CLUSTAL W (1.82) multiple sequence alignment SINFRUP00000158523 ------------------------------------------------------------ ENST00000315480 ------------------------------------------------------------ ENST00000263184 DPPRAALRGRFPALLTRHCPSPRAEKEKRSLRRCGCRPLLVELAGPAGQAVEVLPHFESL ENSMUST00000026507 GKRRAAVG---------FCG-PRCG---TVLRPCGSERSGSEEE-CAGRRAEVLPDLKSL SINFRUP00000157999 ------------------------------------------------------------ CG8494-RA ------------------------------------------------------------ SINFRUP00000158523 ------------------------------------------------------------ ENST00000315480 ---------MGDSRDLCPHLDSIGEVTKEDLLLKSKGTCQSCGVTGPNLWACLQVACPYV ENST00000263184 GKQEKIPNKMSAFRNHCPHLDSVGEITKEDLIQKSLGTCQDCKVQGPNLWACLENRCSYV ENSMUST00000026507 EKEKENCKKMTTFRNHCPHLDSVGEITKEDLIQKSLGACQDCKVRGPNLWACLENRCSYV SINFRUP00000157999 ------------------------------------GQCQDCKVGGPNLWACLENGCMYV CG8494-RA ------------------------------------------------------------ SINFRUP00000158523 ---------------AKKHNLTVNLTTFRIWCYVCEREVFLDHRATLVPVPAVSHH---C ENST00000315480 GCGESFADHSTIHAQAKKHNLTVNLTTFRLWCYACEKEVFLEQR---LAAPLLGSS---S ENST00000263184 GCGESQVDHSTIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTQPSLPHVRQPHQI ENSMUST00000026507 GCGESQVDHSTIHSQETKHYLTVNLTTLRVWCYACSKEVFLDRKLGTPPSLPHVRQPQQT SINFRUP00000157999 GCGESHADHSTVHSQETRHNLTVNLTTLRVWCYACSKEVFLERKLG--PHSLHVSG---- CG8494-RA ------------------MSLSSNPNPHNPYVEHRNRTIHSSQGHTLANGYAMGDP---- *: * .. . : .: :. .: SINFRUP00000158523 KATEHKAAAQPAGHPLKGVPIAVAEEDGSES-EEDELKPRGLTGMKNIGNSCYMNAALQA ENST00000315480 KFSEQ--DSPPPSHPLKAVPIAVADEGESES-EDDDLKPRGLTGMKNLGNSCYMNAALQA ENST00000263184 QENSVQDFKIPSNTTLKTPLVAVFDDLDIEADEEDELRARGLTGLKNIGNTCYMNAALQA ENSMUST00000026507 QENSVQDFKIPSNPALKTPMVAVSEDLDIEVEEEDELKARGLTGLKNIGNTCYMNAALQA SINFRUP00000157999 --EVLPSPKDPGQ-------VNVFHWLCIWP----------------LFVTCYF-----S CG8494-RA -RSSRCHDKLFSGSLKSLARREDSNASDSEGTDTAKGSGTGLVGLQNIANTCYMNSALQA . : : : :**: : : SINFRUP00000158523 LSNC-PPLTQFFLDCSGLVRTDKKP--------ALCKSYQKLISELWHKKR--PSYVVPT ENST00000315480 LSNC-PPLTQFFLECGGLVRTDKKP--------ALCKSYQKLVSEVWHKKR--PSYVVPT ENST00000263184 LSNC-PPLTQFFLDCGGLARTDKKP--------AICKSYLKLMTELWHKSR--PGSVVPT ENSMUST00000026507 LSNC-PPLTQFFLDCGGLARTDKKP--------AICKSYLKLMTELWHKSR--PGSVVPA SINFRUP00000157999 LCNCSPPLTQFFLECGGMVRTDKKP--------ALCKSYQKLVSDLWHKNR--SSYVVPT CG8494-RA LSNL-PPMTHYFINCSDLVEYIAEQSARRCKPGGLAKSYRRLMQEIWQDVDDPKEFIAPR *.* **:*::*::*..:.. : .:.*** :*: ::*:. :.