CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000040580 ------------------------------------------------------------ ENST00000221736 ------------------------------------------------------------ ENSMUST00000039517 ------------------------------------------------------------ ENST00000234668 ------------------------------------------------------------ SINFRUP00000139693 ------------------------------------------------------------ SINFRUP00000127072 ------------------------------------------------------------ CG1976-RA MTVQPAEMAENGRSVPDVTASPGRAPPGPLPANQMPAMGNQQHHGNQQHHGNQQQHHGNQ ENSMUST00000040580 ------------------------------------------------------------ ENST00000221736 ------------------------------------------------------------ ENSMUST00000039517 ---------------------------------------------------SPRIQLSSC ENST00000234668 ------------------------------------------------------------ SINFRUP00000139693 ------------------------------------------------------------ SINFRUP00000127072 ------------------------------------------------------------ CG1976-RA HSNHRGQSGSLSNAAGVKDPVMLQGDFRKVSGISSEIFRQIEAVENDHDPNTAAALEAVE ENSMUST00000040580 ------------------------------------------------------------ ENST00000221736 ------------------------------------------------------------ ENSMUST00000039517 RSLESLRVSRRPPLLQRWASDSCIRCGAHRDRDEPQPRGGGMDGWSPGSHRAATSAALLP ENST00000234668 ------------------------------------------------------------ SINFRUP00000139693 ------------------------------------------------------------ SINFRUP00000127072 ------------------------------------------------------------ CG1976-RA RRGEMIVRVLEPRCMGSKQAVDAAHKLMNKADARHTVQLVEIVKRPGQTLGLYIREGNGA ENSMUST00000040580 ------------------------------------------------------------ ENST00000221736 ------------------------------------------------------------ ENSMUST00000039517 PICHDPSGSSGRPFKDPVGTSVISSSQEDHPEDLP-LKPPAVTVKKLQKWMYKGRLLSLG ENST00000234668 -----------------AGSSVIRSGKGDRQEGPSFLRPPAVTVKKLQKWMYKGRLLSLG SINFRUP00000139693 ------------------------------------------------------------ SINFRUP00000127072 ------------------------------------------------------------ CG1976-RA DRTDGVFISRIALESAVYNSGCLRVGDEILAVNLVDVTHMSLDDVVIIMSIPRRLVLAIR ENSMUST00000040580 ---MAEPLLRKTFSRLRGREKLPRKKSEAKDRGHPAQRSEPKPPEPEPRVLEGSQAGAEV ENST00000221736 ---MAEPLLRKTFSRLRGREKLPRKKSDAKER---------------------------- ENSMUST00000039517 MKGRDRGTAPKVPGAQTTSPNLGSWKVHENHVLSVTTDQRITLTDLFENVYGSPLKKREP ENST00000234668 MKGRARGTAPKVTGTQAASPNVGALKVRENRVLSVPPDQRITLTDLFENAYGSSMKGREL SINFRUP00000139693 ------------------------------------------------------------ SINFRUP00000127072 -------QAAKASSDLPTTTTVNSKSAQHAYLQSLDHSS--------------------- CG1976-RA QRRGNRGTGSPGPPTLSRPEQKPPPVVVIKRDLRDEDLDETDRMPRPRSSRDGREMTESR ENSMUST00000040580 PPSPETPRSPTRGAYLQSLEPSSRRWVLGG------------------------------ ENST00000221736 ------------------------------------------------------------ ENSMUST00000039517 EDVRGPAELRGHQPLNNITVSKKRNWLYQSTLRSQSLDE-SKRSQDRRYFSLSPVSPPKH