CLUSTAL W (1.82) multiple sequence alignment ENSMUST00000021698 MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELIS ENST00000216281 MPEETQTQDQPMEEEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELIS P87397_Oncorhynchus_tschawytsc MPEKAGHT----MDEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELIS SINFRUP00000136102 -----------------------------------------EIFLRELIS SINFRUP00000145961 MPEEMLQ------EAEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELIS Q9W6K6_Salmo_salar MPEEMRQ------EEEAETFAFQAEIAQLMSLIINTFYSNKEIFLRELIS ENSMUST00000024739 MPEEVHHG-----EEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELIS ENST00000323814 MPEEVHHG-----EEEVETFAFQAEIAQLMSLIINTFYSNKEIFLRELIS CG1242-RA MP------------EEAETFAFQAEIAQLMSLIINTFYSNKEIFLRELIS : : : : :: ::: : ********* ENSMUST00000021698 NSSDALDKIRYESLTDPSKLDSGKELHINLIPSKQDRTLTIVDTGIGMTK ENST00000216281 NSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTK P87397_Oncorhynchus_tschawytsc NSSDALDKIRYESLTDPTKLDSCKELKIEVTPDLRTRTLTLVDTGIGMTK SINFRUP00000136102 NSSDALDKIRYESLTDPTRLESCKELKIEIRPDLHARTLTLIDTGIGMTK SINFRUP00000145961 NSSDALDKIRYESLTEPSKLDSGKDLKIDIIPDKDENTLTIIDTGIGMTK Q9W6K6_Salmo_salar NASDALDKIRYESLTDPTKLDNGKELKIDVIPNVEERTLTLIDTGIGMTK ENSMUST00000024739 NASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTK ENST00000323814 NASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTK CG1242-RA NASDALDKIRYESLTDPSKLDSGKELYIKLIPNKTAGTLTIIDTGIGMTK *:*************:*::*:. *:* *.: *. ***::******** ENSMUST00000021698 ADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTV ENST00000216281 ADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTV P87397_Oncorhynchus_tschawytsc ADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAERVTV SINFRUP00000136102 ADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTV SINFRUP00000145961 ADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAERVKV Q9W6K6_Salmo_salar ADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAERVTV ENSMUST00000024739 ADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVV ENST00000323814 ADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVV CG1242-RA SDLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVADKVTV :**:*****************************************::* * ENSMUST00000021698 ITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEE ENST00000216281 ITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEE P87397_Oncorhynchus_tschawytsc ITKHNDDEQYIWESAAGGSFTVKVDTGESIGRGTRVILHMKEDQFEYCEE SINFRUP00000136102 ITKHNDDEQYVWESAAGGSFTVKPDTGESIGRGTKVILHLKEDQTEYCEE SINFRUP00000145961 ITKHNDDEQYVWESSAGGSFTVRTDNDASMGRGTKIILYLKEDQTEYCED Q9W6K6_Salmo_salar ITKHNDDEQYIWESSAGGSFTVKVDTGEPMLRGTKVILHMKEDQTEYVEE ENSMUST00000024739 ITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEE ENST00000323814 ITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEE CG1242-RA TSKNNDDEQYVWESSAGGSFTVRADNSEPLGRGTKIVLYIKEDQTDYLEE :*:****** ***:*******: * . .: ***:::*::**** :* *: ENSMUST00000021698 RRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAEEKEEKEEEKEKEEK ENST00000216281 RRIKEIVKKHSQFIGYPITLFVS--------------------------- P87397_Oncorhynchus_tschawytsc KRVKEVVKKHSQFIGYPITLFVEKSREKEVDLEEGEKDEEADKDSAAEDQ SINFRUP00000136102 KRVKEVVKKHSQFIGYPITLFVKPT------------------------- SINFRUP00000145961 KRVKEIVKKHSQFIGYPITLFVEKERDKEISDDEAEEDKADKEEQ-EEDK Q9W6K6_Salmo_salar KRVKEVVKKHSQFIGYPITLFVEKEREKEISDDEEEKAEEEKEEK-EAE- ENSMUST00000024739 RRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKEDE ENST00000323814 RRVKEVVKKHSQFIGYPITLYLEKEREKEISDDEAEEEKGEKEEEDKDDE CG1242-RA SKIKEIVNKHSQFIGYPIKLLVEKEREKEVSDDEADDEKKEGDEKKEMET ::**:*:**********.