* SINFRUP00000158523 SLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELKEPLTECSMSGEG-----SDGEDI ENST00000315480 SLSHGIKLVNPMFRGYAQQDTQEFLRCLMDQLHEELKEPVVATVALTEARDSDSSDTDEK ENST00000263184 TLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEVEEDPQT-----ITTEET ENSMUST00000026507 NLFQGIKTVNPTFRGYSQQDAQEFLRCLMDLLHEELKEQVMEMEEEPQT-----LTSEET SINFRUP00000157999 NLFQGIKAINPMFRGYSQQDSQEFLRCLMDQLHEELKEPMTEPYGHSNT-----AMIDGN CG8494-RA GILYGIRTVHPMFRGYQQHDTQEFLRCFMDQLHEELTEQVSMLPQTQNQ----------- : **: ::* **** *:*:******:** *****.* : : SINFRUP00000158523 RDGEHSPSEDEFLSCDSGSSSDRGEGGGAG-ESELLLQDVCDGIAPPTGGSVGNSTGGVI ENST00000315480 REGDRSPSEDEFLSCDS--SSDRGEGDGQG-RGGGSSQAETELLIP-------DEAGRAI ENST00000263184 MEEDKSQSDVDFQSCESCSNSDRAENENGS-RCFSEDNNETTMLIQDD-------ENNSE ENSMUST00000026507 VEEEKSQSDVDFQSCESCSSSEKAENESGS-KGFPEDSNETTMLIQD--------EDDLE SINFRUP00000157999 PEEDNHSQSDDFQSCESCDSSERADSEVRVGNMLRDDTNEAEMLIPE--------QDEIH CG8494-RA ------PQYQSLQQQQPSETDDENDDEAAP------------------------------ . .: . :. ..:. :. : : SINFRUP00000158523 SEKERLKEKRVSGSPLRGGSQE-------MDEDADVDTAAEETVADRGEEEALTDTDSQN ENST00000315480 SEKERMKDRKFSWGQQRTNSEQ-------VDEDADVDT-------------AMAALDDQP ENST00000263184 MSKDWQKEK-MCNKINKVNSE--------GEFDKDRDS---------------------I ENSMUST00000026507 MAKDWQKEK-VCNKINKANAD--------VELDKDRDT---------------------V SINFRUP00000157999 ATQEWQKEKNMINDLYRSSIQSVMGGGTGVDMDKDVDT---------------------T CG8494-RA ------------------------------------------------------------ . : : SINFRUP00000158523 QEAHQITDTGPEQTESNTPEPDNEASMAQPQSTHCSPVRTLQELQPKLSSSPPRSSPLRS ENST00000315480 AEAQPPSPRSS--SPCRTPEPDNDAHLRSS-SRPCSPVH-HHEGHAKLSSSPPRASPVRM ENST00000263184 SETVDLNNQETVKVQIHSRASEYITDVHSNDLSTPQILPSNEGVNPRLSASPPKSGNLWP ENSMUST00000026507 CETVDLNSQETVKVQIHGRASESITDVHLNDLATSQILPSNESVSPRLSASPPKLGSLWP SINFRUP00000157999 TETTPIISCQG-AMKFQGRAS----DIQMSNITKPQSPVLMEGHIPKLSSSPPKTASGWH CG8494-RA ASLSHASESEYDTCESSMSERSAEVLLKTEYFVTPCRTNGSNSGLPEGHSVQLQQAPLQH . : . .. : : . SINFRUP00000158523 AGPSYSFKKSQTMLS-SKKKKQFHFRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLS ENST00000315480 A-PSYVLKKAQVLSAGSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLS ENST00000263184 G-LAPPHKKAQSASP-KRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLS ENSMUST00000026507 G-LSPPHKKAQSTSA-KRKKQHKKYRSVISDIFDGTVISSVQCLTCDRVSITLETFQDLS SINFRUP00000157999 S-LNPAHKKVTTFSQ-PKNKHQKKYRSVVSDVFDGTIVSSVQCLTCDRVSVTLENFQDIS CG8494-RA Q---------QKNASSAEQKPIEAARSIISDVFDGKLLSSVQCLTCDRVSTREETFQDLS ..: **::**:***.::* ********** *.