CLUSTAL W (1.82) multiple sequence alignment SINFRUP00000140330 ------------------------FCCPVSTPLGQGRVNQLGGVFINGRP O57416_Brachydanio_rerio MTALAGGISRMMRPTPPQNYPRGGYSLEVSTPLGQGRVNQLGGVFINGRP SINFRUP00000137143 MTALAGSIPRMMRPALAQNYPRSGFPLEVSTPLGQGRVNQLGGVFINGRP ENST00000258386 MTTLAGAVPRMMRPGPGQNYPRSGFPLEVSTPLGQGRVNQLGGVFINGRP ENSMUST00000004994 MTTLAGAVPRMMRPGPGQNYPRSGFPLEVSTPLGQGRVNQLGGVFINGRP O57419_Brachydanio_rerio MATLPGTVPRMMRPAPGQNYPRTGFPLEVSTPLGQGRVNQLGGVFINGRP O57418_Brachydanio_rerio MATLPGTVPRMMRPAPGQNYPRTGFPLEVSTPLGQGRVNQLGGVFINGRP O57420_Brachydanio_rerio MATLPGTVPRMMRPAPGQNYPRTGFPLEVSTPLGQGRVNQLGGVFINGRP ENST00000234492 MAALPGTVPRMMRPAPGQNYPRTGFPLEVSTPLGQGRVNQLGGVFINGRP ENSMUST00000030508 MAALPGAVPRMMRPGPGQNYPRTGFPLEVSTPLGQGRVNQLGGVFINGRP O57417_Brachydanio_rerio MATLPGTVPRMMRPAPGQNYPRTGFPLEVSTPLGQGRVNQLGGVFINGRP ci0100137248 ----------MMHPG---SNFRPAFPLE-----GQGRVNQLGGMFINGRP CG6716-RB -------MTVTAFAAAMHRPFFNGYSTMQDMNSGQGRVNQLGGVFINGRP : **********:****** SINFRUP00000140330 LPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGA O57416_Brachydanio_rerio LPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGA SINFRUP00000137143 LPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGA ENST00000258386 LPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGA ENSMUST00000004994 LPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGA O57419_Brachydanio_rerio LPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGA O57418_Brachydanio_rerio LPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGA O57420_Brachydanio_rerio LPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGA ENST00000234492 LPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGA ENSMUST00000030508 LPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGA O57417_Brachydanio_rerio LPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGA ci0100137248 LPSHVRHKIVEMAAHGVRPCVISRQLRVSHGCVSKILCRYQETGSIKPGA CG6716-RB LPNNIRLKIVEMAADGIRPCVISRQLRVSHGCVSKILNRYQETGSIRPGV **.::* ****** .*:******************** ********:**. SINFRUP00000140330 IGGSKPKPTASPELDKKIEEYKRENPGMFSWEIRDKLLKDGICDRNNVPS O57416_Brachydanio_rerio IGGSKPKQSTTPDVEKKIEEYKRENPGMFSWEIRDKLLKDGICDRNNVPS SINFRUP00000137143 IGGSKPKQGTTPDVEKRIEEYKRENPGMFSWEIRDKLLKDGICDRNNVP- ENST00000258386 IGGSKPKQVTTPDVEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPS ENSMUST00000004994 IGGSKPKQVTTPDVEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPS O57419_Brachydanio_rerio IGGSKPRQVATPDVEKRIEEYKRENPGMFSWEIRDKLLKDGVCDRGTVPS O57418_Brachydanio_rerio IGGSKPRQVATPDVEKRIEEYKRENPGMFSWEIRDKLLKDGVCDRGTVPS O57420_Brachydanio_rerio IGGSKPRQVATPDVEKRIEEYKRENPGMFSWEIRDKLLKDGVCDRGTVPS ENST00000234492 IGGSKPRQVATPDVEKKIEEYKRENPGMFSWEIRDRLLKDGHCDRSTVPS ENSMUST00000030508 IGGSKPRQVATPDVEKKIEEYKRENPGMFSWEIRDRLLKDGHCDRSTVPS O57417_Brachydanio_rerio IGGSKPRQVATPDVEKRIEEYKRENPGMFSWEIRDKLLKDGVCDRGTVPS ci0100137248 IGGSKPK-VATADVDNKIEEYKKENPGIFSWEIRERLIKEGICDRSNVPS CG6716-RB IGGSKPR-IATPEIENRIEEYKRSSPGMFSWEIREKLIREGVCDRSTAPS ******: ::.:::::*****:..