENSMUST00000034876 -------------------MG-------QCGITSSKTVLVFLNLIFWGAA-----GILCY ENST00000267970 -------------------MG-------QCGITSSKTVLVFLNLIFWGAA-----GILCY SINFRUP00000154901 ---------------------------------SS----------LQAAG-----AALAY ENSMUST00000026584 -------------MGEFNEKK------ATCGTVCLKYLLFTYNCCFW-----LAGLAVMA ENST00000322008 -------------MGEFNEKK------TTCGTVCLKYLLFTYNCCXLXXXXGLAGLAVMA ci0100141511 -------------MARKNSDKRHGNSGGMCDLSCLRGVLIAFNFLFI-----IGGCGALA ENSMUST00000026407 -------------------------MAVEGGMKCVKFLLYVLLLAFCACA-----VGLIA ENST00000257857 -------------------------MAVEGGMKCVKFLLYVLLLAFCACA-----VGLIA ENSMUST00000029800 ------------------MSGKH--YKGPEVSCCIKYFIFGFNVIFWFLG-----ITFLG ENST00000305798 ------------------MSGKH--YKGPEVSCCIKYFIFGFNVIFWFLG-----ITFLG ENSMUST00000026993 ------------------MPGKHQQFQDPEVGCCGKYFLFGFNIVFWVLG-----ALFLA ENSMUST00000046750 ---------MARRPGVPAAYGDEFSFVSP----LVKYLLFFFNMLFWVIS-----MVMVA ENST00000289407 --------------------GEEFSFVSP----LVKYLLFFFNMLFWVIS-----MVMVA CG4591-RA MSNHRYHQGGNYMHPRISTYPHHFSYVSS----CVKYMIFLLNFLFWLFG-----GLLLA ENST00000286824 VGVWGKLTLGTYIS------LIAENSTNAPYVLIG-TGTTIVVFGLFGCFATCRGSPWML ENSMUST00000033514 VGVWGKLTLGTYIS------LIAENSTNAPYVLIG-TGTTIVVFGLFGCFATCRGSPWML SINFRUP00000140037 VGVWGKLMLGPYIS------LIADNSTNAPYVLIG-TGTVIIVFGLFGCFATCRGSPWML SINFRUP00000133548 VGLWWKFMLGPYML------LISNSPSNGPYVLIG-TGVAIVLFGLFGCFATCKGRPWML ENSMUST00000048113 FGVWGQLTLGVYLS------LLA---IDVPTVLIG-TGIVIIIFGLFGCFSTCRGSPRML SINFRUP00000133051 VGVWGKVSLESYFS------LASEESTNAPYVLIG-TGAAIIIFGLFGCFATCRGSPWML ENST00000003603 VGIWGKVSLENYFS------LLNEKATNVPFVLIA-TGTVIILLGTFGCFATCRASAWML ENSMUST00000033604 VGIWGKVSLENYFS------LLNEKATNVPFVLIG-TGTVIILLGTFGCFATCRASAWML ci0100140307 AGTYSKISLTSYNL------LSTTDFTSVPYVMIG-VGAFIVVVGLAGCCATMKGNTCLL ENSMUST00000034876 VGAYVFITYDDYDH------FFEDVYTLFPAVVIIAVGALLFIIGLIGCCATIRESRCGL ENST00000267970 VGAYVFITYDDYDH------FFEDVYTLIPAVVIIAVGALLFIIGLIGCCATIRESRCGL SINFRUP00000154901 VGAYVIKSYDNFDS------FIQDRYTLIPAVIIICISVVMFIFGLVGCCATIRESKVGL ENSMUST00000026584 VGIWTLALKSDYIS------LLASSTYLATAYILVVAGVVVMVTGVLGCCATFKERRNLL ENST00000322008 VGIWTLALKSDYIS------LLASGTYLATAYILVVAGTVVMVTGVLGCCATFKERRNLL ci0100141511 IGIWTVISKMKYAA------LLGSIYYNLITYLLIGAGVLVLITGVLGCMGAVRKNSGML ENSMUST00000026407 IGVAVQVVLKQAITHETTAGSLLP-------VVIIAVGAFLFLVAFVGCCGACKENYCLM