CLUSTAL W (1.82) multiple sequence alignment SINFRUP00000165605 ---VFRSEEMCLAQLFLQSGSEYDCISELGELGLVEFRDLNPSVSSFQRRFVSEIKRCEE SINFRUP00000155131 MGSLFRGEEMCLAQLFLQSGSAYDCISELGELGLVEFRDLNPTVNTFQRKYVSEIKKCEE ci0100142086 MGSLFRSEEMCLSQLYLQSEAAFTCVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDE CG1709-RB MGSLFRSEEMALCQLFLQSEAAYACVSELGELGLVQFRDLNPDVNAFQRKFVNEVRRCDE ENSMUST00000044721 MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEE ENST00000264649 MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEE ENST00000297478 MVSVFRSEEMCLSQLFLQVEAAYCCVAELGELGLVQFKDLNMNVNSFQRKFVNEVRRCES ENSMUST00000040259 MASVFRSEEMCLSQVFLQVEAAYCCVAELGELGLVQFKDLNANVNSFQRKFVNEVRRCES ENSMUST00000001801 MGSMFRSEEVALVQLLLPTGSAYNCVSQLGELGLVEFRDLNESVSAFQRRFVVDVRRCEE ENST00000312779 MGSMFRSEEVALVQLFLPTAAAYTCVSRLGELGLVEFRDLNASVSAFQRRFVVDVRRCEE :**.**: * *: * : : *::.***** *:*:*** *. ***::* ::::*:. SINFRUP00000165605 MERILGYLLREIQKANIAVPEEDESPLAPPPRQVLEIMEQLQRLEMELSEVTRNKDKLQR SINFRUP00000155131 MERILGYLMKEVKKADISLPEGDVNPIAPLPKHILSIMEQLQRLEVELGEVTRNKEKLQR ci0100142086 MERKLRFLEKEVKKDDLHIDDNGENPTAPLPREMIDLENKFEKLENELRSVNSNQEALKK CG1709-RB MERKLRYLEKEIKKDGIPMLDTGESPEAPQPREMIDLEATFEKLENELREVNQNAEALKR ENSMUST00000044721 MDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKR ENST00000264649 MDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKR ENST00000297478 LERILRFLEDEMQN-EIVVQLLEKSPLTPLPREMITLETVLEKLEGELQEANQNQQALKQ ENSMUST00000040259 LERILRFLEDEMQN-EILIQVPEKDAETPLPREMITLETTLEKLEGELQEANQSHQALKK ENSMUST00000001801 LEKTFTFLREEVQRAGLTLAPPEGTLPAPPPRDLLRIQEETDRLAQELRDVRGNQQALRA ENST00000312779 LEKTFTFLQEEVRRAGLVLPPPKGRLPAPPPRDLLRIQEETERLAQELRDVRGNQQALRA ::: : :: *::. : : .* *:.:: : ::: ** . . : *: SINFRUP00000165605 NLLELKEYTHMLKITRTFIHSR-------------SRHEALGPQYEEFPTMETDSVTGCT SINFRUP00000155131 NLLELTEYMHMLRITRSFVQR------------------SAELHYEEFPFLDKDTMMDYS ci0100142086 NFLELTELKHILRKTQQFFEQYAVKYIIFITFIYQAALYQQDRQQVEVPQYDDEAPLITS CG1709-RB NFLELTELKHILRKTQVFFDE-------------QEGGVNQTTESMTRALITDEARTAGA ENSMUST00000044721 NFLELTELKFILRKTQQFFDE------------------MADPDLLE----ESSSLLEPN ENST00000264649 NFLELTELKFILRKTQQFFDE------------------MADPDLLE----ESSSLLEPS ENST00000297478 SFLELTELKYLLKKTQDFFET-------------------ETNLADDFFTEDTSGLLELK ENSMUST00000040259 SFLELTELKYLLKKTQDFFET-------------------ETNLGEDFFVEDTSGLLELR ENSMUST00000001801 QLHQLRLHSAVLGQSHSPPVA---------------------ADHTEGPFSETTPLLPGT ENST00000312779 