CLUSTAL W (1.82) multiple sequence alignment ENST00000236877 ----------MAPLALVGVTLLLAAPPCSGAATPTPSLPPPPANDSDTST ENSMUST00000006175 -------------------------------------------------- SINFRUP00000155047 -------------------------------------------------- Q9PT19_Oncorhynchus_mykiss MRRTGTSSFLFCALQLTVLLAVFSSEIKFVTAGNSNPSLGTNSSIGNQTN ENST00000216568 -----MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNN SINFRUP00000138833 -------------------------------------------EDAGRTA ci0100151850 ------------------------MVVFLDQPLSANAQLPKLDDGLDRCH CG5685-RA -MQLLLKSIFTCALFVIFVYATAQSLLKVQETEARQAYLNVTSSSSSNLS ENST00000236877 GG-----------------------------------------CQGSY-R ENSMUST00000006175 -------------------------------------------------- SINFRUP00000155047 -E-----------------------------------------CSKPE-K Q9PT19_Oncorhynchus_mykiss KK-----------------------------------------CDSVDTE ENST00000216568 ES-----------------------------------------CSGSS-D SINFRUP00000138833 GN-----------------------------------------CSSED-N ci0100151850 PN-----------------------------------------KTAKPRV CG5685-RA QDDGHFLSRRLRQVSHGEEGDEGAPSQMDDELEQMTKVHGEAPDAEELRE ENST00000236877 CQPGVLLPVWEPDDP---SLGDKAARAVVYFVAMVYMFLGVSIIADRFMA ENSMUST00000006175 -------------------------------------------------- SINFRUP00000155047 CSAGVILPVWEPPNP---SFGDKVARATVYFVALAYMFLGVSIIADRFMA Q9PT19_Oncorhynchus_mykiss CKVGVILPIWLPENT---SFGDKLARATVYFVALFYMFLGVSIIADRFMA ENST00000216568 CKEGVILPIWYPENP---SLGDKIARVIVYFVALIYMFLGVSIIADRFMA SINFRUP00000138833 CPEGVVLPLWNPQNP---AVGDKVARAIVYFAALIYMFLGMSIIADRFMS ci0100151850 CQPGVILPLWPPAEITHITTADTVGRAIVYLVALIYLFLGVSIIADRFMA CG5685-RA CSEGLVLPLWMPQRN--ISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMA ::: : : : : ::: : :: :: ENST00000236877 AIEVITSKEKEITITKANGETSVGTVRIWNETVSNLTLMALGSSAPEILL ENSMUST00000006175 --------------------------------------MALGSSAPEILL SINFRUP00000155047 SIEVITSQEREITIKKPNGETTTTTVRIWNETVSNLTLMALGSSAPEILL Q9PT19_Oncorhynchus_mykiss SIEVITSQEREITIKKPNGEKVTTTVRIWNETVSNLTLMALGSSAPEILL ENST00000216568 SIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILL SINFRUP00000138833 SIEVITSQEKEITIKKPNGETTTTTVRIWNETVSNLTLMALGSSAPEILL ci0100151850 SIEVITSKEKVVVYRKPNGEEAKTTVRIWNETVSNLTLMALGSSAPEIML CG5685-RA AIEAITSIERAVVVKGPNNTKQVMHVRIWNETVANLTLMALGSSAPEILL : : : : : : : :**********:* ENST00000236877 SVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVCIYVIPAGESRKIKHL ENSMUST00000006175 TVIEVCGHNFQAGELGPGTIVGSAAFNMFVVIAVCVYVIPAGESRKIKHL SINFRUP00000155047 SVIEIIGHKFDAGTLGPSTIVGSAAFNMFVIIGLCVYVVPDGETRKVKHL Q9PT19_Oncorhynchus_mykiss SVVEVCGHNFDAGDLGPNTIVGSAAFNMFVIIGFCVSVIPDGEHRKVKHL ENST00000216568 SLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHL SINFRUP00000138833 SVIEVIGHNFDAGSLGPSTIVGSAAFNMFIIIAICVYVVPENETRKIKHL ci0100151850 SVIEIIGKRFEAGDLGPSTIVGSASFNLFIIIAICMYVIPDGEIRKVKHP CG5685-RA SVIEIYAKDFESGDLGPGTIVGSAAYNLFMIIAVCMIWIPAGEVRRIRHL :::*: .: * :* ***.