ENST00000257857 VGVGAQLVLSQTIIQGATPGSLLP-------VVIIAVGVFLFLVAFVGCCGACKENYCLM ENSMUST00000029800 IGLWAWNEKGVLSN----ISSITDLGGFDPVWLFLVVGGVMFILGFAGCIGALRENTFLL ENST00000305798 IGLWAWNEKGVLSN----ISSITDLGGFDPVWLFLVVGGVMFILGFAGCIGALRENTFLL ENSMUST00000026993 IGLWAWGEKGVLSN----ISALTDLGGLDPVWLFVVVGGVMSVLGFAGCIGALRENTFLL ENSMUST00000046750 VGVYARLMKHAEAA----LACLA----VDPAILLIVVGVLMFLLTFCGCIGSLRENICLL ENST00000289407 VGVYARLMKHAEAA----LACLA----VDPAILLIVVGVLMFLLTFCGCIGSLRENICLL CG4591-RA IGVYAFMDKLMDGNGWLRLDTIYD-VIFNISLVMIIAGVIVFTVSFAGCLGALRENTWLL * :: . : ** .: : : ENST00000286824 KLYAMFLSLVFLAELVAGISGFVFRHEIKDTFLRTYTD-AMQTY-NGN-DERSRAVDHVQ ENSMUST00000033514 KLYAMFLSLVFLAELVAGISGFVFRHEIKDTFLRTYTD-AMQNY-NGN-DERSRAVDHVQ SINFRUP00000140037 KLYAMFLSLVFLAELVAGISGFVFRHEIKGTFYRTYND-AVLNY-NAE-DEVSHAVDNLQ SINFRUP00000133548 KLYAVFLALVFMMELIAGISGFIFRHEIKGTFLMTYNE-AVMSY-DGL-DDRSLAVDGIQ ENSMUST00000048113 KLYSLFLSLVFLAELAASISGVLLHREIKNRFLKIYTN-AVRNY-NSN-DRKSQAVDQVQ SINFRUP00000133051 KLYAMFLTLMFLAELVAGISGFIFRHEIKAKLKVAFKN-DLMSY-NSS-DSSRSVVDTIQ ENST00000003603 KLYAMFLTLVFLVELVAAIVGFVFRHEIKNSFKNNYEK-ALKQY-NSTGDYRSHAVDKIQ ENSMUST00000033604 KLYAMFLTLIFLVELVAAIVGFVFRHEIKNSFKSNYEN-ALKEY-NSTGDYRSEAVDKIQ ci0100140307 RTYAVCLGVVFLAEVVGALAVIISRNKINNGFEAGMQN-AMKKY-KTD-GAYKTAVDNAQ ENSMUST00000034876 ATFVFILLLVFVTEVVVVVLGYVYRAKVENEVDRSIQK-VYKTYNGTNSDAASRAIDYVQ ENST00000267970 ATFVIILLLVFVTEVVVVVLGYVYRAKVENEVDRSIQK-VYKTYNGTNPDAASRAIDYVQ SINFRUP00000154901 GFFFMIIMLIFAAEVAALVFGFIYRGKITQDLERSMND-VFMKYDGQSSE--SNAADYLQ ENSMUST00000026584 RLYFILLLIIFLLEIIAGILAYVYYQQLNTELKENLKDTMVKRYHQSGHEGVSSAVDKLQ ENST00000322008 RLYFILLLIIFLLEIIAGILAYAYYQQLNTELKENLKDTMTKRYHQPGHEAVTSAVDQLQ ci0100141511 TCYFALLVTIFLCECVAGILAFVYYQSLHDELVSELKSNLNKNYNQTGQESFSMAVDDMQ ENSMUST00000026407 ITFAIFLSLIMLVEVAVAIAGYVFRDQVKSEFN-KSFQQQMQNYLKDN--KTATILDKLQ ENST00000257857 ITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFN-NNFRQQMENYPKNN--HTASILDRMQ ENSMUST00000029800 KFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLY-FFINNNIRAYRDDI--DLQNLIDFTQ ENST00000305798 KFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLY-FFINNNIRAYRDDI--DLQNLIDFTQ ENSMUST00000026993 KFFSVFLGLIFFLELAAGILAFVFKDWIRDQLN-LFINNNVKAYRDDL--DLQNLIDFAQ ENSMUST00000046750 QTFSLCLTIVFLLQLAAGILGFVFSDKARGKVS-EIINNAIVHYRDDL--DLQNLIDFGQ ENST00000289407 QTFSLCLTAVFLLQLAAGILGFVFSDKARGKVS-EIINNAIVHYRDDL--DLQNLIDFGQ CG4591-RA KLYSMCLLLFFILEMSLAIICFVFPQYMNSFLEYQFTDKIIHSYRDDS--DLQNFIDFAQ : : .: : : . * * * ENST00000286824 R------SLSCCGVQ--NYTNWSTSPYFL---------EHGIPPSCCMNETDCNPQDLHN ENSMUST00000033514 R------SLSCCGVQ--NYTNWSSSPYFL---------DHGIPPSCCMNETDCNPLDLHN SINFRUP00000140037 H------RLRCCGVY--NYTSWLGSVYYP---------SNGIPASCCLNSSDCNQEDLRN SINFRUP00000133548 R------RLRCCGVQ--NYTSWFNSVHFP---------ASGIPASCCISLSDCSFADLKN ENSMUST00000048113 Y------SLMCCGVK--NYTDWNDNPYFL---------NHGIPPSCCKDEADCSLQDRQN SINFRUP00000133051 Q------SLYCCGVK--NFTDWSETPYFQ---------DKGIPTSCCRDPTKCSPETLKD ENST00000003603 N------TLHCCGVT--DYRDWTDTNYYS---------EKGFPKSCCK-LEDCTPQ---- ENSMUST00000033604 S------TLHCCGVT--NYGDWKGTNYYS---------ETGFPKSCCK-LEGCYPQ---- ci0100140307 K------TLHCCGSN--NYTDYYTLPGWN---------PNTVPMSCCSNLTYCKEHLVDN ENSMUST00000034876 R------QLHCCGIH--NYSDWENTDWFKET------KNQSVPLSCCRETAKSCNGSLAN ENST00000267970 R------QLHCCGIH--NYSDWENTDWFKET------KNQSVPLSCCRETASNCNGSLAH SINFRUP00000154901 T------QLNCCGVH--NYTSWISTPWYTSH------NN-TVPLSCCKNSTG-CTGRL-- ENSMUST00000026584 Q------EFHCCGSN--NSQDWQDSEWIRSGE----ADSRVVPDSCCKTMVAGCGKRDHA ENST00000322008 QXALFLMQFHCCGSN--NSQDWRDSEWIRSQE----AGGRVVPDSCCKTVVALCGQRDHA ci0100141511 Q------DFQCCGVS--AYSDWSGSKFITTN-----QDGLKTPESCCKSPSPGCSVRDHP ENSMUST00000026407 K------KNNCCGAS--NYTDWEN---------IPGMAKDRVPDSCCIN--------ITV ENST00000257857 A------DFKCCGAA--NYTDWEK---------IPSMSKNRVPDSCCIN--------VTV ENSMUST00000029800 E------YWQCCGAF--GADDWNLNIYFNCTDSNASRERCGVPFSCCT--KDPAEDVINT ENST00000305798 E------YWQCCGAF--GADDWNLNIYFNCTDSNASRERCGVPFSCCT--KDPAEDVINT ENSMUST00000026993 E------YWSCCGAR--GPNDWNLNIYFNCTDLNPSRERCGVPFSCCV--RDPAEDVLNT ENSMUST00000046750 K------KFSCCGGI--SYRDWSQNMYFNCSEDNPSRERCSVPYSCCL--PTPNQAVINT ENST00000289407 K------KFSCCGGI--SYKDWSQNMYFNCSEDNPSRERCSVPYSCCL--PTPDQAVINT CG4591-RA Q------EFNCCGLSNAGYQDWSKNEYFNCS--SPSVERCGVPYSCCINATDISSGLVNI *** .: * *** ENST00000286824 ----------LTVAATKVNQKGCYDLVTSFMETNMGIIAGVAFGIAFSQLIGMLLACCLS ENSMUST00000033514 ----------LTVAATKVNQKGCYDLVTSFMETNMGIIAGVAFGIAFSQLIGMLLACCLS SINFRUP00000140037 ----------ATVAPSKVYHQGCYELVTSFMETNMAIIAGVTFGIAFSQVKDGANAR--- SINFRUP00000133548 ----------STLAARKVHKQGCYELVTSFIERNMGIVAGITFGIAFSQV---------- ENSMUST00000048113 ----------LTAVATKVNQRGCYVLMVGFLEANMVIIIGVLFTVTFSQLIGVRLSCCLS SINFRUP00000133051 ----------LDKAATEVYTTGCFTLVTNVMEANLGIIAGISFGIAFFQV---------- ENST00000003603 ------------RDADKVNNEGCFIKVMTIIESEMGVVAGISFGVACFQLIGIFLAYCLS ENSMUST00000033604 ------------RDADKVNEEGCFIKVMTTIESEMGVVAGISFGVACFQLIGIFLAYCLS ci0100140307 KV--EIVGLPTQDASEYVYNQGCPQLVFGVVNKNLGIVIGSMFGVAFFQLVGLILSCCLA ENSMUST00000034876 --------------PSDLYAEGCEALVVKKLQEILMHVIWAALAFAAIQLLGMLCACIVL ENST00000267970 --------------PSDLYAEGCEALVVKKLQEIMMHVIWAALAFAAIQLLGMLCACIVL SINFRUP00000154901 ------------------------------------------------------------ ENSMUST00000026584 SN---------IYKVEG----GCITKLETFIQEHLRVIGAVGIGIACVQVFGMIFTCCLY ENST00000322008 SN---------IYKVEG----GCITKLETFIQEHLRVIGAVGIGIACVQVFGMIFTCCLY ci0100141511 SN---------IYRVLGSDSMGCLTRLEQYIKDHLFILAITGTAVACLEILVMIFTCCLR ENSMUST00000026407 GCGNDFK-------ESTIHTQGCVETIAIWLRKNILLVAAAALGIAFVEVLGIIFSCCLV ENST00000257857 GCGINFN-------EKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEVLGIVFACCLV ENSMUST00000029800 QCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLV ENST00000305798 QCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLV ENSMUST00000026993 QCGYDIRLKLELEQQGSIYTKGCVGQFEKWLQDNLIVVAGVLVGIALLQIFGLCLAQNLV ENSMUST00000046750 MCGQGMQALDYLEASKVIYTNGCIDKLVNWIHSNLFLLGGVALGLAIPQLVGILLSQVLV ENST00000289407 MCGQGMQAFDYLEASKVIYTNGCIDKLVNWIHSNLFLLGGVALGLAIPQLVGILLSQILV CG4591-RA MCGYGVQVRSVAAASKRIWTSGCIEIVRVWVERNLYVIAGVALGIALLQLFVIYLAKTLE . : : : . : ENST00000286824 RFITANQYEMV----------- ENSMUST00000033514 RFITANQYEMV----------- SINFRUP00000140037 ---------------------- SINFRUP00000133548 ---------------------- ENSMUST00000048113 RLIMTQHYETV----------- SINFRUP00000133051 ---------------------- ENST00000003603 RAITNNQYEIV----------- ENSMUST00000033604 RAITNNQYEIV----------- ci0100140307 SSINANKYELV----------- ENSMUST00000034876 CRRSRDPAYELLITGGTYA--- ENST00000267970 CRRSRDPAYELLITGGTYA--- SINFRUP00000154901 ---------------------- ENSMUST00000026584 RSLKLEHY-------------- ENST00000322008 RSLKLEHY-------------- ci0100141511 SRIREEEDEPY----------- ENSMUST00000026407 KSIR---------SGYEVM--- ENST00000257857 KSIR---------SGYEVM--- ENSMUST00000029800 SDIE----------AVRAS-W- ENST00000305798 SDIE----------AVRAS-W- ENSMUST00000026993 SDIK----------AVKAN-W- ENSMUST00000046750 NQIKDQIKLQLYNQQHRADPWY ENST00000289407 NQIKDQIKLQLYNQQHRADPWY CG4591-RA GQID-----------LQKSRWS