CLUSTAL W (1.82) multiple sequence alignment ENST00000230731 --------------------------------------------MVTSLNE-DNESVTVE ENSMUST00000042181 --------------------------------------------MVTSLNE-DNESVTVE SINFRUP00000136486 ------------------------------------------------------------ SINFRUP00000151230 -------------------------------------TGRIHQAMVTSMND-ENESVTVE ENST00000271119 ---------------MAMDSSLQARLFPGLAIKIQRSNGLIHSANVRTVNL-EKSCVSVE ENSMUST00000030440 -----------------MES-LHARLFPGLSINIQRSNGLIHPANISTVNV-EKSCVSVE ENST00000268919 MASQFCLPESPCLSPLKPLKPHFGDIQEGIYVAIQRSDKRIHLAVVTEINR-ENYWVTVE ci0100146176 ------------------MNVDFGGLEKGTSIHIRRSNGRVHKAIVTQLQP-TTASVTVE CG3219-RA ----------------------MDKLSIEQKIFIRRSDGRVHLAEIIKLEGGDSKLITVE ENST00000230731 WIENGDTKGKEIDLESIFSLNPDLVPDEEIEPSPETPPPPASSAKVNKIVKNRRTVASIK ENSMUST00000042181 WIENGDTKGKEIDLESIFSLNPDLVPDEDIEPSPELPPP-SSSSKVNKIVKNRRTVAAVK SINFRUP00000136486 ------------------------------------------------------------ SINFRUP00000151230 WIENGDTKGKEIDLESIFALNPDVAPIEDIPPSPETPPP--------------PTPACVK ENST00000271119 WAEGGATKGKEIDFDDVAAINPELLQLLPLHPKDNLPLQENVTIQKQKRRSVNSKIPAPK ENSMUST00000030440 WIEGGTTKGKEIDIDDVAAINPELLQLLPLRPKDSLPLQENVTVPKQKRKSVNSKIPALK ENST00000268919 WVEKAVKKGKKIDLETILLLNPALDSAEHPMPPPPLSPL------------------ALA ci0100146176 WFEDDETKGKEVSLEMIFELNQDLAPENKKPVPQERPTSRRADARPANQRRTMLQAPTAS CG3219-RA WPEGHTVRGKELPLELVVLMNPHIFDSPRCSGGNAASAN-----------------QTAS ENST00000230731 NDPPSRDNRVVGSARARPSQFPE-------------------------QSSSAQQNGSVS ENSMUST00000042181 NDPPPRDNRVVGSARARPSQLPE-------------------------QSSSAQQNGSVS SINFRUP00000136486 ------------------------------------------------------------ SINFRUP00000151230 VSKIAKDALVWVGSDTKVLFIKI-------------------------LCAHN------- ENST00000271119 ESLRSRSTRMSTVSELRITAQENDMEVELPAAANSRKQFSVPPAPTRPSCPAVAEIPLRM ENSMUST00000030440 EGLRSRSTRMSTVSEVRIPAQENEMEVELPVPTNSRKQFAIPSHP-RASCSTVTELPLLM ENST00000268919 PSSAIRDQRTATKWVAMIPQKNQ-------------------------TASGD------- ci0100146176 VRNQQKENRSPSPGYGPRRVAKPDYQ---------------PPPPAARQSILNLPKPYDN CG3219-RA ISPRSMKQRIATGSLSPVLATAP------------------------------------- ENST00000230731 DISPVQAAKKEFGPPS--------RRKSNCVKEVEKLQEKREKRRLQQQELREKRAQ--D ENSMUST00000042181 DISPVQAAKKEFGPPS--------RRKSNCVKEVEKLQEKREKRRLQQQELREKRAQ--D SINFRUP00000136486 ---------------A--------RKKSNCVKEVEKLQEKREKRRLQQQELREKKAQ--E SINFRUP00000151230 ----LVEFCFFFFLTA--------RRKSNCVKEVEKLQEKRERRRLQQQELREKRAQ--E ENST00000271119 VSEEMEEQVHSIRGSSSANPVNSVRRKSCLVKEVEKMKNKREEKKAQNSEMRMKRAQ--E