ENST00000234668 EELKDNIEFRGHKPLNSITVSKKRNWLYQSTLRPLNLEEENKKCQDRSHLSISPVSLPKH SINFRUP00000139693 ------------------------------------------------------------ SINFRUP00000127072 -----------------------RAWVLSS------------------------------ CG1976-RA SRLGLGLNNYSPQSEQLDMYYNTRGGGGGAMGEPPNWGYKPPPPPSSVITEQPTKAHAFA ENSMUST00000040580 -----------------------AKPPEEISLGPRTPSSGEPAGEIWYNPIPEED----- ENST00000221736 --------------------------------GPGVPGTGEPAGEIWYNPIPEED----- ENSMUST00000039517 WVSH------RPHCTHAVCNAARATLSRNGSSAFSEDNDADDEGEIWYNPIPEDDSLGIA ENST00000234668 QLSQSFLKSSKEYCTYVVCNATNSSLSKNCALDFNEENDADDEGEIWYNPIPEDDDLGIS SINFRUP00000139693 ------------------------------------------------------------ SINFRUP00000127072 ------------------------GKPQGSSVALSEETGSN----IWYNPIPEEEDAAD- CG1976-RA PSHAYYQNAGTLESLAEKVHAFYPGQPGGPPVGPSRRMSTGTGNVGLAQQHARFPRSGSD ENSMUST00000040580 --------------------------------------------------PRPPAPEPLG ENST00000221736 --------------------------------------------------PRPPAPEPPG ENSMUST00000039517 HVLSLEEANTAALKLP---VSMLSARDLMKAEPPSED-------RGDVQTSQSNGINSAD ENST00000234668 SALSFGEADSAVLKLPAVNLSMLSGSDLMKAERHTEDSLCSSEHAGDIQTTRSNGMNPIH SINFRUP00000139693 ------------------------------------------------------------ SINFRUP00000127072 ------------------------------------------------RSEPADGFSSRQ CG1976-RA QHLPRVEYSDYSNSLGRHSLLRSSLKPGTTGGAPMQVGVGGTLGRYGRYDQQRAGVSKYG ENSMUST00000040580 SQLASS----------------------------------------------EPEGPNIQ ENST00000221736 PQPGSA----------------------------------------------ESEGLAPQ ENSMUST00000039517 SMHSTEIMQHCKQRLGHRTQESPTAEDSPVLKSASTGPGIIVSTNRTELRAMEPSSPSPS ENST00000234668 PAHSTEFVQQYKQKLGHKTQEGIMVEDSPMLKSPFAGSGILAATNSTELGIMEPSSPNPS SINFRUP00000139693 -----------------------------------------------------PSSPNP- SINFRUP00000127072 PGEGTNVG--------------------------------------------HHPDDCRE CG1976-RA PPSGGAQSLTRRSRPNLDYSSDTEATIGPRPSYYYYNRPAIGSMSRGSGGAGGGVGAAST . ENSMUST00000040580 GAAPTSPP--TKTSRTKSPGPARRLS----------------------MKMKKLPELRRR ENST00000221736 GAAPASPP--TKASRTKSPGPARRLS----------------------IKMKKLPELRRR ENSMUST00000039517 PGKKGSSITWSLPDKIKSPRTVRKLS----------------------MKMKRLPEFSRK ENST00000234668 PVKKGSSINWSLPDKIKSPRTVRKLS----------------------MKMKKLPEFSRK SINFRUP00000139693 -AKKSSSINWSFPDRIKSPRTVRKIS----------------------MKMKKLPELSRK SINFRUP00000127072 GADCGSTSQKNRIDRLRSPGTVRKLS----------------------LKMKKLPELRRK CG1976-RA AALLAGAADLNKFNSLPRERPGTRLQGIRSRMGDRLVDENDGNTSAPEFDVRRGRDLRQR .. . . . ::. :.::: :: :: ENSMUST00000040580 LSLRS----------------------------------TRTGRDRERTAPAG------- ENST00000221736 LSLRG----------------------------------PRAGRERERAAPAG------- ENSMUST00000039517 LGARGALHYVNNPDS-----------------------TPPLSKWNCREIPQGVTLT--S ENST00000234668 LSVKGTLNYINSPDN-----------------------TPSLSKYNCREVHHTDILP--S SINFRUP00000139693 LSVKGTPSSSNSGNSQLEPRAH----------------SPRNNGSSSEAIPHSSGPPRLA SINFRUP00000127072 LSLRSSSRSNRQETD-----------------------ASGGDQATSSSVTSPPVLS--- CG1976-RA