******::*:*::*..*: :* .* *:::* ENST00000236877 RVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCVVFAWM ENSMUST00000006175 RVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLIFFPVCVVFAWM SINFRUP00000155047 RVFFVTASWSIFAYIWLYLILSVITPGVVQVWEGLLTFLFFPICVVFAWV Q9PT19_Oncorhynchus_mykiss RVFFVTATWSIFAYTWLYLILAVISPGIVQVWEGLVTLFFFPLCVGMAYV ENST00000216568 RVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWV SINFRUP00000138833 RVFFVTAAWSIFAYIWLYLILSVFSPGEVQVWEAVLTFCFFPLCVLQAWI ci0100151850 RVFFITATWSILAYVWLYVILAVSSYGVVEIWEGVLTFLFFPMLVVLAWI CG5685-RA RVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVLWAYI ****:** :*::** **::**:* : * : :**.::*: ***: * *:: ENST00000236877 ADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS----IELDGTFVGAEA ENSMUST00000006175 ADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKS----IELDGTFVGTEV SINFRUP00000155047 ADRRLLFYKYVYKRYRTGKQRGMIIETEGDRPLP---------------- Q9PT19_Oncorhynchus_mykiss ADRRLLVYKYMYKRYRAGKRRGVIIETEGEAQIPSKMDIEMDGKMLNSES ENST00000216568 ADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKG----IEMDGKMMNSHF SINFRUP00000138833 ADRRLLFYKYVHKRYRADKTRGIIIESEGDAMFT-KMDLEMDGQGVNSHT ci0100151850 ADRRLLVYKYMYKRYRMRKNKNMIVETEGSALDE--DNRQDGTTVLNMDS CG5685-RA AERRLLVYKYMDKNYRVNK-RGTVVAGEHD-------QVEMDAEKGPKQP *::***.***: *.** . :: * . ENST00000236877 PGELGGLGPGPAEAR---------ELDASRREVIQILKDLKQKHPDKDLE ENSMUST00000006175 PGELGALGTGPAEAR---------ELDASRREVIQILKDLKQKHPDKDLE SINFRUP00000155047 ----------PKVWS-----------HELARQSVFISAVAKHK---KQVK Q9PT19_Oncorhynchus_mykiss FMDGAMGFDEKDLDE-----------EEARREMVRILKELKQKHPEKETE ENST00000216568 LDGNLVPLEGKEVD-------------ESRREMIRILKDLKQKHPEKDLD SINFRUP00000138833 HPKEALDGMLEGLEEGAGMISEQDQEEEARREMARTLKELKQRHPEKDIE ci0100151850 LEDGKANTDDDQVGN--VMDPLIVDPESNRKAMIRIMRELRKTHPDADMA CG5685-RA MVTSARGNDAEAFDE-------------ARREYITLLTELRQKYPDADLE : :: : ENST00000236877 QLVGIANYYALLHQQKSRAFYRIQATRLMTGAGNVLR--RHAADASRRAA ENSMUST00000006175 QLMGIAKYYALLHQQKSRAFYRIQATRLMTGAGNVLR--RHAADAARRPG SINFRUP00000155047 QLIELANYQVLSQQQKSRAFYRCQATRLMTGAGNILK--KHAADQARKAV Q9PT19_Oncorhynchus_mykiss QLIELANYQVLTQQQKSRAFYRCQATRIMTGAGNVLK--KHAADQARKAV ENST00000216568 QLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILK--KHAAEQAKKAS SINFRUP00000138833 QLIEMANYQVLIQQQKSRAFYRIQATRMMIGAGNILK--KHAADQARKVV ci0100151850 ELAKMASSEALSNQPKSRAFYRIQATRKMTGAGNILN--KGKNDQAKTAD CG5685-RA QLEMMAQEQVLARSSKSRAFYRIQATRKMVGSGNLMRKIQERAHSDLTEV :* :*. .