* :. : ENSMUST00000021698 ESDDKPEIEDVGSDEEEEEKKDGDKKKKKKIKEKYIDQEELNKTKPIWTR ENST00000216281 ----------------------------FYVIAEFLSVEELNKTKPIWTR P87397_Oncorhynchus_tschawytsc ---DKPKIEDVGSDEDED-TKDSKNKRKKKVKEKYIDAEELNKTKPIWTR SINFRUP00000136102 ---DKPKIEDVGSDEDED-TKDGKNKRKKKVKEKYMDVQELNKTKPIWTR SINFRUP00000145961 ---DTPTIEDLGSEEE-----SKDKKKKKTIKERYTDQEELNKTKPIWTR Q9W6K6_Salmo_salar ---DKPKIEDVGSDDEED-SKDKDKKKTKKIKEKYIDQEELNKTKPIWTR ENSMUST00000024739 ---EKPKIEDVGSDEEDD-SGKDKKKKTKKIKEKYIDQEELNKTKPIWTR ENST00000323814 ---EKPKIEDVGSDEEDD-SGKDKKKKTKKIKEKYIDQEELNKTKPIWTR CG1242-RA ---DEPKIEDVGEDEDAD-KKDKDAKKKKTIKEKYTEDEELNKTKPIWTR : : : .: . :*********** ENSMUST00000021698 NPDDITNEEYGEFYKSLTNDWEEHLAVKHFSVEGQLEFRALLFVPRRAPF ENST00000216281 NPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPF P87397_Oncorhynchus_tschawytsc NPDDITNEEYGEFYKSLTNDWEDHLAIKHFSVEGQLEFRALLFVPRRASF SINFRUP00000136102 NPDDISNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPF SINFRUP00000145961 NPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPF Q9W6K6_Salmo_salar NPDDITMEEYGEFYKSLTNDWEEHLAVKHFSVEGQLEFRALLFIPRRAPF ENSMUST00000024739 NPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPF ENST00000323814 NPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPF CG1242-RA NPDDISQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRTPF *****: ***************:***:****************:***:.* ENSMUST00000021698 DLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNIS ENST00000216281 DLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNIS P87397_Oncorhynchus_tschawytsc DLFENKKKKNNIKLYVRRVFIMDNCDELMPEYLNFIKGVVDSEDLPLNIS SINFRUP00000136102 DLFENKKKKNNIKLYVRRVFIMDNCDELIPEYLNFIRGVVDSEDLPLNIS SINFRUP00000145961 DLFENKKKKNNIKLYVRRVFIMDNCEELIPEYLNFVRGVVDSEDLPLNIS Q9W6K6_Salmo_salar DLFENKKKKNNIKLYVRRVFIMDSCEELIPEYLNFVRGVVDSEDLPLNIS ENSMUST00000024739 DLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNIS ENST00000323814 DLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNIS CG1242-RA DLFENQKKRNNIKLYVRRVFIMDNCEDLIPEYLNFMKGVVDSEDLPLNIS *****:**:**************.*::*:******::************* ENSMUST00000021698 REMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGI ENST00000216281 REMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGI P87397_Oncorhynchus_tschawytsc REMLQQSKILKVIRKNLVKKCMDLFVELSEDKDNYKKFYEQFSKNIKLGI SINFRUP00000136102 REMLQQSKILKVIRKNLVKKCMELFTELAEDKDNYKKYYEHFSKNMKLGI SINFRUP00000145961 REMLQQSKILKVIRKNIVKKCLELFAELAEDKENYKKFYEGFSKNIKLGI Q9W6K6_Salmo_salar REMLQQSKILKVIRKNIVKKCMELFGELAEDRENYNKFYDGFSKNLKLGI ENSMUST00000024739 REMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGI ENST00000323814 REMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGI CG1242-RA REMLQQNKVLKVIRKNLVKKTMELIEELTEDKENYKKFYDQFSKNLKLGV ******.*:*******:*** ::*: **:**::**:*:*: ****:***: ENSMUST00000021698 HEDSQNRKKLSELLRYYTSAS-GDEMVSLKDYCTRMKENQKHIYFITGET ENST00000216281 HEDSQNRKKLSELLRYYTSAS-GDEMVSLKDYCTRMKENQKHIYYITGET P87397_Oncorhynchus_tschawytsc HEDAQNRKKLSDMLRYYTSNSNADEMVSLKEYVSRMKDTQKHIYYITGET SINFRUP00000136102 HEDSQNRKKLSDLLRYYTSAS-GDEMVSLKEYVSRMKDNQKHIYYITGET SINFRUP00000145961 HEDSQNRKKLSELLRYHSSQS-GDEVTSLTEYITRMKENQKSIYYITGES Q9W6K6_Salmo_salar HEDSQNRKKLSELLRYHSSQS-GDELTSLTEYLTRMKDNQKSIYYITGES ENSMUST00000024739 HEDSTNRRRLSELLRYHTSQS-GDEMTSLSEYVSRMKETQKSIYYITGES ENST00000323814 HEDSTNRRRLSELLRYHTSQS-GDEMTSLSEYVSRMKETQKSIYYITGES CG1242-RA HEDSNNRAKLADFLRFHTSAS-GDDFCSLADYVSRMKDNQKHVYFITGES ***: ** :*:::**:::* * .