QLHQLQLHAAVLRQGHEPQLA---------------------AAHTDG-ASERTPLLQAP .: :* :* : SINFRUP00000165605 GMQRLG-AKLGFVSGLIQRVKMEAFERMLWRVCKGYTILSYAEVDENLADLETGEMSKSV SINFRUP00000155131 SMQRLG-AKLGFVSGIIQRVKIEAFERMLWRVCKGYTILTHAEVEEYVENPDTGEPTKSV ci0100142086 EFSQGSFNKFGFVPGVLLREKVAAFERVIWRACRGNVFLRYTEIEAELEDPHTGDKVYKC CG1709-RB SMGP---VQLGFVAGVILRERLPAFERMLWRACRGNVFLRQAMIETPLEDPTNGDQVHKS ENSMUST00000044721 EMGRGAPLRLGFVAGVINRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKS ENST00000264649 EMGRGTPLRLGFVAGVINRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKS ENST00000297478 AVPAYMTGKLGFIAGVINRERMASFERLLWRICRGNVYLKFSEMDAPLEDPVTKEEIQKN ENSMUST00000040259 TIPAFMTGKLGFTAGVINRERMASFERLLWRVCRGNVYLKFSEMDTLLEDPVTKEEIKKN ENSMUST00000001801 -RGPHSDLKVNFVAGAVEPYKAAALERLLWRACRGFLIASFRETEGQLEDPVTGEPATWM ENST00000312779 -GGPHQDLRVNFVAGAVEPHKAPALERLLWRACRGFLIASFRELEQPLEHPVTGEPATWM :..* .* : : ::**::** *:* : : . . : SINFRUP00000165605 VFLISFWGDQIGQKVQKICDCYHCHLYPHPENDEERADVLDNLKTRIQDLNNVLHRTEDY SINFRUP00000155131 VFLISYWGDQIGQKVKKICDCYHCHLYPYPSSNEERNDVLEGLKTRIQDLHTVLHRTEDY ci0100142086 VFIVFFQGDQLKNRIKKICEGFRATLYPCPETPQERREIAIGVMTRIEDLQTVLNQTADH CG1709-RB VFIIFFQGDQLKTRVKKICEGFRATLYPCPEAPADRREMAMGVMTRIEDLNTVLGQTQDH ENSMUST00000044721 VFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDH ENST00000264649 VFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDH ENST00000297478 IFIIFYQGEQLRQKIKKICDGFRATVYPCPEPAVERREMLESVNVRLEDLITVITQTESH ENSMUST00000040259 IFIIFYQGEQLRLKIKKICDGFRATIYPCPEHAAERREMLTSVNVRLEDLITVITQTESH ENSMUST00000001801 TFVISYWGEQIGQKIRKITDCFHCHVFPYLEQEEARFRTLQQLQQQSQELQEVLGETDRF ENST00000312779 TFLISYWGEQIGQKIRKITDCFHCHVFPFLQQEEARLGALQQLQQQSQELQEVLGETERF *:: : *:*: :::** : ::. ::* . * : : ::* *: .* . SINFRUP00000165605 LRQVLQKASEAAYSWVVQVKKMKAIYHILNLCSFDVTNKCLIAEVWCPVSDLANLRGALE SINFRUP00000155131 LRQVLIKASESIYTWIIQVKKMKAIYYILNLCSFDVTNKCLIAEVWCPVNDIPKLRRALE ci0100142086 RRIVLSQVALNIRVWMIKVRKLKAIYHTLNLFNVNIAEKCLIAECWCPVVEIDRIQFALR CG1709-RB RHRVLVAAAKNLKNWFVKVRKIKAIYHTLNLFNLDVTQKCLIAECWVPLLDIETIQLALR ENSMUST00000044721 RQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQFALR ENST00000264649 RQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQFALR ENST00000297478 RQRLLQEAAANWHSWLIKVQKMKAVYHILNMCNIDVTQQCVIAEIWFPVADATRIKRALE ENSMUST00000040259 RQRLLQEAAANWHSWVIKVQKMKAVYHVLNMCNIDVTQQCIIAEIWFPVADTRHIKKALE ENSMUST00000001801 LSQVLGRVQQLLPPWQVQIHKMKAVYLTLNQCSVNTTHKCLIAEVWCAARDLPTVQQALQ ENST00000312779 