* .. ******* **** * *:**::. : . ENST00000236877 PAEGAGE--DEDDGASRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFY ENSMUST00000006175 ATDGAPD--DEDDGASRIFFEPSLYHCLENCGSVLLSVACQGGEGNSTFY SINFRUP00000155047 SMHEVRSDAGENDPVSKVFFEPGSYQCLENCGTVAVNVVRRGGDLTKTIS Q9PT19_Oncorhynchus_mykiss GAYEIRSEVSENDFSSKVFFDPGTYQCLENCGTVALNVVRLGGDLTNTVS ENST00000216568 SMSEVHTDEPE-DFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMY SINFRUP00000138833 SCHEATG-QEEDPHTIYLQFDPSHYQCFENCGSLKLSVSRHGGESGCTVK ci0100151850 NLSMVLE--DPDDAVAKIYFEPAEYKVMENCGVAELQVVRTGGDLNTTLY CG5685-RA KAQLHAGDDEEADDPIRMYFEPGHYTVMENCGEFEVRVVRRG-DISTYAS : *:* * :**** : * * : ENST00000236877 VDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHF ENSMUST00000006175 VDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKDLRIGIIDDDIFEEDEHF SINFRUP00000155047 VDYRTEDGTANAGSDYEFTEGMVVFKPGETLKEIRVGIIDDDIFEEDENF Q9PT19_Oncorhynchus_mykiss VEYRTEDGTANAGSDYQFTEGVVVFNPGETEKEIRIDIIDDDIFEEDEHF ENST00000216568 VDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHF SINFRUP00000138833 VDYRTEDATASAGSDYEFAEGTLVFKPGETTKEFTVGIIDDDIFEEDEHF ci0100151850 VDYQTEDGTANAGSDFEHAEDTIVFKPGETTKTIAITIMDDDIFEEDEYF CG5685-RA VEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFEEDECF *:*.*:*.:*.**:*: :. : : ** : : : ::***:***** * ENST00000236877 FVRLLNLRVGD--AQGMFEPDGGGRPKG------------RLVAPLLATV ENSMUST00000006175 FVRLLNLRVGD--AQGMFEPDGGGRPKG------------RLVAPLLATV SINFRUP00000155047 LIHLSNVKVLTSEGEEPEDGESANHVDS----------VACLGLPSTATV Q9PT19_Oncorhynchus_mykiss LVHLSNVKVIS-EGTGYVQPR-ANHLDT----------LAGLGLPCSATV ENST00000216568 FVRLSNVRIEEEQPEEGMPPAIFNSLPLP---------RAVLASPCVATV SINFRUP00000138833 YVRLSNPRVAHRAEVSVLEPNSITSSNSTVGTSSHVPPKAALGKDHTATV ci0100151850 RVKLCNVRSGD--ADGMFDTKANSTQVAR------------LEPPAVATV CG5685-RA YIRLFNPSEGV-----------------------------KLAVPMIATV ::* * * *** ENST00000236877 TILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDG ENSMUST00000006175 TILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVRLPYRTVDG SINFRUP00000155047 TIFDDDHAGIFTFEEPVCHVSESVGTMEVKVLRTSGARGVVMLPYKTVEG Q9PT19_Oncorhynchus_mykiss TIFDDDHAGIFTFEEPVMTISESIGMMEVKVLRTSGARGLVVVPYKTMEG ENST00000216568 TILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEG SINFRUP00000138833 TIYDDDHAGIFTFESDTTKVSESIGNMQVKVHRTSGARGKVAVPYHTVEG ci0100151850 VILDDDHAGVFSFPEPTITVSEGVGVLKVEVQRNSGARGRITVPYKTVSG CG5685-RA MILDDDHAGIFAFTDSVFEITESVGRFELKVMRYSGARGTVIVPYWTEND * ******:*:* ::* :* ..:.