CLUSTAL W (1.82) multiple sequence alignment ENST00000265069 MATGNYFGFTHSGAAAAAAAAQYSQQPASGVAYSHPTTVASYTVHQAPVAAHTVTAAYAP ENSMUST00000022814 -----------------SSTSHYSQQPASGVAYSHPTTVASYTVHQAPVAAHTVTAAYAP SINFRUP00000128493 -----------------------SHQPAAGVAYTHPTTVASYTVHQAPVAAHTVAAAYAP ENST00000262961 ------------------------------------------------------TPGMD- ENSMUST00000047123 ------------------------------------------------------------ SINFRUP00000156994 -------------------------------AYSHPSTAT-YSVQQASAVGHPVTASYA- CG5215-RA ------------------------------------------------------------ : : : ENST00000265069 AAATVAVARPAPVAVAAAATAAAYGGYPTAHTATDYGYTQRQQEAPPPPPPATTQNYQDS ENSMUST00000022814 AAATVAVARPAPVAVAAAATAAAYGGYPTAHTATDYGYTQRQQEAPPPPPPATTQNYQDS SINFRUP00000128493 TAATVAVARPAPVAVAAAATAAAYGGYQPAHATTDYGYPQRQPEVAPPPPPVTSQNYQDS ENST00000262961 ---------PAVNPAFPPAAPAGYGGYQP-HSGQDFAYGSRPQEPVP--TATTMATYQDS ENSMUST00000047123 ------------------------------------------------------------ SINFRUP00000156994 ---------PAPVQAARPVVSAPYAAYQN-HQAPPEYAYRQPEPPAPPQPTTTPQTYQDN CG5215-RA ------------------MANNNYAGFNYGGTQYNTGQVSYP--------AVTNATYANA : : ENST00000265069 YSYVRSTAPAVAYDSKQYYQQPTATAAAVAAAAQPQPSVAETYYQTAPKAGYSQGATQYT ENSMUST00000022814 YSYVRSTAPAVAYDSKQYYQQPTATAAAVAAAAQPQPSVAETYYQTAPKAGYSQGATQYT SINFRUP00000128493 YSYVRSTASAVGYDSKQYYQQPTATAA--VAAAQPQPSVADSYYQSAPKPAYSQGVTSYT ENST00000262961 YSYGQS-AAARSYEDRPYFQSAALQSGRMTAADSGQPGTQEACGQPSPHGSHSH-----A ENSMUST00000047123 ---------------------------------------------PGPQ----------- SINFRUP00000156994 YSYGRP-AAVSTFENKQFYQTSIASAQRTPAEAYYQTVGVKTAYSPSPSTVYSQ-----P CG5215-RA AAYQNAAVAAGQGGYGGAAGAGAGATSGPGAGGYGGYGDYRSAMQYDATKTFYQ------ . ENST00000265069 QAQQTRQVTAIKPATPSPATTTFSIYPVSSTVQPVAAAATVVPSYTQSATYSTTAVTYSG ENSMUST00000022814 QAQQARQVTAIKPATPSPATTTFSIYPVSSTVQPVAAAATVVPSYTQSATYSTTAVTYSG SINFRUP00000128493 QTQQTRQVTVIKPAAPSPASSTFSIYPVTSTVQPVAAAASVVPTYSQSPTYSTNAVTYSG ENST00000262961 QPPQQAPIVESGQPASTLSSGYTYPTATGVQPESSASIVTSYPPPS----YNPTCTAYTA ENSMUST00000047123 -----------------------------------------RPPPS----SQRAPQKLQA SINFRUP00000156994 PPPQRQVTALKPLAPSSSVSTSYNIYPVSTSVQQPSTPISSYNLDSS-FGSTVSATTYSG