***:* SINFRUP00000158523 LPIPGKEDLAKLHSSIHQNLPVKTGTCPDSYNSQGWISYIMDSIRRFVVSCIPTWFWGPM ENST00000315480 LPIPGKEDLAKLHSAIYQNVPAKPGACGDSYAAQGWLAFIVEYIRRFVVSCTPSWFWGPV ENST00000263184 LPIPGKEDLAKLHSSSHPTSIVKAGSCGEAYAPQGWIAFFMEYVKRFVVSCVPSWFWGPV ENSMUST00000026507 LPIPGKEDLAKLHSSSHPT-IVKAGSCGEAYAPQGWIAFFMEYVK--------SWFWGPV SINFRUP00000157999 LPIPGKEDLAKLHSSTHQTSLVKAGSCGEAYAPQGWIAFVMEYIK--------SWFWGPV CG8494-RA LPIPNRDFLNVLHQTHSLSVQSLNAAETSARTNEGWLSWMWNMLR--------SWIYGPS ****.:: * **.: . .: .: :**:::. : :: ::: :*::** SINFRUP00000158523 VTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLKLPEILCIHLKRFRHEVMYS ENST00000315480 VTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLKRFRHEVMYS ENST00000263184 VTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRFRHELMFS ENSMUST00000026507 VTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQKFPEILCIHLKRFRHELMFS SINFRUP00000157999 VTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKMQNLPEILCIHLKRFRHELMFS CG8494-RA VTLYDCMASFFSADELKGDNMYSCERCNKLRTGIKYSRVLTLPEVLCIHLKRFRNDLSYS *** **:*:**: ************:*:***.*:*:.:: :**:*********::: :* SINFRUP00000158523 FKIGSHVSFPLEGLNMQPFLAKDSPSQVTTYDLLSVICHHGTAGSGHYIAYCQNVINGQW ENST00000315480 FKINSHVSFPLEGLDLRPFLAKECTSQITTYDLLSVICHHGTAGSGHYIAYCQNVINGQW ENST00000263184 TKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLW ENSMUST00000026507 TKISTHVSFPLEGLDLQPFLAKDSPAQIVTYDLLSVICHHGTASSGHYIAYCRNNLNNLW SINFRUP00000157999 TKISTHVSFPLEGLDLQPFLAKDSFSQTTNYDLLSVICHHGTASSGHYIAYCRNDENNLW CG8494-RA SKISSDVYFPLEGFDMRPYIHKDCKSEVAIYNLSSVICHHGTVGGGHYTCFARNTLNGKW **.:.* *****::::*:: *:. :: . *:* ********...*** .:.:* *. * SINFRUP00000158523 YEFDDQYVTEVHETVVQNAEAYVLFYRKSSEESVRERQKVVALASMK--EPSLLQFYISR ENST00000315480 YEFDDQYVTEVHETVVQNAEGYVLFYRKSSEEAMRERQQVVSLAAMR--EPSLLRFYVSR ENST00000263184 YEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIM--EPSLLQFYISR ENSMUST00000026507 YEFDDQSVTEVSESTVQNAEAYVLFYRKSSEEAQKERRRISNLLNIM--EPSLLQFYISR SINFRUP00000157999 YEFDDHRVTEVSESCVQNAEAYVLFYKKSNEEALKERRRVSVLYNMM--EPSLLQFYISR CG8494-RA YEFDDQFVTEVSSELVQSCQAYVLFYHKHNPQMKLVRDEAMTLSTSHPLCDSDIQFYITR *****: **** . **..:.*****:* . : * . * * ::**::* SINFRUP00000158523 EWLNKFNTFAEPGPISNHTFLCQHGGIPPNKYQYIDDLVVIVPQNVWEYLYNRFGGGPAV ENST00000315480 EWLNKFNTFAEPGPITNQTFLCSHGGIPPHKYHYIDDLVVILPQNVWEHLYNRFGGGPAV ENST00000263184 QWLNKFKTFAEPGPISNNDFLCIHGGVPPRKAGYIEDLVLMLPQNIWDNLYSRYGGGPAV ENSMUST00000026507 QWLNKFKTFAEPGPISNNDFLCIHGGIPPRKASYIEDLVLMLPQNIWDNLYSRYGGGPAV SINFRUP00000157999 QWLNKFKTFAEPGPISNTDFLCSHGGVPPNKASFIDDLIVMLPQNVWDHLYSKYGGGPAV CG8494-RA EWLSRLATFSEPGPINNQEMLCPHGGILHSKADVISQIAVPISQPLWDYLYRTFGGGPAV :**.:: **:*****.* :** ***: * *.:: : :.