CLUSTAL W (1.82) multiple sequence alignment ENST00000205061 MAACGRVRRMFRLSAALHLLLLFAAGAEKLPGQGVHSQGQGPGANFVSFVGQAGGGGPAG ENSMUST00000003404 ------------------------------------------------------------ SINFRUP00000141478 ------------------------------------------------------------ SINFRUP00000146985 ------------------------------------------------------------ ci0100153442 ---------MVIKLGVLCLSLVLVQCVWGQPGVNMHGGQNVNSNIVNKHANVPVARHGND CG7190-RA ------------------------------------------------------------ ENST00000205061 QQLPQLPQSSQLQQQQQQQQQQQQPQPPQPPFPAGGPPARRGGAGAGGGWKLAEEESCRE ENSMUST00000003404 ------------------------------------------------------------ SINFRUP00000141478 ------------------------------------------------GWKLSEEEACRE SINFRUP00000146985 ---------------------------------AASPPRRRST-----GWKLAEEAVCRE ci0100153442 ADVSIDGDQHNIVAQPIDNNPPQVADGHRTGLSRKPAPPGIKKGLRKHSDSIADSVECSN CG7190-RA ------------MLHVLFSVLLMATANTAADTLQRSRRVAIDVDNAKDMHSIIDLAEC-Q : ENST00000205061 DVTRVC-PKHTWSNNLAVLECLQDVREPENE-------ISSDCNHLLWNYKLNLTTDPKF ENSMUST00000003404 ---------------------------PENE-------ISSDCNHLLWNYKLNLTTDPKF SINFRUP00000141478 DLTRLC-PKHTWANNLAVLECLQDRREVRHHRHSRTAIMCCCLLQLLWNYKLNLTTDPKF SINFRUP00000146985 DVTRLC-PKHSWTNNLSVLECLQDRKE-ETE-------ISTECNHLLWNYKLNLTTDPKF ci0100153442 DVEMYCGSTLTSRDNLAVLTCLNNRQD--DD-------LSDECHHYLWTYKLNITKNPKF CG7190-RA DLKKLC-AHHKSTDNLSMLECALTFSSSQLMD------LPEGCQNALWMQQRQLQLPAWL : : :: : : ** : :: . : ENST00000205061 ES-VAREVCKSTITEIKECADEPVGKGYMVSCLVDHRG-NITEYQCHQYITKMTAIIFSD ENSMUST00000003404 ES-VAREVCKSTISEIKECAEEPVGKGYMVSCLVDHRG-NITEYQCHQYITKMTAIIFSD SINFRUP00000141478 ES-VATEVCKSTIAEIKECNDEERGRGYLVSCLVDHRG-NISEYQCNQYITKMTSIIFSD SINFRUP00000146985 ES-VAVEVCKSTISEVKECAAEELGKGYLMSCLVDHRG-NISDYECRKYITKMTGIVFSD ci0100153442 DS-IARQTCKSALQTHTDCDNAEPGSGKLVSCLLEYKD-IIKAHSCVNFLNKIAGIVFSD CG7190-RA ESTFLPAYCPAERPKLESCLN----AVHLWSCLEQQRLKLLQNNACHQHLRRAYESLGQD :* . * : .* : *** : : : * :.: : : .