CG5215-RA ----------QSPASYNASGSTASVSKTHYSAPPVKNQVKGKMDKSNGGPKPPSSAPPAG : . ENST00000265069 TSYSGYEAAVYSAASS-----------YYQQQQQQQKQAAAAAAAAAATAAWTGTTFTKK ENSMUST00000022814 TSYSGYEAAVYSAASS-----------YYQQQQQQQKQAAAAAAAAAATAAWTGTTFTKK SINFRUP00000128493 TSYSGYEAAVYSAASS-----------YYQQQQQQQQ--KQAVAAVAASAAWTGNTFTKK ENST00000262961 PSYPNYDASVYSAASP---------FYPPAQPPPPPGPPQQLPPPPAPAGSGSSPRADSK ENSMUST00000047123 PS-------------------------------PPPAPVGSDPWGGPVLGPWDPTFTSDA SINFRUP00000156994 INYSSYDSTGYTSTSTPSYHYQPAQQNLAQPQPPPQQPQPQQPSVQPPLKQLTSSSWSNS CG5215-RA NNYSGYDTALYNAASMY---------------VAQQHQGNPNQKPNGGANNWYQRKMGAT . ENST00000265069 AP----------------FQNKQLKPKQPPKPPQIHYCDVCKISCAGPQTYKEHLEGQKH ENSMUST00000022814 TP----------------FQNKQLKPKQPPKPPQIH-CDVCKISCAGPQTYKEHLEGQKH SINFRUP00000128493 AP----------------FQNKTLRPKQPPKPPQIHYCDVCKISCAGPQTYKEHLEGQKH ENST00000262961 PP----------------LPSKLPRPKAGPRQLQLHYCDICKISCAGPQTYREHLGGQKH ENSMUST00000047123 LP----------------FLDRLPKPKAGPRPPSMHYCEVCRVSCAGPQTYRDHLEGQKH SINFRUP00000156994 GSNMVTAPSVNTYKKPTFHQNKLQKPKRPPKQPQLHYCDICKISCAGPQTYREHLEGQKH CG5215-RA IPG--------------ATAIRGMRPKAPPRPQQLHYCEVCKISCAGPQTYREHLEGQKH . : :** *: .:* *::*::********::** **** ENST00000265069 KKKEAALKASQNTSSSNSS----TRGTQNQLRCELCDVSCTGADAYAAHIRGAKHQKVVK ENSMUST00000022814 KKKEAALKASQNTSSSNNS----TRGTQNQLRCELCDVSCTGADAYAAHIRGAKHQKVVK SINFRUP00000128493 KKKEAALKVSQSSSSSGSSGGVLARNAQNQLRCELCDVSCTGADAYAAHIRGAKHQKVVK ENST00000262961 RKKEAAQKTGVQP--NGSP-----RGVQAQLHCDLCAVSCTGADAYAAHIRGSKHQKVFK ENSMUST00000047123 RKKQAAQRTSTQP--SGGP-----RGSQS-LHCGLCAVSCTGADAYAAHMRGARHQKVFK SINFRUP00000156994 KKKEAALKTGVQSGATNGP-----RGIQTQLRCELCDVSCTGVDAYAAHIRGSKHQKVVK CG5215-RA KKREASLKMSASANSATQN-------RGNNYHCELCDVTCTGTDAYAAHVRGAKHQKVVK :*::*: : . .. :: :* ** *:***.******:**::****.