* :*: ** :****** SINFRUP00000158523 NHLYMCAICQVEIEALAKRRKMEIDTFIKLNKEFQAEEAPTVILCISMQWFREWESFVKG ENST00000315480 NHLYVCSICQVEIEALAKRRRIEIDTFIKLNKAFQAEESPGVIYCISMQWFREWEAFVKG ENST00000263184 NHLYICHTCQIEAEKIEKRRKTELEIFIRVKKAFQKEDSPATFYCISMQWFREWESFVKG ENSMUST00000026507 NHLYICHTCQIELEKIEKRRKTELEIFIRLNRAFQEEDSPATFYCISMQWFREWESFVKG SINFRUP00000157999 NHLYVCHTCQMEIEKFEKRRKSELDMFVRH----------CNYSTICLFILKE------- CG8494-RA NIIFECEICKRAAETLSRRQQYELNEFTKYN-GLQNEFDSTAIYAIAMPWLRSWQQFSRG * :: * *: * : :*:: *:: * : : *.: ::. : SINFRUP00000158523 KDNEPPGPVDNSKIGVMKG-GHIQL---KQGADYGQISEETWQYLLGIYGGGPEIAVRQT ENST00000315480 KDNEPPGPIDNSRIAQVKGSGHVQL---KQGADYGQISEETWTYLNSLYGGGPEIAIRQS ENST00000263184 KDGDPPGPIDNTKIAVTKC-GNVML---RQGADSGQISEETWNFLQSIYGGGPEVILRPP ENSMUST00000026507 KDGDPPGPIDNTKIAVTKC-GSVML---KQGADSGQISEETWNFLQSIYGGGPEVILRPP SINFRUP00000157999 ----PPGPVDNTKISVNKN-GHLTL---KQGADSGQISEETWNFLHSIYGGGPLVTVHPN CG8494-RA KTHKDPGPITNEGIAAPTENGSATVSCVRLGSDYAQLNARLWRFLHNIYGGGPEIILRQA ***: * *. . * : : *:* .*:. . * :* .:***** : :: SINFRUP00000158523 VTLPD-SDSLHGERKIEAETRAL------------------------------------- ENST00000315480 VAQPLGPENLHGEQKIEAETRAV------------------------------------- ENST00000263184 VVHVD-PDILQAEEKIEVETRSL------------------------------------- ENSMUST00000026507 VVHVD-PDVLQAEEKIEVETRSL------------------------------------- SINFRUP00000157999 ISHQE-AESSLSEEKIEVETRSI------------------------------------- CG8494-RA LSDEDDAEEIEIIDQDDECDDDEDQDLEGEGEDEEIAAASYQHNHSDTESNLGIRNTPSP : .: : : SINFRUP00000158523 ------------------------------------------------------------ ENST00000315480 ------------------------------------------------------------ ENST00000263184 ------------------------------------------------------------ ENSMUST00000026507 ------------------------------------------------------------ SINFRUP00000157999 ------------------------------------------------------------ CG8494-RA SPSTSPSPSLTGTRQPMETESDLRPSSSKSKRSRSKMKVSALRLNMRNRGKRNRSAFKQY SINFRUP00000158523 ------------------------------------------------------------ ENST00000315480 ------------------------------------------------------------ ENST00000263184 ------------------------------------------------------------ ENSMUST00000026507 ------------------------------------------------------------ SINFRUP00000157999 ------------------------------------------------------------ CG8494-RA AEMFGAKGNYNAHSNAEPVVSEKDEKDKDNDRTVAFPSEYSLPISIPFQSDNFQVNGVHE SINFRUP00000158523 -------------------------------------------- ENST00000315480 -------------------------------------------- ENST00000263184 -------------------------------------------- ENSMUST00000026507 -------------------------------------------- SINFRUP00000157999 -------------------------------------------- CG8494-RA KSRDKGKLRNSSKSGSTAATKENVTLQKFVTLREANGPSDETDI