LSQVLGRVLQLLPPGQVQVHKMKAVYLALNQCSVSTTHKCLIAEAWCSVRDLPALQEALR :* . ::::*:**:* ** ... :.:*:*** * . : :: **. SINFRUP00000165605 EGSRKGDATVPSFVNRIPCTDTPPTLLRTNKFTSGFQSIVEAYGVGDYREVSPAPYTIIT SINFRUP00000155131 EGSRKSGATVPSFVNRIPTNNTPPTLIRTNKFTSGFQNIVDAYGVGSYREVNPAPFTIIT ci0100142086 KGTELSGSSVPSIMQRMNTKEAPPTYNRTDKFTQGFQAIIDAFGVANYREVNPAPFTIIT CG1709-RB RGTERSGSSVPPILNRMQTFENPPTYNRTNKFTKAFQALIDAYGVASYREMNPAPYTIIT ENSMUST00000044721 RGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTHGFQNIVDAYGIGTYREINPAPYTVIT ENST00000264649 RGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIIT ENST00000297478 QGMELSGSSMAPIMTTVQSKTAPPTFNRTNKFTAGFQNIVDAYGVGSYREINPAPYTIIT ENSMUST00000040259 QGMELSGSSMIPIMTEVETKTDPPTFNRTNKFTAGFQNIVDAYGVGSYREINPAPYTIIT ENSMUST00000001801 SGSSEEG--VSAVAHRIPCQDMPPTLIRTNRFTSSFQGIVDAYGVGRYREVNPAPYTIIT ENST00000312779 DSSMEEG--VSAVAHRIPCRDMPPTLIRTNRFTASFQGIVDAYGVGRYQEVNPAPYTIIT . . : .. : *** :*::** .** :::*:*:. *:*:.***:*:** SINFRUP00000165605 FPFLFAVMFGDLGHGIVMSLFALWMVLTEKKQKKKRSSNEIWATFFSGRYIILMMGLFSI SINFRUP00000155131 FPFLFAVMFGDLGHGLIMALFASWMVLYENNRKLKNTRNEIWNMFFEGRYIILMMGLFSI ci0100142086 FPFLFAVMFGDIGHGLLMFLFALFLVRKERAFMQHKLDNEIFEMMFDGRYLILLMGIFSM CG1709-RB FPFLFAVMFGDLGHGAIMALFGLWMIRKEKGLAAQKTDNEIWNIFFGGRYIIFLMGVFSM ENSMUST00000044721 FPFLFAVMFGDFGHGILMTLFAVWMVLRESRILSQKHENEMFSMVFSGRYIILLMGLFSI ENST00000264649 FPFLFAVMFGDFGHGILMTLFAVWMVLRESRILSQKNENEMFSTVFSGRYIILLMGVFSM ENST00000297478 FPFLFAVMFGDCGHGTVMLLAALWMILNERRLLSQKTDNEIWNTFFHGRYLILLMGIFSI ENSMUST00000040259 FPFLFAVMFGDCGHGMVMLMAALWMVLNERHLLAQKSTNEMWNIFFNGRYLILLMGIFSI ENSMUST00000001801 FPFLFAVMFGDVGHGLLMFLFALAMVLTENRPAVKAAQNEIWQTFFGGRYLLLLMGLFSV ENST00000312779 FPFLFAVMFGDVGHGLLMFLFALAMVLAENRPAVKAAQNEIWQTFFRGRYLLLLMGLFSI *********** *** :* : . :: * : **:: .* ***::::**:**: SINFRUP00000165605 YTGLIYNDCFSKSLNMFGSGWSVKAMFANQQWTNKTLRSNALLTLDPNVSG--------- SINFRUP00000155131 YTGLIYNDCFSKSLNIFGSGWSVNAMFKENVWKMEDIYGNRYLTLDPNVTG--------- ci0100142086 YTGFLYNECFSRSINVFGSAWNVN----AMNYSETTLATNEYLTLDPNETGVFRGYPFSY CG1709-RB YTGLIYNDIFSKSLNIFGSHWHL-------SYNKSTVMENKFLQLSPKGD---------- ENSMUST00000044721 YTGLIYNDCFSKSLNIFGSSWSVRPMFTQGNWTEETLLGSSVLQLNPAIPG--------- ENST00000264649 YTGLIYNDCFSKSLNIFGSSWSVRPMFTY-NWTEETLRGNPVLQLNPALPG--------- ENST00000297478 YTGLIYNDCFSKSLNIFGSSWSVQPMFRNGTWNTHVMEESLYLQLDPAIPG--------- ENSMUST00000040259 YTGLIYNDCFSKSFNIFGSSWSVQPMFRNGTWNTHIVENSPYLQLDPAIPG--------- ENSMUST00000001801 YTGFIYNECFSRATTIFPSGWSVAAMANQSGWSDEYLSQHSMLTLNPNITG--------- ENST00000312779 YTGFIYNECFSRATSIFPSGWSVAAMANQSGWSDAFLAQHTMLTLDPNVTG--------- ***::**: **:: .:* * * : : :. : * *.