* ENST00000265069 LHTKLGKPIPSTEPNVVSQATSSTAVSASKP-TASPSSIAANNCTVNTSSVATSS----- ENSMUST00000022814 LHTKLGKPIPSTEPNVVSQATSSTAASASKP-TASPSSIGASNCTLNTSSIATSS----- SINFRUP00000128493 LHTKLGKPIPSTEPSMVAQTSSSSTTSTSKAATATLSSTSSSLCSASTSSTTSSSGPPYL ENST00000262961 LHAKLGKPIPTLEPALATE--------------SPPGAEAKPTSPTGPSVCASSR----- ENSMUST00000047123 LHTRLGKPIPSEPTPRSVT--------------YTRGSDSTPETSVKHEAHARHS----- SINFRUP00000156994 LHTKLGKPIPSTEPVLVNANPVLSMATVGKP--TAASSTASPVSTSSSSATASKQ----- CG5215-RA LHQKLGKPIPSEEP-------------------KKMGKINFVPAAAGGAGVAKTEG---- ** :******: . . . : : ENST00000265069 -MKGLTTTGNSSLNSTSNTKVSAVPTNMAAKKTSTPKINFVGKGNKLQSTGNKAEDIKGT ENSMUST00000022814 -VKGLSTTGNSSLNSTSNTKVSAIPTNMAAKKTSTPQNKLCG--NKLQSTGNKTEDLKGI SINFRUP00000128493 KPVNIVSSAVGGLKNPLTSNPSAVNNASVGKKVGAPKINFVG-GNKLQTT-VKMDDTRTE ENST00000262961 -----PALA----------KRPVASK---ALCEGPPEPQAAG------------------ ENSMUST00000047123 -----SHTQ----------GRPAPAKGSAASRKGPPELQTMH------------------ SINFRUP00000156994 -----ASVSNPVKTAAAPVKKSAPSRITGILTPAAAATTAAS------------------ CG5215-RA ---------------------------------GANESDAAG------------------ : .. : ENST00000265069 ECVKSTPVTSAVQIPEVKQDTVSEPVTPASLAALQSDVQPVGHDYVEEVRNDEGKVIRFH ENSMUST00000022814 DCVKNTPAASAVQIPEVKQDAGSEPVTPASLAALQSDVQPVGHDYVEEVRNDEGKVIRFH SINFRUP00000128493 VKMDSSKASTPLSGLQDSKGDLSDPLTCSALAALQSDVQPVGHDYVEEVRNDEGKVIRFH ENST00000262961 ----CRPQWGKPAQPKLEGPGAPTQGGSKEAPAGCSDAQPVGPEYVEEVFSDEGRVLRFH ENSMUST00000047123 ----GRPGDRRPSHFKVEA----TRGGPGEASGSSGDMAPVGTEYVEEVCSDEGKVIRFR SINFRUP00000156994 ----AVSKVEVLTLQPPQKVDSLSDNEDSDVSGGQGDIQPVGHDYVEEVRNDDGKVIRFH CG5215-RA ---------------------DLDDNLDDSLGENTDNIKPVGGEYIEEVKDEEGKILSFN : .: *** :*:*** .::*::: *. ENST00000265069 CKLCECSFNDPNAKEMHLKGRRHRLQYKKKVNPDLQVEVKPSIRARKIQEEKMRKQMQKE ENSMUST00000022814 CKLCECSFNDPNAKEMHLKGRRHRLQYKKKVNPDLQVEVKPSIRARKIQEEKMRKQMQKE SINFRUP00000128493 CKLCECSFNDPNAKEMHLKGRRHRLQYKKKVNPDLQVEVKPSIRARKIQEEKMRKQMQKE ENST00000262961 CKLCECSFNDLNAKDLHVRGRRHRLQYRKKVNPDLPIATEPSSRARKVLEERMRKQRH-- ENSMUST00000047123 CKLCECSFNDRNARDMHLTGRRHRLQYRKKVDPTLPVAARPSGPIQRVLAKRLQRHWQ-- SINFRUP00000156994 CKLCECSFNDPNAKDMHLKGRRHRLQYKKKVNPELPVEIKPSNRVRKLQENKLKKQKQKA CG5215-RA CKLCDCKFNDPNAKEMHMKGRRHRLQYKRKVQPDLVVDFKPTPRQRRLAEARANRAMMSS ****:*.*** **:::*: ********::**:* * : .