* * ***** : :*: * .. ENST00000236877 TARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQP ENSMUST00000006175 TARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQP SINFRUP00000155047 TARGGGEDFEDTHGILEFQNDEILN-----------FDR-TLFFAEFYQL Q9PT19_Oncorhynchus_mykiss TAKGGGEDFEDTHGALEFQNDEIFKSIQINIIDDEEYEKNKNFFLEMGEP ENST00000216568 TAKGGGEDFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGP SINFRUP00000138833 TAKAG-EDYEEVSGKLEFQNDETMKLLNVKIIDDEEYEKNKTFTIVLEEP ci0100151850 TAKGGGEDYIDAIGELDFDNDETTKCINVTIIDDEEYEKNKSFFVELSQP CG5685-RA TATES-KDYEGARGELVFENNESEKFIDLFILEESSYEKDVSFKVHIGEP ** . .: . * * * ::* : ::: : : ENST00000236877 QWLKRGIS--------------------------------ALLLNQGDG- ENSMUST00000006175 QWLKRGIS--------------------------------ALLLNQGNG- SINFRUP00000155047 PCHLLPDAHDFLFTPFIRVIAN-------VVGVNNEN-----KKQEDDE- Q9PT19_Oncorhynchus_mykiss QLLEMSERKAVLLQEIGGFVKTGRDVYRKVQGRDNPVPATIISLAEEGD- ENST00000216568 RMVDMS-------------------------------------FQKDVT- SINFRUP00000138833 ILLEVGQKHG----------------------ERRRSAAILLFVSRDTN- ci0100151850 KLYSDKDSGLVMDFKGPDFSARICLTKLGHKIVYDATVLIVRTCNRGSDS CG5685-RA RLAPDDE---------------------------------LAAKIKEVE- .: . . ENST00000236877 -------DRKLTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVD ENSMUST00000006175 -------DKKITAEQEEAQRIAEMGKPVLGENNRLEVIIEESYDFKNTVD SINFRUP00000155047 -------QEPLAGKDEEERRIAEMGRPMLGDHVKLEVIIEESYEFKNTVD Q9PT19_Oncorhynchus_mykiss -------EEALSKKEEEERRIAEMGRPTLGEHVKLEVVIEESYEFKNTVD ENST00000216568 -------DRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVD SINFRUP00000138833 -------DNKATVGPED---VSKMGCPSLGEHTKLEVVIEESYEFKSTVD ci0100151850 GINGKEIDKKATEEEEEARRIAELGKPRLGAETTVEIIIEESYEFKNTVD CG5685-RA --------KKPVQDLTELDRILLLSKPRNGELTTAYVRIRESQEFKATVD . : : :. * * : *.** :** *** ENST00000236877 KLIKKTNLALVIGTHSWREQFLEAITVSAGDEEEEEDGSREERLPSCFDY ENSMUST00000006175 KLIKKTNLALVIGTHSWREQFIEAVTVSAGDEEEDEDGPREERLPSCFDY SINFRUP00000155047 KLIKKTNLALLVGTNSWRDQFIEAITVSAGEDDDDEE-CGEEKLPSCFDY Q9PT19_Oncorhynchus_mykiss KLIKKTNLALLIGTNSWRQQFMEAITVSSGDDDEDE--CGEEKLPSCFDY ENST00000216568 KLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDE-SGEERLPSCFDY SINFRUP00000138833 KLIKKTNLALVVGSSSWREQFVSAVTVSAGDDDEEE--SGEERLPSCFDY ci0100151850 KLIKKANLAVIVGTSSWREQFIEALSVNGGDDDDSDE---EESEPSCFDY CG5685-RA KLVAKANVSAVLGTSSWKEQFKDALTVIPADESEFDNDDEEEEVPSCFSY **: *:*:: ::*: **::** .*::* . :.: : ** ****.