CLUSTAL W (1.82) multiple sequence alignment ENST00000297325 ------------------------------------------------------------ ENSMUST00000043377 ------------------------------------------------------------ SINFRUP00000143267 ------------------------------------------------------------ SINFRUP00000127701 ------------------------------------------------------------ SINFRUP00000142186 ------------------------------------------------------------ ENST00000216064 ----------------------PVLLLSLLRFSSGEESTSHLIMSRRSQRLTRYSQGDDD ENSMUST00000046259 ------------------------------------------IMSRRSQRLTRYSQDDND ENST00000297445 MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLAT ENSMUST00000053259 MDFSRLHTYTPPQCVPENTGYTYALSSSYSSDALDFETEHKLEPVFDSPRMSRRSLRLVT ENST00000080856 ------------------------------------------------------------ ENSMUST00000038860 ------------------------------------------------------------ ENST00000300429 ------------------------------------------------------------ ENSMUST00000028982 ------------------------------------------------------------ CG18584-RA ------------------------------------------------------------ ENST00000297325 ------------------------------------------------------------ ENSMUST00000043377 ------------------------------------------------------------ SINFRUP00000143267 ------------------------------------------------------------ SINFRUP00000127701 ------------------------------------------------------------ SINFRUP00000142186 ------------------------------------------------------------ ENST00000216064 G-SSSSGGSSVAGSQSTLFKDSPLRTLKRKSSNMKRLSPAPQLGP---SSDAHTSYYSES ENSMUST00000046259 GGSSSSGASSVAGSQGTVFKDSPLRTLKRKSSNMKHLSPAPQLGP---SSDSHTSYYSES ENST00000297445 TA-CTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSHG ENSMUST00000053259 TASYSSGDSQAIDSHISTSRATPAKGRETRTVKQRRSASKPAFSINHLSGKGLSSSTSHD ENST00000080856 ------------------------------------------------------------ ENSMUST00000038860 ------------------------------------------------------------ ENST00000300429 ------------------------------------------------------------ ENSMUST00000028982 ------------------------------------------------------------ CG18584-RA ------------------------------------------------------------ ENST00000297325 ------------------------------------------------------------ ENSMUST00000043377 ------------------------------------------------------------ SINFRUP00000143267 ------------------------------------------------------------ SINFRUP00000127701 ------------------------------------------------------------ SINFRUP00000142186 ------------------------------------------------------------ ENST00000216064 