* ENST00000205061 YRLICGFMDDCKNDINILKCGSIRLGEKD----AHSQGEVVSCLEKGLVKEAEEREPKIQ ENSMUST00000003404 YRLICGFMDDCKNDINLLKCGSIRLGEKD----AHSQGEVVSCLEKGLVKEAEEKEPKIQ SINFRUP00000141478 YRLICGFMDKCKEDVNNLHCGSINVGHKD----IHSQGEVISCLEKALVKEAEQPDRVRT SINFRUP00000146985 YRLICGFMDNCREDINTLLCGSVNTGRR-----VHSQGEVIACLEKGLVREAEQQLGAHA ci0100153442 YRLICNFMEDCHKDIMENHCGRVDSSARGDADMPHSQGQVVECLEEKLGENK-------- CG7190-RA YSAVDEFYTACGPLVEENKCGRLNVDHLP---SVLSQLTTVQCLQESATKTG-------- * : * * : ** : . ** .: **:: . ENST00000205061 VSELCKKAILRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEG-RVYKCLFNHKFEE ENSMUST00000003404 VSELCKKAILRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEG-RVYKCLFNHKFEE SINFRUP00000141478 IKDECQKAILRVAELSSDDFHLDRHLYFSCRDDRERFCQNIQAGEG-KVYKCLFNHKFEE SINFRUP00000146985 IRDQCKKAIMRVAELSSDDFHLDRYLYFSCREDRERFCENVCSGWGGRVYKCLFNHKFEE ci0100153442 LKPECLQQIKRLGELSADDYNLDRNLYLNCRDDRERLCPDVLHGDG-RVYKCLFNHKFDE CG7190-RA IEPVCQAAIN------------SIELFRVCQEDFSSFCSQEKSGTA-AGYKCLVRHKNHP : * * : : :. *: *::* . :* : * . ****..** . ENST00000205061 SMSEKCREALTTRQKLIAQDYKVSYSLAKSCKSDLKKYRCNVEN--LPRSREARLSYLLM ENSMUST00000003404 SMSEKCREALTTRQKLIAQDYKVSYSLAKSCKSDLKKYRCNVEN--LPRSREARLSYLLM SINFRUP00000141478 AMSEKCRDALTVRQKLISQDYRVSYSLAKACKLDLRKQRCSLDTS-LPRAREARLSYLLL SINFRUP00000146985 AMSERCREALTTRQKLIAQDYKVSYSLARSCKSDLRKYRCNAENN-MPRAREARLSYLLL ci0100153442 GMSTTCRDALTVRQKLVAKDYKSSYQIQTQCKSEISNNFCFVSHNSNDHSDLVGSSGILL CG7190-RA SMSSQCSARITLRDQQIGRDYRVSHGLAKACKDDIKLYHCRRGVS---EDKHVRLAQILL .** * :* *:: :.:**: *: : ** :: * . . : :*: ENST00000205061 CLESAVHRGRQVSSECQGEMLDYRRMLMEDFSLSPEIILSCRGEIEHHCSG--------- ENSMUST00000003404 CLESAVHRGRQVSSECQGEMLDYRRMLMEDFSLSPEIILSCRGEIEHHCSG--------- SINFRUP00000141478 CLEAAVHRGRSVSGECQGEMLDYRRMLMEDFSLSPEIVLHCRAEIETHCSG--------- SINFRUP00000146985 CLESAVHRGRVVSGECQGEMMDYRRMLMEDFSLSPEIVLHCRSEIEGHCSG--------- ci0100153442 CLENARSNPGKISAVCNNALDDFRAMLMSDYNLSPEITHNCATEIQANCSGT-------- CG7190-RA CLESVSKNGTKLAPPCLTELTDHRRMLMTDYQLSPELLNDCADDIPKFCPDEHKAQLVNG *** . . :: * : *.* *** *:.