*: ::: : .: ENST00000265069 EYWRRREEEERWRMEM-RRYEEDMYWRRMEEEQHHWDDRRRMPDGGYPHGPPGPLGLLGV ENSMUST00000022814 EYWRRREEEERWRMEI-RRYEEDMYWRRMEEEQHHWDDRRRMPDGGYPHGPPGPLGLLGV SINFRUP00000128493 EYWRRREEEERWRMEM-RRYEEDMYWRRVEEEQHHWDDRRRLPDGGYPQGPP---GLLGV ENST00000262961 LAEERLEQLRRWHAER-RRLEEEP--PQDVPPHAP-------PDWAQP--------LLMG ENSMUST00000047123 QVQTQLEDTRRWDSEL-RQPEETP--QPQVEEQLPG-----LPAWALP--------APTT SINFRUP00000156994 VLKRQRDDEQRWHMEM-RRYEEDIYWRRMEEEQIYWGEQ--RRRMAPL--------PLMS CG5215-RA HRGGDDHDGGYWEEQRNRQYNEEYDYNNWMSRSFGGAQRFGRMGNGPP------------ .: * : *: :* . ENST00000265069 RPGMP-PQPQGPAPLRRPDSSDDRYVMTKHATIYPTEEELQAVQKIVSITERALKLVSDS ENSMUST00000022814 RPGMP-PQPQGPAPLRRPDSSDDRYVMTKHATIYPTEEELQAVQKIVSITERALKLVSDS SINFRUP00000128493 RPGMPGLQPQGPVPPRRPDSSDDRYVMTKHAAIYPSEDELQSIQKIVSITERALKLVSDI ENST00000262961 RPESPASAPLQPG--RRPASSDDRHVMCKHATIYPTEQELLAVQRAVSHAERALKLVSDT ENSMUST00000047123 RP-GMATARRQSG--RRPESSDDRHVMCKHASIYPTEEELQAIQTAVSHTERALRLVSDT SINFRUP00000156994 RPGMPVPPLLACV--RRPDSPDDRHIMAKHSTIYPVEEELQAVQRIVSHAERALKLVSDS CG5215-RA ----PHFGMMPGGNVRRPESTDDRHAIARHAEIYPKEEELQTIQRIVSHTERALKLVSDA *** *.***: : :*: *** *:** ::* ** :****:**** ENST00000265069 LSEHEK---NKNKEGDDKKEGGK--------------------DRALKGVLRVGVLAKGL ENSMUST00000022814 LSEHEK---SKNKEGDDKKEGGK--------------------DRALKGVLRVGVLAKGL SINFRUP00000128493 ISDQDK---PNEEEAEDPP---K--------------------DRLLKGVMRVGVLAKGL ENST00000262961 LAEEDRGR-REEEGDKRSSVAPQ--------------------TRVLKGVMRVGILAKGL ENSMUST00000047123 LAEES--------SQHGTLASPP--------------------PRMLKGVVRVGILAKGL SINFRUP00000156994 LLDKDTQA-ATEDNDKGTESS----------------------ARVLKGVMRVGILAKGL CG5215-RA LAEQPSDAGAANKKDKAEKPSEKDGRDNQIFSFQKDADNGGNVVRILKGVMRVGYLAKGL : :. . * ****:*** ***** ENST00000265069 LLRGDRNVNLVLLCSEKPSKTLLSRIAENLPKQLAVISPEKYDIKCAVSEAAIILNSCVE ENSMUST00000022814 LLRGDRNVNLVLLCSEKPSKSLLSRIAENLPKQLAVISPEKYDIKCAVSEAAIILNSCVE SINFRUP00000128493 LLRGDKNVNLVLLCAEKPTKDLLSRIVEHLPKQLTIVTPEKYEVKGSDQEAAIILNSCTE ENST00000262961 LLRGDRNVRLALLCSEKPTHSLLRRIAQQLPRQLQMVTEDEYEVSSD-PEANIVISSCEE ENSMUST00000047123 VLRGDHSVQLTLLCSKKPTHSLLQRIKQELPRELSIVAEDKYEVSSD-HDANIVISACVE SINFRUP00000156994 LLRGDRNVQLILLTAKKPTVSLLTSIATQLPKELETFSEDQYEVQAHPEEANIVILSSKE CG5215-RA LLHGDNAVELVVLCAEKPTSGLLQRVANVLPDKLKEVAAS---LSAG------------- :*:**. *.