LVHESWFPP-------RSSL--EELHGDANWGEDLRVRRRRGTGGSESSRASGLVGR-KA ENSMUST00000046259 VVRESYIGSPRAVSLARSALLDDHLHSEPYWSGDLRGRRRRGTGGSESSKANGLTAESKA ENST00000297445 GTVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGAAAATA ENSMUST00000053259 SSCSLRSATVLRHPVLDESLIREQTKVDHFWGLDDDGDLKGGNKAATQGNGELAAEVASS ENST00000080856 ------------------------------------------------------------ ENSMUST00000038860 ------------------------------------------------------------ ENST00000300429 ------------------------------------------------------------ ENSMUST00000028982 ------------------------------------------------------------ CG18584-RA ------------------------------------------------------------ ENST00000297325 ------------------------------------------------------------ ENSMUST00000043377 ------------------------------------------------------------ SINFRUP00000143267 ------------------------------------------------------------ SINFRUP00000127701 ------------------------------------------------------------ SINFRUP00000142186 ------------------------------------------------------------ ENST00000216064 TEDFLGSSSGYSSEDDYVGYSDVDQQSSSSRLRS-------------------------- ENSMUST00000046259 SEDFFGSSSGYSSEDDLAGYTDSDQHSSGSRLRS-------------------------- ENST00000297445 HNGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQKCDDCKGKRHLDAHTAAHSQS ENSMUST00000053259 -NGYTCRDCRMLSARTDALTAHSAIHGTTSRVYSRDRTLKPRD----------------- ENST00000080856 ------------------------------------------------------------ ENSMUST00000038860 ------------------------------------------------------------ ENST00000300429 ------------------------------------------------------------ ENSMUST00000028982 ------------------------------------------------------------ CG18584-RA ------------------------------------------------------------ ENST00000297325 ------------------------------------------------------------ ENSMUST00000043377 ------------------------------------------------------------ SINFRUP00000143267 ------------------------------------------------------------ SINFRUP00000127701 ------------------------------------------------------------ SINFRUP00000142186 ------------------------------------------------------------ ENST00000216064 ----------------------------------AVSRAGSLLWMVATSPGKHLRVLPGW ENSMUST00000046259 ----------------------------------AASRAGSFVWTLVTFPGRLFGLLYWW ENST00000297445 PRLPGRAGTLWHIWACAGYFLLQILRRIGAVGQAVSRTAWSALWLAVVAPGKAASGVFWW ENSMUST00000053259 -------------------LLVQALRRTRAAGWSVAEAVWSVLWLAVSAPGKAASGTFWW ENST00000080856 ------------------------------------------------------------ ENSMUST00000038860 ------------------------------------------------------------ ENST00000300429 ------------------------------------------------------------ ENSMUST00000028982 ------------------------------------------------------------ CG18584-RA --------------------------MEVPTVRSPQREAEAIKVNMASIEQNIQKALTAE ENST00000297325 ------------------------------------------------------------ ENSMUST00000043377 ------------------------------------------------------------ SINFRUP00000143267 ------------------------------------------------------------ SINFRUP00000127701 ------------------------------------------------------------ SINFRUP00000142186 ------------------------------------------------------------ ENST00000216064 NVEAWSSPHTSASPVLPSRVVRRFSS-LKTFLWFLLPLLLLTCLTYGAWYFYPYGLQTFH ENSMUST00000046259 IGTTWYRLTTAASLLDVFVLTRHFSLNLKSFLWFLLLLLLLTGLTYGAWHFYPLGLQTLQ ENST00000297445 LGIGWYQFVTLISWLNVFLLTRCLRNICKFLVLLIPLFLLL-----AGLSLRGQGNFFSF ENSMUST00000053259 LGSGWYQFVTLISWLNVFLLTRCLRNICKVFVLLLPLLLLLG----AGVSLWGQGNFFSL ENST00000080856 ------------------------------------------------------------ ENSMUST00000038860 ------------------------------------------------------------ ENST00000300429 ------------------------------------------------------------ ENSMUST00000028982 ------------------------------------------------------------ CG18584-RA EYENILNHVNSYVQQLVELKMQQHSKELAPQQIELFVKLMKENLKQIMYKTELSEKDLSD ENST00000297325 ------------------------------------------------------------ ENSMUST00000043377 ------------------------------------------------------------ SINFRUP00000143267 ------------------------------------------------------------ SINFRUP00000127701 ------------------------------------------------------------ SINFRUP00000142186 ------------------------------------------------------------ ENST00000216064 PALVSWWAAKDSRRPDEGWEARDSSPHFQAEQRVMSRVHSLERRLEALAAEFSSNWQKEA ENSMUST00000046259 PAVVSWWAAKESRKQPEVWESRDASQHFQAEQRVLSRVHSLERRLEALAADFSSNWQKEA ENST00000297445 LPVLNWASMHRTQRVDDPQDVFKPTTSRLKQPLQGDSEAFPWHWMSGVEQQVASLSGQCH ENSMUST00000053259 LPVLNWTAMQPTQRVDDSKGMHRPGPLPPSPPPKVDHKASQWPQESDMGQKVASLSAQCH ENST00000080856 --------MRRSSRPGSASSSRKHTPNFFSENS--SMSITSEDSKGLRSAEPGPGEPEGR ENSMUST00000038860 --------MRRSPRSGSAASSHNHTPNFYSENSNSSHSATSGDSNGRRSAGPELGEPEGR ENST00000300429 ------------------------------------------------------------ ENSMUST00000028982 ------------------------------------------------------------ CG18584-RA LAIKLKLELQSSGGWQDGAKLSQANLEEITKLIKAEVHLHESHYTIQLDRIDFASLLERI ENST00000297325 ------------------------------------------------------------ ENSMUST00000043377 ------------------------------------------------------------ SINFRUP00000143267 ------------------------------------------------------------ SINFRUP00000127701 ---------MGYYDKDGNPTICYRDSVSRVDKRRQNR----------------AITS-DT