* SINFRUP00000165605 --VFSGPYPFGIDPIWNMA-VNRLSFLNSYKMKMSVIIGVIHMSFGVVLSIFNYLHFRQK SINFRUP00000155131 --VFNGPYPFGIDPIWNLA-FNRLTFLNSYKMKMSVIVGIIHMSFGVILSTYNYMHFRKR ci0100142086 PTSTGLPYFYGIDPIWQSA-ENKISVQNSYKMKNAVLMGFGQMVFGLVLAMYNHRNFGDK CG1709-RB --YEGAPYPFGMDPIWQVAGANKIIFHNAYKMKISIIFGVIHMIFGVVMSWHNHTYFRNR ENSMUST00000044721 --VFGGPYPFGIDPIWNIA-TNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKP ENST00000264649 --VFGGPYPFGIDPIWNIA-TNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKP ENST00000297478 -VYFGNPYPFGIDPIWNLA-SNKLTFLNSYKMKMSVILGIVQMVFGVILSLFNHIYFRRT ENSMUST00000040259 -VYSGNPYPFGIDPIWNLA-SNKLTFLNSYKMKMSVILGIAHMIFGVILSLFNHIYFRRT ENSMUST00000001801 --VFLGPYPFGIDPIWSLA-TNHLSFLNSFKMKMSVILGVTHMAFGVFLSIFNHVHFGQA ENST00000312779 --VFLGPYPFGIDPIWSLA-ANHLSFLNSFKMKMSVILGVVHMAFGVVLGVFNHVHFGQR ** :*:****. * *:: . *::*** :::.*. :* **: :. .*: * SINFRUP00000165605 FNVYLLFLPELLFLLCLFGYLIFMIVYKWLAYGAR-----DSSQAPSILIHFINMFVMQG SINFRUP00000155131 HHLFLVFLPELLFLLCLFGYLVFMIMYKWLVFSAK-----DSRHAPSVLIHFINMFLMQG ci0100142086 IALYCEWLPQVLFLFALIGYLCVAILYKWSAWTVR-----QAGTAPSLLIGLIDMYMFTD CG1709-RB ISLLYEFIPQLVFLLLLFFYMVLLMFIKWIKFAATNDKPYSEACAPSILITFIDMVLFNT ENSMUST00000044721 LNIYFGFIPEIIFMSSLFGYLVILIFYKWTAYDAH-----SSRNAPSLLIHFINMFLFSY ENST00000264649 LNIYFGFIPEIIFMTSLFGYLVILIFYKWTAYDAH-----TSENAPSLLIHFINMFLFSY ENST00000297478 LNIILQFIPEMIFILCLFGYLVFMIIFKWCCFDVH-----VSQHAPSILIHFINMFLFNY ENSMUST00000040259 LNIILQFIPEMIFMLSLFGYLVFMIIFKWCRYDAH-----TSRKAPSILIHFIGMFLFDY ENSMUST00000001801 HRLLLETLPELIFLLGLFGYLVFLIVYKWVNVSAA-----SASSAPSILIHFINMFLFSQ ENST00000312779 HRLLLETLPELTFLLGLFGYLVFLVIYKWLCVWAA-----RAASAPSILIHFINMFLFSH : :*:: *: *: *: . :. ** . ***:** :*.* :: SINFRUP00000165605 KDI------APLFPGQTGLQIFLVFIALLSVPVLLLGKPLYLYWTYRGGKGLHRCR---V SINFRUP00000155131 RGM------QPLYPGQNGLQIFLVVIAVLSVPVLFLGKPLYLYWLHNGNQHLRMYR---G ci0100142086 PES---NGRSALYTGQYTIQKILVVVTVICIPWMLFSKPYILYKRSQQKKGYTLVVDAED CG1709-RB PKPPPENCETYMFMGQHFIQVLFVLVAVGCIPVMLLAKPLLIMQARKQAN---------- ENSMUST00000044721 PES----GNAMLYSGQKGIQCFLIVVAMLCVPWMLLFKPLILRHQYLRKKHLG------- ENST00000264649 PES----GYSMLYSGQ-------------------------------------------- ENST00000297478 SDS----SNAPLYKHQQEVQSFFVVMALISVPWMLLIKPFILRASHRKSQLQASR----- ENSMUST00000040259 DDS----SNAPLYGHQQEVQTFFVIIALVSVPWMLLIKPFVLRAKHQKSQLQSFT----- ENSMUST00000001801 