* ENST00000236877 VMHFLTVFWKVLFACVPPTEYCHGWACFGVSILVIGLLTALIGDLASHFG ENSMUST00000006175 VMHFLTVFWKVLFACVPPTEYCNGWACFGVCILVIGVLTALIGDLASHFG SINFRUP00000155047 VMHFLTVFWKVLFAFVPPTEYWNGWACFFVSICMIGLLTAVIGDLACHFG Q9PT19_Oncorhynchus_mykiss VMHFLTVFWKLLFAFVPPTDYWNGWACFVVSISMIGLLTAFIGDLASHFG ENST00000216568 VMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFG SINFRUP00000138833 IMHFLTVFWKVLFAFVPPTEYWNGWACFFVSISLIGVLTAVTGDLASHFG ci0100151850 VMHFLTVFWKLLFAFVPPTEYFSGWACFTVSIIMIGVLTAVIGDVASAFG CG5685-RA VSHFVCLFWKVLFAFVPPTDICGGYVTFVVSIFVIGVITAIIGDAASYFG : **: :***:*** ****: *:. * *.* :**::**. ** *. ** ENST00000236877 CTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAV ENSMUST00000006175 CTVGLKDSVNAVVFVALGTSIPDTFASKVAALQDQCADASIGNVTGSNAV SINFRUP00000155047 CTVGLKDSVTAVVFVALGTSVPDTFASKVAAIQDQYADASIGNVTGSNAV Q9PT19_Oncorhynchus_mykiss CTVGLKDSVTAVVFVALGTSVPDTFASKVAAIQDQYADAFIGNVTGSNAV ENST00000216568 CTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAV SINFRUP00000138833 CTIGLKDSVTAVVFVALGTSVPDTFASKVAAIQDQYADASIGNVTGSNAV ci0100151850 CVVNLNDAVTAVTLVAMGTSVPDTFASKVAAVGDQYADASIGNVTGSNAV CG5685-RA CALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEGADNCIGNVTGSNAV *.:.::*:*.*: :**:***:****** ** * ** ********** ENST00000236877 NVFLGLGVAWSVAAVYWAVQGRP-----FEVRTGTLAFSVTLFTVFAFVG ENSMUST00000006175 NVFLGLGVAWSVAAVYWAVQGRP-----FEVRAGTLAFSVTLFTVFAFVC SINFRUP00000155047 NVFLGIGVAWSIAAIYHNSQGRD-----FKVNPGTLAFSVTLFTIFAFIS Q9PT19_Oncorhynchus_mykiss NVFLGIGVAWSIAAIYHNSKGND-----FRVDPGTLAFSVTLFTIFAFVA ENST00000216568 NVFLGIGLAWSVAAIYWALQGQE-----FHVSAGTLAFSVTLFTIFAFVC SINFRUP00000138833 NVFLGIGVAWTIATVYWHSKGKP-----FKVNPGSLAFSVTVFTIMAVVC ci0100151850 NVFLGIGIAWTIAAIYWAVTGRTPEEQKFRVNPGNLAFSVTVFSSFAIIA CG5685-RA NVFLGIGLAWTIAAVYHSSHGMT-----FNVEPGTIGFAVALFCGEALIA *****:*:**::*::* * *.* .*.:.*:*::* *.: ENST00000236877 IAVLLYRRRPHIGG-ELGGPRGPKLATTALFLGLWLLYILFASLEAYCHI ENSMUST00000006175 IAVLLYRRRPQIGG-ELGGPRGPKLATTALFLGLWFLYILFSSLEAYCHI SINFRUP00000155047 VATLMYRRRPEIGG-ELGGPRTPKVLTTMLFVSLWLLYILFSSLEAYCHI Q9PT19_Oncorhynchus_mykiss VAVLMYRRRPEIGG-ELGGPRGPKIATTCLFFSLWLMYIVFSSLEAYCHV ENST00000216568 ISVLLYRRRPHLGG-ELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYI SINFRUP00000138833 VLVLLYRRRPSVSGGELGGPRTAKLITFFLFISLWFIYILLASLEAYCHF ci0100151850 IAILMIRRRSKSIGAELGGPRVPKIICSLFFLTLWLVYIILAALDSYCVI CG5685-RA IMLIMFRRWHKGIGAELGGPKVSKYISAAILVFLWVFYVVICILEAYDVI : :: ** * *****: * ::. **..*:::. *::* . ENST00000236877 RGF ENSMUST00000006175 RGF SINFRUP00000155047 KGF Q9PT19_Oncorhynchus_mykiss KGF ENST00000216568 KGF SINFRUP00000138833 --- ci0100151850 RTF CG5685-RA RV- :