* :* ::**: ** : ** :* .: . :. ::: ENST00000265069 PKMQVTITLTSPIIREENMREG---DVTSGMVKDPPDVLDRQKCLDALAALRHAKWFQAR ENSMUST00000022814 PKMQVTITLTSPIIREENMREG---DVTSGMVKDPPDVLDRQKCLDALAALRHAKWFQAR SINFRUP00000128493 PKMQVTITLTSPIIREETGRDG---DVTSGMVKDPADVLDRQKCLDALAALRHAKWFQAR ENST00000262961 PRMQVTISVTSPLMREDPSTDP---EGVEEPQADAGDVLSPKKCLESLAALRHARWFQAR ENSMUST00000047123 PGVKVTVSATSPLMREDPSVK----QGQQDALSDPEDVLDRERCLETLAALRHAKWFQAR SINFRUP00000156994 PKMQVTISLTSPLMREDTAAEKDKQAGGKAAEKDPPDLLNKKKCLEYLAALRHAKWFQAR CG5215-RA ------------------------------------------------------------ : : : :: :: : : : : ENST00000265069 ANGLQSCVIIIRILRDLCQRVPTWSDFPSWAMELLVEKAISSASSPQSPGDALRRVFECI ENSMUST00000022814 ANGLQSCVIIIRILRDLCQRVPTWSDFPSWAMELLVEKAISSASSPQSPGDALRRVFECI SINFRUP00000128493 ANGLQACVIIIRILRDLCQRVPTWSPFPGWAMELLVEKAISSASAPLSPGDALRRVFECI ENST00000262961 ASGLQPCVIVIRVLRDLCRRVPTWGALPAWAMELLVEKAVSSAAGPLGPGDAVRRVLECV ENSMUST00000047123 ASGLQPCVIVIRVLRELCRCLPPWGALPAWAMELLVEKVLSSAPRPLSPGDAMRRVLEYV SINFRUP00000156994 ANGLQSCVIIIRVLRDLCQRVSTWTKMSGWAMELLVEKVISSAAGPLSPGEALRRVLECI CG5215-RA ------------------------------------------------------------ : :::: :: : : : : ::: : : :: : ENST00000265069 SSGIILKGSPGLLDPCEKDPFDTLATMTDQQREDITSSAQFALRLLAFRQIHKVLGMDPL ENSMUST00000022814 SSGIILKGSPGLLDPCEKDPFDTLATMTDQQREDITSSAQFALRLLAFRQIHKVLGMDPL SINFRUP00000128493 SSGILLPGGPGLLDPCEKKLVDTLASMGGQQREDITSSAQFALRLLAFRQIHKVLGMDPL ENST00000262961 ATGTLLTDGPGLQDPCERDQTDALEPMTLQEREDVTASAQHALRMLAFRQTHKVLGMDLL ENSMUST00000047123 ATGALLTDGPGLQDPCEKGPQDALEPMTPQQREDLTASAQRALRLVAFRQIHKVLHMEQL SINFRUP00000156994 STGILLSDGPGLMDPCEKEPTDALDNMVPQDREEITVDAQQALRQLAFRQIHKILGMEPL CG5215-RA ------------------------------------------------------------ :: : : : : : : : :: : : ENST00000265069 PQMSQRFNIHNNRKRRRD-SDGMD-LKLRGKKTKKIMITFKKCL ENSMUST00000022814 PQMNQRFNIHNNRKRRRD-SDGVDGFEAEGKKDKKDYDNF---- SINFRUP00000128493 PQMNPRFNVRNSRKRRRDNSDGNDSFEGEGKKDKKDYDSF---- ENST00000262961 PPRHRLG--ARFRKRQRGPGEGEE-GAGEKKRGRRGGEGLV--- ENSMUST00000047123 PPRTR--------------------------------------- SINFRUP00000156994 PTSKAS---ARNRKRRLDGSNVGE-GEGEGKKDKKE-------- CG5215-RA -------------------------------------------- : :