****: * :* *.. ENST00000205061 -LHRKGRTLHCLMKVVRGEKGN--LGMNCQQALQTLIQETDPGADYRIDRALNEACESVI ENSMUST00000003404 -LHRKGRTLHCLMKVVRGEKGN--LGMNCQQALQTLIQETDPGADYRIDRALNEACESVI SINFRUP00000141478 -LHRKGRTLHCLMRIGRDRSTA--IEGVCXSALQTLIQSADLGSDYRIDRALNEACESVI SINFRUP00000146985 -LHRKGRTLHCLMRVSRGD-----IDANCQMAVQTLIQEADPGADYRIDRALSEACESVI ci0100153442 -VEKEGATIHCLMSHLREES----EVTSCEKALLDLLKETDVAGKYKMDVALATDCNGVI CG7190-RA MTSTGGEIIHCLLEHVKARRPQRRVTAQCQRGLETLIKASDAGEDWRVDPVLRRACKPVV * :***: : * .: *:: :* . .:::* .* *: *: ENST00000205061 QTACKHIRSGDPMILSCLMEHLYTEKMVEDCEHRLLELQYFISRDWKLDPVLYRKCQGDA ENSMUST00000003404 QTACKHIRSGDPMILSCLMEHLYTEKMVEDCEHRLLELQYFISRDWKLDPVLYRKCQGDA SINFRUP00000141478 QTACKHIRNGDPMILSCLMEHLYTEKMVEECEHRLLELQYFISRDWKLDPVLYKKCQDDA SINFRUP00000146985 QTACKHIRTGDPMILSCLMEHLYTDKMVEDCEHRLLELQYFIARDWKLDPILYKKCQGDA ci0100153442 QSVCSKYADGDPMVLSCLMENLYSAQMEVACQDRLLELQYFISRDFNSDPSFHKACKAES CG7190-RA DVVCRDVQGGEARVMGCLMEHIGTPVMLPDCEQALLIIEYFVARDFKLDPQLYKHCRDDA : .* . *:. ::.****:: : * *:. ** ::**::**:: ** ::: *: :: ENST00000205061 SRLCHT---------HGWNETSEFMPQGAVFSCLYRHAYRTEE-----QGRRLSRECRAE ENSMUST00000003404 SRLCHT---------HGWNETSELMPPGAVFSCLYRHAYRTEE-----QGRRLSRECRAE SINFRUP00000141478 ARLCHT---------HGWNETSELMPPGAVFSCLYRHAYRTEE-----QGRRLSRDCKME SINFRUP00000146985 SRLCHT---------HGWNETSEMMPPGAIFSCLYRHAYRSVE-----QGRRLSRDCKVE ci0100153442 KVLCNHDFAAGAGNGQSENIDADAMPLSLVISCLYRHIQLPGEDRSDIEGSILSAGCTRE CG7190-RA VKYCRAK----KQWDDAQNIQMDPERGPMILPCLHRMAFSEDE------HQTLRKDCFQE *. .. * : ::.**:* * * * * ENST00000205061 VQRILHQRAMDVKLDPALQDKCLIDLGKWCS-EKTETGQELECLQDHLDDLVV---ECRD ENSMUST00000003404 VQRILHQRAMDVKLDPALQDKCLIDLGKWCS-EKTETGQELECLQDHLDDLAV---ECRD SINFRUP00000141478 VQRILHQRALDVKLDPELQKRCMTDLGKWCS-EKTDTGQELDCLQDHLEDLGS---ACRE SINFRUP00000146985 VQRILHQRALDVKLDPELQRRCMTDLGKWCS-EKTEAGQELECLQDHLEDLVP---DCRE ci0100153442 VHRMLKQRALDFNLNPDLEHTCRTALGQYCSNEMPEPGMELVCLQDNLENITETNIECAN CG7190-RA VKRVMRQRAISMDLIPEVEDYCLNDLSAFCA-DCTEKGSEMECLQKNMDQLQP---ECKT *:*:::***:...* * :: * *. :*: : .: * *: ***.::::: * ENST00000205061 IVGNLTELESEDIQIEALLMRACEPIIQNFCHDVADNQIDSGDLMECLIQNK--HQKDMN ENSMUST00000003404 IVGNLTELESEDIQIEALLMRACEPIIQNFCHDVADNQIDSGDLMECLIQNK--HQKDMN SINFRUP00000141478 VVGNLTELESEDIQIDALLVRACEPIIQAHCHDVADNQIDTGDLMECLVQNK--HQKEMN SINFRUP00000146985 VVGNLTELESEDIQMEALLMRACEPVIQGHCHEVADNQIDSGDLMDCLVQNK--HQKEMN ci0100153442 MITDLTVMESKDSDLENVLISACEPMLQQHCKDFLD-SGDEGEIMECLIRNK--DQMDN- CG7190-RA VVVKYTEEEAAHVELNPVIMNVCGEAMQQHCSAILKSGKDNGDMMDCLIAHKNDADLRKD :: . * *: . ::: ::: .* :* .* . . * *::*:**: :* : ENST00000205061 EKCAIGVTHFQLVQMKDFRFSYKFKMACKEDVLKLCPNIKKKVDVVICLSTTVRNDTLQE ENSMUST00000003404 EKCAIGVTHFQLVQMKDFRFSYKFKMACKEDVLKLCPNIKKKVDVVICLSTTVRNDTLQE SINFRUP00000141478 DKCSVGVTHFQLIQMKDFRFSYKFKMACKEDVLRLCPNIKKKVDVVICLSTTVRNDTLQD SINFRUP00000146985 DKCVVGVTHFQLIQIKDFRFSYKFKTACKEDVLKLCPNIKKKVDVVMCLSTMVRNDTLQE ci0100153442 ALCAAGVNHFQLIEMKDYHFSPKFMKACKDDVRLHCSDKKTKADVVKCLSEDVRNAVLQK CG7190-RA LRCRAAIEHFQIISLKSFHFTTKFKEACRPYVQRFCSSSATKNEVVACLSEVMRNDTIKA * .: ***::.:*.::*: ** **: * *.. .* :** *** :** .:: ENST00000205061 AKEHRVSLKCRRQLRVEELEMTEDIRLEPDLYEACKSDIKNFCSAVQYGNAQIIECLKEN ENSMUST00000003404 AKEHRVSLKCRKQLRVEELEMTEDIRLEPDLYEACKSDIKNYCSTVQYGNAQIIECLKEN SINFRUP00000141478 AKEQRVSLKCRKQLRVEELEMSEDIRLEPELYDPCKSDISRLCPNVAFGNAQMIECLKEQ SINFRUP00000146985 VKEQRVSLKCRKQLRVEEVEMMVPPLFPHICVRVEPVFVKRQLDDFVF---VVIECLKES ci0100153442 R-QSRISKKCQGQLTVENLQLHEKIDFLPGLHKACQADYRTLCSNVEPGKAMVIECLRNN CG7190-RA Q-RHQIPKECRHQVKAQLYQQRESIQLDPKLANACKRELEQFCE-EEKGPGQALECLIRK . ::. :*: *: .: : : :*** .. ENST00000205061 KKQLSTRCHQKVFKLQETEMMDPELDYTLMRVCKQMIKRFCP----EADSKTMLQCLKQN ENSMUST00000003404 KKQLSTRCHQKVFKLQETEMMDPELDYTLMRVCKQMIKRFCP----EADSKTMLQCLKQN SINFRUP00000141478 KKQLSQRCHQRIFRLQEVEMSDPELDYQLMRVCKQMIKRFCT----EAD-ATVLQCLKQN SINFRUP00000146985 KKQLTQRCHQRIFKLQEVEMADPELDYQLMKVCKPMIRRFCT----ESEGKNVLQCLKQN ci0100153442 KDKVSHECRKELFEVEEEESLDPKIDFSLMRTCKSDIKEFCFTHLEDGRPHEILDCLIHN CG7190-RA THSLGKPCHHAIFMVKKSELGDSGTDYTLLTTCKEMIYKFCP----STDSSKLLDCLKTY ...: *:: :* ::: * *. *: *: .** * .** . :*:** ENST00000205061 KNSELMDPKCKQMITKRQITQNTDYRLNPMLRKACKADIPKFCHGILTKAKDDSE----L ENSMUST00000003404 KNSELMDPKCKQMITKRQITQNTDYRLNPVLRKACKADIPKFCHGILTKAKDDSE----L SINFRUP00000141478 KNSELMDPKCKQMITKRQITQNTDYRLNPVLRKACRADIPKFCQNILNKASEDSE----L SINFRUP00000146985 KNSELMDPKCKQMITKRQITQNTDYRLNPVLRKACKADIPKFCQHILTKAASDSE----L ci0100153442 KKK--LQSQCRNLIKSREADILSDVDLDPDLKESCSKDIKDFCGKESQQAKLDHERGEDP CG7190-RA KDDTQFDQRCHLVVVNRMIEQNTDFRFNPSLQSACGKNIDRYCSNIVASALPNEE----- *.. :: :*: :: .