NPT-----NHLLFHGQEVVQYVLVVLALATVPILLLGTPLYLLRQHRHRRNTQRRP--AG ENST00000312779 SPS-----NRLLYPRQEVVQATLVVLALAMVPILLLGTPLHLL--HRHRRRLRRRP--AD :: * : ::.: : : ::: : SINFRUP00000165605 RAFTARSAARPVLVLVVCNLR-CCLASGLR------------EDVLLYQTIHTIEYCLGC SINFRUP00000155131 YERVRHDSDEELFLLSAHNMEEGSSHSDLSSSGDHEPENFNFADELLHQAIHGIEYCLGC ci0100142086 TDGTQMTSLMEAGQSDEDDVAILHHEETGHAHDVKESEKFDMSEVLIYQVIHTIEYCLSC CG1709-RB ------VQPIAGATSDAEAGGVSNSGSHGGGGGHEEEE--ELSEIFIHQSIHTIEYVLGS ENSMUST00000044721 --TLNFGGIRVGNGPTEEDAEIIQHDQLSTHS--EDAEEFDFGDTMVHQAIHTIEYCLGC ENST00000264649 ------------------------------------------------------------ ENST00000297478 -IQEDATENIEGDSSSPSSRSGQRTSADTHGALDDHGEEFNFGDVFVHQAIHTIEYCLGC ENSMUST00000040259 -IHEDA---VEGDHSGHSSK----KTAGAHGMKDGHEEEFNFGDIFVHQAIHTIEYCLGC ENSMUST00000001801 QQDEDTDKLLASPDASTLENSWSPDEEKAGSPGDEE-TEFVPSEIFMHQAIHTIEFCLGC ENST00000312779 RQEENKAGLLDLPDAS--VNGWSSDEEKAGGLDDEEEAELVPSEVLMHQAIHTIEFCLGC :: : : : SINFRUP00000165605 ISNTASYLRLWALSLAHAQLSEVLWAMVMR------------------------------ SINFRUP00000155131 ISNTASYLRLWALSLAHAQLSEVLWSMVMRVGLRM--DISLGILFLVPVFGLFAVLTVSI ci0100142086 ISHTASYLRLWALSLAHSELSEVLWSMVMSIGLGT--SGTAGAVMTFLLFWFFSGLTVGI CG1709-RB VSHTASYLRLWALSLAHAQLAEVLWTMVLSIGLKQ--EGPVGGIVLTCVFAFWAILTVGI ENSMUST00000044721 ISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLHV--RSLAGGLGLFFIFAAFATLTVAI ENST00000264649 ------------------------------------------------------------ ENST00000297478 ISNTASYLRLWALSLAHAQLSEVLWTMVMNSGLQT--RGWGGIVGVFIIFAVFAVLTVAI ENSMUST00000040259 ISNTASYLRLWALSLAHAELSEVLWTMVMSIGLRL--QGWAGLVGVFIIFAVFAVLTVAI ENSMUST00000001801 ISNTASYLRLWALSLAHAQLSEVLWAMVMRIGLGMGREIGVAAVVLVPVFAAFAVLTVAI ENST00000312779 VSNTASYLRLWALSLAHAQLSEVLWAMVMRIGLGLGREVGVAAVVLVPIFAAFAVMTVAI : : : : : : :: ::: SINFRUP00000165605 --------------------------------------------------- SINFRUP00000155131 LLVMEGLSAFLHALRLHWVEFQNKFYSGNGVKFYPFSFSLLPSSLESD--- ci0100142086 LLVMEGLSAFLHAIRLHWVEFQSKFYKGEGYLFTPFSFSLIVEG---RVDE CG1709-RB LVLMEGLSAFLHTLRLHWVEFQSKFYKGQGYAFQPFSFDAIIENGAAAAEE ENSMUST00000044721 LLIMEGLSAFLHALRLHWVEFQNKFYTGTGFKFLPFSFEHIREG---KFDE ENST00000264649 --------------------------------------------------- ENST00000297478 LLIMEGLSAFLHALRLHWVEFQNKFYVGDGYKFSPFSFKHILDG---TAEE ENSMUST00000040259 LLVMEGLSAFLHALRLHWVEFQNKFYEGAGSKFSPFSFKHVLEG---TAEE ENSMUST00000001801 LLVMEGLSAFLHALRLHWVEFQNKFYSGTGYKLSPFTFTVDSD-------- ENST00000312779 LLVMEGLSAFLHALRLHWVEFQNKFYSGTGYKLSPFTFAATDD--------