**:******::*:::. ***...* SINFRUP00000140330 -----VSAISRVIRSKFGGVGDDEEDDEEV-KREMDESEPRTKHSIDGIL O57416_Brachydanio_rerio -----VSSISRMLRCKFGGNGDEDEDDDEVEKREIEENERRAKHSIDGIL SINFRUP00000137143 ------SEIAHFVVAEN--------------------SFLIVLSSMT--- ENST00000258386 -----VSSISRILRSKFG---KGEEEEADLERKEAEESEKKAKHSIDGIL ENSMUST00000004994 -----VSSISRILRSKFG---KGEEEEADLERKEAEESEKKAKHSIDGIL O57419_Brachydanio_rerio GEASSVSSISRVLRARFG-----KKDDDDECDKKDEDGEKKTKHSIDGIL O57418_Brachydanio_rerio GEASSVSSISRVLRARFG-----KKDDDDECDKKDEDGEKKTKHSIDGIL O57420_Brachydanio_rerio GEASSVSSISRVLRARFG-----KKDDDDECDKKDEDGEKKTKHSIDGIL ENST00000234492 G---LVSSISRVLRIKFG-----KKEEEDEADKKEDDGEKKAKHSIDGIL ENSMUST00000030508 -----VSSISRVLRIKFG-----KKEDDEEGDKKEEDGEKKAKHSIDGIL O57417_Brachydanio_rerio GEASSVSSISRVLRARFG-----KKDDDDECDKKDEDGEKKTKHSIDGIL ci0100137248 -----VSSISRTLRAKGC-----DVENESESSARLDPGNRSSSS--GG-- CG6716-RB -----VSAISRLVRGRDAP---LDNDMSSASGSPAGDGTKASSSCGSDVS :* *:: : . . : SINFRUP00000140330 GD----RSSHSDDTSDVDSEPGLPLKRKQRRSRTTFTAEQLEELERAFER O57416_Brachydanio_rerio GD----RSSHSDEGSDVDSEPGLPLKRKQRRSRTTFTAEQLEELERAFER SINFRUP00000137143 -------ASHSDEGSDIESEPDLPLKRKQRRSRTTFTAEQLEELERAFER ENST00000258386 SERA--SAPQSDEGSDIDSEPDLPLKRKQRRSRTTFTAEQLEELERAFER ENSMUST00000004994 SERA--SAPQSDEGSDIDSEPDLPLKRKQRRSRTTFTAEQLEELERAFER O57419_Brachydanio_rerio GD----KGNRTDEGSDVESEPDLPLKRKQRRSRTTFTAEQLEELEKAFER O57418_Brachydanio_rerio GD----KGNRTDEGSDVESEPDLPLKRKQRRSRTTFTAEQLEELEKAFER O57420_Brachydanio_rerio GD----KGNRTDEGSDVESEPDLPLKRKQRRSRTTFTAEQLEELEKAFER ENST00000234492 GD----KGNRLDEGSDVESEPDLPLKRKQRRSRTTFTAEQLEELEKAFER ENSMUST00000030508 GD----KGNRLDEGSDVESEPDLPLKRKQRRSRTTFTAEQLEELEKAFER O57417_Brachydanio_rerio GD----KGNRTDEGSDVESEPDLPLKRKQRRSRTTFTAEQLEELEKAFER ci0100137248 -------EPNEVGGSDSESEPDLPLKRKQRRSRTTFSAEQLDELERCFER CG6716-RB GGHHNNGKPSDEDISDCESEPGIALKRKQRRCRTTFSASQLDELERAFER ** :***.:.*******.****:*.**:***:.*** SINFRUP00000140330 THYPDIYTREEVAQRAKLTEARVQVWFSNRRARWRKQAGASQLM------ O57416_Brachydanio_rerio THYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQLM------ SINFRUP00000137143 THYPDIYTREELAQRAKLTEARVQV------------------------- ENST00000258386 THYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQLM------ ENSMUST00000004994 THYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQLM------ O57419_Brachydanio_rerio THYPDIYTREELAQRTKLTEARVQVWFSNRRARWRKQAGANQLA------ O57418_Brachydanio_rerio THYPDIYTREELAQRTKLTEARVQVWFSNRRARWRKQAGANQLA------ O57420_Brachydanio_rerio THYPDIYTREELAQRTKLTEARVQVWFSNRRARWRKQAGANQLA------ ENST00000234492 THYPDIYTREELAQRTKLTEARVQVWFSNRRARWRKQAGANQLA------ ENSMUST00000030508 THYPDIYTREELAQRTKLTEARVQVWFSNRRARWRKQAGANQLA------ O57417_Brachydanio_rerio THYPDIYTREELAQRTKLTEARVQVRYVHLRY----------LQ------ ci0100137248 THYPDIYTREELAQRTRLTEARVQVWFSNRRARWRKQMAAQQFHGIPAHH CG6716-RB TQYPDIYTREELAQRTNLTEARIQVWFSNRRARLRKQHTSVSGGAPGG-- *:*********:***:.