ENSMUST00000030440 VSEEAEEQAHSTRSTSSANPGNSVRRKSCIVKEMEKMKNKREEKRAQNSELRIKRAQ--E ENST00000268919 -SLDVRVPSKPCLMKQ---------KKSPCLWEIQKLQEQREKRRRLQQEIRARRAL--D ci0100146176 DKVANNVPINGNGMAMPPPKAPPRGRKSNVVDEVEKLRKNREERRAAQVIERERRQQ--Y CG3219-RA -------PRQQTAPPV---------REDEVVHQAERMRKERERRREAQARTRLDREQGKN ::. : : ::::::**.:: : * : ENST00000230731 VDATNPNYEIMCMIRDFRGSLDY---RPLTTADPIDEHRICVCVRKRPLNKKETQMKDLD ENSMUST00000042181 VDATNPNYEIMCMIRDFRGSLDY---RPLTTADPIDEHRICVCVRKRPLNKKETQMKDLD SINFRUP00000136486 VDVNVPNYEIMCMIRDFRASLDY---RPLTGNDAIEEHRICVCVRARPLNKKESSMKELD SINFRUP00000151230 IDTTIPNYEILQMIRDFRASLDY---RPLTTTDVIEEHRICVCVRKRPLNKKELSMKDLD ENST00000271119 YDSSFPNWEFARMIKEFRATLEC---HPLTMTDPIEEHRICVCVRKRPLNKQELAKKEID ENSMUST00000030440 YDSSFPNWEFARMIKEFRVTMEC---SPLTVTDPIEEHRICVCVRKRPLNKQELAKKEID ENST00000268919 VNTRNPNYEIMHMIEEYRRHLDS---SKISVLEPPQEHRICVCVRKRPLNQRETTLKDLD ci0100146176 YDPNNANWEFAIMIKEFRASLEM---KPLTAADPVLDHRICVCVRKRPLNKKELGRKEID CG3219-RA EDPGNPNWEVARMIRLQREQMESQRVRSGTTNERINCHQIMVCVRKRPLRRKELADREQD : .*:*. **. * :: : : *:* **** ***.::* :: * ENST00000230731 VITIPSKDVVMVHEPKQKVDLTRYLENQTFRFDYAFDDSAPNEMVYRFTARPLVETIFER ENSMUST00000042181 VITIPSKDVVMVHEPKQKVDLTRYLENQTFRFDYAFDDSAPNEMVYRFTARPLVETIFER SINFRUP00000136486 VITIPSKDVVMVHEPKQKVDLTRYLENQTFRFDYAFDENTTNEMVYRFTAQPLVETIFDR SINFRUP00000151230 VITIPSKDVVMVHEPKQKVDLTRFLENQTFRFDYAFDESTTNEMVYRFTARPLVETIFDR ENST00000271119 VISIPSKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVYRFTARPLVQTIFEG ENSMUST00000030440 VISVPSKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVYRFTARPLVQTIFEG ENST00000268919 IITVPSDNVVMVHESKQKVDLTRYLQNQTFCFDHAFDDKASNELVYQFTAQPLVESIFRK ci0100146176 VVTVPSKNIVMVSEPKSKVDMTKYLENQNFRFDYSFDETCTNEMVYWYTARPLVECIFEG CG3219-RA VVSIPSKHTLVVHEPRKHVNLVKFLENHSFRFDYVFDEECSNATVYEFTARPLIKHIFDG ::::**. ::* *.: :*::.::*:*: * **. **: .* ** :**:**:: ** ENST00000230731 GMATCFAYGQTGSGKTHTMGGDF-SGKNQDCSKGIYALAARDVFLMLKKPNYKKLELQVY ENSMUST00000042181 GMATCFAYGQTGSGKTHTMGGDF-SGKNQDCSKGIYALAARDVFLMLKKPNYKKLELQVY SINFRUP00000136486 GMATCFAYGQTGSGKTH------------------------------------------- SINFRUP00000151230 GMATCFAYGQTGSGKTH------------------------------------------- ENST00000271119 GKATCFAYGQTGSGKTHTMGGDL-SGKAQNASKGIYAMASRDVFLLKNQPCYRKLGLEVY ENSMUST00000030440 GKATCFAYGQTGSGKTHTMGGDL-SGKSQNASKGIYAMASRDVFLLKNQPRYRNLNLEVY ENST00000268919 GMATCFAYGQTGSGKTYTMGGDF-SGTAQDCSKGIYALVAQDVFLLLRNSTYEKLDLKVY ci0100146176 GMATCFAYGQTGSGKTHTMGGDFTMGKAQDTRKGIYALAAQDVFHLLQKPTYRHHNLDVY CG3219-RA