SINFRUP00000142186 ---------MGDYDEDGNPTICYTERVYRVFKQRRKR----------------KSTSNTT ENST00000216064 MRLERLELRQGAPGQGGGGGLSHEDTLALLEGLVSRREAALKEDFRRETAARIQEELSAL ENSMUST00000046259 IRLERLELRQGAAGHGGGSSLSHEDALSLLEGLVSRREATLKEDLRRDTVAHIQEELATL ENST00000297445 HHGENLRELTTLLQKLQARVDQMEGGAAGPSASVRDAVGQ----------PPRETDFMAF ENSMUST00000053259 NHDERLAELTVLLQKLQIRVDQVDDGREGLSLWVKNVVGQHLQEMGTIEPPDAKTDFMTF ENST00000080856 RARGPSCGEPALSAGVPGGTTWAGSSQQKPAPRSHNWQTA-----------CGAATVRGG ENSMUST00000038860 RARGSSCGEPALSPGMPGGDTWAGSSRPKLAPRSHNGQTA-----------CGAATVRGG ENST00000300429 ---------------MPRSSRSPGDPGALLEDVAHNPRPR-----------RIAQRGRNT ENSMUST00000028982 ---------------MPR-TRNIGALCTLPEDTTHSGRPR-----------RGVQRS-YI CG18584-RA LAAPALADFVDARISLRVGELEPKESSGSSDAEVQIERLNREIAFIKLALSDKQAENADL ENST00000297325 ------------------------------------MPKEQLELLKKESQNLENNFRQIL ENSMUST00000043377 ------------------------------------MPKEQQELLKKESQTLENNFREIL SINFRUP00000143267 ------------------------------------------------------------ SINFRUP00000127701 SDRTDRDSYDIKRFLNYLKESISSESSSSGSCMSSSSKDTVITYKTKWLIFSSLVVLALM SINFRUP00000142186 SDSIGEESYDTKQMLCYLTEWSSSESSSSESCMSSSTEDTV---KTKWLIFSSLLILGLI ENST00000216064 RAEHQQDSEDLFKKIVRASQESEARIQQLKSEWQSMTQESFQESSVKELRRLEDQLAGLQ ENSMUST00000046259 RAEHHQDSEDLFKKIVQASQESEARVQQLKTEWKSMTQEAFQESSVKELGRLEAQLASLR ENST00000297445 HQEHEVRMSHLEDILGKLREKSEAIQKELEQTKQKTISAVGEQ-LLPTVEHLQLELDQLK ENSMUST00000053259 HHDHEVRLSNLEDVLRKLTEKSEAIQKELEETKLKAGSRDEEQPLLDRVQHLELELNLLK ENST00000080856 ASEPTGSPVVSEEPLDLLPTLDLRQEMPPPRVFKSFLSLLFQGLSVLLSLAGDVLVSMYR ENSMUST00000038860 ASEPSGSSVVLEEQLNLLPILDLRQEMPTPRVSKSFLSLLFQVLSMVLSLAVDGLVCVCR ENST00000300429 SRMAEDTSPNMNDNI-LLPVRNNDQALGLTQCMLGCVSWFTCFACSLRTQAQQVLFNTCR ENSMUST00000028982 SRMAEPAPANM--------------------------TWLTYLACFLRTQTQQVFLNTCR CG18584-RA HQSISNLKLGQEDLLERIQQHELSQDRRFHGLLAEIENKLSALNDSQFALLNKQIKLSLV ENST00000297325 FLIEQIDVLKALLRDMKDGMDNNHNWNTHGDPVEDPDHT--------------------- ENSMUST00000043377 FLIEQIDVLKALLKDMKDGVHN-HSLPVHRDAVQDQATTD----------VLDEARQAGV SINFRUP00000143267 -----------------------------------------------------MMMYIDK SINFRUP00000127701 LPVISYHVDINSIERPTSYDLVPTSPVCHKCTNQS---------------FGNVMMRIQK SINFRUP00000142186 LPIIFYRLDVISFERPTNYDPVPTSPVYHKCTNQR---------------FENLTMHIEK ENST00000216064 QELAALALKQSSVAEEVGLLPQQIQAVRDDVESQFPAWIS--QFLARGGGGRVGLLQREE ENSMUST00000046259 QELAALTLKQNSVADEVGLLPQKIQAARADVESQFPDWIR--QFLLGDRGARSGLLQRDE ENST00000297445 SELSSWRHVKTGCETVDAVQERVDVQVREMVKLLFSEDQQGGSLEQLLQRFSSQFVSKGD ENSMUST00000053259 SQLSDWQHLKTSCEQAGAR-------IQETVQLMFSEDQQGGSLEWLLEKLSSRFVSKDE ENST00000080856 EVCSIRFLFTAVSLLSLFLSAFWLGLLYLVSPLENEPKE-----MLTLSEYHERVRSQGQ ENSMUST00000038860 EICSIRFLFTAVSLLSIFLAALWWGLLYLIPPLENEPTE-----MLTLSQYHHRVHSQGQ ENST00000300429 CKLLCQKLMEKTGILLLCAFGFWMFSIHLPSKMKVWQDDSINGPLQSLRLYQEKVRHHSG ENSMUST00000028982 CKLFCQKVMEKMGLLVLCVFGFWMFSMHLPSKVEVWQDDSINGPLQSLRMYQEKVRHHTG CG18584-RA EILGFKQSTAGGSAGQLDDFDLQTWVRSMFVAKDYLEQQLLELNKRTNNNIRDEIERSSI ENST00000297325 --EEVSNLVNYVLKKLRE------------------------------------------ ENSMUST00000043377 WIGEMSNLVHYVLKKFRG------------------------------------------ SINFRUP00000143267 LQVELDDVKEKLKLNYQHPDSN-------------------------------------- SINFRUP00000127701 LQTELHYLKEKL--NYQLTDAN-------------------------------------- SINFRUP00000142186 LQTKLHSMKEKL--NYQLPNAN-------------------------------------- ENST00000216064 MQAQLRELESKILTHVAEMQGKSARE-AAASLSLTLQKEGVIGVTEEQVHHIVKQALQRY ENSMUST00000046259 MHAQLQELENKILTKMAEMQGKSARE-AAASLGQILQKEGIVGVTEEQVHRIVKQALQRY ENST00000297445 LQTMLRDLQLQILRNVTHHVSVTKQLPTSEAVVSAVSEAGASGITEAQARAIVNSALKLY ENSMUST00000053259 LQVLLHDLELKLLQNITHHITVTGQAPTSEAIVSAVNQAGISGITEAQAHIIVNNALKLY ENST00000080856 QLQQLQAELDKLHKEVSTVRAANSE-------------------------RVAKLVFQRL ENSMUST00000038860 QLQQLQAELNKLHKEVSSVRAAHSE-------------------------RVAKLVFQRL ENST00000300429 EIQDLRGSMNQLIAKLQEMEAMSDEQ------------------------KMAQKIMKMI ENSMUST00000028982 EIQDLRGSMNQLIAKLQKMEAISDEQ------------------------KMAQKIMKMI CG18584-RA LLMSDISQRLKREILLVVEAKHNESTKALKG-----------HIREEEVRQIVKTVLAIY ENST00000297325 --DQVEMADYALKSAGASIIEAGTSESYKNNKAKLYWHGIGFLNHEMPPDIIL-QPDVYP ENSMUST00000043377 --DQIQLADYALKSAGASVIEAGTSESYKNNKAKLYWHGIGFLNYEMPPDMIL-QPDVHP SINFRUP00000143267 -----FWTNFALESHGAKVDKKRSSSTYGR-IVGEKLLGIQLFSKVVPAAVIQGQHPPIP SINFRUP00000127701 -----FWTNFALESDGAKVDKKRSSSTYER-IAGEKLLGIQLFSKVVPAAVIGGQHPPIP SINFRUP00000142186 -----FWTNFALEFHGAKVYKKRSSSTYER-IAGINILGIQLFSRVVPATVIQGQHPPIP ENST00000216064 SEDRIGLADYALESGGASVISTRCSETYETKTALLSLFGIPLWYHSQSPRVIL-QPDVHP ENSMUST00000046259 SEDRIGMVDYALESGGASVISTRCSETYETKTALLSLFGIPLWYHSQSPRVIL-QPDVHP ENST00000297445 SQDKTGMVDFALESGGGSILSTRCSETYETKTALMSLFGIPLWYFSQSPRVVI-QPDIYP ENSMUST00000053259 SQDKTGMVDFALESGGGSILSTRCSETYETKTALLSLFGVPLWYFSQSPRVVI-QPDIYP ENST00000080856 NEDFVRKPDYALSSVGASIDLQKTSHDYADRNTAYFWNRFSFWNYARPPTVIL-EPHVFP ENSMUST00000038860 NEDFVRKPDYALSSVGASIDLEKTSSDYEDQNTAYFWNRLSFWNYARPPSVIL-EPDVFP ENST00000300429 HGDYIEKPDFALKSIGASIDFEHTSVTYNHEKAHSYWNWIQLWNYAQPPDVIL-EPNVTP ENSMUST00000028982 QGDYIEKPDFALKSIGASIDFEHTSATYNHDKARSYWNWIRLWNYAQPPDVIL-EPNVTP CG18584-RA DADKTGLVDFALESAGGQILSTRCTESYQTKSAQISVFGIPLWYPTNTPRVAI-SPNVQP ::**. *..: : * . . : .. : . * ENST00000297325 GKCWAFPGSQGHT------LIKLATKIIPTAVTMEHISEKVSPSGNISSAPKEFSVYGIT ENSMUST00000043377 GKCWAFPGSQGHI------LIKLARKIIPTAVTMEHISEKVSPSGNISSAPKEFSVYGVM