ITASPSIFTADEYRAWLRRAPSSSAIAEQMRMTRDMFAQPRAQRFSCSAENIHDALRN-- : : . : ENSMUST00000040580 ---------SVISRYHLDSSVGTPGQASVA----GGSRSPRGGYLSDGDSP-------ER ENST00000221736 ---------SVISRYHLDSSVGGPGPAAGP----GGTRSPRAGYLSDGDSP-------ER ENSMUST00000039517 GNTT----RNVISRYHLDTTVSSRHSYRKK-PLGSSKYSCKGGYLSDGDSP-------EL ENST00000234668 GNTTTAAKRNVISRYHLDTSVSSQQSYQKK-NSMSSKYSCKGGYLSDGDSP-------EL SINFRUP00000139693 ASGAGPASRNVISRYHLDSSVSTQHSFNKKKNNGSSKSASKGGYLSDGDSP-------EL SINFRUP00000127072 -------NQNVLSRYHLDSSTPAARPQRRP-SRGCS--GSKGGHLSDGDSP-------EL CG1976-RA TESIYSSRNHILGTGTLDRNMGLTRPISALPVRSMSSQHIGGAGSIRSPSIRRMRQLLEL ::. ** . . .. . * * ENSMUST00000040580 PGGPPSP--------------------------------TAFRPYEVGPSARTPPSALWG ENST00000221736 PAGPPSP--------------------------------TSFRPYEVGPAARAPPAALWG ENSMUST00000039517 RTRSSKHGSEH-KLGKGRE---TVPSS----CSKNELDIGAFRHYSFADQPKCS-QYISG ENST00000234668 TTKASKHGSEN-KFGKGKE---IISNS----CSKNEIDIDAFRHYSFSDQPKCS-QYISG SINFRUP00000139693 VAKSGKHSSAEGKAGKVKDPEGSVPNSK---LSGTELDIDAFRHYSFTEQPKCS-QYISG SINFRUP00000127072 LPRQQAAAVTP--------------------SQEMLCDVTSFQLYLGSNLQRCS-QRVTG CG1976-RA SAGPASPSGSILSTGGHQSPAPTPSATLPRPHRQIDINPAEFAKYKLDK-PIVDIGGISG * * : * ENSMUST00000040580 RLSLHLYGLGGLRPSPG--------ATPRDLCCLLQVDGVARARTGPLRSGPDFLRLDHT ENST00000221736 RLSLHLYGLGGLRPAPG--------ATPRDLCCLLQVDGEARARTGPLRGGPDFLRLDHT ENSMUST00000039517 LMSVHFYGAEGLKPPR---------IDSKDVFCAIQVDSVNKARTALLTCRTTFLDMDHT ENST00000234668 LMSVHFYGAEDLKPPR---------IDSKDVFCAIQVDSVNKARTALLTCRTTFLDMDHT SINFRUP00000139693 LMSLHFYGAEDLKPPR---------VDSRDVYCAIQVDSVNKARTALLTCRTTFLDMDHT SINFRUP00000127072 LLTVHLLGLEAMKTSRS--------EDSKEVFLAIQVDGVTRARTAPLALRGPALSLNHA CG1976-RA MLWIHLLAGRGLRTAPEGAAGTATQGQTRDLYCVIECDRVHKARTVVRS-GDLQFDWDES : :*: . ::.. .::: :: * :*** : :.: ENSMUST00000040580 FHLELEAARLLRALVLAWDPGVRRHRPCAQGTVLLPTIFRGCQAQQLAVRLEPQGLLYAK ENST00000221736 FHLELEAARLLRALVLAWDPGVRRHRPCAQGTVLLPTVFRGCQAQQLAVRLEPQGLLYAK ENSMUST00000039517 FNIEIENAQHLKLVVFSWEPTPRRNRVCCHGTVVLPALFRVTKTHQLAVKLEPRGLIYVK ENST00000234668 FNIEIENAQHLKLVVFSWEPTPRKNRVCCHGTVVLPTLFRVTKTHQLAVKLEPRGLIYVK SINFRUP00000139693 FNIDLENAQHLKLVVFSWEPTPRRNRVCCHGTVVLPALFRVTRCHQLAVKLEPRGLIYVK SINFRUP00000127072 FHLELERAQLLRIILLT--PGENQNKVCCLGGVSIPPLFKATRSQQLCVKLEPRGLLYVK CG1976-RA FELDLVGNKQLDVLVYSWDPQHR-HKLCYRGAISLSSILRQSPLHQLALKVEPRGTIYIR *.::: : * :: : * . :: * * : :..::: :**.:::**:* :* : ENSMUST00000040580 LTLSEQQEAPATA--------EPRVFGLPLQLLVEREQSPGQ----VPLIIRKCVGQIEC ENST00000221736 LTLSEQQEAPATA--------EPRVFGLPLPLLVERERPPGQ----VPLIIQKCVGQIER ENSMUST00000039517 VTLMEQWENSLHG-L--DKNREAVMFGVDIQKVVEKENVGLM----VPLLIQKCIVEIEK ENST00000234668 VTLMEQWENSLHG-L--DINQEPIIFGVDIQKVVEKENIGLM----VPLLIQKCIMEIEK SINFRUP00000139693 LSLMEQWQNSLDGGP--DGDREPQVFGVEAWRAVERENTGLM----VPLLISKCINEIEK SINFRUP00000127072 LSLQEKWDTQPIS----SSSGPTNVFGVELHHLVEKEESPVP----IPLLIQKCVKEIEV CG1976-RA MRHTDPLALYKRRGLPSLRAGYPTLFGADLETVVNRESKNAPGSAPVPIVLRRCVEEVER : : . :** *::* :*::: :*: ::* ENSMUST00000040580 RGLRVVGLYRLCG----------------------------------------------- ENST00000221736 