*****:** SINFRUP00000140330 --------AFNHLIPGGFPSSAM------SSLQPYQLSDSPYTPTSISQA O57416_Brachydanio_rerio --------AFNHLIPGGFPPSAM------SSLQPYQLADSPYPPSSISQV SINFRUP00000137143 -------------------------------------------------- ENST00000258386 --------AFNHLIPGGFPPTAM------PTLPTYQLSETSYQPTSIPQA ENSMUST00000004994 --------AFNHLIPGGFPPTAM------PTLPTYQLSETSYQPTSIPQA O57419_Brachydanio_rerio --------AFNHLLPGGFPPTGM------PTLPTYQLPESTYPSTTLSQ- O57418_Brachydanio_rerio --------AFNHLLPGGFPPTGM------PTLPTYQLPESTYPSTTLSQ- O57420_Brachydanio_rerio --------AFNHLLPGGFPPTGM------PTLPTYQLPESTYPSTTLSQ- ENST00000234492 --------AFNHLLPGGFPPTGM------PTLPPYQLPDSTYPTTTISQ- ENSMUST00000030508 --------AFNHLLPGGFPPTGM------PTLPPYQLPDSTYPTTTISQ- O57417_Brachydanio_rerio --------CMTLI------------------------------------- ci0100137248 PHHLSPHLGYPHTMPGSVGQAAHNYMLQTSGAHHVQSMHESFAHTASSHV CG6716-RB -----AAASVSHVAASSSLPSVVS---SVPSMAPLAMMPGSLDPATVYQQ SINFRUP00000140330 -------------------------------ASEQPSTVHRPQP-LPPTS O57416_Brachydanio_rerio -------------------------------S-EQPSTVHRPQP-LPPTS SINFRUP00000137143 -----------------------------------PDAVHAIQ------- ENST00000258386 -------------------------------VSDPSSTVHRPQP-LPPST ENSMUST00000004994 -------------------------------VSDPSSTVHRPQP-LPPST O57419_Brachydanio_rerio ---------------------------------DGSSTLHRPQP-LPPSS O57418_Brachydanio_rerio ---------------------------------DGSSTLHRPQP-LPPSS O57420_Brachydanio_rerio ---------------------------------DGSSTLHRPQP-LPPSS ENST00000234492 ---------------------------------DGGSTVHRPQP-LPPST ENSMUST00000030508 ---------------------------------DGGSTVHRPQP-LPPST O57417_Brachydanio_rerio -------------------------------------------------- ci0100137248 NLHHYNKNAIYILYMCEAMKPESKARVGSFSPEYHGSSLHRPHASVLTSP CG6716-RB QYDFYG------------------SHANISVSAAAPMASSNLSPGITTTP : SINFRUP00000140330 MHQNGL---------------------SSSAGSQDGNSAYCLPSGRHGFS O57416_Brachydanio_rerio VHQSGL---------------------GSGPGAQEGSSAYCLSSGRHGFS SINFRUP00000137143 -RQCGE---------------------DGS--QAEGGSPYCLASGRHTFS ENST00000258386 VHQSTI---------------------PSN---PDSSSAYCLPSTRHGFS ENSMUST00000004994 VHQSTI---------------------PSN---ADSSSAYCLPSTRHGFS O57419_Brachydanio_rerio MHQGGL---------------------SADSGSAYGLSSN-----RHTFS O57418_Brachydanio_rerio MHQGGL---------------------SADSGSAYGLSSN-----RHTFS O57420_Brachydanio_rerio