CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000034754 ------------------------------------------------------------ ENSMUST00000059866 ------------------------------------------------------------ ENST00000267859 ------------------------------------------------------------ SINFRUP00000132680 ------------------------------------------------------------ ENSMUST00000044176 ALLDCEQPFASESPAVLTDIFLTSDTCLDVSEAALDHSFSDASGLNTSTGTIDDMSKLTL ENST00000223609 ALFDGDPHLSTENPALVPDALLASDTCLDISEAAFDHSFSDASGLNTSTGTIDDMSKLTL SINFRUP00000143671 ------------------------------------------------------------ SINFRUP00000156995 ------------------------------------------------------------ SINFRUP00000144386 ------------------------------------------------------------ ENST00000301260 ------------------------------------------------------------ ENSMUST00000047408 ------------------------------------------------------------ ENSMUST00000029760 ------------------------------------------------------------ ENST00000295294 ------------------------------------------------------------ ci0100140308 ------------------------------------------------------------ CG11593-RA ------------------------------------------------------------ ENSMUST00000034754 ------------------------------------------------------------ ENSMUST00000059866 ------------------------------------------------------------ ENST00000267859 ------------------------------------------------------------ SINFRUP00000132680 ------------------------------------------------------------ ENSMUST00000044176 SEGHPETPVDGDAGKQDVCSSEASWGDFEYDAMGQNIDEELMREPEHFLYGGDLPSEESA ENST00000223609 SEGHPETPVDGDLGKQDICSSEASWGDFEYDVMGQNIDEDLLREPEHFLYGGDPPLEEDS SINFRUP00000143671 ------------------------------------------------------------ SINFRUP00000156995 ------------------------------------------------------------ SINFRUP00000144386 ------------------------------------------------------------ ENST00000301260 ------------------------------------------------------------ ENSMUST00000047408 ------------------------------------------------------------ ENSMUST00000029760 ------------------------------------------------------------ ENST00000295294 ------------------------------------------------------------ ci0100140308 ------------------------------------------------------------ CG11593-RA ------------------------------------------------------------ ENSMUST00000034754 ------------------------------------------------------------ ENSMUST00000059866 ------------------------------------------------------------ ENST00000267859 ------------------------------------------------------------ SINFRUP00000132680 ------------------------------------------------------------ ENSMUST00000044176 LKQSLTPYTPPFDLSYLTEPTGCTETAQGAESPGDESLGSDAAEMLLSALPDHREE-DKA ENST00000223609 LKQSLAPYTPPFDLSYLTEPAQSAETIEEAGSPEDESLGCRAAEIVLSALPDRRSEGNQA SINFRUP00000143671 ------------------------------------------------------------ SINFRUP00000156995 ------------------------------------------------------------ SINFRUP00000144386 ------------------------------------------------------------ ENST00000301260 ------------------------------------------------------------ ENSMUST00000047408 ------------------------------------------------------------ ENSMUST00000029760 ------------------------------------------------------------ ENST00000295294 ------------------------------------------------------------ ci0100140308 ------------------------------------------------------------ CG11593-RA ------------------------------------------------------------ ENSMUST00000034754 ------------------------------------------------------------ ENSMUST00000059866 ------------------------------------------------------------ ENST00000267859 ------------------------------------------------------------ SINFRUP00000132680 ------------------------------------------------------------ ENSMUST00000044176 ETNIRKPRYQMTVLHIHEDPEALSSPVG-GTGSNNESNIDWEIETDNSDSPAGGDMKPPN ENST00000223609 ETKNRLPGSQLAVLHIREDPESVYLPVGAGSNILSPSNVDWEVETDNSDLPAGGDIGPPN SINFRUP00000143671 ------------------------------------------------------------ SINFRUP00000156995 ------------------------------------------------------------ SINFRUP00000144386 ------------------------------------------------------------ ENST00000301260 ------------------------------------------------------------ ENSMUST00000047408 ------------------------------------------------------------ ENSMUST00000029760 ------------------------------------------------------------ ENST00000295294 ------------------------------------------------------------ ci0100140308 ------------------------------------------------------------ CG11593-RA ------------------------------------------------------------ ENSMUST00000034754 ------------------------------------------------------------ ENSMUST00000059866 ------------------------------------------------------------ ENST00000267859 ------------------------------------------------------------ SINFRUP00000132680 ------------------------------------------------------------ ENSMUST00000044176 G--KEILELEEDEKVIPTKGPKQTELEYKEEKQPEQSEDHQVLAVDYILVSHEKDSPLKP ENST00000223609 GASKEISELEE-EKTIPTKEPEQIKSEYKEERCTEKNEDRHALHMDYILVNREENSHSKP SINFRUP00000143671 ------------------------------------------------------------ SINFRUP00000156995 ------------------------------------------------------------ SINFRUP00000144386 ------------------------------------------------------------ ENST00000301260 ------------------------------------------------------------ ENSMUST00000047408 ------------------------------------------------------------ ENSMUST00000029760 ------------------------------------------------------------ ENST00000295294 ------------------------------------------------------------ ci0100140308 ------------------------------------------------------------ CG11593-RA ------------------------------------------------------------ ENSMUST00000034754 ------------------------------------------------------------ ENSMUST00000059866 ------------------------------------------------------------ ENST00000267859 ------------------------------------------------------------ SINFRUP00000132680 ------------------------------------------------------------ ENSMUST00000044176 EAREARENIPELEQLSIGSRETGLPETQLSGTPDTCQSEFLNDVKVHSAERMSSSSNHES ENST00000223609 ETCEERESIAELELY-VGSKETGLQGTQLASFPDTCQPASLNERKGLSAEKMSSKSDTR- SINFRUP00000143671 ------------------------------------------------------------ SINFRUP00000156995 ------------------------------------------------------------ SINFRUP00000144386 ------------------------------------------------------------ ENST00000301260 ------------------------------------------------------------ ENSMUST00000047408 ------------------------------------------------------------ ENSMUST00000029760 ------------------------------------------------------------ ENST00000295294 ------------------------------------------------------------ ci0100140308 ------------------------------------------------------------ CG11593-RA --------------------------------------MDISETPTDSTGVSPLADDVLP ENSMUST00000034754 ------------------------------------------------------------ ENSMUST00000059866 ------------------------------------------------------------ ENST00000267859 ------------------------------------------------------------ SINFRUP00000132680 ------------------------------------------------------------ ENSMUST00000044176 ASLENPAQDQSWMVLSHSEVGDPPTETRDSGPESPGRTPEPFLSLSLDKGPKSQVLERNK ENST00000223609 SSFESPAQDQSWMFLGHSEVGDPSLDARDSGPGWSGKTVEPFSELGLGEGPQLQILEEMK SINFRUP00000143671 ------------------------------------------------------------ SINFRUP00000156995 ------------------------------------------------------------ SINFRUP00000144386 ------------------------------------------------------------ ENST00000301260 -----------------------------PSSDAESAPASILFLLGSEGPGSVSDAQLHP ENSMUST00000047408 ------------------------------------------------------------ ENSMUST00000029760 ------------------------------------------------------------ ENST00000295294 ------------------------------------------------------------ ci0100140308 ------------------------------------------------------------ CG11593-RA TAPEKNILKLEQAKQDHDKEELEFKTTSALDNRILRPELLPMEAMPQRHNIIERTLANSH ENSMUST00000034754 -----------------------------------------MEGVELKEEWQDEDFPIPL ENSMUST00000059866 -----------------------------------------IEGVELKEEWQDEDFLISL ENST00000267859 -----------------------------------------MEGVELKEEWQDEDFPIPL SINFRUP00000132680 ------------------------------------------------------------ ENSMUST00000044176 PLNSLALEEVAGLSSQSRNIERQGQAGLDAVPTQAATHDNEWEMLSPQLSRKNRNPPQEM ENST00000223609 PLESLALEEASGPVSQSQKSKSRGRAGPDAVTLQAVTHDNEWEMLSPQPVQKNMIPDTEM SINFRUP00000143671 ------------------------------------------------------------ SINFRUP00000156995 -------------------LLPPPGPCSPLRGMGTTEATLRMENMEVKDEWQDEDFP--- SINFRUP00000144386 ------------------------------------------------------------ ENST00000301260 GRARLCLPVRRRGCLSCRGVIPASSQCLFPAPMGTTEATLRMENVDVKEEWQDEDLPRPL ENSMUST00000047408 --------------------------------MGTTEATLRMENVDVRDEWQDEDLPRPL ENSMUST00000029760 ---------------------------------------MKLGELELREEWQDEEFPRLL ENST00000295294 -----------------SFLLGGCLRVREIAEAPELGAALRHGELELKEEWQDEEFPRLL ci0100140308 ------------------------MKDLEDGIADTSIKDRSNSEVVNNNESTEIMFEGNW CG11593-RA PLMSPTNTDSDSEPFQLKKQEKQLPRSNFPDVVPTTETVQVKNNLNQCRNKPQDAKVSLL ENSMUST00000034754 PEDDSIEADT---------------------------LDGTDPDRQPGSLEVNG------ ENSMUST00000059866 PEDDSIEADT---------------------------LDVTDSDRQPGSLEVNG------ ENST00000267859 PEDDSIEADI---------------------------LAITGPEDQPGSLEVNG------ SINFRUP00000132680 -----------------------------------------------------G------ ENSMUST00000044176 EEETQCPEPGPRKPRLKGPPSEDEGMDIHFEEGVLSPSAADMRPEPPNSLDLNG------ ENST00000223609 EEETEFLELGTRISRPNGLLSEDVGMDIPFEEGVLSPSAADMRPEPPNSLDLND------ SINFRUP00000143671 ---------------------------------------------PPTTLPLQG------ SINFRUP00000156995 STETWTPLVV---------------------------SQMTDPVAPPNSLNVSPPGGGGV SINFRUP00000144386 ---------------------------------------------PPTTLNVG------- ENST00000301260 PEETGVELLG---------------------------SPVEDTSSPPNTLNFNG------ ENSMUST00000047408 PEDTGVERLG---------------------------GAVEDSSSPPSTLNLSG------ ENSMUST00000029760 PEEPGSPGDPED-----------------------PQRGSQ--AGTPSSLALCG------ ENST00000295294 PEEAGTSEDPED-----------------------PKGDSQAAAGTPSTLALCG------ ci0100140308 EEDDLVALSG----------------------------QPGQSFQRLETVERES------ CG11593-RA RANSPDILSSES------------------DADVSQYLAAVESNFQSVSLMPNGNG---- : ENSMUST00000034754 ---NKVRKKLMAPDISLTLDPGEDSLWSDDLDEAG-------EVDLEGLDTPSE------ ENSMUST00000059866 ---NKVRKKLMAPDISLTLDPGEDSLWSDDLDEAG-------EVDLEGLDTPPE------ ENST00000267859 ---NKVRKKLMAPDISLTLDPSDGSVLSDDLDESG-------EIDLDGLDTPSE------ SINFRUP00000132680 ---KKAKKKLTAPNISLTLDRSEGSLLSDELDEST-------ELDLDGIDTPSD------ ENSMUST00000044176 --SHPRRIKLTAPNINLSLDQSEGSILSDDNLDSPDE----IDINVDELDTPDEA----- ENST00000223609 --THPRRIKLTAPNINLSLDQSEGSILSDDNLDSPDE----IDINVDELDTPDEA----- SINFRUP00000143671 --GPGHRKKLSAPRISLSLDQSE-----DDLGETPDD----LDINVDELDTPDEG----- SINFRUP00000156995 ASSHRKRRTLIAPELNLSLDHSEGSLLSDDFLDTPDD----LDINVDDIDTPDET----- SINFRUP00000144386 ---ERKRRTLVAPDMNLSLDQSEGSVLSDDFLETPDD----LDINVDDIETPDET----- ENST00000301260 --AHRKRKTLVAPEINISLDQSEGSLLSDDFLDTPDD----LDINVDDIETPDET----- ENSMUST00000047408 --AHRKRKTLVAPEINISLDQSEGSLLSDDFLDTPDD----LDINVDDIETPDET----- ENSMUST00000029760 --QRPMRKRLSAPEWQLSLTEGTGENGASPTRSASSSSAGSLDLEVDELETPSD------ ENST00000295294 --QRPMRKRLSAPELRLSLTKGPGNDGASPTQSAPSSPDGSSDLEIDELETPSD------ ci0100140308 -EYERARKKLTA-QFGDAEDSDIDGMLTPEELATP-----------DDLDSSVD------ CG11593-RA KKSKRSTALPGGEDISSLDSISNHSFDDDEDIEHNLASLSPSSSLIDGLDGEDDDDDCEG . . :: :: : ENSMUST00000034754 -NSDEFEWEDDLPKPKTTEVIRKG--SITEYT---------ATEEKGDGRRWRMFRIGE- ENSMUST00000059866 -NSDEFEWEYDLPNPETTEVITEG--SITKYT---------ATEEKEDGR---MFRTGE- ENST00000267859 -NSNEFEWEDDLPKPKTTEVIRKG--SITEYT---------AAEEKEDGRRWRMFRIGE- SINFRUP00000132680 -NSNEFEWEDDLPKPKTTELLQKGMKSVQEYS---------AAEEREESRRWRVFRIGE- ENSMUST00000044176 -DSFEYTNHEDPTANKSSGQESES---IPEYT--------AEEEREDN-RLWRTVVIGE- ENST00000223609 -DSFEYTGHEDPTANKDSGQESES---IPEYT--------AEEEREDN-RLWRTVVIGE- SINFRUP00000143671 -DYLDYTDHETDWEEPSEPSRSDPRDPIPTYG--------AEEERQDV-RLWRTVVIGE- SINFRUP00000156995 -DSLEFITNGNELEWEDDAPVASAK-AAPAD-----GLGDAEDEGNTNGRLWRTVLIGE- SINFRUP00000144386 -DSLEFINNGNDLEWEDDTPVATAK-HLP---------GEGEEERDSSGRLWRTVIIGD- ENST00000301260 -DSLEFLGNGNELEWEDDTPVATAK-NMPGDSADLFGDGTTEDGSAANGRLWRTVIIGE- ENSMUST00000047408 -DSLEFLGNGNELEWEDDTPVATAK-NMPGDSADLFGDGSAEDGSAANGRLWRTVIIGE- ENSMUST00000029760 ---SEQLDSGHEFEWEDDLPRAEGLGASEAAER--LGRGCVCDVAGEDGHRWRVFRTGQ- ENST00000295294 ---SEQLDSGHEFEWEDELPRAEGLGTSETAER--LGRGCMWDVTGEDGHHWRVFRMGP- ci0100140308 ---SPQQNSGVDLEWDNDTPVVQKTPSEPTTP-----------DVTTAPTNWRTVMIGE- CG11593-RA PELLPDHDDDLELDLEFGLATTPTPNAPASATAASTLPQYTAAEERRDSRNWQKITLPDG . ENSMUST00000034754 QDHRVDMKAIEPYKKVISHGGYY-GDGLNAIVVFAVCFMPESGQPNYRYLMDNLFK---- ENSMUST00000059866 QDHRVDMKAIEP---VVSHGGYD-GDGLNAIVVFAVCFMPESGQPNYRYLMDSLFN---- ENST00000267859 QDHRVDMKAIEPYKKVISHGGYY-GDGLNAIVVFAVCFMPESSQPNYRYLMDNLFK---- SINFRUP00000132680 QEHRVDMKAIEPYKRVISHGGYY-GDGLNAIIVFAVCFMPESNQPNYRYIMDNLFK---- ENSMUST00000044176 QEQRIDMKVIEPYRRVISHGGYY-GDGLNAIIVFAACFLPDSSRADYHYVMENLFL---- ENST00000223609 QEQRIDMKVIEPYRRVISHGGYY-GDGLNAIIVFAACFLPDSSRADYHYVMENLFL---- SINFRUP00000143671 QEHRINMKVIEPYMRVISHGGYY-GNQVNAIIVFAACFLPDSDREDYHEIMENLFL---- SINFRUP00000156995 QEHRIDMQIIRPYLRVITHGGYY-GEGLNAIIVFSACYLPDSSCSDYHYIMENLFLSVPW SINFRUP00000144386 QEQRIDMQVIRPYLRVVTHGGYY-GEGLNAIIVFAACHLPDSSCEDYAYIMENLFLGAVF ENST00000301260 QEHRIDLHMIRPYMKVVTHGGYY-GEGLNAIIVFAACFLPDSSLPDYHYIMENLFL---- ENSMUST00000047408 QEHRIDLHMIRPYMKVVTHGGYY-GEGLNAIIVFAACFLPDSSSPDYHYIMENLFL---- ENSMUST00000029760 REQRVDMTIIEPYKKVLSHGGYH-GDGLNAVILFASCYLPRSSIPNYTYIMEHLFR---- ENST00000295294 REQRVDMTVIEPYKKVLSHGGYH-GDGLNAVILFASCYLPRSSIPNYTYVMEHLFR---- ci0100140308 KNYKLDMGAVTPYRQILSHGGYY-GEGLNAIVVFSACYLPDTQQTDYRYIMDNLFL---- CG11593-RA RTREIDMRVIEPYKRVLSHGGYLKSGGQNAIVIFCACHLPDRSRADYSYVMDNLFL---- : .::: : * :::**** . **:::*. *.:* :* :*: ** ENSMUST00000034754 --------------------------------YVIGTLELLVAENYMIIYLNGATTRRKM ENSMUST00000059866 --------------------------------YCIVTLELLVAETYMIIYLNGETTQRKM ENST00000267859 --------------------------------YVIGTLELLVAENYMIVYLNGATTRRKM SINFRUP00000132680 --------------------------------YVIGTLELLVAENYMIVYLNGATSRKRM ENSMUST00000044176 --------------------------------YVISTLELMVAEDYMIVYLNGATPRRKM ENST00000223609 --------------------------------YVISTLELMVAEDYMIVYLNGATPRRRM SINFRUP00000143671 --------------------------------YVISTLELMVAEDYVIVYLNGATPHRRM SINFRUP00000156995 LTSFSGPCSTLTCPSCS---------------YVVSSLEMLVAEDYLIIYMNGATPRSRM SINFRUP00000144386 GMILGDKCKKNRWKPCNDATGELFPCVASILRYVVSSLELLVAEDYMIVYLNGATPRRKM ENST00000301260 --------------------------------YVISSLELLVAEDYMIVYLNGATPRRRM ENSMUST00000047408 --------------------------------YVISSLELLVAEDYMIVYLNGATPRRRM ENSMUST00000029760 --------------------------------YMVGTLELLVAENYLLVHLSGGTSRAQV ENST00000295294 --------------------------------YMVGTLELLVAENYLLVHLSGGTSRAQV ci0100140308 --------------------------------YIVSTLEMLVAEDYMIIFFNGGCRRKNL CG11593-RA --------------------------------YVVKTLEQLVTDDYVLIYLHGGSNRRNV * : :** :*:: *:::.: * : .: ENSMUST00000034754 PSLGWLRRCYQQIDRRLRKNLKSLIIVHPSWFIRTLLAVTRPFISSKFSQKIRYVFNLAE ENSMUST00000059866 PSLGWLGRCYQQTDRRLRENLKSLIIMHPSWFMRTLLAVTRPFISSKFGQKIIYFFKLAE ENST00000267859 PSLGWLRKCYQQIDRRLRKNLKSLIIVHPSWFIRTLLAVTRPFISSKFSQKIRYVFNLAE SINFRUP00000132680 PTVGWLRKCYQQIDRRLRKNLKSLIIVHPSWFIRTLLALTKPFISSKFSQKIKYVYSLAE ENSMUST00000044176 PGLGWMKKCYQMIDRRLRKNLKSFIIVHPSWFIRTILAVTRPFISSKFSSKIKYVTSLSE ENST00000223609 PGLGWMKKCYQMIDRRLRKNLKSFIIVHPSWFIRTILAVTRPFISSKFSSKIKYVNSLSE SINFRUP00000143671 PGLGWLKKCYQMIDRRLRKNLKSFIILHPSWFIRTVLAITKPFI---------------- SINFRUP00000156995 PGISWLKKCYQMIDRRLRKNLK-LVIAHPTWFIRTVLAISRPFISMKFLNKIQYVHSLDE SINFRUP00000144386 PGIVWLKRCYQMIDRKLRKNLKCLIIAHPTWFIRTVLAISRPFISVKFMDKIRYVHTLEE ENST00000301260 PGIGWLKKCYQMIDRRLRKNLKSLIIVHPSWFIRTVLAISRPFISVKFINKIQYVHSLED ENSMUST00000047408 PGIGWLKKCYHMIDRRLRKNLKSLIIVHPSWFIRTVLAISRPFISVKFISKIQYVHSLEE ENSMUST00000029760 PPLSWIRQCYRTLDRRLRKNLRALVVVHATWYVKAFLALVRPFISSKFTRKIRFLDSLGE ENST00000295294 PPLSWIRQCYRTLDRRLRKNLRALVVVHATWYVKAFLALLRPFISSKFTRKIRFLDSLGE ci0100140308 PPLNWLKRCYQMIHRRLRKNLKCLVVVHPSWYIRFLIGFFRPFISSKFSKKLKLVSTLHR CG11593-RA PPFPWLKRCYQLLDRRLRKSLKHMYLVHPTFWIKSLVWMARPFVSTKFWRKLVYVKSLEE * . *: :**: .*:**:.*: : : *.::::: .: . :**: ENSMUST00000034754 LAELVPMEYVGIPECIKQYEEEKFKKRQKRVDQELNGKQEPPKSEQ-------------- ENSMUST00000059866 LVEL-PKEYVGIPECIK------------------------------------------- ENST00000267859 LAELVPMEYVGIPECIKQ------------VDQELNGKQDEPKNEQ-------------- SINFRUP00000132680 LAELVPMEYVSIPDCLKQ------------------------------------------ ENSMUST00000044176 LSGLIPMDCIHIPESIIKLDEELREASEAAKTSCLYNDPEMSSMEKDIDMKLKEKP---- ENST00000223609 LSGLIPMDCIHIPESIIKLDEELREASEAAKTSCLYNDPEMSSMEKE------------- SINFRUP00000143671 ------------------------------------------------------------ SINFRUP00000156995 LAEIVPMEHVHVPDCVM------------------------------------------- SINFRUP00000144386 LSQFIPMEHVQIPECVL------------------------------------------- ENST00000301260 LEQLIPMEHVQIPDCVLQYEEERLKARRESARP-QPEFVLPRSEEKPEVAPVENRSALVS ENSMUST00000047408 LERLIPMEHVQLPDCVLQYEEQRLRAKRESTRPPQPEFLLPRSEEKPETVEEEDRAAEAT ENSMUST00000029760 LAQLISLEQVHIPEVVRQLDRDLHGSKGT------------------------------- ENST00000295294 LAQLISLDQVHIPEAVRQLDRDLHGSGGT------------------------------- ci0100140308 LADVVTLDNVVIPDMVQQYDLKISSPKKERPSNDTVVVNTDGSTECVKTSTSSEEG---- CG11593-RA LGMHVVVEKAAIPEKVKQYDAKRH------------------------------------ ENSMUST00000034754 ----- ENSMUST00000059866 ----- ENST00000267859 ----- SINFRUP00000132680 ----- ENSMUST00000044176 ----- ENST00000223609 ----- SINFRUP00000143671 ----- SINFRUP00000156995 ----- SINFRUP00000144386 ----- ENST00000301260 EDQET ENSMUST00000047408 EDQET ENSMUST00000029760 ----- ENST00000295294 ----- ci0100140308 ----- CG11593-RA -----