SINFRUP00000143267 GNCWSFPGSHGNL------FIELSHTITVSNVTLDHVLKSVSPNDTIPSAPRHFTVYGLQ SINFRUP00000127701 GNCWSFPGSHGNL------FIELSHTITVSHVTLDHVLKSVSPNDTIPSAPRHFTVYGLQ SINFRUP00000142186 GNCWSFPGSHGNL------FIELSHNITVSHVTLDHVLKSVSPIDTIPSAPHHFVVYGLQ ENST00000216064 GNCWAFQGPQGFA------VVRLSARIRPTAVTLEHVPKALSPNSTISSAPKDFAIFGFD ENSMUST00000046259 GNCWAFQGPQGFA------VVRLSARIRPTAVTLEHVPKALSPNSTISSAPKDFAIFGFD ENST00000297445 GNCWAFKGSQGYL------VVRLSMMIHPAAFTLEHIPKTLSPTGNISSAPKDFAVYGLE ENSMUST00000053259 GNCWAFKGSQGYL------VVRLSMKIYPTTFTMEHIPKTLSPTGNISSAPKDFAVYGLE ENST00000080856 GNCWAFEGDQGQV------VIQLPGRVQLSDITLQHPPPSVEHTGGANSAPRDFAVFGLQ ENSMUST00000038860 GNCWAFEGDKGQV------VIRLPGHVQLSDITLQHPPPTVAHTGGASSAPRDFAVYGLQ ENST00000300429 GNCWAFEGDRGQV------TIQLAQKVYLSNLTLQHIPKTISLSGSLDTAPKDFVIYGME ENSMUST00000028982 GNCWAFASDRGQV------TIRLAQKVYLSNITLQHIPKTISLSGSLDTAPKDFVIYGLE CG18584-RA GECWAFQGFPGFLGKSRVNMLKLNSLVYVTGFTLEHIPKSLSPTGRIESAPRNFTVWGLE *:**:* . * :.* : : .*::* : . :**:.* ::*. ENST00000297325 KKCEGEEIFLGQFIYNKTGTTVQTFE-LQHAVSEYLLCVKLNIFSNWGHPKYTCLYRFRV ENSMUST00000043377 KKCEGEEIFLGQFIYNKMEATIQTFE-LQNEASESLLCVKLQILSNWGHPKYTCLYRFRV SINFRUP00000143267 S-LDDKAVHLGKFMYDLEGNPSQTFA-VKVHDSIRSKYIDLQIESNYGHADYTCLYGFRV SINFRUP00000127701 S-LDDKAVHLGKFMYDLEGNPSQTFA-VKVHDSIRSKYIDLQIESNYGHADYTCLYGFRV SINFRUP00000142186 S-LDEKAVHLGKFIYDLDGNPTQTFA-VKDHDSIPFKYVDLRIESNYGHADYTCLYGFRV ENST00000216064 EDLQQEGTLLGKFTYDQDGEPIQTFH-FQAPTMATYQVVELRILTNWGHPEYTCIYRFRV ENSMUST00000046259 EDLQQEGTLLGTFAYDQDGEPIQTFY-FQASKMATYQVVELRILTNWGHPEYTCIYRFRV ENST00000297445 NEYQEEGQLLGQFTYDQDGESLQMFQALKRPDDTAFQIVELRIFSNWGHPEYTCLYRFRV ENSMUST00000053259 TEYQEEGQPLGRFTYDQEGDSLQMFHTLERPD-QAFQIVELRVLSNWGHPEYTCLYRFRV ENST00000080856 V-YDETEVSLGKFTFDVEKSEIQTFH-LQNDPPAAFPKVKIQILSNWGHPRFTCLYRVRA ENSMUST00000038860 A-DDETEVFLGKFIFDVQKSEIQTFH-LQNDPPSAFPKVKIQILSNWGHPRFTCLYRVRA ENST00000300429 G-SPKEEVFLGAFQFQPE-NIIQMFP-LQNQPARAFSAVKVKISSNWGNPGFTCLYRVRV ENSMUST00000028982 S-LPREEVFLGAFQFQPE-NIIQTFQ-LQNLPPRSFAAVKVKISSNWGNPRFTCMYRVRV CG18584-RA QEKDQEPVLFGDYQFEDNGASLQYFAVQNLDIKRPYEIVELRIETNHGHPTYTCLYRFRV :* : :: * * : :.:.: :* *:. :**:* .*. ENST00000297325 HGTPGKHI------------- ENSMUST00000043377 HGIPSDYT------------- SINFRUP00000143267 HGRI----------------- SINFRUP00000127701 HGRI----------------- SINFRUP00000142186 HGRI----------------- ENST00000216064 HGEPAH--------------- ENSMUST00000046259 HGEPAH--------------- ENST00000297445 HGEPVK--------------- ENSMUST00000053259 HGEPIQ--------------- ENST00000080856 HGVRTSEGAEGSAQ----GPH ENSMUST00000038860 HGVRTSEWADDNATGVTGGPH ENST00000300429 HGSVAPPREQPHQNPYPKRD- ENSMUST00000028982 HGSVTPPKD-SHLEPLS---- CG18584-RA HGKPPAT-------------- **