*:. ** :* :***:.** :*:****: ENSMUST00000021698 KDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEG ENST00000216281 KDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVS----- P87397_Oncorhynchus_tschawytsc KEQVANSSFVERLRKAGLEVIYMIEPIDEYCVQQLKEYDGKNLVSVTKEG SINFRUP00000136102 KDQVANSAFVERLRKAGLEVIYMIEPIDEYCVQQLKEYDGKNLVSVTKEG SINFRUP00000145961 KDQVANSAFVERVRKRGFEVLYMTEPIDEYCVQQLKEFDGKSLVSVTKEG Q9W6K6_Salmo_salar KDQVANSAFVERVRKRGFEVLYMTEPIDEYCVQQLKEFDGKTLVSVTKEG ENSMUST00000024739 KEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG ENST00000323814 KEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEG CG1242-RA KDQVSNSAFVERVKARGFEVVYMTEPIDEYVIQHLKEYKGKQLVSVTKEG *:**:**:****:: *:**:** ****** :*:***:.** ***: ENSMUST00000021698 LELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCC ENST00000216281 -------------------------------------VVVSNRLVTSPCC P87397_Oncorhynchus_tschawytsc LELPEDEDEKKKQEELNTKFENLCKTMKDILDKKIEKVSVSNRLVSSPCC SINFRUP00000136102 LELPEDEEEKKKLEELKNKFENLCKIMKDILDKKIEKVTVSNRLVSSPCC SINFRUP00000145961 LELPEDEEEKKKMEEDKAKFESLCKIMKEILDKKVEKVTVSNRLVSSPCC Q9W6K6_Salmo_salar LELPEDEEEKKKMDEDKTKFENLCKLMKEILDKKVEKVTVSNRLVSSPCC ENSMUST00000024739 LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCC ENST00000323814 LELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCC CG1242-RA LELPEDESEKKKREEDKAKFESLCKLMKSILDNKVEKVVVSNRLVDSPCC : : : : : :: : * :***** **** ENSMUST00000021698 IVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQ ENST00000216281 IVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQ P87397_Oncorhynchus_tschawytsc IVTSTYGWTANMERIMKSQALRDNSTMGYMTAKKHLEINPTHPIVETLRE SINFRUP00000136102 IVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHPIMETLRQ SINFRUP00000145961 IVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIMETLRQ Q9W6K6_Salmo_salar IVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQ ENSMUST00000024739 IVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQ ENST00000323814 IVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQ CG1242-RA IVTSQFGWSANMERIMKAQALRDTATMGYMAGKKQLEINPDHPIVETLRQ **** :**:********:*****.:***** .**:***** *.*:****: ENSMUST00000021698 KAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGI ENST00000216281 KAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGI P87397_Oncorhynchus_tschawytsc KAEADKNDKAVKDLVILLFETALLSSGFTLDDPQTHANRIYRMIKLGLGI SINFRUP00000136102 KAEADKNDKSVKDLVILLFETALLSSGFTLDDPQTHSNRIYRMIKLGLGI SINFRUP00000145961 KAEADKNDKAVKDLVILLFETALLSSGFSLDDPQTHSNRIYRMIKLGLGI Q9W6K6_Salmo_salar KADLDKNDKAVKDLVILLFETALLSSGFSLDDPQTHSNRIYRMIKLGLGI ENSMUST00000024739 KAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGI ENST00000323814 KAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGI CG1242-RA KADADKNDKAVKDLVILLFETSLLSSGFSLDSPQVHASRIYRMIKLGLGI **: *****:*****:**:**:******:*:.**.*:.************ ENSMUST00000021698 DEDDPTVDDTS---AAVTEEMPPLEGD-DD-TSRMEEVD ENST00000216281 DEDDPTADDTS---AAVTEEMPPLEGD-DD-TSRMEEVD P87397_Oncorhynchus_tschawytsc DGDDSAVEEIL---QPSEDDMPVLEGD-DD-TSRMEEVD SINFRUP00000136102 DEDEVTPEEST---AAPTEDMPPLEGD-DDDTSRMEEVD SINFRUP00000145961 DDDDLPTEETTSASASVPDEIPPLEGDGEEDASRMEEVD Q9W6K6_Salmo_salar DDDEVIPEEPTSAPA--PDEIPPLEGD--DDASRMEEVD ENSMUST00000024739 DEDEVTAEEPS---AAVPDEIPPLEGD--EDASRMEEVD ENST00000323814 DEDEVAAEEPN---AAVPDEIPPLEGD--EDASRMEEVD CG1242-RA DEDEPMTTDDA----QSAGDAPSLVED-TEDASHMEEVD * *: : : * * * : :*:*****