RGLRVVGLYRLCG----------------------------------------------- ENSMUST00000039517 RGCQVVGLYRLCGSAAVKKELREAFEKDSKTVGLCENQYPDINVITGVLKDYLRELPSPL ENST00000234668 RGCQVLSYY--------------------------------------------------- SINFRUP00000139693 RGCQVVGLYRLCG----------------------------------------------- SINFRUP00000127072 RGLRVVGLYRLCG----------------------------------------------- CG1976-RA RGLDIIGLYRLCG----------------------------------------------- ** ::. * : ENSMUST00000040580 -----------------------------------------------SAAVKKELRDAFE ENST00000221736 -----------------------------------------------SAAVKKELRDAFE ENSMUST00000039517 ITKQLYEAVLDAMAKSPLKMSSSGCENEPSDSRLTVDLLDCLPDVEKASATLKMLLDHLK ENST00000234668 -----------------------------------------------GSLLLPLLID--- SINFRUP00000139693 -----------------------------------------------SAAVKKELREAFE SINFRUP00000127072 -----------------------------------------------SAAVKKELRDWFE CG1976-RA -----------------------------------------------SATKKRLLREAFE .: * : : ENSMUST00000040580 QDSAAVCLSEDVYPDINVITGILKDYLRELPTPLITQPLYQVVLEAMAQGHPSRASLGPE ENST00000221736 RDSAAVCLSEDLYPDINVITGILKDYLRELPTPLITQPLYKVVLEAMARDPPNRVPPTTE ENSMUST00000039517 LVASYHEVNKMTCQNLAVCFGPVLLNQRQEAS---------------------------- ENST00000234668 ------------------------------------------------------------ SINFRUP00000139693 RDSYAVELCENMYPDVNVITGTTK------------------------------------ SINFRUP00000127072 RNSSAVCLSEDLYPDINVITGL-------------------------------------- CG1976-RA RNSRAVELTPEHVPDINVITGVLKDYLRELPEPLFTRCLFQMTVDALAVCLPDDPEGNAK : : : ENSMUST00000040580 GTRGLLRCLPDVERATLTLLLDHLRLVSSFHTHNRMTPQNLAVCFGPVLLPARQTPSRPR ENST00000221736 GTRGLLSCLPDVERATLTLLLDHLRLVSSFHAYNRMTPQNLAVCFGPVLLPARQAPTRPR ENSMUST00000039517 -------------------------------------------------------THNNR ENST00000234668 ------------------------------------------------------------ SINFRUP00000139693 ------------------------------------------------------------ SINFRUP00000127072 ------------------------------------------------------------ CG1976-RA LMLSILDCLPRANRATLVFLLDHLSLVVSNSERNKMSAQALATVMG----------PPLM ENSMUST00000040580 LRSSGPGVTSAVDFKRHIEVLHYLLQSWPDTRRPSDTPDGA-------VAPYLRPKRQPP ENST00000221736 ARSSGPGLASAVDFKHHIEVLHYLLQSWPDPRLPRQSPD---------VAPYLRPKRQPP ENSMUST00000039517 VFTDSEELASALDFKKHIEVLHYLLQLWPVQRLTVKEPRDSLCLEQSSSLNYLRRKKERP ENST00000234668 ------------------------------------------------------------ SINFRUP00000139693 ------------------------------------------------------------ SINFRUP00000127072 ------------------------------------------------------------ CG1976-RA LHSASAQPGADIDHAQPIAVLKYLLQIWPQPQAQHQQMAQHMGGAAGAMMGGLVTAGSMS ENSMUST00000040580 LHLPLAGPEVVTRPRGRGG-PESPPSNRYAGDWSVCGGDLLPCGRDFLSGPDYDHVTGSD ENST00000221736 LHLPLADPEVVTRPRGRGG-PESPPSNRYAGDWSVCGRDFLPCGRDFLSGPDYDHVTGSD ENSMUST00000039517 CVLNLSGPDSSGVLRTRQARLDSPLSNRYAGDWSSCGESYSLNTRGNVKNLDYDDGPLEG ENST00000234668 ------------------------------------------------------------ SINFRUP00000139693 ------------------------------------------------------------ SINFRUP00000127072 ------------------------------------------------------------ CG1976-RA NMAGVASGNTGRRGESTGQRGSKVSALPADRQQLLLQQQAQLMAAGNLLRSSTSVTNILS ENSMUST00000040580 SEEDDDETGE--------------------PRGTTDFED--------------------- ENST00000221736 SEDEDEEVGE--------------------PRVTGDFED--------------------- ENSMUST00000039517 GESRQYSKTAGAEVMTAQRIPMSGGCTFQTYLTVQTIES--------------------- ENST00000234668 ------------------------------------------------------------ SINFRUP00000139693 ------------------------------------------------------------ SINFRUP00000127072 ------------------------------------------------------------ CG1976-RA QGHPQLSATANNHLYQSVVGQLAQSHRALQQAVQQPYQLGGSVGSAIPDPSPLPLPGTPS ENSMUST00000040580 ----------------------------------EFDAPFNPHLNLKDFDALILDLEREL ENST00000221736 ----------------------------------DFDAPFNPHLNLKDFDALILDLEREL ENSMUST00000039517 ----------------------------------TVDQKANLRDLQESIDTLIGNLEREL ENST00000234668 ------------------------------------------------------------ SINFRUP00000139693 ------------------------------------------------------------ SINFRUP00000127072 ------------------------------------------------------------ CG1976-RA PGSSSASTGSGSGSGKSTDTIKRGASPVSVKQVKIVDQPSSPYSIVMKKPPLQKDAPVEI ENSMUST00000040580 SKQINVCL---------------------------------------------------- ENST00000221736 SKQINVCL---------------------------------------------------- ENSMUST00000039517 NKNKLNMSV--------------------------------------------------- ENST00000234668 ------------------------------------------------------------ SINFRUP00000139693 ------------------------------------------------------------ SINFRUP00000127072 ------------------------------------------------------------ CG1976-RA TTPTTQADTESTLGCKESNGTASRRGNVDFYDTHKTQAKSVVNEESSYSSKYTGSETKKI ENSMUST00000040580 ------------------------------------------------------------ ENST00000221736 ------------------------------------------------------------ ENSMUST00000039517 ------------------------------------------------------------ ENST00000234668 ------------------------------------------------------------ SINFRUP00000139693 ------------------------------------------------------------ SINFRUP00000127072 ------------------------------------------------------------ CG1976-RA IPGNSSYTPSKANASGLSGGEDYKAMRNKSSATSSSSSSQATVLSAGSTATSAPTTSSDD ENSMUST00000040580 ------------------------------------------------------------ ENST00000221736 ------------------------------------------------------------ ENSMUST00000039517 ------------------------------------------------------------ ENST00000234668 ------------------------------------------------------------ SINFRUP00000139693 ------------------------------------------------------------ SINFRUP00000127072 ------------------------------------------------------------ CG1976-RA SDDLVSYKSSASTNALLAQSQAMTTSQLMSKYLKREPRVQFTPIKSPESPSPPGSGDGLP ENSMUST00000040580 ------------------------------------------------------------ ENST00000221736 ------------------------------------------------------------ ENSMUST00000039517 ------------------------------------------------------------ ENST00000234668 ------------------------------------------------------------ SINFRUP00000139693 ------------------------------------------------------------ SINFRUP00000127072 ------------------------------------------------------------ CG1976-RA KGTYQLVTPISGSSSKPGATTGAISKYTTGSVESSINANSQKLSSPSRLCNSKDSNSRTG ENSMUST00000040580 ------------------------------------------------------------ ENST00000221736 ------------------------------------------------------------ ENSMUST00000039517 ------------------------------------------------------------ ENST00000234668 ------------------------------------------------------------ SINFRUP00000139693 ------------------------------------------------------------ SINFRUP00000127072 ------------------------------------------------------------ CG1976-RA TASSTTPATSMVSTGRRLFDSLASSSSSETETKTYIGGTTAASGAITTTIYTNDTKNSGS ENSMUST00000040580 ------------------------------------------------------------ ENST00000221736 ------------------------------------------------------------ ENSMUST00000039517 ------------------------------------------------------------ ENST00000234668 ------------------------------------------------------------ SINFRUP00000139693 ------------------------------------------------------------ SINFRUP00000127072 ------------------------------------------------------------ CG1976-RA SSSKSGIGGGSGTGLGAVSGASSETRSFGSTLFGSSGLGNGNGSSHNHSSASPSPFTTTN ENSMUST00000040580 ------------------------------------------------------------ ENST00000221736 ------------------------------------------------------------ ENSMUST00000039517 ------------------------------------------------------------ ENST00000234668 ------------------------------------------------------------ SINFRUP00000139693 ------------------------------------------------------------ SINFRUP00000127072 ------------------------------------------------------------ CG1976-RA GNGNHNTMHLYGTLPKNGTSTGAALFGGSANSSSYHSSASGSGAGTASSSGVSSMTGSTN ENSMUST00000040580 ------------------------------------------------------------ ENST00000221736 ------------------------------------------------------------ ENSMUST00000039517 ------------------------------------------------------------ ENST00000234668 ------------------------------------------------------------ SINFRUP00000139693 ------------------------------------------------------------ SINFRUP00000127072 ------------------------------------------------------------ CG1976-RA SYDFYTSTSSTVSSSRPFANGGNNYHTLGTYRAQYAATNPFLDAFDEKPGSNGGNAHGEE ENSMUST00000040580 --------------------------------- ENST00000221736 --------------------------------- ENSMUST00000039517 --------------------------------- ENST00000234668 --------------------------------- SINFRUP00000139693 --------------------------------- SINFRUP00000127072 --------------------------------- CG1976-RA KLGADKGHHRAAVMAFQSSGDSKNGSDEYDDIK