* :* ::* *:.:* :* :* .* : * ENST00000205061 EGQVISCLKLRY--ADQR--LSSDCEDQIRIIIQESALDYRLDPQLQLHCSDEISSLCAE ENSMUST00000003404 EGQVISCLKLRY--ADQR--LSSDCEDQIRIIIQESALDYRLDPQLQLHCSDEIANLCAE SINFRUP00000141478 EGQVIGCLKLKY--ADQR--LSPDCEDQIRVILQESALDYRLDPQLQLHCSEEISRLCAE SINFRUP00000146985 EGQVISCLKLKY--ADQR--LSPDCEDQIRVILQESALDYRLDPQLQIQCTHEISRLCAE ci0100153442 HGVIYACLKKVHTSADHKNKLSPSCNNHITFVVREEEQDYRLDPRLMLACVNEIRKHCDT CG7190-RA ------------------------------------------------------------ : : : : .:: : : : : ENST00000205061 EAAAQEQTGQVEECLKVNLLKIKTEL---CKKEVLNMLKESKADIFVDPVLHTACALDIK ENSMUST00000003404 EAAAQEQTGQVEECLKVNLLKIKTEL---CKKEVLNMLKESKADIFVDPVLHTACALDIK SINFRUP00000141478 EAAAQEQTGQVEECLKVNLLKLKQDT---CKKEVLNMLKESKADIFVDPVLHTACALDLK SINFRUP00000146985 EAAAQEQTGQVEECLKVNLLKIKQEG---CKKEVLNMLKESKADIFVDPVLHTACALDIK ci0100153442 EHED------IVECLKRNFYDEKLSASPTCVVEVARLLLEGRSDIMADPVLHEACAIDLE CG7190-RA --------------------------------------LNGKVSEMSTGILFCLLS---- : : : : :: :.: . : :*. :: : ENST00000205061 HHCAAITPGRGRQMSCLMEALEDKRVRLQPECKKRLNDRIEMWSYAAKVAPADGFSDLAM ENSMUST00000003404 HHCAAITPGRGRQMSCLMEALEDKRVRLQPECKKRLNDRIEMWSYAAKVAPADGFSDLAM SINFRUP00000141478 HHCAAITPGRGRQMSCLMETLQDKRVRLQPECKKRLQDRIDMWSYAAKVAPAEGFSDLAV SINFRUP00000146985 HQCAAIPPGKGRQMSCLMEALQDKRVRLQPECKKRLQDRIDMWSYAAKVAPAEGFSDLAM ci0100153442 EHCDQIPEGDGRKIQCLTRILSKHKTQLSQGCREELQVRQSMWAHAAKKN-IDGFAELSM CG7190-RA ------------------------------------------------------------ : : : : : : : : : : ENST00000205061 QVMTSPSKNYILSVISGSICILFLIGLMCGRITKRVTRELKDR ENSMUST00000003404 QVMTSPSKNYILSVISGSICILFLIGLMCGRITKRVTRELKDR SINFRUP00000141478 QVMTSPSKNYILLVITLSVCVLFLVGLICGRLTKRVTRELKDR SINFRUP00000146985 QVMTSPSKNYILTVIGAGVALLFLMGLFCGRFTKRVTQELKDR ci0100153442 MVLASEQSSYLLSMLTLLVVAILILGTMCGRCTKRVARDRKTR CG7190-RA ------------------------------------------- :: :: :: : :::: : :