MHQGGL---------------------SADSGSAYGLSSN-----RHTFS ENST00000234492 MHQGGL---------------------AAAAAAADTSSAYGA---RHSFS ENSMUST00000030508 MHQGGL---------------------AAAAAAADTSSAYGA---RHSFS O57417_Brachydanio_rerio -------------------------------------------------- ci0100137248 VHHASQAIRYDTTDPLNQSAAAAYGLMGASAAAAAAAARYSQYPSAAAFG CG6716-RB PHHHQFYN---------PSANTASYIMPGENGNTTPTGNIIVSSYETQLG : SINFRUP00000140330 G------YSDNFVAPAGH-------------TNAVNPTIGNSLS------ O57416_Brachydanio_rerio G------YSDGYVAAPGH-------------ANPVNPSISNGLP------ SINFRUP00000137143 G------YSDSFVGPGGP-------------ANPMNPAIGNGLS------ ENST00000258386 S------YTDSFVPPSGP-------------SNPMNPTIGNGLS------ ENSMUST00000004994 S------YTDSFVPPSGP-------------SNPMNPTIGNGLS------ O57419_Brachydanio_rerio S------YSETFMSPTAS-------------SNHMNP-VSNGLS------ O57418_Brachydanio_rerio S------YSETFMSPTAS-------------SNHMNP-VSNGLS------ O57420_Brachydanio_rerio S------YSETFMSPTAS-------------SNHMNP-VSNGLS------ ENST00000234492 S------YSDSFMNPAAP-------------SNHMNP-VSNGLS------ ENSMUST00000030508 S------YSDSFMNPGAP-------------SNHMNP-VSNGLS------ O57417_Brachydanio_rerio -------------------------------------------------- ci0100137248 DAYPIHYHHHSTSPPSGSSIFGFPSHTRQTATNPVELTTGNPHSGPNSSP CG6716-RB SVYGTETETHQTMPRNESP------------NESVSSAFGQLPP------ : SINFRUP00000140330 --------------PQVMGLLN-PSGVPHQSQTD---------------- O57416_Brachydanio_rerio --------------SQVMGLLN-PGAVPHQPQSD---------------- SINFRUP00000137143 --------------PQVMGLLN-PGGVPHQPQSD---------------- ENST00000258386 --------------PQVMGLLTNHGGVPHQPQTD---------------- ENSMUST00000004994 --------------PQVMGLLTNHGGVPHQPQTD---------------- O57419_Brachydanio_rerio --------------PQVMSILSNPSAVPSQPQHD---------------- O57418_Brachydanio_rerio --------------PQVMSILSNPSAVPSQPQHD---------------- O57420_Brachydanio_rerio --------------PQVS------AAEPSFQ------------------- ENST00000234492 --------------PQVMSILGNPSAVPPQPQAD---------------- ENSMUST00000030508 --------------PQVMSILSNPSAVPPQPQAD---------------- O57417_Brachydanio_rerio -------------------------------------------------- ci0100137248 IDVGSPGEAGNHPLHQQHFVLAQSARRAHQASNQRNHHNQHHSGETTTAP CG6716-RB -------------TPNSLSAVVSGAGVTSSSGANSG-------------- : SINFRUP00000140330 ----------------FALS---PLTGGLEP-----SGGMATSCHTS--Q O57416_Brachydanio_rerio ----------------FALS---PLTGGLEP-----STGMPASCHSS--Q SINFRUP00000137143 ----------------YAIS---PLTSGLEP-----PSCSQRMDHIKGLE ENST00000258386 ----------------YALS---PLTGGLEP-----TTTVSASCSQR--- ENSMUST00000004994 ----------------YALS---PLTGGLEP-----TTTVSASCSQR--- O57419_Brachydanio_rerio ----------------FSIS---PLHGGLEA-----SNPISASCSQR--- O57418_Brachydanio_rerio ----------------FSIS---PLHGGLEA-----SNPISASCSQR--- O57420_Brachydanio_rerio -------------------------------------------------- ENST00000234492 ----------------FSIS---PLHGGLDS-----ATSISASCSQR--- ENSMUST00000030508 ----------------FSIS---PLHGGLDS-----ASSISASCSQR--- O57417_Brachydanio_rerio -------------------------------------------------- ci0100137248 STSPASNGDGHPTTGIYSVSLTLPYFTGIESQSRAYSALAGQQHHNTDLH CG6716-RB ------------ADPSQSLANASAGSEELSAALKVESVDLIAASQSQLYG : : SINFRUP00000140330 RLEVLPGLTSMPALPSTQSYCPPSYTSPAYAMDHHPS-YQYGQYSQSK-- O57416_Brachydanio_rerio RLEALPGLPSMPALPSSQSYCPSSYSSPGYSVDHVAS-YQYSQYGQSKVN SINFRUP00000137143 GLTSVPSMSALPSLPSSQSYCTPAYNSPGYTVDHVAS-YQYGQYGQSK-- ENST00000258386 ----LDHMKSLDSLPTSQSYCPPTYSTTGYSMDPVTG-YQYGQYGQSKPW ENSMUST00000004994 ----LEHMKNVDSLPTSQPYCPP--------MDPVTG-YQYGQYGQSKPW O57419_Brachydanio_rerio ----SDPIKSVDSLASTQSYCPPTYSATSYSVDPVTAGYQYSQYGQS--- O57418_Brachydanio_rerio ----SDPIKSVDSLASTQSYCPPTYSATSYSVDPVTAGYQYSQYGQT-AV O57420_Brachydanio_rerio -------------------------------------------------- ENST00000234492 ----ADSIKPGDSLPTSQAYCPPTYSTTGYSVDPV-AGYQYGQYGQSECL ENSMUST00000030508 ----ADSIKPGDSLPTSQSYCPPTYSTTGYSVDPV-AGYQYSQYGQT-AV O57417_Brachydanio_rerio -------------------------------------------------- ci0100137248 SSTSVAGQQSTAMLSSSVDHSSNVFAGQERGAPSSRAGYGVGPSGFATGE CG6716-RB GWSSMQALRPNAPLSPEDSLNSTSSTSQALDVTAHQMFHPYQHTPQYASY : SINFRUP00000140330 -------------------------------------------------- O57416_Brachydanio_rerio TSTVTTVER---------------------------------LSRVYPLK SINFRUP00000137143 -------------------------------------------------- ENST00000258386 TF------------------------------------------------ ENSMUST00000004994 TF------------------------------------------------ O57419_Brachydanio_rerio TYCTVPASHTLYR------------------------------AAFL--- O57418_Brachydanio_rerio DYLAKNVSLSTQRR-----------------------MKLGDHSAVLGLL O57420_Brachydanio_rerio -------------------------------------------------- ENST00000234492 VPWASPVPIPSPTPRASCLFM------------ESYKVVSGWGMSISQME ENSMUST00000030508 DYLAKNVSLSTQR-----------------------RMKLGEHSAVLGLL O57417_Brachydanio_rerio -------------------------------------------------- ci0100137248 VLPTSSAASHQSYASCQYSPYGQASGDYGSAGIAALRMKSREHSASIGLI CG6716-RB PAPGHAHSHHGHPHAPHPHAHPHPQYAGAHPHYPPPSSSAHFMPQNFNAA SINFRUP00000140330 ----------------------- O57416_Brachydanio_rerio RASFGLVE--------------- SINFRUP00000137143 ----------------------- ENST00000258386 ----------------------- ENSMUST00000004994 ----------------------- O57419_Brachydanio_rerio ----------------------- O57418_Brachydanio_rerio QVETGQAY--------------- O57420_Brachydanio_rerio ----------------------- ENST00000234492 KLKSSQMEQFT------------ ENSMUST00000030508 PVETGQAY--------------- O57417_Brachydanio_rerio ----------------------- ci0100137248 PVGGGPSVQHAY----------- CG6716-RB AFPSPSKVNYTTMPPQPFYPSWY