GMATCFAYGQTGSGKTYTMGGQF-PGRHQSSMDGIYAMAAKDVFSTLKTVPYNKLNLKVY * **************: ENST00000230731 ATFFEIYSGKVFDLLN-RKTKLRVLEDGKQQVQVVGLQEREVKCVEDVLKLIDIGNSCRT ENSMUST00000042181 ATFFEIYSGKVFDLLN-RKTKLRVLEDGKQQVQVVGLQEREVKCVEDVLKLIDIGNSCRT SINFRUP00000136486 ----------VFDLLN-RKAKLRVLEDGKQQVQVVGLQEREVKCTEDVLKLIEVGNSCRT SINFRUP00000151230 ----------VFDLLN-RKAKLRVLEDGKQQVQVVGLQEKEVRCTEDVLKLIEVGNSCRT ENST00000271119 VTFFEIYNGKLFDLLN-KKAKLRVLEDGKQQVQVVGLQEHLVNSADDVIKMIDMGSACRT ENSMUST00000030440 VTFFEIYNGKVFDLLN-KKAKLRVLEDSRQQVQVVGLQEYLVTCADDVIKMINMGSACRT ENST00000268919 GTFFEIYGGKVYDLLN-WKKKLQVLEDGNQQIQVVGLQEKEVCCVEEVLNLVEIGNSCRT ci0100146176 ASFFEIYSGKVFDLLN-KKCRLRVLEDGRQQVQVVGLQERRVTSIEEVLQLISDGTRCRT CG3219-RA CSFFEIYGTRVFDLLMPGKPQLRVLEDRNQQVQVVGLTQNPVQNTAEVLDLLELGNSVRT ::*** * :*:**** .**:***** : * :*:.::. *. ** ENST00000230731 SGQTSANAHSSRSHAVFQIILRRKG---KLHGKFSLIDLAGNERGADTSSADRQTRLEGA ENSMUST00000042181 SGQTSANAHSSRSHAVFQIILRRKG---KLHGKFSLIDLAGNERGADTSSADRQTRLEGA SINFRUP00000136486 SGQTAANAHSSRSHAVFQIILRRRG---KMHGKFSLIDLAGNERGADTSSADRQTRLEGA SINFRUP00000151230 SGQTSANAHSSRSHAVFQIILRRKD---KMHGKFSLIDLAGNERGADTSSADRQTRLEGA ENST00000271119 SGQTFANSNSSRSHACFQIILRAKG---RMHGKFSLVDLAGNERGADTSSADRQTRMEGA ENSMUST00000030440 SGQTFANSNSSRSHACFQILLRTKG---RLHGKFSLVDLAGNERGADTSSADRQTRMEGA ENST00000268919 SRQTPVNAHSSRSHAVFQIILKSGR---IMHGKFSLVDLAGNERGADTTKASRKRQLEGA ci0100146176 SGVTSANQHSSRSHAVFQLILRRSGPRQLLHGKFSLIDLAGNERGADTTSADRQTRVEGS CG3219-RA SGHTSANSKSSRSHAVFQIVLRSAAG-EKLHGKFSLIDLAGNERGADNSSADRQTRLEGS * * .* :****** **::*: :******:**********.:.*.*: ::**: ENST00000230731 EINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFIG-ENSRTCMIATISPGMASCE ENSMUST00000042181 EINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFIG-ENSRTCMIATISPGMASCE SINFRUP00000136486 EINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFIG-ENSRTCMIATISPGMGSCE SINFRUP00000151230 EINKSLLALKECIRALGRNKAHTPFRASKLTQVLRDSFIG-ENSRTCMVNVDRRSPAIFV ENST00000271119 EINKSLLALKECIRALGQNKAHTPFRESKLTQVLRDSFIG-ENSRTCMIATISPGISSCE ENSMUST00000030440 EINKSLLALKECIRALGQNKAHTPFRESKLTQVLRDSFIG-ENSRTCMIAMISPGISSCE ENST00000268919 EINKSLLALKECILALGQNKPHTPFRASKLTLVLRDSFIG-QNSSTCMIATISPGMTSCE ci0100146176 EINKSLLALKECIRAMSQNKQHLPFRASKLTQVLRDSFIG-ERSRTCMIATISPGITSCE CG3219-RA EINKSLLVLKECIRALGRQSSHLPFRGSKLTQVLRDSFIGGKKVKTCMIAMISPCLHSVE *******.***** *:.::. * *** **** ******** :. ***: ENST00000230731 NTLNTLRYAN--------------------------------------RVKELTVDPT-- ENSMUST00000042181 NTLNTLRYANRVKEFGISPSDIPFSQGGGSRPDLSPSYDYDDFSPSITRVKELTVNPA-- SINFRUP00000136486 NTLNTLRYAN--------------------------------------RVKELTLNPA-- SINFRUP00000151230 SSLVFL-----------------------------------------CRVKELTVVPN-- ENST00000271119 YTLNTLRYAD--------------------------------------RVKELSPHSG-- ENSMUST00000030440 YTLNTLRYAD--------------------------------------RVKELSPHSG-- ENST00000268919 NTLNTLRYAN--------------------------------------RVKKLNVDVR-- ci0100146176 HSLNTLRYAD--------------------------------------RVKELALDDGGD CG3219-RA HTLNTLRYAD--------------------------------------RVKELSVESIP- :* * ***:* ENST00000230731 ----AAGDVRPIMHHPPNQIDDLETQW--GVGSSPQRDDLKLLCEQNEEEVSPQLFTFHE ENSMUST00000042181 ----AAGDVHPIMHHPPSQIDDLETQW--GVGSSPQRDDLKLLCEQNEEEVSPQLFTFHE SINFRUP00000136486 ----ATMDTR--HRGHANHLEVLER----DVGSSPQRDDLKLLCEQNEEEVSPQLFSFHE SINFRUP00000151230 ----QIIEGVRPNIHAVNQLDVMDEN---WLSISPQRDDLKLLCEQNEEEVSPQLFTFHE ENST00000271119 ----PSGEQL-----IQMETEEMEAC--------SNGALIPGNLSKEEEELSSQMSSFNE ENSMUST00000030440 ----PSGEQP-----VQMETEVMEAS--------SNGTSLTG---NEEEELSSQMSSFNE ENST00000268919 ----PYHRGH---YPIGHEAPRMLKS--------HIGNSEMSLQRDEFIKIPYVQSEEQK ci0100146176 EPFKKRHAAAGGAAGGGGMLDRIDESPQQAGMHSPNNSDLALISSICENEISREMFEVHQ CG3219-RA --------------------------------------------SKRMPDANLGSTSMSD : . . ENST00000230731 AVSQMVEMEEQVVEDHRAVFQESIRWLEDEKALLEMTEEVDYDVDSYATQLEAILEQKID ENSMUST00000042181 AVSQMVEMEEQVVEDHRAVFQESIRWIEDEKALLEMTEEVDYDVDSYATQLEAILEQKID SINFRUP00000136486 AVSQLVEMEEQVLEDHRAVFGESILWLEDEKRLLEMTEEVDYDSEIYATQLEHILDLKID SINFRUP00000151230 VVSQLVEMEEQVLEDHRAVFQESIRWLEDEKMLLEMTEEVDYDVESYATQLEQILDQKID ENST00000271119 AMTQIRELEEKAMEELKEIIQQGPDWLE----LSEMTEQPDYDLETFVNKAESALAQQAK ENSMUST00000030440 AMTQIRELEERALEELREIIQQGPNWLE----LSEMTDQPDYDLETFVNKAESALTQQAK ENST00000268919 EIEEVETLPTLLGKDTTISGKGSSQWLEN---IQERAGGVHHDIDFCIARSLSILEQKID ci0100146176 TVSSLQEIEEETVECHRNFLQGMSTSMAASTNLFNMTEDVDFDAEGYVARVKDHLETFEQ CG3219-RA IVCQSSTQRLFPCASSTSMPGGGNQAQQHTNTANDLNRSQKPTSKPTYPTSGQQLVQRKG : . : . . * ENST00000230731 ----ILTELRDKVKSFRAALQEEEQASKQINPKRPRAL- ENSMUST00000042181 ----ILTELRDKVKSFRAALQEEEQASKQINPKRPRAL- SINFRUP00000136486 ----ILTELRDKVKSFRCALQQEEQASKQITPKRPRAL- SINFRUP00000151230 ----ILIELRDKVKLFRSALQEEEQASKQINPKKPRGL- ENST00000271119 ----HFSALRDVIKALRLAMQLEEQASRQISSKKRPQ-- ENSMUST00000030440 Q-AKHFSALREVIKALRLAMQLEEQASKQINSKKRHQ-- ENST00000268919 ----ALTEIQKKLKLLLADLHVKSKVE------------ ci0100146176 ENKKLLEDFKEKLNLFEQTLLEEEAVSQNMKNKAGNRKV CG3219-RA ------SSQREASMMLTKSLAQFRGRNFP---------- : :. : : . :